Development Level

Tbio 967 | 11,445
Tchem 181 | 1,598
Tdark 157 | 6,588
Tclin 54 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 85 | 979
preweaning lethality, incomple... 45 | 499
embryonic lethality prior to t... 34 | 278
embryonic lethality prior to o... 26 | 239
abnormal embryo size 24 | 220
decreased total body fat amoun... 19 | 207
increased total body fat amoun... 19 | 134
decreased bone mineral content 18 | 151
decreased lean body mass 16 | 135
increased lean body mass 16 | 172
increased startle reflex 16 | 112
abnormal behavior 14 | 298
enlarged heart 14 | 210
embryonic growth retardation 13 | 106
abnormal seminal vesicle morph... 12 | 114
decreased circulating glucose ... 12 | 126
increased circulating alkaline... 12 | 122
abnormal bone structure 11 | 187
decreased circulating HDL chol... 11 | 68
decreased circulating choleste... 11 | 93
decreased body weight 10 | 161
decreased mean corpuscular vol... 10 | 79
decreased vertical activity 10 | 208
hyperactivity 10 | 148
hypoactivity 10 | 132
increased bone mineral content 10 | 108
abnormal heart morphology 9 | 162
decreased circulating serum al... 9 | 82
increased or absent threshold ... 9 | 101
abnormal testis morphology 8 | 43
decreased blood urea nitrogen ... 8 | 51
decreased circulating insulin ... 8 | 76
decreased lymphocyte cell numb... 8 | 83
decreased prepulse inhibition 8 | 82
impaired glucose tolerance 8 | 75
abnormal gait 7 | 69
decreased bone mineral density 7 | 126
decreased circulating triglyce... 7 | 79
decreased grip strength 7 | 116
decreased hemoglobin content 7 | 68
increased blood urea nitrogen ... 7 | 48
increased circulating triglyce... 7 | 42
increased mean corpuscular vol... 7 | 92
limb grasping 7 | 41
short tibia 7 | 97
abnormal kidney morphology 6 | 65
abnormal lens morphology 6 | 81
abnormal neural tube closure 6 | 46
abnormal retina morphology 6 | 71
cataract 6 | 92
decreased body length 6 | 101
decreased circulating alanine ... 6 | 47
decreased erythrocyte cell num... 6 | 62
decreased fasted circulating g... 6 | 65
improved glucose tolerance 6 | 79
increased bone mineral density 6 | 72
increased circulating HDL chol... 6 | 80
increased circulating choleste... 6 | 66
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 76
increased grip strength 6 | 41
increased leukocyte cell numbe... 6 | 47
increased mean corpuscular hem... 6 | 96
increased monocyte cell number 6 | 63
increased prepulse inhibition 6 | 32
increased red blood cell distr... 6 | 34
small testis 6 | 58
thrombocytopenia 6 | 56
abnormal coat-hair pigmentatio... 5 | 64
abnormal eye morphology 5 | 68
abnormal femur morphology 5 | 14
abnormal joint morphology 5 | 23
abnormal sleep behavior 5 | 70
decreased circulating LDL chol... 5 | 38
decreased circulating alkaline... 5 | 46
decreased circulating amylase ... 5 | 28
decreased circulating creatini... 5 | 39
decreased circulating total pr... 5 | 49
decreased hematocrit 5 | 46
decreased mean corpuscular hem... 5 | 50
decreased red blood cell distr... 5 | 41
edema 5 | 59
increased circulating creatini... 5 | 38
increased neutrophil cell numb... 5 | 46
pallor 5 | 34
vertebral fusion 5 | 23
abnormal cranium morphology 4 | 36
abnormal epididymis morphology 4 | 42
abnormal vibrissa morphology 4 | 25
decreased circulating aspartat... 4 | 34
decreased circulating bilirubi... 4 | 19
decreased startle reflex 4 | 75
enlarged kidney 4 | 14
increased circulating amylase ... 4 | 25
increased circulating calcium ... 4 | 34
increased circulating total pr... 4 | 28
increased heart weight 4 | 62
increased mean platelet volume 4 | 45
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87

