Development Level

Tbio 775 | 11,445
Tchem 144 | 1,598
Tdark 140 | 6,588
Tclin 44 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 80 | 979
preweaning lethality, incomple... 38 | 499
embryonic lethality prior to t... 33 | 278
embryonic lethality prior to o... 26 | 239
abnormal embryo size 24 | 220
increased lean body mass 16 | 172
decreased total body fat amoun... 15 | 207
increased total body fat amoun... 15 | 134
decreased lean body mass 14 | 135
decreased bone mineral content 13 | 151
embryonic growth retardation 13 | 106
increased startle reflex 13 | 112
abnormal behavior 12 | 298
abnormal bone structure 10 | 187
decreased circulating glucose ... 9 | 126
hyperactivity 9 | 148
decreased blood urea nitrogen ... 8 | 51
decreased vertical activity 8 | 208
enlarged heart 8 | 210
hypoactivity 8 | 132
increased bone mineral content 8 | 108
increased circulating alkaline... 8 | 122
abnormal gait 7 | 69
abnormal retina morphology 7 | 71
decreased body weight 7 | 161
decreased circulating HDL chol... 7 | 68
decreased circulating choleste... 7 | 93
decreased circulating triglyce... 7 | 79
decreased mean corpuscular vol... 7 | 79
increased mean corpuscular vol... 7 | 92
increased or absent threshold ... 7 | 101
abnormal neural tube closure 6 | 46
abnormal seminal vesicle morph... 6 | 114
abnormal testis morphology 6 | 43
decreased bone mineral density 6 | 126
decreased circulating insulin ... 6 | 76
decreased circulating serum al... 6 | 82
decreased fasted circulating g... 6 | 65
decreased prepulse inhibition 6 | 82
increased leukocyte cell numbe... 6 | 47
increased mean corpuscular hem... 6 | 96
increased prepulse inhibition 6 | 32
thrombocytopenia 6 | 56
abnormal lens morphology 5 | 81
cataract 5 | 92
decreased circulating alanine ... 5 | 47
decreased circulating alkaline... 5 | 46
decreased grip strength 5 | 116
decreased hemoglobin content 5 | 68
decreased lymphocyte cell numb... 5 | 83
improved glucose tolerance 5 | 79
increased bone mineral density 5 | 72
increased circulating sodium l... 5 | 71
increased grip strength 5 | 41
increased red blood cell distr... 5 | 34
limb grasping 5 | 41
pallor 5 | 34
small testis 5 | 58
abnormal epididymis morphology 4 | 42
abnormal heart morphology 4 | 162
abnormal joint morphology 4 | 23
abnormal kidney morphology 4 | 65
abnormal pericardium morpholog... 4 | 26
abnormal sleep behavior 4 | 70
abnormal vibrissa morphology 4 | 25
decreased circulating LDL chol... 4 | 38
decreased circulating phosphat... 4 | 27
decreased erythrocyte cell num... 4 | 62
decreased red blood cell distr... 4 | 41
edema 4 | 59
enlarged epididymis 4 | 31
impaired glucose tolerance 4 | 75
increased blood urea nitrogen ... 4 | 48
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
increased circulating creatini... 4 | 38
increased fasted circulating g... 4 | 76
increased mean platelet volume 4 | 45
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
syndactyly 4 | 23
vertebral fusion 4 | 23
abnormal coat-hair pigmentatio... 3 | 64
abnormal eye morphology 3 | 68
abnormal limb bud morphology 3 | 17
decreased circulating creatini... 3 | 39
decreased eosinophil cell numb... 3 | 24
decreased hematocrit 3 | 46
impaired pupillary reflex 3 | 26
increased anti-nuclear antigen... 3 | 19
increased circulating amylase ... 3 | 25
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
pale yolk sac 3 | 25

