Development Level

Tbio 703 | 10,625
Tchem 165 | 1,890
Tdark 152 | 7,003
Tclin 42 | 602

Collection

Kinase: IDG Consortium (Targets) 5 | 125
GPCR: IDG Consortium (Complete/Control) 1 | 26
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 56 | 633
decreased lean body mass 20 | 195
embryonic lethality prior to t... 20 | 187
preweaning lethality, incomple... 17 | 260
decreased bone mineral content 15 | 157
decreased total body fat amoun... 13 | 186
embryonic lethality prior to o... 13 | 148
abnormal behavior 11 | 226
increased total body fat amoun... 11 | 57
abnormal embryo size 10 | 112
decreased body weight 10 | 174
decreased circulating choleste... 10 | 85
decreased circulating glucose ... 10 | 121
abnormal retina morphology 9 | 100
decreased circulating alanine ... 9 | 53
decreased circulating triglyce... 9 | 83
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 77
decreased circulating insulin ... 8 | 75
increased circulating alkaline... 8 | 119
increased lean body mass 8 | 107
increased mean corpuscular hem... 8 | 93
increased or absent threshold ... 8 | 128
abnormal gait 7 | 51
abnormal retinal pigmentation 7 | 61
hyperactivity 7 | 108
increased bone mineral content 7 | 92
increased grip strength 7 | 83
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
decreased fasted circulating g... 6 | 49
decreased mean corpuscular vol... 6 | 50
abnormal neural tube closure 5 | 37
abnormal testis morphology 5 | 30
decreased circulating aspartat... 5 | 27
decreased grip strength 5 | 123
decreased prepulse inhibition 5 | 52
enlarged heart 5 | 111
hypoactivity 5 | 89
limb grasping 5 | 35
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
abnormal lens morphology 4 | 73
decreased NK T cell number 4 | 28
decreased NK cell number 4 | 16
decreased T cell number 4 | 31
decreased blood urea nitrogen ... 4 | 31
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased heart weight 4 | 44
enlarged epididymis 4 | 27
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
persistence of hyaloid vascula... 4 | 22
prenatal lethality prior to he... 4 | 64
small testis 4 | 37
abnormal QRS complex 3 | 25
abnormal coat appearance 3 | 25
abnormal coat-hair pigmentatio... 3 | 54
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal seminal vesicle morph... 3 | 47
abnormal sleep behavior 3 | 63
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased CD8-positive, alpha-... 3 | 26
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating free fat... 3 | 39
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased hemoglobin content 3 | 53
decreased threshold for audito... 3 | 32
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased T cell number 3 | 15
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased mean platelet volume 3 | 19
increased rib number 3 | 41
increased startle reflex 3 | 38
male infertility 3 | 62
shortened RR interval 3 | 19
vertebral fusion 3 | 23
decreased caudal vertebrae num... 2 | 49
decreased circulating glycerol... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased vertical activity 2 | 22
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
thrombocytosis 2 | 23

