Development Level

Tbio 1,095 | 10,625
Tchem 255 | 1,890
Tdark 239 | 7,003
Tclin 74 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 72 | 633
preweaning lethality, incomple... 28 | 260
decreased lean body mass 27 | 195
embryonic lethality prior to t... 24 | 187
decreased bone mineral content 23 | 157
decreased total body fat amoun... 20 | 186
decreased body weight 18 | 174
abnormal behavior 17 | 226
decreased bone mineral density 16 | 126
decreased circulating HDL chol... 15 | 77
decreased circulating choleste... 15 | 85
decreased grip strength 15 | 123
decreased circulating glucose ... 14 | 121
embryonic lethality prior to o... 14 | 148
increased circulating alkaline... 14 | 119
increased lean body mass 14 | 107
abnormal embryo size 13 | 112
increased or absent threshold ... 13 | 128
increased bone mineral content 12 | 92
increased total body fat amoun... 12 | 57
abnormal bone structure 11 | 131
abnormal retina morphology 11 | 100
abnormal retinal pigmentation 11 | 61
decreased circulating alanine ... 11 | 53
decreased circulating insulin ... 11 | 75
decreased circulating triglyce... 11 | 83
hypoactivity 11 | 89
increased grip strength 11 | 83
increased mean corpuscular hem... 11 | 93
abnormal gait 10 | 51
enlarged heart 10 | 111
hyperactivity 10 | 108
decreased fasted circulating g... 9 | 49
decreased circulating serum al... 8 | 79
impaired glucose tolerance 8 | 52
increased circulating choleste... 8 | 53
increased mean corpuscular vol... 8 | 91
limb grasping 8 | 35
thrombocytopenia 8 | 46
abnormal lens morphology 7 | 73
decreased mean corpuscular vol... 7 | 50
increased bone mineral density 7 | 52
increased hemoglobin content 7 | 45
short tibia 7 | 82
abnormal neural tube closure 6 | 37
abnormal seminal vesicle morph... 6 | 47
abnormal testis morphology 6 | 30
decreased T cell number 6 | 31
decreased body length 6 | 108
decreased circulating LDL chol... 6 | 37
decreased circulating aspartat... 6 | 27
decreased startle reflex 6 | 48
increased circulating HDL chol... 6 | 63
tremors 6 | 34
abnormal bone mineralization 5 | 55
abnormal heart morphology 5 | 51
abnormal locomotor activation 5 | 26
decreased CD8-positive, alpha-... 5 | 26
decreased NK T cell number 5 | 28
decreased NK cell number 5 | 16
decreased caudal vertebrae num... 5 | 49
decreased circulating alkaline... 5 | 41
decreased hemoglobin content 5 | 53
decreased prepulse inhibition 5 | 52
increased blood urea nitrogen ... 5 | 44
increased circulating calcium ... 5 | 32
increased circulating phosphat... 5 | 24
increased circulating sodium l... 5 | 71
increased heart weight 5 | 37
increased leukocyte cell numbe... 5 | 37
increased mean corpuscular hem... 5 | 25
persistence of hyaloid vascula... 5 | 22
small testis 5 | 37
abnormal QRS complex 4 | 25
abnormal epididymis morphology 4 | 31
abnormal femur morphology 4 | 14
abnormal hindbrain development 4 | 24
abnormal kidney morphology 4 | 30
abnormal sleep behavior 4 | 63
cardiovascular system phenotyp... 4 | 35
decreased blood urea nitrogen ... 4 | 31
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased circulating total pr... 4 | 41
decreased heart weight 4 | 44
decreased mean corpuscular hem... 4 | 34
enlarged epididymis 4 | 27
increased B cell number 4 | 23
increased T cell number 4 | 15
increased body length 4 | 20
increased circulating free fat... 4 | 17
increased circulating serum al... 4 | 25
increased fasted circulating g... 4 | 68
increased mean platelet volume 4 | 19
increased prepulse inhibition 4 | 21
male infertility 4 | 62
prenatal lethality prior to he... 4 | 64
shortened RR interval 4 | 19
small adrenal glands 4 | 15
thrombocytosis 4 | 23

