Development Level

Tbio 27 | 10,625
Tchem 9 | 1,890
Tdark 6 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
embryonic lethality prior to t... 3 | 187
increased grip strength 3 | 83
decreased circulating insulin ... 2 | 75
embryonic lethality prior to o... 2 | 148
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased circulating choleste... 1 | 85
decreased circulating triglyce... 1 | 83
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
hyperactivity 1 | 108
increased circulating glucose ... 1 | 16
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
vertebral fusion 1 | 23

Disease

osteosarcoma 22 | 7,933
lung cancer 17 | 4,473
ovarian cancer 17 | 8,491
Cancer 16 | 2,346
psoriasis 15 | 6,685
medulloblastoma, large-cell 12 | 6,234
glioblastoma 10 | 5,572
Breast cancer 9 | 3,098
atypical teratoid / rhabdoid tumor 8 | 4,369
diabetes mellitus 8 | 1,663
group 3 medulloblastoma 8 | 2,254
Alzheimer's disease 7 | 644
Multiple myeloma 7 | 1,327
Vascular disease 7 | 281
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
malignant mesothelioma 7 | 3,163
Rheumatoid Arthritis 6 | 1,170
astrocytic glioma 6 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
non-small cell lung cancer 6 | 2,798
oligodendroglioma 6 | 2,849
Pick disease 5 | 1,893
hepatocellular carcinoma 5 | 550
lung adenocarcinoma 5 | 2,714
pancreatic cancer 5 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pituitary cancer 5 | 1,972
posterior fossa group B ependymoma 5 | 1,530
Neurodegenerative disease 4 | 383
Obesity 4 | 616
Toxic encephalopathy 4 | 131
acute myeloid leukemia 4 | 785
acute quadriplegic myopathy 4 | 1,157
adult high grade glioma 4 | 2,148
cystic fibrosis 4 | 1,670
ependymoma 4 | 2,514
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
spina bifida 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 1,563
tuberculosis and treatment for 6 months 4 | 686
Amyotrophic Lateral Sclerosis 3 | 432
Asbestosis 3 | 10
Carcinoma 3 | 2,147
Fatty liver disease 3 | 86
Intellectual disability 3 | 573
Parkinson's disease 3 | 364
Pontocerebellar hypoplasia 3 | 29
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
group 4 medulloblastoma 3 | 1,875
invasive ductal carcinoma 3 | 2,950
medulloblastoma 3 | 1,524
non primary Sjogren syndrome sicca 3 | 840
pancreatic carcinoma 3 | 567
primitive neuroectodermal tumor 3 | 3,031
ulcerative colitis 3 | 2,087
Bipolar Disorder 2 | 266
COPD 2 | 116
Chromosome 3q29 microduplication syndrome 2 | 6
Deglutition Disorders 2 | 4
DiGeorge syndrome 2 | 46
Diabetes Mellitus, Insulin-Dependent 2 | 77
Down syndrome 2 | 548
Gaucher disease type 1 2 | 171
Heart disease 2 | 279
IGA Glomerulonephritis 2 | 454
Kidney disease 2 | 397
Microcephaly 2 | 149
Movement Disorders 2 | 21
Multiple Sclerosis 2 | 498
Myocardial Infarction 2 | 126
Pontocerebellar Hypoplasia Type 2 2 | 4
Prostate cancer 2 | 172
Prostatic Neoplasms 2 | 471
Schizophrenia 2 | 503
Squamous cell carcinoma of esophagus 2 | 82
Systemic scleroderma 2 | 66
Vision Disorders 2 | 5
Waldenstrons macroglobulinemia 2 | 764
active Crohn's disease 2 | 918
adrenocortical carcinoma 2 | 1,427
astrocytoma 2 | 1,493
breast carcinoma 2 | 1,614
cutaneous lupus erythematosus 2 | 1,056
dermatomyositis 2 | 966
gastric cancer 2 | 436
hereditary spastic paraplegia 2 | 313
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
progressive supranuclear palsy 2 | 674
Barrett's esophagus 1 | 185
Melanoma 1 | 261
Nerve Degeneration 1 | 73
Pontocerebellar Hypoplasia Type 1 1 | 5
Vaccinia 1 | 37
Weight Gain 1 | 87
sarcoidosis 1 | 368

Tissue

Blood and immune system 42 | 17,994
Cardiovascular System 42 | 17,957
Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Male tissues 42 | 17,968
Nervous System 42 | 18,560
Respiratory system 42 | 17,483
Skin and soft tissues 42 | 18,114
Urinary Tract 42 | 18,443

Target Family

Enzyme 23 | 4,146
Non-IDG 11 | 11,969
Kinase 4 | 634
Transcription Factor 4 | 1,400

Compartment GO Term

Endoribonuclease complex 42 | 42
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Microprocessor complex subunit DGCR8 DGCR8 Tbio Non-IDG -2.44183 254.1 201
Inactive caspase-12 CASP12 Tbio Enzyme -2.56929 347.7 375
RISC-loading complex subunit TARBP2 TARBP2 Tbio Non-IDG -3.05298 1074.1 256
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tchem Non-IDG -2.80914 642.9 498
Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 Tchem Kinase -2.40076 210.9 439
Tripartite motif-containing protein 3 TRIM3 Tbio Non-IDG -1.41136 26.2 164
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.90188 671.8 624
Caspase-4 CASP4 Tchem Enzyme -2.15733 137.5 459
Endoplasmin HSP90B1 Tchem Non-IDG -2.74041 604.5 748
Ribonuclease P/MRP protein subunit POP5 POP5 Tdark Enzyme -1.16639 13.3 27