Development Level

Tbio 818 | 10,625
Tchem 198 | 1,890
Tdark 169 | 7,003
Tclin 45 | 602

Collection

Kinase: IDG Consortium (Targets) 5 | 125
GPCR: IDG Consortium (Complete/Control) 1 | 26
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 59 | 633
decreased lean body mass 23 | 195
embryonic lethality prior to t... 21 | 187
preweaning lethality, incomple... 20 | 260
decreased bone mineral content 17 | 157
decreased total body fat amoun... 15 | 186
abnormal behavior 13 | 226
embryonic lethality prior to o... 13 | 148
decreased body weight 12 | 174
increased total body fat amoun... 12 | 57
abnormal embryo size 11 | 112
decreased circulating glucose ... 11 | 121
increased or absent threshold ... 11 | 128
decreased circulating choleste... 10 | 85
decreased circulating insulin ... 10 | 75
decreased circulating triglyce... 10 | 83
increased circulating alkaline... 10 | 119
decreased bone mineral density 9 | 126
decreased circulating HDL chol... 9 | 77
decreased circulating alanine ... 9 | 53
increased bone mineral content 9 | 92
abnormal retina morphology 8 | 100
abnormal retinal pigmentation 8 | 61
decreased grip strength 8 | 123
enlarged heart 8 | 111
increased grip strength 8 | 83
increased lean body mass 8 | 107
increased mean corpuscular hem... 8 | 93
abnormal gait 7 | 51
decreased mean corpuscular vol... 7 | 50
hyperactivity 7 | 108
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
abnormal testis morphology 6 | 30
decreased body length 6 | 108
decreased fasted circulating g... 6 | 49
hypoactivity 6 | 89
limb grasping 6 | 35
abnormal lens morphology 5 | 73
abnormal neural tube closure 5 | 37
decreased circulating aspartat... 5 | 27
decreased hemoglobin content 5 | 53
decreased prepulse inhibition 5 | 52
impaired glucose tolerance 5 | 52
increased circulating choleste... 5 | 53
persistence of hyaloid vascula... 5 | 22
small testis 5 | 37
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
abnormal femur morphology 4 | 14
abnormal heart morphology 4 | 51
abnormal seminal vesicle morph... 4 | 47
decreased NK T cell number 4 | 28
decreased NK cell number 4 | 16
decreased T cell number 4 | 31
decreased blood urea nitrogen ... 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased circulating serum al... 4 | 79
decreased heart weight 4 | 44
enlarged epididymis 4 | 27
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 68
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
prenatal lethality prior to he... 4 | 64
short tibia 4 | 82
abnormal QRS complex 3 | 25
abnormal coat appearance 3 | 25
abnormal coat-hair pigmentatio... 3 | 54
abnormal hindbrain development 3 | 24
abnormal kidney morphology 3 | 30
abnormal sleep behavior 3 | 63
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased CD8-positive, alpha-... 3 | 26
decreased circulating alkaline... 3 | 41
decreased circulating free fat... 3 | 39
decreased circulating total pr... 3 | 41
decreased eosinophil cell numb... 3 | 41
decreased mean corpuscular hem... 3 | 34
decreased startle reflex 3 | 48
decreased threshold for audito... 3 | 32
hydrops fetalis 3 | 22
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating creatini... 3 | 29
increased heart weight 3 | 37
increased mean platelet volume 3 | 19
increased startle reflex 3 | 38
male infertility 3 | 62
shortened RR interval 3 | 19
thrombocytosis 3 | 23
tremors 3 | 34
vertebral fusion 3 | 23