Disease

ovarian cancer 877 | 8,484
osteosarcoma 737 | 7,933
psoriasis 656 | 6,685
glioblastoma 598 | 5,572
medulloblastoma, large-cell 586 | 6,234
lung cancer 470 | 4,466
atypical teratoid / rhabdoid tumor 434 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 386 | 3,289
pilocytic astrocytoma 358 | 3,086
invasive ductal carcinoma 342 | 2,950
Breast cancer 325 | 3,094
Cancer 324 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 316 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 314 | 2,956
malignant mesothelioma 304 | 3,162
pediatric high grade glioma 300 | 2,712
lung adenocarcinoma 291 | 2,713
lung carcinoma 290 | 2,844
diabetes mellitus 286 | 1,663
non-small cell lung cancer 286 | 2,798
pancreatic cancer 286 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 271 | 1,795
oligodendroglioma 260 | 2,849
primitive neuroectodermal tumor 258 | 3,031
ulcerative colitis 250 | 2,087
interstitial cystitis 247 | 2,299
subependymal giant cell astrocytoma 241 | 2,287
ependymoma 229 | 2,514
pituitary cancer 223 | 1,972
Pick disease 212 | 1,893
Multiple myeloma 202 | 1,327
breast carcinoma 196 | 1,614
cystic fibrosis 194 | 1,665
ductal carcinoma in situ 193 | 1,745
group 4 medulloblastoma 193 | 1,875
astrocytic glioma 186 | 2,241
adult high grade glioma 184 | 2,148
posterior fossa group A ependymoma 183 | 1,511
astrocytoma 178 | 1,493
tuberculosis 175 | 1,557
Carcinoma 172 | 2,147
group 3 medulloblastoma 171 | 2,254
Rheumatoid Arthritis 169 | 1,160
active Crohn's disease 163 | 918
adrenocortical carcinoma 152 | 1,427
primary pancreatic ductal adenocarcinoma 152 | 1,271
juvenile dermatomyositis 145 | 1,189
medulloblastoma 140 | 1,524
acute quadriplegic myopathy 137 | 1,157
colon cancer 130 | 1,475
sonic hedgehog group medulloblastoma 126 | 1,482
esophageal adenocarcinoma 109 | 737
posterior fossa group B ependymoma 109 | 1,530
Alzheimer's disease 107 | 644
Obesity 105 | 616
cutaneous lupus erythematosus 104 | 1,056
dermatomyositis 102 | 933
Kidney disease 97 | 396
Neurodegenerative disease 96 | 383
atypical teratoid/rhabdoid tumor 95 | 1,095
gastric carcinoma 94 | 832
non primary Sjogren syndrome sicca 94 | 840
nasopharyngeal carcinoma 93 | 1,056
Arthritis 90 | 248
spina bifida 90 | 1,064
Prostatic Neoplasms 87 | 471
Atopic dermatitis 86 | 944
pancreatic carcinoma 86 | 567
Duchenne muscular dystrophy 85 | 602
Ankylosing spondylitis 83 | 138
Hypersensitivity reaction type II disease 83 | 235
primary Sjogren syndrome 79 | 789
Down syndrome 77 | 548
Waldenstrons macroglobulinemia 77 | 765
Acquired immunodeficiency syndrome 74 | 164
Liver disease 74 | 219
progressive supranuclear palsy 74 | 674
Multiple Sclerosis 73 | 498
acute myeloid leukemia 72 | 780
Heart disease 71 | 279
aldosterone-producing adenoma 71 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 71 | 499
Hypertension 70 | 287
fibroadenoma 70 | 557
Schizophrenia 68 | 501
Atherosclerosis 67 | 275
Intellectual disability 66 | 573
Juvenile rheumatoid arthritis 66 | 104
tuberculosis and treatment for 6 months 66 | 686
hepatocellular carcinoma 65 | 532
IGA Glomerulonephritis 64 | 454
Vascular disease 64 | 281
Uveitis 61 | 103
active ulcerative colitis 60 | 477
Anemia 58 | 252
Behcet's disease 58 | 74
Cerebrovascular disease 58 | 231
Parkinson's disease 57 | 364
Psoriatic arthritis 57 | 83
Endometriosis 54 | 535

Tissue

Female tissues 1,573 | 18,647
Nervous System 1,573 | 18,561
Blood and immune system 1,564 | 17,995
Urinary Tract 1,564 | 18,444
Digestive Tract 1,562 | 18,473
Liver and Pancreas 1,560 | 18,136
Endocrine System 1,559 | 18,512
Male tissues 1,546 | 17,969
Skin and soft tissues 1,546 | 18,115
Cardiovascular System 1,544 | 17,958
Respiratory system 1,531 | 17,484

Target Family

Non-IDG 886 | 11,971
Enzyme 603 | 4,146
Transporter 52 | 473
Kinase 40 | 634
Ion Channel 39 | 341
Transcription Factor 29 | 1,400
GPCR 12 | 406
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum 1,663 | 1,663
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297