Disease

Carcinoma 669 | 11,493
ovarian cancer 583 | 8,520
osteosarcoma 502 | 7,950
psoriasis 427 | 6,694
glioblastoma 390 | 5,792
medulloblastoma, large-cell 373 | 6,241
atypical teratoid / rhabdoid tumor 313 | 5,112
lung cancer 298 | 4,740
ependymoma 279 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 237 | 3,291
Breast cancer 226 | 3,578
adult high grade glioma 225 | 3,801
Astrocytoma, Pilocytic 222 | 3,081
group 3 medulloblastoma 215 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 212 | 1,962
Cancer 207 | 2,499
invasive ductal carcinoma 204 | 2,951
diabetes mellitus 185 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 184 | 2,955
malignant mesothelioma 184 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 181 | 2,989
lung carcinoma 174 | 2,843
non-small cell lung cancer 172 | 2,890
tuberculosis 170 | 2,010
lung adenocarcinoma 168 | 2,716
pancreatic cancer 166 | 2,398
oligodendroglioma 159 | 2,850
primitive neuroectodermal tumor 148 | 3,035
subependymal giant cell astrocytoma 147 | 2,287
interstitial cystitis 145 | 2,312
astrocytic glioma 139 | 2,597
Pick disease 136 | 1,894
Multiple myeloma 135 | 1,332
pituitary cancer 133 | 1,972
Autosomal recessive predisposition 130 | 1,442
group 4 medulloblastoma 129 | 1,855
Kidney cancer 123 | 2,613
Rheumatoid arthritis 120 | 1,191
cystic fibrosis 115 | 1,696
ductal carcinoma in situ 114 | 1,745
active Crohn's disease 112 | 922
breast carcinoma 109 | 1,638
ulcerative colitis 108 | 1,819
astrocytoma 101 | 1,146
dermatomyositis 91 | 966
juvenile dermatomyositis 90 | 1,187
adrenocortical carcinoma 87 | 1,428
acute quadriplegic myopathy 85 | 1,158
Schizophrenia 84 | 1,160
Epilepsy 81 | 792
pediatric high grade glioma 81 | 1,064
Ankylosing spondylitis 80 | 140
Arthritis 76 | 290
Intellectual disability 75 | 1,016
Behcet's disease 73 | 89
Hypersensitivity reaction type II disease 73 | 253
colon cancer 73 | 1,478
active ulcerative colitis 71 | 764
primary pancreatic ductal adenocarcinoma 68 | 1,109
Alzheimer's disease 66 | 658
cutaneous lupus erythematosus 66 | 1,057
esophageal adenocarcinoma 66 | 737
non primary Sjogren syndrome sicca 66 | 891
Acquired immunodeficiency syndrome 64 | 197
Juvenile rheumatoid arthritis 64 | 111
Prostatic Neoplasms 60 | 495
spina bifida 59 | 1,074
Uveitis 58 | 103
Obesity 57 | 678
Herpes zoster 56 | 68
Human immunodeficiency virus infectious disease 56 | 138
Seizures 56 | 596
Stevens-Johnson syndrome 56 | 92
Liver Cirrhosis, Experimental 55 | 769
Psoriatic arthritis 55 | 86
Muscle hypotonia 54 | 571
Atopic dermatitis 52 | 952
Liver disease 52 | 237
Neurodegenerative disease 51 | 414
Anemia 50 | 365
Dull intelligence 50 | 645
Low intelligence 50 | 645
Mental Retardation 50 | 645
Mental deficiency 50 | 645
Multiple Sclerosis 50 | 540
Poor school performance 50 | 645
pancreatic carcinoma 50 | 562
Cognitive delay 49 | 608
Global developmental delay 49 | 608
Mental and motor retardation 49 | 608
acute myeloid leukemia 49 | 783
progressive supranuclear palsy 49 | 676
nasopharyngeal carcinoma 48 | 1,058
Down syndrome 47 | 499
Kidney disease 47 | 430
aldosterone-producing adenoma 47 | 665
Waldenstrons macroglobulinemia 46 | 765
Hypertension 45 | 396
primary Sjogren syndrome 45 | 735
Bipolar Disorder 44 | 666

Tissue

Endocrine System 1,000 | 18,159
Digestive Tract 999 | 17,369
Female tissues 994 | 17,400
Skin and soft tissues 994 | 17,230
Liver and Pancreas 988 | 16,750
Male tissues 986 | 17,142
Urinary Tract 977 | 16,678
Blood and immune system 976 | 16,909
Nervous System 965 | 16,725
Respiratory system 958 | 16,393
Cardiovascular System 911 | 15,192

Target Family

Non-IDG 566 | 12,091
Enzyme 421 | 4,145
Transporter 39 | 473
Kinase 26 | 634
Ion Channel 23 | 344
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum membrane 1,103 | 1,103
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
N-terminal EF-hand calcium-binding protein 3 NECAB3 Tbio Non-IDG -0.72732 5.89 90
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150
Small integral membrane protein 14 SMIM14 Tdark Non-IDG 0.00000 1.00 84
Lipase maturation factor 2 LMF2 Tdark Enzyme -0.22185 1.90 91
Choline-phosphate cytidylyltransferase B PCYT1B Tbio Enzyme -1.46937 28.8 40