Disease

ovarian cancer 662 | 8,491
osteosarcoma 554 | 7,933
psoriasis 481 | 6,685
glioblastoma 431 | 5,572
medulloblastoma, large-cell 415 | 6,234
lung cancer 335 | 4,473
atypical teratoid / rhabdoid tumor 314 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 284 | 3,289
pilocytic astrocytoma 273 | 3,086
invasive ductal carcinoma 241 | 2,950
Breast cancer 236 | 3,098
Cancer 227 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 225 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 222 | 2,956
pediatric high grade glioma 222 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 218 | 1,795
lung adenocarcinoma 211 | 2,714
diabetes mellitus 209 | 1,663
non-small cell lung cancer 205 | 2,798
malignant mesothelioma 203 | 3,163
pancreatic cancer 203 | 2,300
lung carcinoma 197 | 2,844
oligodendroglioma 181 | 2,849
subependymal giant cell astrocytoma 178 | 2,287
interstitial cystitis 177 | 2,299
primitive neuroectodermal tumor 175 | 3,031
ependymoma 170 | 2,514
ulcerative colitis 162 | 2,087
Pick disease 158 | 1,893
pituitary cancer 158 | 1,972
Multiple myeloma 145 | 1,327
cystic fibrosis 141 | 1,670
group 4 medulloblastoma 140 | 1,875
ductal carcinoma in situ 137 | 1,745
posterior fossa group A ependymoma 137 | 1,511
adult high grade glioma 133 | 2,148
astrocytoma 133 | 1,493
active Crohn's disease 132 | 918
astrocytic glioma 132 | 2,241
group 3 medulloblastoma 132 | 2,254
tuberculosis 132 | 1,563
Rheumatoid Arthritis 131 | 1,170
breast carcinoma 128 | 1,614
Carcinoma 112 | 2,147
primary pancreatic ductal adenocarcinoma 112 | 1,271
juvenile dermatomyositis 108 | 1,189
dermatomyositis 105 | 966
adrenocortical carcinoma 103 | 1,427
medulloblastoma 98 | 1,524
acute quadriplegic myopathy 96 | 1,157
sonic hedgehog group medulloblastoma 87 | 1,482
esophageal adenocarcinoma 82 | 737
Ankylosing spondylitis 80 | 138
colon cancer 80 | 1,475
posterior fossa group B ependymoma 77 | 1,530
Arthritis 76 | 248
Hypersensitivity reaction type II disease 75 | 235
cutaneous lupus erythematosus 75 | 1,056
gastric carcinoma 68 | 832
non primary Sjogren syndrome sicca 68 | 840
Acquired immunodeficiency syndrome 67 | 164
Obesity 66 | 616
atypical teratoid/rhabdoid tumor 66 | 1,095
nasopharyngeal carcinoma 66 | 1,056
Alzheimer's disease 65 | 644
Juvenile rheumatoid arthritis 64 | 105
Prostatic Neoplasms 64 | 471
Kidney disease 62 | 397
Atopic dermatitis 61 | 944
pancreatic carcinoma 60 | 567
spina bifida 60 | 1,064
Behcet's disease 58 | 74
Duchenne muscular dystrophy 58 | 602
Uveitis 58 | 103
Liver disease 57 | 219
Stevens-Johnson syndrome 57 | 91
primary Sjogren syndrome 56 | 788
Human immunodeficiency virus infectious disease 55 | 129
Multiple Sclerosis 55 | 498
Psoriatic arthritis 54 | 85
progressive supranuclear palsy 54 | 674
Neurodegenerative disease 53 | 383
Down syndrome 51 | 548
aldosterone-producing adenoma 51 | 664
active ulcerative colitis 50 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 50 | 499
Intellectual disability 49 | 573
acute myeloid leukemia 48 | 785
tuberculosis and treatment for 6 months 48 | 686
Waldenstrons macroglobulinemia 47 | 764
IGA Glomerulonephritis 46 | 454
Congenital adrenal hyperplasia 44 | 74
hepatocellular carcinoma 44 | 550
fibroadenoma 43 | 557
Anemia 40 | 252
Schizophrenia 40 | 503
Synovitis 40 | 72
Dermatitis 39 | 141
Nephritis 39 | 63
Vascular disease 38 | 281

Tissue

Urinary Tract 1,149 | 18,443
Digestive Tract 1,147 | 18,472
Female tissues 1,147 | 18,646
Liver and Pancreas 1,147 | 18,135
Nervous System 1,145 | 18,560
Endocrine System 1,144 | 18,511
Blood and immune system 1,143 | 17,994
Male tissues 1,137 | 17,968
Skin and soft tissues 1,136 | 18,114
Cardiovascular System 1,134 | 17,957
Respiratory system 1,128 | 17,483

Target Family

Non-IDG 648 | 11,969
Enzyme 472 | 4,146
Transporter 38 | 473
Kinase 23 | 634
Ion Channel 21 | 341
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum part 1,230 | 1,230
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1 Tbio Enzyme -1.71423 54.0 77
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Folate receptor alpha FOLR1 Tchem Non-IDG -2.27944 181.4 235
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.28111 210.7 117
Putative nuclear envelope pore membrane protein POM 121B POM121B Tdark Non-IDG 0.00000 0
Transmembrane emp24 domain-containing protein 6 TMED6 Tdark Non-IDG -0.21085 1.53 63