Development Level

Tbio 84 | 10,625
Tchem 34 | 1,890
Tclin 14 | 602
Tdark 2 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

abnormal behavior 5 | 226
abnormal bone mineralization 5 | 55
preweaning lethality, complete... 5 | 633
abnormal bone structure 4 | 131
decreased bone mineral content 4 | 157
decreased total body fat amoun... 4 | 186
increased heart weight 4 | 37
decreased body weight 3 | 174
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
hypoactivity 3 | 89
increased circulating phosphat... 3 | 24
preweaning lethality, incomple... 3 | 260
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating phosphat... 2 | 15
decreased lean body mass 2 | 195
decreased prepulse inhibition 2 | 52
enlarged spleen 2 | 26
increased CD4-positive, alpha ... 2 | 15
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
thrombocytopenia 2 | 46
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased circulating amylase ... 1 | 24
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased dendritic cell numbe... 1 | 3
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased immature NK cell num... 1 | 1
decreased kidney weight 1 | 7
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
enlarged seminal vesicle 1 | 1
hyperactivity 1 | 108
impaired righting response 1 | 19
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mature NK cell numbe... 1 | 1
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased plasmacytoid dendrit... 1 | 1
increased respiratory quotient 1 | 12
male infertility 1 | 62
small testis 1 | 37
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 80 | 7,933
ovarian cancer 76 | 8,484
medulloblastoma, large-cell 70 | 6,234
glioblastoma 60 | 5,572
Cancer 54 | 2,346
psoriasis 50 | 6,685
atypical teratoid / rhabdoid tumor 46 | 4,369
pilocytic astrocytoma 43 | 3,086
lung cancer 38 | 4,466
oligodendroglioma 38 | 2,849
lung carcinoma 37 | 2,844
subependymal giant cell astrocytoma 34 | 2,287
non-small cell lung cancer 33 | 2,798
primitive neuroectodermal tumor 33 | 3,031
invasive ductal carcinoma 32 | 2,950
pancreatic cancer 32 | 2,300
ulcerative colitis 32 | 2,087
Breast cancer 31 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
Carcinoma 28 | 2,147
interstitial cystitis 28 | 2,299
adult high grade glioma 27 | 2,148
malignant mesothelioma 27 | 3,162
ependymoma 26 | 2,514
pediatric high grade glioma 26 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,289
medulloblastoma 23 | 1,524
Pick disease 22 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
lung adenocarcinoma 22 | 2,713
astrocytoma 21 | 1,493
group 4 medulloblastoma 21 | 1,875
pituitary cancer 21 | 1,972
astrocytic glioma 20 | 2,241
ductal carcinoma in situ 19 | 1,745
group 3 medulloblastoma 19 | 2,254
tuberculosis 19 | 1,557
Blastic phase chronic myeloid leukemia 18 | 58
Chronic Myelocytic Leukemia Accelerated Phase 18 | 59
colon cancer 18 | 1,475
juvenile dermatomyositis 18 | 1,189
primary Sjogren syndrome 18 | 789
Rheumatoid Arthritis 17 | 1,160
posterior fossa group A ependymoma 17 | 1,511
Chronic phase chronic myeloid leukemia 16 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 16 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 16 | 47
breast carcinoma 15 | 1,614
cystic fibrosis 15 | 1,665
diabetes mellitus 14 | 1,663
Obesity 13 | 616
cutaneous lupus erythematosus 13 | 1,056
posterior fossa group B ependymoma 13 | 1,530
primary pancreatic ductal adenocarcinoma 13 | 1,271
Multiple myeloma 12 | 1,327
acute quadriplegic myopathy 12 | 1,157
Alzheimer's disease 10 | 644
Atopic dermatitis 10 | 944
Kidney disease 10 | 396
Schizophrenia 10 | 501
adrenocortical carcinoma 10 | 1,427
dermatomyositis 10 | 933
spina bifida 10 | 1,064
Duchenne muscular dystrophy 9 | 602
Waldenstrons macroglobulinemia 9 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
mucosa-associated lymphoid tissue lymphoma 9 | 480
pancreatic carcinoma 9 | 567
Asthma 8 | 349
Crohn's disease 8 | 304
Down syndrome 8 | 548
Epilepsy 8 | 346
Hypertension 8 | 287
IGA Glomerulonephritis 8 | 454
esophageal adenocarcinoma 8 | 737
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Chronic Lymphocytic Leukemia 7 | 242
Endometriosis 7 | 535
Intellectual disability 7 | 573
active Crohn's disease 7 | 918
non primary Sjogren syndrome sicca 7 | 840
Adenoma 6 | 165
Agammaglobulinemia 6 | 24
Amyotrophic Lateral Sclerosis 6 | 431
Cholera 6 | 33
Fibrous dysplasia 6 | 15
Hypertensive disease 6 | 193
Mammary Neoplasms 6 | 410
McCune Albright syndrome 6 | 19
Polycystic Ovary Syndrome 6 | 332
Pseudohypoparathyroidism 6 | 17
Stomach Neoplasms 6 | 282
atypical teratoid/rhabdoid tumor 6 | 1,095
chronic lymphosyte leukemia 6 | 232
fibroadenoma 6 | 557
gastric carcinoma 6 | 832
periodontitis 6 | 269
urothelial carcinoma 6 | 318
Prostatic Neoplasms 5 | 471
gastric cancer 5 | 430

Tissue

Blood and immune system 133 | 17,995
Digestive Tract 133 | 18,473
Endocrine System 133 | 18,512
Female tissues 133 | 18,647
Liver and Pancreas 133 | 18,136
Nervous System 133 | 18,561
Urinary Tract 133 | 18,444
Cardiovascular System 132 | 17,958
Male tissues 132 | 17,969
Respiratory system 131 | 17,484
Skin and soft tissues 131 | 18,115

Target Family

Non-IDG 78 | 11,971
Kinase 37 | 634
Enzyme 13 | 4,146
GPCR 3 | 406
Ion Channel 3 | 341

Compartment GO Term

Extrinsic component of cytopla... 134 | 134
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
G-protein-signaling modulator 1 GPSM1 Tbio Non-IDG -1.32467 28.6 99
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.93602 11.4 104
Regulator of G-protein signaling 16 RGS16 Tbio Non-IDG -1.59717 42.2 162
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.47805 3222.2 1533