Development Level

Tbio 2,677 | 10,625
Tchem 633 | 1,890
Tdark 391 | 7,003
Tclin 172 | 602

Collection

Eligible Ion Channel Proteins 13 | 117
Eligible Kinase Proteins 8 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 146 | 633
decreased lean body mass 57 | 195
preweaning lethality, incomple... 55 | 260
abnormal behavior 53 | 226
embryonic lethality prior to t... 51 | 187
decreased total body fat amoun... 48 | 186
decreased bone mineral content 43 | 157
embryonic lethality prior to o... 40 | 148
decreased body weight 38 | 174
enlarged heart 37 | 111
increased circulating alkaline... 36 | 119
abnormal bone structure 34 | 131
decreased grip strength 34 | 123
increased or absent threshold ... 32 | 128
decreased bone mineral density 30 | 126
abnormal embryo size 29 | 112
decreased body length 29 | 108
abnormal retina morphology 26 | 100
short tibia 26 | 82
increased mean corpuscular vol... 25 | 91
abnormal lens morphology 24 | 73
decreased circulating insulin ... 24 | 75
hyperactivity 24 | 108
hypoactivity 24 | 89
increased mean corpuscular hem... 23 | 93
increased lean body mass 20 | 107
decreased circulating glucose ... 19 | 121
decreased circulating triglyce... 19 | 83
decreased mean corpuscular vol... 19 | 50
impaired glucose tolerance 19 | 52
increased bone mineral content 18 | 92
abnormal heart morphology 17 | 51
abnormal seminal vesicle morph... 17 | 47
improved glucose tolerance 17 | 56
abnormal bone mineralization 16 | 55
decreased circulating HDL chol... 16 | 77
decreased hemoglobin content 16 | 53
increased exploration in new e... 16 | 56
increased grip strength 16 | 83
abnormal retinal pigmentation 15 | 61
decreased circulating serum al... 15 | 79
decreased erythrocyte cell num... 15 | 43
increased blood urea nitrogen ... 15 | 44
increased fasted circulating g... 15 | 68
decreased leukocyte cell numbe... 14 | 54
male infertility 14 | 62
decreased circulating choleste... 13 | 85
decreased heart weight 13 | 44
decreased startle reflex 13 | 48
decreased threshold for audito... 13 | 32
increased circulating sodium l... 13 | 71
abnormal QRS complex 12 | 25
abnormal cranium morphology 12 | 32
abnormal kidney morphology 12 | 30
abnormal neural tube closure 12 | 37
abnormal sleep behavior 12 | 63
decreased mean corpuscular hem... 12 | 34
increased bone mineral density 12 | 52
increased circulating HDL chol... 12 | 63
increased hematocrit 12 | 36
increased total body fat amoun... 12 | 57
prenatal lethality prior to he... 12 | 64
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating alanine ... 11 | 53
decreased circulating alkaline... 11 | 41
decreased circulating free fat... 11 | 39
decreased eosinophil cell numb... 11 | 41
decreased prepulse inhibition 11 | 52
decreased rib number 11 | 59
enlarged epididymis 11 | 27
increased heart weight 11 | 37
increased leukocyte cell numbe... 11 | 37
decreased caudal vertebrae num... 10 | 49
decreased lumbar vertebrae num... 10 | 62
increased circulating choleste... 10 | 53
increased hemoglobin content 10 | 45
abnormal epididymis morphology 9 | 31
abnormal skin morphology 9 | 23
cardiovascular system phenotyp... 9 | 35
decreased circulating total pr... 9 | 41
decreased fasted circulating g... 9 | 49
immune system phenotype 9 | 17
increased circulating chloride... 9 | 43
increased sacral vertebrae num... 9 | 62
thrombocytopenia 9 | 46
abnormal behavioral response t... 8 | 52
abnormal eye morphology 8 | 38
abnormal gait 8 | 51
abnormal tooth morphology 8 | 24
cataract 8 | 26
corneal opacity 8 | 25
enlarged spleen 8 | 26
increased body weight 8 | 42
limb grasping 8 | 35
small testis 8 | 37
abnormal cornea morphology 7 | 24
decreased circulating calcium ... 7 | 33
decreased neutrophil cell numb... 7 | 37
increased circulating potassiu... 7 | 31
increased circulating total pr... 7 | 20

