Development Level

Tbio 818 | 10,625
Tchem 198 | 1,890
Tdark 169 | 7,003
Tclin 45 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 59 | 633
decreased lean body mass 23 | 195
embryonic lethality prior to t... 21 | 187
preweaning lethality, incomple... 20 | 260
decreased bone mineral content 17 | 157
decreased total body fat amoun... 15 | 186
abnormal behavior 13 | 226
embryonic lethality prior to o... 13 | 148
decreased body weight 12 | 174
increased total body fat amoun... 12 | 57
abnormal embryo size 11 | 112
decreased circulating glucose ... 11 | 121
increased or absent threshold ... 11 | 128
decreased circulating choleste... 10 | 85
decreased circulating insulin ... 10 | 75
decreased circulating triglyce... 10 | 83
increased circulating alkaline... 10 | 119
decreased bone mineral density 9 | 126
decreased circulating HDL chol... 9 | 77
decreased circulating alanine ... 9 | 53
increased bone mineral content 9 | 92
abnormal retina morphology 8 | 100
abnormal retinal pigmentation 8 | 61
decreased grip strength 8 | 123
enlarged heart 8 | 111
increased grip strength 8 | 83
increased lean body mass 8 | 107
increased mean corpuscular hem... 8 | 93
abnormal gait 7 | 51
decreased mean corpuscular vol... 7 | 50
hyperactivity 7 | 108
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
abnormal testis morphology 6 | 30
decreased body length 6 | 108
decreased fasted circulating g... 6 | 49
hypoactivity 6 | 89
limb grasping 6 | 35
abnormal lens morphology 5 | 73
abnormal neural tube closure 5 | 37
decreased circulating aspartat... 5 | 27
decreased hemoglobin content 5 | 53
decreased prepulse inhibition 5 | 52
impaired glucose tolerance 5 | 52
increased circulating choleste... 5 | 53
persistence of hyaloid vascula... 5 | 22
small testis 5 | 37
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
abnormal femur morphology 4 | 14
abnormal heart morphology 4 | 51
abnormal seminal vesicle morph... 4 | 47
decreased NK T cell number 4 | 28
decreased NK cell number 4 | 16
decreased T cell number 4 | 31
decreased blood urea nitrogen ... 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased circulating serum al... 4 | 79
decreased heart weight 4 | 44
enlarged epididymis 4 | 27
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 68
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
prenatal lethality prior to he... 4 | 64
short tibia 4 | 82
abnormal QRS complex 3 | 25
abnormal coat appearance 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal hindbrain development 3 | 24
abnormal kidney morphology 3 | 30
abnormal sleep behavior 3 | 63
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased CD8-positive, alpha-... 3 | 26
decreased circulating alkaline... 3 | 41
decreased circulating free fat... 3 | 39
decreased circulating total pr... 3 | 41
decreased eosinophil cell numb... 3 | 41
decreased mean corpuscular hem... 3 | 34
decreased startle reflex 3 | 48
decreased threshold for audito... 3 | 32
hydrops fetalis 3 | 22
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating creatini... 3 | 29
increased heart weight 3 | 37
increased mean platelet volume 3 | 19
increased startle reflex 3 | 38
male infertility 3 | 62
shortened RR interval 3 | 19
thrombocytosis 3 | 23
tremors 3 | 34
vertebral fusion 3 | 23

