Development Level

Tbio 703 | 10,625
Tchem 165 | 1,890
Tdark 152 | 7,003
Tclin 42 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 56 | 633
decreased lean body mass 20 | 195
embryonic lethality prior to t... 20 | 187
preweaning lethality, incomple... 17 | 260
decreased bone mineral content 15 | 157
decreased total body fat amoun... 13 | 186
embryonic lethality prior to o... 13 | 148
abnormal behavior 11 | 226
increased total body fat amoun... 11 | 57
abnormal embryo size 10 | 112
decreased body weight 10 | 174
decreased circulating choleste... 10 | 85
decreased circulating glucose ... 10 | 121
abnormal retina morphology 9 | 100
decreased circulating alanine ... 9 | 53
decreased circulating triglyce... 9 | 83
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 77
decreased circulating insulin ... 8 | 75
increased circulating alkaline... 8 | 119
increased lean body mass 8 | 107
increased mean corpuscular hem... 8 | 93
increased or absent threshold ... 8 | 128
abnormal gait 7 | 51
abnormal retinal pigmentation 7 | 61
hyperactivity 7 | 108
increased bone mineral content 7 | 92
increased grip strength 7 | 83
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
decreased fasted circulating g... 6 | 49
decreased mean corpuscular vol... 6 | 50
abnormal neural tube closure 5 | 37
abnormal testis morphology 5 | 30
decreased circulating aspartat... 5 | 27
decreased grip strength 5 | 123
decreased prepulse inhibition 5 | 52
enlarged heart 5 | 111
hypoactivity 5 | 89
limb grasping 5 | 35
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
abnormal lens morphology 4 | 73
decreased NK T cell number 4 | 28
decreased NK cell number 4 | 16
decreased T cell number 4 | 31
decreased blood urea nitrogen ... 4 | 31
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased heart weight 4 | 44
enlarged epididymis 4 | 27
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
persistence of hyaloid vascula... 4 | 22
prenatal lethality prior to he... 4 | 64
small testis 4 | 37
abnormal QRS complex 3 | 25
abnormal coat appearance 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal seminal vesicle morph... 3 | 47
abnormal sleep behavior 3 | 63
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased CD8-positive, alpha-... 3 | 26
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating free fat... 3 | 39
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased hemoglobin content 3 | 53
decreased threshold for audito... 3 | 32
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased T cell number 3 | 15
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased mean platelet volume 3 | 19
increased rib number 3 | 41
increased startle reflex 3 | 38
male infertility 3 | 62
shortened RR interval 3 | 19
vertebral fusion 3 | 23
decreased caudal vertebrae num... 2 | 49
decreased circulating glycerol... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased vertical activity 2 | 22
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
thrombocytosis 2 | 23

