Development Level

Tbio 1,982 | 10,625
Tchem 461 | 1,890
Tdark 282 | 7,003
Tclin 124 | 602

Collection

Eligible Ion Channel Proteins 13 | 117
Eligible Kinase Proteins 7 | 134
Eligible non-olfactory GPCR Proteins 5 | 145

IMPC Term

preweaning lethality, complete... 113 | 633
abnormal behavior 47 | 226
preweaning lethality, incomple... 44 | 260
decreased lean body mass 42 | 195
embryonic lethality prior to t... 41 | 187
decreased total body fat amoun... 36 | 186
embryonic lethality prior to o... 34 | 148
decreased bone mineral content 29 | 157
decreased grip strength 29 | 123
increased circulating alkaline... 28 | 119
increased or absent threshold ... 27 | 128
abnormal bone structure 26 | 131
enlarged heart 26 | 111
decreased body weight 25 | 174
decreased body length 23 | 108
decreased bone mineral density 23 | 126
hyperactivity 22 | 108
abnormal embryo size 21 | 112
hypoactivity 21 | 89
increased mean corpuscular vol... 21 | 91
abnormal retina morphology 20 | 100
increased mean corpuscular hem... 20 | 93
short tibia 20 | 82
decreased circulating insulin ... 19 | 75
abnormal lens morphology 17 | 73
decreased mean corpuscular vol... 16 | 50
impaired glucose tolerance 16 | 52
increased lean body mass 16 | 107
decreased circulating glucose ... 15 | 121
increased bone mineral content 15 | 92
abnormal bone mineralization 14 | 55
decreased circulating triglyce... 14 | 83
increased exploration in new e... 14 | 56
decreased circulating HDL chol... 13 | 77
decreased hemoglobin content 13 | 53
improved glucose tolerance 13 | 56
increased fasted circulating g... 13 | 68
abnormal retinal pigmentation 12 | 61
abnormal seminal vesicle morph... 12 | 47
increased blood urea nitrogen ... 12 | 44
increased grip strength 12 | 83
decreased circulating serum al... 11 | 79
decreased erythrocyte cell num... 11 | 43
decreased leukocyte cell numbe... 11 | 54
decreased startle reflex 11 | 48
abnormal QRS complex 10 | 25
abnormal heart morphology 10 | 51
decreased circulating choleste... 10 | 85
decreased threshold for audito... 10 | 32
increased circulating sodium l... 10 | 71
male infertility 10 | 62
prenatal lethality prior to he... 10 | 64
abnormal neural tube closure 9 | 37
decreased circulating alkaline... 9 | 41
decreased heart weight 9 | 44
decreased mean corpuscular hem... 9 | 34
cardiovascular system phenotyp... 8 | 35
decreased caudal vertebrae num... 8 | 49
decreased eosinophil cell numb... 8 | 41
decreased lumbar vertebrae num... 8 | 62
decreased prepulse inhibition 8 | 52
decreased rib number 8 | 59
enlarged epididymis 8 | 27
increased bone mineral density 8 | 52
increased circulating chloride... 8 | 43
increased heart weight 8 | 37
increased hematocrit 8 | 36
increased sacral vertebrae num... 8 | 62
small testis 8 | 37
abnormal cranium morphology 7 | 32
abnormal kidney morphology 7 | 30
corneal opacity 7 | 25
decreased circulating alanine ... 7 | 53
immune system phenotype 7 | 17
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 37
increased red blood cell distr... 7 | 21
increased total body fat amoun... 7 | 57
thrombocytopenia 7 | 46
abnormal body wall morphology 6 | 7
abnormal cornea morphology 6 | 24
abnormal epididymis morphology 6 | 31
abnormal skin morphology 6 | 23
abnormal sleep behavior 6 | 63
abnormal testis morphology 6 | 30
decreased circulating free fat... 6 | 39
decreased circulating glycerol... 6 | 19
decreased circulating total pr... 6 | 41
decreased fasted circulating g... 6 | 49
enlarged lymph nodes 6 | 27
enlarged spleen 6 | 26
increased body weight 6 | 42
increased circulating HDL chol... 6 | 63
increased circulating choleste... 6 | 53
increased circulating iron lev... 6 | 25
abnormal coat/hair pigmentatio... 5 | 54
abnormal gait 5 | 51
abnormal lung morphology 5 | 15
increased circulating potassiu... 5 | 31
increased circulating total pr... 5 | 20

