Development Level

Tbio 1,975 | 10,625
Tchem 453 | 1,890
Tdark 282 | 7,003
Tclin 118 | 602

Collection

Ion Channel: IDG Consortium (Targets) 13 | 102
GPCR: IDG Consortium (Targets) 6 | 127
Kinase: IDG Consortium (Targets) 5 | 125
Kinase: IDG Consortium (Complete/Control) 3 | 37
GPCR: IDG Consortium (Complete/Control) 2 | 26

IMPC Phenotype

preweaning lethality, complete... 112 | 633
abnormal behavior 46 | 226
preweaning lethality, incomple... 43 | 260
decreased lean body mass 42 | 195
embryonic lethality prior to t... 41 | 187
decreased total body fat amoun... 36 | 186
embryonic lethality prior to o... 34 | 148
decreased bone mineral content 29 | 157
decreased grip strength 28 | 123
increased circulating alkaline... 28 | 119
increased or absent threshold ... 27 | 128
abnormal bone structure 26 | 131
enlarged heart 26 | 111
decreased body weight 25 | 174
decreased body length 23 | 108
decreased bone mineral density 23 | 126
abnormal embryo size 21 | 112
hyperactivity 21 | 108
hypoactivity 21 | 89
increased mean corpuscular vol... 21 | 91
abnormal retina morphology 20 | 100
increased mean corpuscular hem... 20 | 93
short tibia 20 | 82
decreased circulating insulin ... 19 | 75
abnormal lens morphology 17 | 73
decreased mean corpuscular vol... 16 | 50
impaired glucose tolerance 16 | 52
increased lean body mass 16 | 107
decreased circulating glucose ... 15 | 121
increased bone mineral content 15 | 92
abnormal bone mineralization 14 | 55
decreased circulating triglyce... 14 | 83
increased exploration in new e... 14 | 56
decreased circulating HDL chol... 13 | 77
decreased hemoglobin content 13 | 53
improved glucose tolerance 13 | 56
increased fasted circulating g... 13 | 68
abnormal retinal pigmentation 12 | 61
abnormal seminal vesicle morph... 12 | 47
increased blood urea nitrogen ... 12 | 44
increased grip strength 12 | 83
decreased circulating serum al... 11 | 79
decreased erythrocyte cell num... 11 | 43
decreased leukocyte cell numbe... 11 | 54
decreased startle reflex 11 | 48
abnormal heart morphology 10 | 51
decreased circulating choleste... 10 | 85
decreased threshold for audito... 10 | 32
increased circulating sodium l... 10 | 71
male infertility 10 | 62
prenatal lethality prior to he... 10 | 64
abnormal QRS complex 9 | 25
abnormal neural tube closure 9 | 37
decreased circulating alkaline... 9 | 41
decreased heart weight 9 | 44
decreased mean corpuscular hem... 9 | 34
cardiovascular system phenotyp... 8 | 35
decreased caudal vertebrae num... 8 | 49
decreased eosinophil cell numb... 8 | 41
decreased lumbar vertebrae num... 8 | 62
decreased prepulse inhibition 8 | 52
decreased rib number 8 | 59
enlarged epididymis 8 | 27
increased bone mineral density 8 | 52
increased circulating chloride... 8 | 43
increased heart weight 8 | 37
increased hematocrit 8 | 36
increased sacral vertebrae num... 8 | 62
small testis 8 | 37
abnormal cranium morphology 7 | 32
abnormal kidney morphology 7 | 30
corneal opacity 7 | 25
decreased circulating alanine ... 7 | 53
immune system phenotype 7 | 17
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 37
increased red blood cell distr... 7 | 21
increased total body fat amoun... 7 | 57
thrombocytopenia 7 | 46
abnormal body wall morphology 6 | 7
abnormal cornea morphology 6 | 24
abnormal epididymis morphology 6 | 31
abnormal skin morphology 6 | 23
abnormal sleep behavior 6 | 63
abnormal testis morphology 6 | 30
decreased circulating free fat... 6 | 39
decreased circulating glycerol... 6 | 19
decreased circulating total pr... 6 | 41
decreased fasted circulating g... 6 | 49
enlarged lymph nodes 6 | 27
enlarged spleen 6 | 26
increased body weight 6 | 42
increased circulating iron lev... 6 | 25
abnormal coat-hair pigmentatio... 5 | 54
abnormal gait 5 | 51
abnormal lung morphology 5 | 15
abnormal spleen morphology 5 | 36
decreased neutrophil cell numb... 5 | 37
increased circulating potassiu... 5 | 31
increased circulating total pr... 5 | 20