Disease

ovarian cancer 558 | 8,484
osteosarcoma 478 | 7,933
psoriasis 414 | 6,685
medulloblastoma, large-cell 360 | 6,234
glioblastoma 358 | 5,572
lung cancer 278 | 4,466
atypical teratoid / rhabdoid tumor 261 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 233 | 3,289
pilocytic astrocytoma 216 | 3,086
invasive ductal carcinoma 201 | 2,950
Breast cancer 194 | 3,094
Cancer 193 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 193 | 1,795
intraductal papillary-mucinous adenoma (IPMA) 179 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,988
diabetes mellitus 177 | 1,663
pediatric high grade glioma 173 | 2,712
lung carcinoma 168 | 2,844
malignant mesothelioma 168 | 3,162
non-small cell lung cancer 167 | 2,798
lung adenocarcinoma 164 | 2,713
oligodendroglioma 157 | 2,849
pancreatic cancer 157 | 2,300
ependymoma 154 | 2,514
subependymal giant cell astrocytoma 147 | 2,287
interstitial cystitis 143 | 2,299
primitive neuroectodermal tumor 142 | 3,031
Pick disease 134 | 1,893
ulcerative colitis 130 | 2,087
pituitary cancer 128 | 1,972
Multiple myeloma 127 | 1,327
group 4 medulloblastoma 125 | 1,875
adult high grade glioma 123 | 2,148
astrocytic glioma 123 | 2,241
Rheumatoid Arthritis 121 | 1,160
group 3 medulloblastoma 115 | 2,254
ductal carcinoma in situ 113 | 1,745
tuberculosis 112 | 1,557
astrocytoma 111 | 1,493
cystic fibrosis 111 | 1,665
active Crohn's disease 109 | 918
breast carcinoma 105 | 1,614
posterior fossa group A ependymoma 104 | 1,511
adrenocortical carcinoma 86 | 1,427
juvenile dermatomyositis 86 | 1,189
medulloblastoma 82 | 1,524
acute quadriplegic myopathy 80 | 1,157
primary pancreatic ductal adenocarcinoma 79 | 1,271
Ankylosing spondylitis 77 | 138
Carcinoma 77 | 2,147
Arthritis 70 | 248
Hypersensitivity reaction type II disease 70 | 235
colon cancer 66 | 1,475
posterior fossa group B ependymoma 66 | 1,530
esophageal adenocarcinoma 65 | 737
Juvenile rheumatoid arthritis 64 | 104
Acquired immunodeficiency syndrome 63 | 164
cutaneous lupus erythematosus 63 | 1,056
sonic hedgehog group medulloblastoma 63 | 1,482
dermatomyositis 60 | 933
non primary Sjogren syndrome sicca 60 | 840
Alzheimer's disease 58 | 644
Behcet's disease 58 | 74
Uveitis 57 | 103
spina bifida 57 | 1,064
Obesity 54 | 616
Prostatic Neoplasms 54 | 471
Psoriatic arthritis 54 | 83
atypical teratoid/rhabdoid tumor 54 | 1,095
Atopic dermatitis 53 | 944
pancreatic carcinoma 52 | 567
Multiple Sclerosis 51 | 498
Neurodegenerative disease 48 | 383
Intellectual disability 46 | 573
Liver disease 46 | 219
acute myeloid leukemia 46 | 780
aldosterone-producing adenoma 46 | 664
progressive supranuclear palsy 46 | 674
tuberculosis and treatment for 6 months 46 | 686
Down syndrome 45 | 548
active ulcerative colitis 45 | 477
gastric carcinoma 45 | 832
nasopharyngeal carcinoma 45 | 1,056
primary Sjogren syndrome 45 | 789
Congenital adrenal hyperplasia 44 | 74
Kidney disease 44 | 396
Stevens-Johnson syndrome 44 | 78
Waldenstrons macroglobulinemia 43 | 765
IGA Glomerulonephritis 40 | 454
Duchenne muscular dystrophy 38 | 602
Schizophrenia 38 | 501
Anemia 37 | 252
hepatocellular carcinoma 37 | 532
Heart disease 35 | 279
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
Peripheral Neuropathy 33 | 303
autosomal dominant Emery-Dreifuss muscular dystrophy 33 | 499
Asthma 32 | 349
Endometriosis 32 | 535

Tissue

Urinary Tract 983 | 18,444
Liver and Pancreas 982 | 18,136
Digestive Tract 981 | 18,473
Female tissues 981 | 18,647
Nervous System 979 | 18,561
Blood and immune system 978 | 17,995
Endocrine System 978 | 18,512
Male tissues 972 | 17,969
Cardiovascular System 971 | 17,958
Skin and soft tissues 971 | 18,115
Respiratory system 966 | 17,484

Target Family

Non-IDG 537 | 11,971
Enzyme 414 | 4,146
Transporter 39 | 473
Ion Channel 22 | 341
Kinase 22 | 634
Transcription Factor 21 | 1,400
GPCR 5 | 406
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum membrane 1,062 | 1,062
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Protein FAM69C FAM69C Tdark Non-IDG 0.27 0.39 3
Vacuolar ATPase assembly integral membrane protein VMA21 VMA21 Tbio Enzyme 1.00 53
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.17754 15.9 54
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3
Transmembrane 6 superfamily member 2 TM6SF2 Tbio Non-IDG -1.59935 44.0 21
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0