Disease

ovarian cancer 1,582 | 8,492
psoriasis 1,241 | 6,685
osteosarcoma 1,220 | 7,933
medulloblastoma, large-cell 968 | 6,234
glioblastoma 965 | 5,572
lung cancer 949 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 700 | 3,289
Cancer 692 | 2,346
atypical teratoid / rhabdoid tumor 685 | 4,369
invasive ductal carcinoma 632 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 630 | 2,956
Breast cancer 623 | 3,099
malignant mesothelioma 622 | 3,163
pancreatic cancer 619 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 617 | 2,988
lung adenocarcinoma 599 | 2,714
non-small cell lung cancer 590 | 2,798
lung carcinoma 588 | 2,844
pilocytic astrocytoma 584 | 3,086
pediatric high grade glioma 479 | 2,712
ulcerative colitis 477 | 2,087
interstitial cystitis 475 | 2,299
oligodendroglioma 468 | 2,849
diabetes mellitus 463 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 462 | 1,795
primitive neuroectodermal tumor 455 | 3,031
subependymal giant cell astrocytoma 439 | 2,287
ependymoma 428 | 2,514
Multiple myeloma 422 | 1,328
breast carcinoma 386 | 1,614
cystic fibrosis 383 | 1,670
ductal carcinoma in situ 383 | 1,745
primary pancreatic ductal adenocarcinoma 365 | 1,271
Carcinoma 351 | 2,147
astrocytoma 349 | 1,493
tuberculosis 348 | 1,563
astrocytic glioma 343 | 2,241
pituitary cancer 342 | 1,972
colon cancer 341 | 1,475
Pick disease 333 | 1,893
adult high grade glioma 323 | 2,148
group 3 medulloblastoma 306 | 2,254
group 4 medulloblastoma 299 | 1,875
posterior fossa group A ependymoma 279 | 1,511
dermatomyositis 274 | 967
acute quadriplegic myopathy 272 | 1,157
juvenile dermatomyositis 270 | 1,189
Rheumatoid Arthritis 259 | 1,171
Waldenstrons macroglobulinemia 257 | 765
adrenocortical carcinoma 257 | 1,427
esophageal adenocarcinoma 245 | 737
sonic hedgehog group medulloblastoma 244 | 1,482
medulloblastoma 242 | 1,524
Duchenne muscular dystrophy 235 | 602
nasopharyngeal carcinoma 231 | 1,056
cutaneous lupus erythematosus 224 | 1,056
gastric carcinoma 216 | 832
Atopic dermatitis 215 | 944
spina bifida 193 | 1,064
active Crohn's disease 187 | 918
posterior fossa group B ependymoma 179 | 1,530
atypical teratoid/rhabdoid tumor 177 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 168 | 499
Kidney disease 164 | 397
Prostatic Neoplasms 158 | 471
acute myeloid leukemia 154 | 785
Down syndrome 149 | 548
non primary Sjogren syndrome sicca 149 | 840
primary Sjogren syndrome 145 | 789
Alzheimer's disease 144 | 644
Obesity 140 | 616
aldosterone-producing adenoma 129 | 664
fibroadenoma 128 | 557
mucosa-associated lymphoid tissue lymphoma 127 | 480
IGA Glomerulonephritis 126 | 454
Multiple Sclerosis 123 | 498
nephrosclerosis 120 | 329
active ulcerative colitis 119 | 477
pancreatic carcinoma 119 | 567
progressive supranuclear palsy 116 | 674
Arthritis 115 | 248
Hypersensitivity reaction type II disease 111 | 235
Endometriosis 105 | 535
non-small cell lung carcinoma 104 | 413
Anemia 102 | 252
Hypertension 102 | 293
Neurodegenerative disease 102 | 383
tuberculosis and treatment for 6 months 99 | 686
Vascular disease 98 | 281
Liver disease 96 | 219
Mammary Neoplasms 96 | 410
Atherosclerosis 95 | 275
hepatocellular carcinoma 95 | 550
Becker muscular dystrophy 93 | 187
Intellectual disability 92 | 573
Polycystic Ovary Syndrome 90 | 335
Stomach Neoplasms 90 | 282
chronic rhinosinusitis 90 | 512
Ankylosing spondylitis 89 | 138
Schizophrenia 87 | 503

Tissue

Female tissues 2,741 | 18,647
Nervous System 2,741 | 18,561
Digestive Tract 2,740 | 18,473
Urinary Tract 2,736 | 18,444
Liver and Pancreas 2,735 | 18,136
Endocrine System 2,734 | 18,512
Blood and immune system 2,731 | 17,995
Male tissues 2,729 | 17,969
Cardiovascular System 2,728 | 17,958
Respiratory system 2,712 | 17,484
Skin and soft tissues 2,696 | 18,115

Target Family

Non-IDG 1,662 | 11,969
Enzyme 932 | 4,146
Kinase 89 | 634
Transporter 82 | 473
Ion Channel 35 | 341
Transcription Factor 20 | 1,400
GPCR 14 | 408
Epigenetic 13 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Extracellular vesicle 2,849 | 2,849
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Vasorin VASN Tbio Non-IDG -1.19472 15.7 108
Latexin LXN Tbio Enzyme -2.51597 319.1 359
Signaling threshold-regulating transmembrane adapter 1 SIT1 Tdark Non-IDG -0.57897 3.19 141