Development Level

Tbio 145 | 10,625
Tdark 32 | 7,003
Tchem 27 | 1,890
Tclin 1 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 19 | 633
embryonic lethality prior to t... 6 | 187
embryonic lethality prior to o... 5 | 148
abnormal behavioral response t... 4 | 52
decreased total body fat amoun... 3 | 186
increased mean corpuscular hem... 3 | 93
male infertility 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal lens morphology 2 | 73
cataract 2 | 26
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased mean corpuscular hem... 2 | 34
embryonic growth retardation 2 | 28
female infertility 2 | 34
increased fasted circulating g... 2 | 68
increased mean corpuscular vol... 2 | 91
small testis 2 | 37
tremors 2 | 34
abnormal behavior 1 | 226
abnormal craniofacial morpholo... 1 | 12
abnormal embryo size 1 | 112
abnormal kidney morphology 1 | 30
abnormal motor learning 1 | 4
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased exploration in new e... 1 | 56
increased heart rate 1 | 17
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased or absent threshold ... 1 | 128
narrow eye opening 1 | 15
prenatal lethality 1 | 16
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19
shortened ST segment 1 | 9
thin tail 1 | 1
thrombocytopenia 1 | 46
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 125 | 8,484
medulloblastoma, large-cell 104 | 6,234
osteosarcoma 100 | 7,933
psoriasis 96 | 6,685
glioblastoma 94 | 5,572
lung cancer 90 | 4,466
primitive neuroectodermal tumor 80 | 3,031
non-small cell lung cancer 72 | 2,798
Breast cancer 71 | 3,094
group 3 medulloblastoma 69 | 2,254
pediatric high grade glioma 68 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 65 | 3,289
atypical teratoid / rhabdoid tumor 63 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,988
lung adenocarcinoma 58 | 2,713
invasive ductal carcinoma 55 | 2,950
adrenocortical carcinoma 53 | 1,427
malignant mesothelioma 53 | 3,162
Cancer 44 | 2,346
colon cancer 40 | 1,475
ductal carcinoma in situ 40 | 1,745
oligodendroglioma 40 | 2,849
Carcinoma 37 | 2,147
posterior fossa group A ependymoma 35 | 1,511
nasopharyngeal carcinoma 34 | 1,056
Endometriosis 32 | 535
pancreatic cancer 31 | 2,300
Atopic dermatitis 30 | 944
breast carcinoma 30 | 1,614
ependymoma 30 | 2,514
astrocytic glioma 28 | 2,241
atypical teratoid/rhabdoid tumor 28 | 1,095
Pick disease 25 | 1,893
pilocytic astrocytoma 25 | 3,086
sonic hedgehog group medulloblastoma 24 | 1,482
IGA Glomerulonephritis 23 | 454
Waldenstrons macroglobulinemia 23 | 765
Multiple myeloma 22 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
ulcerative colitis 20 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
acute quadriplegic myopathy 16 | 1,157
medulloblastoma 16 | 1,524
primary Sjogren syndrome 16 | 789
subependymal giant cell astrocytoma 16 | 2,287
Rheumatoid Arthritis 15 | 1,160
dermatomyositis 15 | 933
pituitary cancer 15 | 1,972
progressive supranuclear palsy 15 | 674
group 4 medulloblastoma 14 | 1,875
interstitial cystitis 14 | 2,299
lung carcinoma 14 | 2,844
non primary Sjogren syndrome sicca 14 | 840
juvenile dermatomyositis 13 | 1,189
Intellectual disability 11 | 573
Male infertility 11 | 170
Microcephaly 11 | 149
adult high grade glioma 11 | 2,148
Cornelia de Lange syndrome 10 | 21
Roberts syndrome 10 | 16
astrocytoma 10 | 1,493
diabetes mellitus 10 | 1,663
inflammatory breast cancer 10 | 404
Infertility 9 | 163
Peripheral Neuropathy 9 | 303
acute myeloid leukemia 9 | 780
cystic fibrosis 9 | 1,665
tuberculosis 9 | 1,557
Amyotrophic Lateral Sclerosis 8 | 431
Mammary Neoplasms 8 | 410
Prostatic Neoplasms 8 | 471
active Crohn's disease 8 | 918
cutaneous lupus erythematosus 8 | 1,056
esophageal adenocarcinoma 8 | 737
pancreatic carcinoma 8 | 567
Fanconi's anemia 7 | 50
Nijmegen breakage syndrome 7 | 23
posterior fossa group B ependymoma 7 | 1,530
tuberculosis and treatment for 6 months 7 | 686
Alzheimer's disease 6 | 644
Ataxia telangiectasia 6 | 31
Bloom syndrome 6 | 30
Melanoma 6 | 261
Neoplastic Syndromes, Hereditary 6 | 48
gastric carcinoma 6 | 832
ovarian neoplasm 6 | 97
primary pancreatic ductal adenocarcinoma 6 | 1,271
Colorectal Neoplasms 5 | 217
Down syndrome 5 | 548
Hereditary Breast and Ovarian Cancer Syndrome 5 | 14
KBG syndrome 5 | 8
Lynch syndrome 5 | 33
Schizophrenia 5 | 501
hereditary spastic paraplegia 5 | 313
non-small cell lung carcinoma 5 | 413
spina bifida 5 | 1,064
Polycystic Ovary Syndrome 4 | 332
aldosterone-producing adenoma 4 | 664
chronic rhinosinusitis 4 | 512
periodontitis 4 | 269

Tissue

Blood and immune system 204 | 17,995
Endocrine System 204 | 18,512
Female tissues 204 | 18,647
Male tissues 204 | 17,969
Nervous System 204 | 18,561
Skin and soft tissues 204 | 18,115
Urinary Tract 204 | 18,444
Cardiovascular System 203 | 17,958
Digestive Tract 203 | 18,473
Liver and Pancreas 203 | 18,136
Respiratory system 202 | 17,484

Target Family

Non-IDG 156 | 11,971
Enzyme 20 | 4,146
Kinase 12 | 634
Transcription Factor 7 | 1,400
Epigenetic 6 | 242
Transporter 2 | 473
Ion Channel 1 | 341
TF/Epigenetic 1 | 38

Compartment GO Term

GO:0000793 205 | 205
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.68837 532.8 347
Putative high mobility group protein B1-like 1 HMGB1P1 Tdark Non-IDG -3.17050 1948.8 0
Protein ELYS AHCTF1 Tbio Non-IDG -1.30356 22.8 57
Structural maintenance of chromosomes protein 1B SMC1B Tbio Non-IDG -1.26509 19.6 93
Inactive serine/threonine-protein kinase TEX14 TEX14 Tbio Kinase -0.93273 10.1 57
Spindle and kinetochore-associated protein 3 SKA3 Tbio Non-IDG -0.97327 11.7 123
Lysine-specific demethylase PHF2 PHF2 Tbio Epigenetic -0.67973 5.14 73