Development Level

Tbio 379 | 10,625
Tdark 42 | 7,003
Tchem 40 | 1,890
Tclin 9 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 23 | 633
decreased total body fat amoun... 7 | 186
hypoactivity 7 | 89
abnormal behavior 6 | 226
preweaning lethality, incomple... 6 | 260
decreased body length 5 | 108
decreased body weight 5 | 174
decreased mean corpuscular vol... 5 | 50
embryonic lethality prior to o... 5 | 148
abnormal retinal pigmentation 4 | 61
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
decreased mean corpuscular hem... 4 | 34
decreased rib number 4 | 59
embryonic lethality prior to t... 4 | 187
increased bone mineral content 4 | 92
increased circulating alkaline... 4 | 119
increased or absent threshold ... 4 | 128
abnormal kidney morphology 3 | 30
abnormal retina morphology 3 | 100
abnormal sleep behavior 3 | 63
decreased bone mineral density 3 | 126
decreased prepulse inhibition 3 | 52
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased leukocyte cell numbe... 3 | 37
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal epididymis morphology 2 | 31
abnormal lens morphology 2 | 73
abnormal vertebrae morphology 2 | 14
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
enlarged epididymis 2 | 27
hyperactivity 2 | 108
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
thrombocytosis 2 | 23
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal retinal inner nuclear... 1 | 5
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
decreased blood urea nitrogen ... 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased red blood cell distr... 1 | 11
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
increased NK cell number 1 | 19
increased bone mineral density 1 | 52
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased erythrocyte cell num... 1 | 26
polycystic kidney 1 | 9
prenatal lethality 1 | 16
shortened ST segment 1 | 9
straub tail 1 | 26

Disease

ovarian cancer 246 | 8,484
psoriasis 200 | 6,685
osteosarcoma 183 | 7,933
medulloblastoma, large-cell 171 | 6,234
glioblastoma 159 | 5,572
Cancer 130 | 2,346
atypical teratoid / rhabdoid tumor 108 | 4,369
lung cancer 106 | 4,466
diabetes mellitus 101 | 1,663
pilocytic astrocytoma 81 | 3,086
Rheumatoid Arthritis 79 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 79 | 3,289
pediatric high grade glioma 79 | 2,712
Ankylosing spondylitis 73 | 138
invasive ductal carcinoma 73 | 2,950
lung carcinoma 70 | 2,844
Hypersensitivity reaction type II disease 69 | 235
non-small cell lung cancer 69 | 2,798
oligodendroglioma 69 | 2,849
subependymal giant cell astrocytoma 68 | 2,287
Breast cancer 66 | 3,094
malignant mesothelioma 66 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 65 | 2,956
Arthritis 64 | 248
ependymoma 64 | 2,514
pancreatic cancer 63 | 2,300
Juvenile rheumatoid arthritis 61 | 104
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,988
tuberculosis 59 | 1,557
Acquired immunodeficiency syndrome 58 | 164
Uveitis 58 | 103
Behcet's disease 56 | 74
Pick disease 55 | 1,893
astrocytic glioma 55 | 2,241
Multiple myeloma 54 | 1,327
lung adenocarcinoma 54 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,795
juvenile dermatomyositis 53 | 1,189
Psoriatic arthritis 52 | 83
interstitial cystitis 52 | 2,299
primitive neuroectodermal tumor 52 | 3,031
ulcerative colitis 50 | 2,087
astrocytoma 49 | 1,493
adult high grade glioma 48 | 2,148
group 4 medulloblastoma 48 | 1,875
breast carcinoma 47 | 1,614
dermatomyositis 45 | 933
Carcinoma 42 | 2,147
Multiple Sclerosis 41 | 498
Stevens-Johnson syndrome 41 | 78
primary pancreatic ductal adenocarcinoma 41 | 1,271
ductal carcinoma in situ 40 | 1,745
medulloblastoma 39 | 1,524
cystic fibrosis 37 | 1,665
acute quadriplegic myopathy 36 | 1,157
pituitary cancer 36 | 1,972
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
posterior fossa group A ependymoma 35 | 1,511
group 3 medulloblastoma 34 | 2,254
adrenocortical carcinoma 33 | 1,427
Liver disease 32 | 219
cutaneous lupus erythematosus 32 | 1,056
Kidney disease 31 | 396
primary Sjogren syndrome 31 | 789
atypical teratoid/rhabdoid tumor 30 | 1,095
esophageal adenocarcinoma 30 | 737
Hepatitis B 29 | 103
active Crohn's disease 29 | 918
posterior fossa group B ependymoma 28 | 1,530
Anemia 27 | 252
Leprosy 27 | 77
Alzheimer's disease 26 | 644
Down syndrome 26 | 548
Waldenstrons macroglobulinemia 26 | 765
colon cancer 26 | 1,475
sonic hedgehog group medulloblastoma 26 | 1,482
Hemochromatosis 25 | 55
spina bifida 24 | 1,064
Neurodegenerative disease 23 | 383
Skin disease 23 | 65
gastric carcinoma 23 | 832
Duchenne muscular dystrophy 22 | 602
Primary immunodeficiency disease 22 | 52
fibroadenoma 21 | 557
non primary Sjogren syndrome sicca 21 | 840
progressive supranuclear palsy 21 | 674
aldosterone-producing adenoma 20 | 664
Human immunodeficiency virus infectious disease 19 | 92
acute myeloid leukemia 19 | 780
mucosa-associated lymphoid tissue lymphoma 19 | 480
IGA Glomerulonephritis 18 | 454
pancreatic carcinoma 18 | 567
tuberculosis and treatment for 6 months 18 | 686
active ulcerative colitis 16 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
hereditary spastic paraplegia 15 | 313
pre-eclampsia 15 | 67
Asthma 14 | 349

Tissue

Nervous System 399 | 18,561
Digestive Tract 398 | 18,473
Female tissues 398 | 18,647
Liver and Pancreas 398 | 18,136
Urinary Tract 398 | 18,444
Endocrine System 397 | 18,512
Male tissues 397 | 17,969
Cardiovascular System 395 | 17,958
Respiratory system 395 | 17,484
Blood and immune system 394 | 17,995
Skin and soft tissues 387 | 18,115

Target Family

Non-IDG 340 | 11,971
Enzyme 79 | 4,146
Transporter 20 | 473
Kinase 19 | 634
Ion Channel 9 | 341
GPCR 2 | 406
Transcription Factor 1 | 1,400

Compartment GO Term

Endosome membrane 470 | 470
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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