Development Level

Tbio 401 | 10,625
Tchem 49 | 1,890
Tdark 46 | 7,003
Tclin 11 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 24 | 633
decreased total body fat amoun... 9 | 186
abnormal behavior 8 | 226
hypoactivity 8 | 89
preweaning lethality, incomple... 8 | 260
decreased body length 6 | 108
decreased grip strength 6 | 123
increased bone mineral content 6 | 92
increased or absent threshold ... 6 | 128
decreased body weight 5 | 174
decreased lean body mass 5 | 195
decreased mean corpuscular hem... 5 | 34
decreased mean corpuscular vol... 5 | 50
decreased prepulse inhibition 5 | 52
embryonic lethality prior to o... 5 | 148
increased circulating alkaline... 5 | 119
abnormal kidney morphology 4 | 30
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
abnormal sleep behavior 4 | 63
decreased rib number 4 | 59
embryonic lethality prior to t... 4 | 187
increased sacral vertebrae num... 4 | 62
short tibia 4 | 82
abnormal lens morphology 3 | 73
cardiovascular system phenotyp... 3 | 35
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 75
decreased circulating serum al... 3 | 79
decreased heart weight 3 | 44
decreased lumbar vertebrae num... 3 | 62
decreased total retina thickne... 3 | 20
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
increased leukocyte cell numbe... 3 | 37
limb grasping 3 | 35
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal bone structure 2 | 131
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
abnormal retinal inner nuclear... 2 | 5
abnormal vertebrae morphology 2 | 14
absent vibrissae 2 | 14
decreased Ly6C low monocyte nu... 2 | 23
decreased NK T cell number 2 | 28
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating bilirubi... 2 | 14
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased heart rate 2 | 10
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 19
decreased monocyte cell number 2 | 28
enlarged epididymis 2 | 27
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased rib number 2 | 41
polydactyly 2 | 22
prenatal lethality prior to he... 2 | 64
thrombocytosis 2 | 23
abnormal behavioral response t... 1 | 52
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal motor capabilities/co... 1 | 4
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased red blood cell distr... 1 | 11
decreased vertical activity 1 | 22
female infertility 1 | 34
increased NK cell number 1 | 19
increased circulating iron lev... 1 | 25
increased grip strength 1 | 83
prenatal lethality 1 | 16
straub tail 1 | 26

Disease

ovarian cancer 272 | 8,484
psoriasis 211 | 6,685
osteosarcoma 202 | 7,933
medulloblastoma, large-cell 186 | 6,234
glioblastoma 172 | 5,572
Cancer 139 | 2,346
atypical teratoid / rhabdoid tumor 118 | 4,369
lung cancer 116 | 4,466
diabetes mellitus 106 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 92 | 3,289
pilocytic astrocytoma 87 | 3,086
Rheumatoid Arthritis 83 | 1,160
invasive ductal carcinoma 82 | 2,950
pediatric high grade glioma 81 | 2,712
lung carcinoma 80 | 2,844
non-small cell lung cancer 79 | 2,798
malignant mesothelioma 75 | 3,162
oligodendroglioma 75 | 2,849
subependymal giant cell astrocytoma 75 | 2,287
Ankylosing spondylitis 73 | 138
Breast cancer 73 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 73 | 2,956
pancreatic cancer 71 | 2,300
Hypersensitivity reaction type II disease 70 | 235
intraductal papillary-mucinous carcinoma (IPMC) 70 | 2,988
Arthritis 69 | 248
ependymoma 69 | 2,514
Pick disease 64 | 1,893
tuberculosis 64 | 1,557
Juvenile rheumatoid arthritis 61 | 104
lung adenocarcinoma 61 | 2,713
Multiple myeloma 60 | 1,327
astrocytic glioma 59 | 2,241
Acquired immunodeficiency syndrome 58 | 164
Uveitis 58 | 103
ulcerative colitis 58 | 2,087
interstitial cystitis 57 | 2,299
juvenile dermatomyositis 57 | 1,189
Behcet's disease 56 | 74
primitive neuroectodermal tumor 56 | 3,031
adult high grade glioma 55 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 55 | 1,795
Psoriatic arthritis 52 | 83
astrocytoma 52 | 1,493
group 4 medulloblastoma 51 | 1,875
breast carcinoma 50 | 1,614
dermatomyositis 49 | 933
Carcinoma 48 | 2,147
primary pancreatic ductal adenocarcinoma 46 | 1,271
ductal carcinoma in situ 45 | 1,745
medulloblastoma 45 | 1,524
cystic fibrosis 44 | 1,665
Multiple Sclerosis 42 | 498
acute quadriplegic myopathy 42 | 1,157
Stevens-Johnson syndrome 41 | 78
group 3 medulloblastoma 40 | 2,254
cutaneous lupus erythematosus 38 | 1,056
pituitary cancer 38 | 1,972
posterior fossa group A ependymoma 38 | 1,511
adrenocortical carcinoma 36 | 1,427
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
esophageal adenocarcinoma 34 | 737
primary Sjogren syndrome 34 | 789
Kidney disease 33 | 396
Liver disease 33 | 219
colon cancer 32 | 1,475
Alzheimer's disease 31 | 644
active Crohn's disease 31 | 918
atypical teratoid/rhabdoid tumor 30 | 1,095
Anemia 29 | 252
Hepatitis B 29 | 103
Neurodegenerative disease 29 | 383
posterior fossa group B ependymoma 29 | 1,530
Leprosy 28 | 77
Waldenstrons macroglobulinemia 28 | 765
Down syndrome 27 | 548
sonic hedgehog group medulloblastoma 27 | 1,482
spina bifida 27 | 1,064
gastric carcinoma 26 | 832
Hemochromatosis 25 | 55
Duchenne muscular dystrophy 24 | 602
non primary Sjogren syndrome sicca 24 | 840
Skin disease 23 | 65
Primary immunodeficiency disease 22 | 52
fibroadenoma 22 | 557
mucosa-associated lymphoid tissue lymphoma 22 | 480
progressive supranuclear palsy 22 | 674
IGA Glomerulonephritis 21 | 454
acute myeloid leukemia 20 | 780
aldosterone-producing adenoma 20 | 664
Human immunodeficiency virus infectious disease 19 | 92
tuberculosis and treatment for 6 months 19 | 686
hereditary spastic paraplegia 18 | 313
pancreatic carcinoma 18 | 567
Prostatic Neoplasms 17 | 471
active ulcerative colitis 16 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
pre-eclampsia 16 | 67

Tissue

Nervous System 436 | 18,561
Digestive Tract 435 | 18,473
Female tissues 435 | 18,647
Liver and Pancreas 435 | 18,136
Urinary Tract 435 | 18,444
Endocrine System 434 | 18,512
Male tissues 434 | 17,969
Cardiovascular System 432 | 17,958
Blood and immune system 431 | 17,995
Respiratory system 430 | 17,484
Skin and soft tissues 424 | 18,115

Target Family

Non-IDG 365 | 11,971
Enzyme 89 | 4,146
Kinase 21 | 634
Transporter 20 | 473
Ion Channel 9 | 341
GPCR 2 | 406
Transcription Factor 1 | 1,400

Compartment GO Term

Endosomal part 507 | 507
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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