Development Level

Tbio 291 | 10,625
Tchem 68 | 1,890
Tclin 18 | 602
Tdark 15 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
preweaning lethality, incomple... 11 | 260
decreased body weight 8 | 174
abnormal behavior 7 | 226
decreased total body fat amoun... 7 | 186
abnormal retina morphology 6 | 100
decreased lean body mass 6 | 195
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased eosinophil cell numb... 4 | 41
improved glucose tolerance 4 | 56
increased lean body mass 4 | 107
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased circulating triglyce... 3 | 24
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal bone mineralization 2 | 55
abnormal head morphology 2 | 10
abnormal pericardium morpholog... 2 | 11
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased basophil cell number 2 | 11
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
hydrops fetalis 2 | 22
hyperactivity 2 | 108
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased mean corpuscular hem... 2 | 93
increased vertical activity 2 | 18
shortened ST segment 2 | 9
thrombocytosis 2 | 23
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal neural tube closure 1 | 37
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
decreased Ly6C high monocyte n... 1 | 18
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
female infertility 1 | 34
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 57
long tibia 1 | 13
polycystic kidney 1 | 9
prenatal lethality 1 | 16
short tibia 1 | 82
shortened PQ interval 1 | 6
small thymus 1 | 11
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 259 | 8,492
osteosarcoma 220 | 7,933
glioblastoma 197 | 5,572
medulloblastoma, large-cell 166 | 6,234
psoriasis 158 | 6,685
Cancer 150 | 2,346
lung cancer 144 | 4,473
atypical teratoid / rhabdoid tumor 141 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 125 | 3,289
pancreatic cancer 123 | 2,300
invasive ductal carcinoma 113 | 2,950
pediatric high grade glioma 112 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 111 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 111 | 2,988
pilocytic astrocytoma 111 | 3,086
non-small cell lung cancer 106 | 2,798
lung adenocarcinoma 105 | 2,714
Breast cancer 102 | 3,099
lung carcinoma 102 | 2,844
malignant mesothelioma 97 | 3,163
oligodendroglioma 94 | 2,849
primary pancreatic ductal adenocarcinoma 92 | 1,271
primitive neuroectodermal tumor 86 | 3,031
ependymoma 85 | 2,514
astrocytoma 78 | 1,493
ulcerative colitis 76 | 2,087
Carcinoma 73 | 2,147
interstitial cystitis 72 | 2,299
diabetes mellitus 71 | 1,663
juvenile dermatomyositis 71 | 1,189
group 4 medulloblastoma 70 | 1,875
acute quadriplegic myopathy 69 | 1,157
subependymal giant cell astrocytoma 69 | 2,287
tuberculosis 66 | 1,563
Multiple myeloma 63 | 1,328
astrocytic glioma 63 | 2,241
breast carcinoma 63 | 1,614
cystic fibrosis 61 | 1,670
dermatomyositis 60 | 967
colon cancer 59 | 1,475
Pick disease 55 | 1,893
ductal carcinoma in situ 55 | 1,745
sonic hedgehog group medulloblastoma 55 | 1,482
pituitary cancer 53 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
Duchenne muscular dystrophy 49 | 602
Rheumatoid Arthritis 47 | 1,171
adrenocortical carcinoma 46 | 1,427
gastric carcinoma 46 | 832
posterior fossa group A ependymoma 46 | 1,511
Waldenstrons macroglobulinemia 45 | 765
adult high grade glioma 42 | 2,148
medulloblastoma 42 | 1,524
autosomal dominant Emery-Dreifuss muscular dystrophy 41 | 499
Prostatic Neoplasms 37 | 471
group 3 medulloblastoma 36 | 2,254
Down syndrome 35 | 548
esophageal adenocarcinoma 35 | 737
spina bifida 35 | 1,064
Alzheimer's disease 31 | 644
posterior fossa group B ependymoma 31 | 1,530
Mammary Neoplasms 29 | 410
Vascular disease 28 | 281
cutaneous lupus erythematosus 28 | 1,056
active Crohn's disease 27 | 918
fibroadenoma 27 | 557
IGA Glomerulonephritis 25 | 454
Kidney disease 25 | 397
pancreatic carcinoma 25 | 567
Neoplasm Metastasis 24 | 138
atypical teratoid/rhabdoid tumor 24 | 1,095
Neoplasm Invasiveness 23 | 127
nasopharyngeal carcinoma 23 | 1,056
Stomach Neoplasms 22 | 282
mucosa-associated lymphoid tissue lymphoma 22 | 480
tuberculosis and treatment for 6 months 22 | 686
aldosterone-producing adenoma 21 | 664
primary Sjogren syndrome 21 | 789
Becker muscular dystrophy 20 | 187
acute myeloid leukemia 20 | 785
progressive supranuclear palsy 20 | 674
Atopic dermatitis 19 | 944
Hypertension 19 | 293
Mammary Neoplasms, Experimental 18 | 150
hereditary spastic paraplegia 18 | 313
non primary Sjogren syndrome sicca 18 | 840
non-small cell lung carcinoma 18 | 413
Animal Mammary Neoplasms 17 | 136
Liver carcinoma 17 | 217
gastric cancer 17 | 436
interstitial lung disease 17 | 292
Amyotrophic Lateral Sclerosis 16 | 432
Endometriosis 16 | 535
Intellectual disability 16 | 573
Leukemia, Myelocytic, Acute 16 | 113
Squamous cell carcinoma 16 | 96
Arthritis 15 | 248
Barrett's esophagus 15 | 185
COPD 15 | 116
hepatocellular carcinoma 15 | 550

Tissue

Blood and immune system 386 | 17,995
Cardiovascular System 386 | 17,958
Digestive Tract 386 | 18,473
Endocrine System 386 | 18,512
Female tissues 386 | 18,647
Liver and Pancreas 386 | 18,136
Male tissues 386 | 17,969
Nervous System 386 | 18,561
Urinary Tract 385 | 18,444
Respiratory system 384 | 17,484
Skin and soft tissues 383 | 18,115

Target Family

Non-IDG 275 | 11,969
Enzyme 72 | 4,146
Kinase 33 | 634
Transcription Factor 4 | 1,400
GPCR 3 | 408
Transporter 3 | 473
Epigenetic 1 | 242
Ion Channel 1 | 341

Compartment GO Term

Focal adhesion 392 | 392
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha PIP5K1A Tbio Kinase -0.55632 4.98 106
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -0.87211 7.62 129
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.54952 37.8 65
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.00824 98.4 170
Talin-1 TLN1 Tbio Non-IDG -1.88948 80.4 340
Talin-2 TLN2 Tbio Non-IDG -1.31287 18.3 45
Hypoxia up-regulated protein 1 HYOU1 Tbio Non-IDG -1.98190 108.3 168
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.01004 73.4 68