Disease

ovarian cancer 1,577 | 8,491
psoriasis 1,229 | 6,685
osteosarcoma 1,215 | 7,933
glioblastoma 958 | 5,572
medulloblastoma, large-cell 956 | 6,234
lung cancer 943 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 693 | 3,289
Cancer 681 | 2,346
atypical teratoid / rhabdoid tumor 676 | 4,369
invasive ductal carcinoma 627 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 625 | 2,956
malignant mesothelioma 618 | 3,163
Breast cancer 616 | 3,098
pancreatic cancer 614 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 613 | 2,988
lung adenocarcinoma 595 | 2,714
non-small cell lung cancer 585 | 2,798
lung carcinoma 581 | 2,844
pilocytic astrocytoma 574 | 3,086
interstitial cystitis 472 | 2,299
pediatric high grade glioma 471 | 2,712
ulcerative colitis 470 | 2,087
oligodendroglioma 459 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 459 | 1,795
diabetes mellitus 455 | 1,663
primitive neuroectodermal tumor 448 | 3,031
subependymal giant cell astrocytoma 434 | 2,287
Multiple myeloma 420 | 1,327
ependymoma 420 | 2,514
breast carcinoma 384 | 1,614
cystic fibrosis 380 | 1,670
ductal carcinoma in situ 380 | 1,745
primary pancreatic ductal adenocarcinoma 362 | 1,271
astrocytoma 346 | 1,493
Carcinoma 343 | 2,147
tuberculosis 342 | 1,563
colon cancer 340 | 1,475
pituitary cancer 337 | 1,972
astrocytic glioma 335 | 2,241
Pick disease 327 | 1,893
adult high grade glioma 319 | 2,148
group 3 medulloblastoma 307 | 2,254
group 4 medulloblastoma 297 | 1,875
posterior fossa group A ependymoma 275 | 1,511
dermatomyositis 273 | 966
acute quadriplegic myopathy 271 | 1,157
juvenile dermatomyositis 271 | 1,189
Waldenstrons macroglobulinemia 255 | 764
adrenocortical carcinoma 255 | 1,427
Rheumatoid Arthritis 253 | 1,170
esophageal adenocarcinoma 244 | 737
sonic hedgehog group medulloblastoma 240 | 1,482
medulloblastoma 238 | 1,524
Duchenne muscular dystrophy 233 | 602
nasopharyngeal carcinoma 230 | 1,056
cutaneous lupus erythematosus 223 | 1,056
Atopic dermatitis 215 | 944
gastric carcinoma 213 | 832
spina bifida 192 | 1,064
active Crohn's disease 187 | 918
posterior fossa group B ependymoma 176 | 1,530
atypical teratoid/rhabdoid tumor 173 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 168 | 499
Kidney disease 157 | 397
Prostatic Neoplasms 153 | 471
acute myeloid leukemia 152 | 785
non primary Sjogren syndrome sicca 149 | 840
Down syndrome 148 | 548
primary Sjogren syndrome 142 | 788
Alzheimer's disease 137 | 644
Obesity 135 | 616
aldosterone-producing adenoma 128 | 664
fibroadenoma 128 | 557
IGA Glomerulonephritis 125 | 454
mucosa-associated lymphoid tissue lymphoma 125 | 480
Multiple Sclerosis 121 | 498
active ulcerative colitis 119 | 477
nephrosclerosis 119 | 329
pancreatic carcinoma 117 | 567
progressive supranuclear palsy 116 | 674
Arthritis 112 | 248
Hypersensitivity reaction type II disease 106 | 235
non-small cell lung carcinoma 102 | 413
Endometriosis 101 | 535
Anemia 98 | 252
tuberculosis and treatment for 6 months 98 | 686
Neurodegenerative disease 97 | 383
Hypertension 96 | 293
Becker muscular dystrophy 93 | 187
Vascular disease 92 | 281
hepatocellular carcinoma 92 | 550
Intellectual disability 91 | 573
Liver disease 91 | 219
Mammary Neoplasms 91 | 410
Atherosclerosis 90 | 275
Ankylosing spondylitis 87 | 138
chronic rhinosinusitis 87 | 512
Polycystic Ovary Syndrome 86 | 334
Stomach Neoplasms 86 | 282
Schizophrenia 83 | 503

Tissue

Female tissues 2,721 | 18,646
Nervous System 2,720 | 18,560
Digestive Tract 2,719 | 18,472
Urinary Tract 2,716 | 18,443
Endocrine System 2,714 | 18,511
Liver and Pancreas 2,714 | 18,135
Blood and immune system 2,710 | 17,994
Cardiovascular System 2,708 | 17,957
Male tissues 2,708 | 17,968
Respiratory system 2,692 | 17,483
Skin and soft tissues 2,676 | 18,114

Target Family

Non-IDG 1,655 | 11,969
Enzyme 924 | 4,146
Kinase 89 | 634
Transporter 78 | 473
Ion Channel 34 | 341
Transcription Factor 19 | 1,400
GPCR 14 | 408
Epigenetic 13 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Extracellular exosome 2,828 | 2,828
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
4-hydroxy-2-oxoglutarate aldolase, mitochondrial HOGA1 Tchem Enzyme -1.32920 1.73 5
CMRF35-like molecule 2 CD300E Tbio Non-IDG -0.85912 7.41 123
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91708 86.7 133
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911