Disease

ovarian cancer 2,006 | 8,484
psoriasis 1,688 | 6,685
osteosarcoma 1,589 | 7,933
glioblastoma 1,284 | 5,572
medulloblastoma, large-cell 1,259 | 6,234
lung cancer 1,257 | 4,466
Cancer 1,020 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 918 | 3,289
atypical teratoid / rhabdoid tumor 891 | 4,369
invasive ductal carcinoma 857 | 2,950
Breast cancer 848 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 842 | 2,956
malignant mesothelioma 841 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 828 | 2,988
lung adenocarcinoma 825 | 2,713
lung carcinoma 825 | 2,844
non-small cell lung cancer 821 | 2,798
pancreatic cancer 816 | 2,300
pilocytic astrocytoma 813 | 3,086
interstitial cystitis 709 | 2,299
ulcerative colitis 681 | 2,087
pediatric high grade glioma 648 | 2,712
diabetes mellitus 637 | 1,663
oligodendroglioma 617 | 2,849
primitive neuroectodermal tumor 591 | 3,031
cystic fibrosis 579 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 557 | 1,795
subependymal giant cell astrocytoma 557 | 2,287
ependymoma 531 | 2,514
breast carcinoma 526 | 1,614
ductal carcinoma in situ 525 | 1,745
Carcinoma 493 | 2,147
pituitary cancer 493 | 1,972
primary pancreatic ductal adenocarcinoma 470 | 1,271
tuberculosis 465 | 1,557
Multiple myeloma 463 | 1,327
colon cancer 461 | 1,475
adult high grade glioma 451 | 2,148
astrocytic glioma 449 | 2,241
astrocytoma 422 | 1,493
posterior fossa group A ependymoma 415 | 1,511
group 3 medulloblastoma 409 | 2,254
Pick disease 406 | 1,893
group 4 medulloblastoma 398 | 1,875
adrenocortical carcinoma 362 | 1,427
Rheumatoid Arthritis 354 | 1,160
sonic hedgehog group medulloblastoma 345 | 1,482
juvenile dermatomyositis 342 | 1,189
cutaneous lupus erythematosus 340 | 1,056
acute quadriplegic myopathy 333 | 1,157
nasopharyngeal carcinoma 321 | 1,056
Atopic dermatitis 320 | 944
esophageal adenocarcinoma 308 | 737
Duchenne muscular dystrophy 296 | 602
gastric carcinoma 291 | 832
dermatomyositis 281 | 933
medulloblastoma 281 | 1,524
Waldenstrons macroglobulinemia 278 | 765
Kidney disease 265 | 396
active Crohn's disease 259 | 918
posterior fossa group B ependymoma 254 | 1,530
spina bifida 247 | 1,064
Obesity 241 | 616
atypical teratoid/rhabdoid tumor 238 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 217 | 499
Prostatic Neoplasms 210 | 471
primary Sjogren syndrome 209 | 789
Alzheimer's disease 207 | 644
Arthritis 198 | 248
Multiple Sclerosis 195 | 498
Down syndrome 194 | 548
Atherosclerosis 192 | 275
fibroadenoma 192 | 557
non primary Sjogren syndrome sicca 191 | 840
mucosa-associated lymphoid tissue lymphoma 186 | 480
acute myeloid leukemia 180 | 780
Hypertension 172 | 287
Endometriosis 170 | 535
Mammary Neoplasms 170 | 410
Hypersensitivity reaction type II disease 169 | 235
Asthma 167 | 349
aldosterone-producing adenoma 167 | 664
Coronary artery disease 165 | 240
IGA Glomerulonephritis 161 | 454
pancreatic carcinoma 160 | 567
Vascular disease 155 | 281
active ulcerative colitis 155 | 477
nephrosclerosis 154 | 329
non-small cell lung carcinoma 153 | 413
Liver disease 149 | 219
progressive supranuclear palsy 149 | 674
Heart disease 148 | 279
Anemia 147 | 252
Cerebrovascular disease 140 | 231
Stomach Neoplasms 134 | 282
Osteoporosis 132 | 257
Polycystic Ovary Syndrome 127 | 332
Schizophrenia 126 | 501
Neurodegenerative disease 122 | 383
periodontitis 120 | 269

Tissue

Digestive Tract 3,734 | 18,473
Female tissues 3,734 | 18,647
Nervous System 3,732 | 18,561
Endocrine System 3,720 | 18,512
Urinary Tract 3,717 | 18,444
Liver and Pancreas 3,695 | 18,136
Blood and immune system 3,682 | 17,995
Cardiovascular System 3,676 | 17,958
Skin and soft tissues 3,672 | 18,115
Male tissues 3,666 | 17,969
Respiratory system 3,637 | 17,484

Target Family

Non-IDG 2,419 | 11,971
Enzyme 1,111 | 4,146
Kinase 120 | 634
Transporter 90 | 473
Transcription Factor 53 | 1,400
Ion Channel 36 | 341
GPCR 19 | 406
Epigenetic 18 | 242
Nuclear Receptor 6 | 48
oGPCR 1 | 421

Compartment GO Term

Extracellular region part 3,873 | 3,873
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788