Disease

Carcinoma 860 | 11,493
ovarian cancer 734 | 8,520
osteosarcoma 609 | 7,950
psoriasis 541 | 6,694
glioblastoma 504 | 5,792
medulloblastoma, large-cell 461 | 6,241
atypical teratoid / rhabdoid tumor 409 | 5,112
lung cancer 395 | 4,740
ependymoma 360 | 4,679
Astrocytoma, Pilocytic 304 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 304 | 3,291
Breast cancer 300 | 3,578
adult high grade glioma 288 | 3,801
Cancer 271 | 2,499
invasive ductal carcinoma 269 | 2,951
group 3 medulloblastoma 262 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 262 | 1,962
malignant mesothelioma 256 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 254 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 250 | 2,989
diabetes mellitus 245 | 1,728
pancreatic cancer 244 | 2,398
lung carcinoma 233 | 2,843
lung adenocarcinoma 232 | 2,716
non-small cell lung cancer 231 | 2,890
tuberculosis 207 | 2,010
oligodendroglioma 197 | 2,850
primitive neuroectodermal tumor 196 | 3,035
interstitial cystitis 194 | 2,312
subependymal giant cell astrocytoma 192 | 2,287
Autosomal recessive predisposition 186 | 1,442
pituitary cancer 181 | 1,972
Kidney cancer 180 | 2,613
Pick disease 168 | 1,894
cystic fibrosis 168 | 1,696
astrocytic glioma 165 | 2,597
group 4 medulloblastoma 163 | 1,855
ulcerative colitis 157 | 1,819
Multiple myeloma 155 | 1,332
ductal carcinoma in situ 155 | 1,745
breast carcinoma 150 | 1,638
active Crohn's disease 143 | 922
Rheumatoid arthritis 140 | 1,191
juvenile dermatomyositis 128 | 1,187
astrocytoma 125 | 1,146
adrenocortical carcinoma 123 | 1,428
dermatomyositis 112 | 966
primary pancreatic ductal adenocarcinoma 112 | 1,109
acute quadriplegic myopathy 111 | 1,158
pediatric high grade glioma 109 | 1,064
Schizophrenia 107 | 1,160
colon cancer 100 | 1,478
esophageal adenocarcinoma 95 | 737
Epilepsy 93 | 792
Arthritis 91 | 290
Liver Cirrhosis, Experimental 89 | 769
active ulcerative colitis 89 | 764
Intellectual disability 85 | 1,016
non primary Sjogren syndrome sicca 85 | 891
cutaneous lupus erythematosus 84 | 1,057
Alzheimer's disease 83 | 658
Ankylosing spondylitis 83 | 140
gastric carcinoma 83 | 807
Obesity 82 | 678
Hypersensitivity reaction type II disease 81 | 253
nasopharyngeal carcinoma 81 | 1,058
Kidney disease 79 | 430
Duchenne muscular dystrophy 77 | 601
Liver disease 76 | 237
Prostatic Neoplasms 75 | 495
Behcet's disease 73 | 89
Atopic dermatitis 72 | 952
Acquired immunodeficiency syndrome 69 | 197
Seizures 69 | 596
Muscle hypotonia 68 | 571
Hypertension 67 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 66 | 510
Juvenile rheumatoid arthritis 65 | 111
spina bifida 65 | 1,074
Anemia 63 | 365
Multiple Sclerosis 63 | 540
Cognitive delay 61 | 608
Down syndrome 61 | 499
Global developmental delay 61 | 608
Mental and motor retardation 61 | 608
aldosterone-producing adenoma 61 | 665
pancreatic carcinoma 61 | 562
Short stature 60 | 531
Uveitis 60 | 103
Neurodegenerative disease 59 | 414
progressive supranuclear palsy 59 | 676
Heart disease 58 | 306
Melanoma 58 | 711
Stevens-Johnson syndrome 58 | 92
Dull intelligence 57 | 645
Low intelligence 57 | 645
Mental Retardation 57 | 645
Mental deficiency 57 | 645
Poor school performance 57 | 645
primary Sjogren syndrome 57 | 735

Tissue

Endocrine System 1,249 | 18,159
Digestive Tract 1,244 | 17,369
Female tissues 1,241 | 17,400
Skin and soft tissues 1,234 | 17,230
Liver and Pancreas 1,232 | 16,750
Male tissues 1,230 | 17,142
Urinary Tract 1,218 | 16,678
Blood and immune system 1,213 | 16,909
Nervous System 1,202 | 16,725
Respiratory system 1,188 | 16,393
Cardiovascular System 1,127 | 15,192

Target Family

Non-IDG 752 | 12,091
Enzyme 491 | 4,145
Transporter 38 | 473
Kinase 27 | 634
Ion Channel 23 | 344
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum part 1,359 | 1,359
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
N-terminal EF-hand calcium-binding protein 3 NECAB3 Tbio Non-IDG -0.72732 5.89 90
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150
Small integral membrane protein 14 SMIM14 Tdark Non-IDG 0.00000 1.00 84
Collagen alpha-1(XIX) chain COL19A1 Tbio Non-IDG -0.75672 6.18 137
Lipase maturation factor 2 LMF2 Tdark Enzyme -0.22185 1.90 91