Development Level

Tbio 15 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal spleen morphology 1 | 55
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
increased mean corpuscular hem... 1 | 96
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

ovarian cancer 12 | 8,520
Carcinoma 9 | 11,493
osteosarcoma 9 | 7,950
Cancer 8 | 2,499
lung cancer 8 | 4,740
Leukoencephalopathy with vanishing white matter 7 | 20
Autosomal recessive predisposition 6 | 1,442
Big calvaria 6 | 147
Dysarthria 6 | 192
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Muscle Spasticity 6 | 195
Muscle hypotonia 6 | 571
glioblastoma 6 | 5,792
Brain hypomyelination 5 | 11
Central nervous system demyelination 5 | 28
Cessation of head growth 5 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 6
Decreased serum progesterone 5 | 5
Delusions 5 | 11
Developmental regression 5 | 95
Epilepsy 5 | 792
Forgetful 5 | 40
Gait, Unsteady 5 | 29
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Loss of developmental milestones 5 | 95
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental deterioration in childhood 5 | 95
Mood swings 5 | 77
Neurodevelopmental regression 5 | 95
OVARIOLEUKODYSTROPHY 5 | 6
Optic Atrophy 5 | 242
Personality change 5 | 23
Premature Menopause 5 | 31
Primary gonadal insufficiency 5 | 9
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Secondary physiologic amenorrhea 5 | 32
Seizures 5 | 596
Vanishing White Matter Leukodystrophy with Ovarian Failure 5 | 5
group 3 medulloblastoma 5 | 4,104
atypical teratoid / rhabdoid tumor 4 | 5,112
medulloblastoma, large-cell 4 | 6,241
psoriasis 4 | 6,694
Adenocarcinoma of lung 3 | 142
Breast Neoplasms 3 | 445
Mammary Neoplasms 3 | 425
Pick disease 3 | 1,894
adult high grade glioma 3 | 3,801
colon cancer 3 | 1,478
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
Adenocarcinoma of lung (disorder) 2 | 60
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cerebellar Ataxia 2 | 304
Kidney cancer 2 | 2,613
Lymphangioleiomyomatosis 2 | 16
Lymphoma, Mantle-Cell 2 | 11
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 2 | 12
Multiple myeloma 2 | 1,332
Neoplasm Invasiveness 2 | 161
Neurodegenerative disease 2 | 414
Renal Cell Carcinoma 2 | 214
Schizophrenia 2 | 1,160
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
Atrophic 1 | 10
Atrophy 1 | 10
Autosomal dominant cerebellar ataxia 1 | 33
Carcinoma, Renal Cell 1 | 124
Delayed myelination 1 | 22
Diphtheria 1 | 40
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Familial primary pulmonary hypertension 1 | 11
Hypertrophy, Left Ventricular 1 | 24
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Left Ventricular Hypertrophy 1 | 47
Leukemia, Myelocytic, Acute 1 | 120
Primary pulmonary hypertension 1 | 14
Vaccinia 1 | 36
Wolcott-Rallison syndrome 1 | 10

Tissue

Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678

Target Family

Non-IDG 16 | 12,091
Kinase 2 | 634
Enzyme 1 | 4,145

Compartment GO Term

Eukaryotic translation initiat... 19 | 19
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
Neuroguidin NGDN Tbio Non-IDG -2.22456 133.1 93
Elongation factor 2 EEF2 Tchem Non-IDG -2.95619 938.4 363
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
eIF-2-alpha kinase GCN2 EIF2AK4 Tchem Kinase -2.43702 276.5 301
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Translation initiation factor eIF-2B subunit gamma EIF2B3 Tbio Non-IDG -1.21999 16.3 170
Eukaryotic translation initiation factor 5 EIF5 Tbio Non-IDG -1.93055 83.2 159
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
Protein argonaute-1 AGO1 Tbio Non-IDG -2.22336 158.4 203