Disease

ovarian cancer 662 | 8,492
osteosarcoma 554 | 7,933
psoriasis 481 | 6,685
glioblastoma 431 | 5,572
medulloblastoma, large-cell 415 | 6,234
lung cancer 335 | 4,473
atypical teratoid / rhabdoid tumor 314 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 284 | 3,289
pilocytic astrocytoma 273 | 3,086
invasive ductal carcinoma 241 | 2,950
Breast cancer 236 | 3,099
Cancer 227 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 225 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 222 | 2,956
pediatric high grade glioma 222 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 218 | 1,795
lung adenocarcinoma 211 | 2,714
diabetes mellitus 209 | 1,663
non-small cell lung cancer 205 | 2,798
malignant mesothelioma 203 | 3,163
pancreatic cancer 203 | 2,300
lung carcinoma 197 | 2,844
oligodendroglioma 181 | 2,849
subependymal giant cell astrocytoma 178 | 2,287
interstitial cystitis 177 | 2,299
primitive neuroectodermal tumor 175 | 3,031
ependymoma 170 | 2,514
ulcerative colitis 162 | 2,087
Pick disease 158 | 1,893
pituitary cancer 158 | 1,972
Multiple myeloma 145 | 1,328
cystic fibrosis 141 | 1,670
group 4 medulloblastoma 140 | 1,875
ductal carcinoma in situ 137 | 1,745
posterior fossa group A ependymoma 137 | 1,511
adult high grade glioma 133 | 2,148
astrocytoma 133 | 1,493
active Crohn's disease 132 | 918
astrocytic glioma 132 | 2,241
group 3 medulloblastoma 132 | 2,254
tuberculosis 132 | 1,563
Rheumatoid Arthritis 131 | 1,171
breast carcinoma 128 | 1,614
Carcinoma 112 | 2,147
primary pancreatic ductal adenocarcinoma 112 | 1,271
juvenile dermatomyositis 108 | 1,189
dermatomyositis 105 | 967
adrenocortical carcinoma 103 | 1,427
medulloblastoma 98 | 1,524
acute quadriplegic myopathy 96 | 1,157
sonic hedgehog group medulloblastoma 87 | 1,482
esophageal adenocarcinoma 82 | 737
Ankylosing spondylitis 80 | 138
colon cancer 80 | 1,475
posterior fossa group B ependymoma 77 | 1,530
Arthritis 76 | 248
Hypersensitivity reaction type II disease 75 | 235
cutaneous lupus erythematosus 75 | 1,056
gastric carcinoma 68 | 832
non primary Sjogren syndrome sicca 68 | 840
Acquired immunodeficiency syndrome 67 | 164
Obesity 66 | 616
atypical teratoid/rhabdoid tumor 66 | 1,095
nasopharyngeal carcinoma 66 | 1,056
Alzheimer's disease 65 | 644
Juvenile rheumatoid arthritis 64 | 105
Prostatic Neoplasms 64 | 471
Kidney disease 62 | 397
Atopic dermatitis 61 | 944
pancreatic carcinoma 60 | 567
spina bifida 60 | 1,064
Behcet's disease 58 | 74
Duchenne muscular dystrophy 58 | 602
Uveitis 58 | 103
Liver disease 57 | 219
Stevens-Johnson syndrome 57 | 91
primary Sjogren syndrome 56 | 789
Human immunodeficiency virus infectious disease 55 | 129
Multiple Sclerosis 55 | 498
Psoriatic arthritis 54 | 85
progressive supranuclear palsy 54 | 674
Neurodegenerative disease 53 | 383
Down syndrome 51 | 548
aldosterone-producing adenoma 51 | 664
active ulcerative colitis 50 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 50 | 499
Intellectual disability 49 | 573
acute myeloid leukemia 48 | 785
tuberculosis and treatment for 6 months 48 | 686
Waldenstrons macroglobulinemia 47 | 765
IGA Glomerulonephritis 46 | 454
Congenital adrenal hyperplasia 44 | 74
hepatocellular carcinoma 44 | 550
fibroadenoma 43 | 557
Anemia 40 | 252
Schizophrenia 40 | 503
Synovitis 40 | 72
Dermatitis 39 | 141
Nephritis 39 | 63
Vascular disease 38 | 281

Tissue

Urinary Tract 1,149 | 18,444
Digestive Tract 1,147 | 18,473
Female tissues 1,147 | 18,647
Liver and Pancreas 1,147 | 18,136
Nervous System 1,145 | 18,561
Endocrine System 1,144 | 18,512
Blood and immune system 1,143 | 17,995
Male tissues 1,137 | 17,969
Skin and soft tissues 1,136 | 18,115
Cardiovascular System 1,134 | 17,958
Respiratory system 1,128 | 17,484

Target Family

Non-IDG 648 | 11,969
Enzyme 472 | 4,146
Transporter 38 | 473
Kinase 23 | 634
Ion Channel 21 | 341
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum part 1,230 | 1,230
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.62300 6.27 55
FK506-binding protein-like FKBPL Tbio Non-IDG -1.37535 26.7 129
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Endoplasmic reticulum resident protein 44 ERP44 Tbio Non-IDG -1.45074 26.7 194
Transmembrane protein 174 TMEM174 Tdark Non-IDG -0.39794 2.90 14
Soluble calcium-activated nucleotidase 1 CANT1 Tbio Enzyme -1.42022 25.3 175
Microsomal glutathione S-transferase 2 MGST2 Tchem Enzyme -1.10891 12.3 89
Serine palmitoyltransferase 3 SPTLC3 Tbio Enzyme -1.24138 18.1 12