Disease

ovarian cancer 558 | 8,491
osteosarcoma 478 | 7,933
psoriasis 414 | 6,685
medulloblastoma, large-cell 360 | 6,234
glioblastoma 358 | 5,572
lung cancer 279 | 4,473
atypical teratoid / rhabdoid tumor 261 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 233 | 3,289
pilocytic astrocytoma 216 | 3,086
invasive ductal carcinoma 201 | 2,950
Breast cancer 194 | 3,098
Cancer 193 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 193 | 1,795
intraductal papillary-mucinous adenoma (IPMA) 179 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,988
diabetes mellitus 177 | 1,663
pediatric high grade glioma 173 | 2,712
lung carcinoma 168 | 2,844
malignant mesothelioma 168 | 3,163
non-small cell lung cancer 167 | 2,798
lung adenocarcinoma 164 | 2,714
oligodendroglioma 157 | 2,849
pancreatic cancer 157 | 2,300
ependymoma 154 | 2,514
subependymal giant cell astrocytoma 147 | 2,287
interstitial cystitis 143 | 2,299
primitive neuroectodermal tumor 142 | 3,031
Pick disease 134 | 1,893
ulcerative colitis 130 | 2,087
pituitary cancer 128 | 1,972
Multiple myeloma 127 | 1,327
group 4 medulloblastoma 125 | 1,875
adult high grade glioma 123 | 2,148
astrocytic glioma 123 | 2,241
Rheumatoid Arthritis 121 | 1,170
group 3 medulloblastoma 115 | 2,254
ductal carcinoma in situ 113 | 1,745
tuberculosis 113 | 1,563
cystic fibrosis 112 | 1,670
astrocytoma 111 | 1,493
active Crohn's disease 109 | 918
breast carcinoma 105 | 1,614
posterior fossa group A ependymoma 104 | 1,511
dermatomyositis 94 | 966
adrenocortical carcinoma 86 | 1,427
juvenile dermatomyositis 86 | 1,189
medulloblastoma 82 | 1,524
acute quadriplegic myopathy 80 | 1,157
primary pancreatic ductal adenocarcinoma 79 | 1,271
Ankylosing spondylitis 77 | 138
Carcinoma 77 | 2,147
Arthritis 70 | 248
Hypersensitivity reaction type II disease 70 | 235
colon cancer 66 | 1,475
posterior fossa group B ependymoma 66 | 1,530
esophageal adenocarcinoma 65 | 737
Juvenile rheumatoid arthritis 64 | 105
Acquired immunodeficiency syndrome 63 | 164
cutaneous lupus erythematosus 63 | 1,056
sonic hedgehog group medulloblastoma 63 | 1,482
non primary Sjogren syndrome sicca 60 | 840
Alzheimer's disease 58 | 644
Behcet's disease 58 | 74
Stevens-Johnson syndrome 57 | 91
Uveitis 57 | 103
spina bifida 57 | 1,064
Human immunodeficiency virus infectious disease 55 | 129
Obesity 54 | 616
Prostatic Neoplasms 54 | 471
Psoriatic arthritis 54 | 85
atypical teratoid/rhabdoid tumor 54 | 1,095
Atopic dermatitis 53 | 944
pancreatic carcinoma 52 | 567
Multiple Sclerosis 51 | 498
Neurodegenerative disease 48 | 383
Intellectual disability 46 | 573
Liver disease 46 | 219
acute myeloid leukemia 46 | 785
aldosterone-producing adenoma 46 | 664
progressive supranuclear palsy 46 | 674
tuberculosis and treatment for 6 months 46 | 686
Down syndrome 45 | 548
active ulcerative colitis 45 | 477
gastric carcinoma 45 | 832
nasopharyngeal carcinoma 45 | 1,056
primary Sjogren syndrome 45 | 788
Congenital adrenal hyperplasia 44 | 74
Kidney disease 44 | 397
Waldenstrons macroglobulinemia 43 | 764
IGA Glomerulonephritis 40 | 454
Dermatitis 39 | 141
Nephritis 39 | 63
Duchenne muscular dystrophy 38 | 602
Schizophrenia 38 | 503
Synovitis 38 | 72
hepatocellular carcinoma 38 | 550
Anemia 37 | 252
Behcet's syndrome 37 | 50
drug-induced hepatitis 36 | 44
Heart disease 35 | 279

Tissue

Urinary Tract 983 | 18,443
Liver and Pancreas 982 | 18,135
Digestive Tract 981 | 18,472
Female tissues 981 | 18,646
Nervous System 979 | 18,560
Blood and immune system 978 | 17,994
Endocrine System 978 | 18,511
Male tissues 972 | 17,968
Cardiovascular System 971 | 17,957
Skin and soft tissues 971 | 18,114
Respiratory system 966 | 17,483

Target Family

Non-IDG 537 | 11,969
Enzyme 414 | 4,146
Transporter 39 | 473
Ion Channel 22 | 341
Kinase 22 | 634
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum membrane 1,062 | 1,062
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1 Tbio Enzyme -1.71423 54.0 77
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Folate receptor alpha FOLR1 Tchem Non-IDG -2.27944 181.4 235
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.28111 210.7 117
Putative nuclear envelope pore membrane protein POM 121B POM121B Tdark Non-IDG 0.00000 0
Transmembrane emp24 domain-containing protein 6 TMED6 Tdark Non-IDG -0.21085 1.53 63
Serine protease hepsin HPN Tchem Enzyme -2.46640 312.3 106