Development Level

Tbio 1,225 | 10,625
Tdark 293 | 7,003
Tchem 276 | 1,890
Tclin 78 | 602

Collection

Eligible Ion Channel Proteins 6 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 75 | 633
preweaning lethality, incomple... 32 | 260
decreased lean body mass 29 | 195
embryonic lethality prior to t... 24 | 187
decreased bone mineral content 23 | 157
abnormal behavior 22 | 226
decreased total body fat amoun... 22 | 186
decreased body weight 19 | 174
decreased bone mineral density 17 | 126
decreased circulating choleste... 17 | 85
decreased circulating HDL chol... 15 | 77
decreased grip strength 15 | 123
increased circulating alkaline... 15 | 119
increased or absent threshold ... 15 | 128
abnormal embryo size 14 | 112
decreased circulating glucose ... 14 | 121
embryonic lethality prior to o... 14 | 148
increased lean body mass 14 | 107
decreased circulating triglyce... 13 | 83
enlarged heart 13 | 111
abnormal retina morphology 12 | 100
abnormal retinal pigmentation 12 | 61
decreased circulating alanine ... 12 | 53
increased bone mineral content 12 | 92
increased grip strength 12 | 83
increased total body fat amoun... 12 | 57
abnormal bone structure 11 | 131
decreased circulating insulin ... 11 | 75
hyperactivity 11 | 108
hypoactivity 11 | 89
increased mean corpuscular hem... 11 | 93
abnormal gait 10 | 51
decreased fasted circulating g... 10 | 49
decreased circulating serum al... 9 | 79
abnormal seminal vesicle morph... 8 | 47
decreased startle reflex 8 | 48
impaired glucose tolerance 8 | 52
increased circulating choleste... 8 | 53
increased mean corpuscular vol... 8 | 91
limb grasping 8 | 35
short tibia 8 | 82
thrombocytopenia 8 | 46
abnormal lens morphology 7 | 73
decreased caudal vertebrae num... 7 | 49
decreased circulating LDL chol... 7 | 37
decreased leukocyte cell numbe... 7 | 54
decreased mean corpuscular vol... 7 | 50
increased bone mineral density 7 | 52
increased hemoglobin content 7 | 45
abnormal heart morphology 6 | 51
abnormal neural tube closure 6 | 37
abnormal sleep behavior 6 | 63
abnormal testis morphology 6 | 30
decreased CD8-positive, alpha-... 6 | 26
decreased NK T cell number 6 | 28
decreased T cell number 6 | 31
decreased body length 6 | 108
decreased circulating alkaline... 6 | 41
decreased circulating aspartat... 6 | 27
decreased hemoglobin content 6 | 53
increased circulating HDL chol... 6 | 63
increased circulating calcium ... 6 | 32
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
increased leukocyte cell numbe... 6 | 37
thrombocytosis 6 | 23
tremors 6 | 34
abnormal QRS complex 5 | 25
abnormal bone mineralization 5 | 55
abnormal locomotor activation 5 | 26
decreased NK cell number 5 | 16
decreased circulating calcium ... 5 | 33
decreased circulating total pr... 5 | 41
decreased prepulse inhibition 5 | 52
increased B cell number 5 | 23
increased blood urea nitrogen ... 5 | 44
increased body length 5 | 20
increased circulating phosphat... 5 | 24
increased heart weight 5 | 37
increased mean corpuscular hem... 5 | 25
increased prepulse inhibition 5 | 21
male infertility 5 | 62
persistence of hyaloid vascula... 5 | 22
prenatal lethality prior to he... 5 | 64
small testis 5 | 37
abnormal coat appearance 4 | 25
abnormal epididymis morphology 4 | 31
abnormal kidney morphology 4 | 30
cardiovascular system phenotyp... 4 | 35
decreased circulating free fat... 4 | 39
decreased eosinophil cell numb... 4 | 41
decreased heart weight 4 | 44
decreased mean corpuscular hem... 4 | 34
decreased neutrophil cell numb... 4 | 37
decreased rib number 4 | 59
increased circulating free fat... 4 | 17
increased circulating serum al... 4 | 25
increased exploration in new e... 4 | 56
increased mean platelet volume 4 | 19
straub tail 4 | 26

Disease

ovarian cancer 967 | 8,492
osteosarcoma 816 | 7,933
psoriasis 711 | 6,685
glioblastoma 661 | 5,572
medulloblastoma, large-cell 651 | 6,234
lung cancer 527 | 4,473
atypical teratoid / rhabdoid tumor 485 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 431 | 3,289
pilocytic astrocytoma 405 | 3,086
invasive ductal carcinoma 374 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 356 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 355 | 2,956
Breast cancer 351 | 3,099
malignant mesothelioma 351 | 3,163
Cancer 348 | 2,346
pediatric high grade glioma 341 | 2,712
lung carcinoma 326 | 2,844
lung adenocarcinoma 320 | 2,714
non-small cell lung cancer 320 | 2,798
diabetes mellitus 319 | 1,663
pancreatic cancer 315 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 295 | 1,795
oligodendroglioma 292 | 2,849
primitive neuroectodermal tumor 291 | 3,031
interstitial cystitis 274 | 2,299
ulcerative colitis 272 | 2,087
subependymal giant cell astrocytoma 267 | 2,287
ependymoma 262 | 2,514
pituitary cancer 243 | 1,972
Pick disease 232 | 1,893
Multiple myeloma 224 | 1,328
cystic fibrosis 222 | 1,670
breast carcinoma 213 | 1,614
ductal carcinoma in situ 211 | 1,745
group 4 medulloblastoma 209 | 1,875
adult high grade glioma 208 | 2,148
astrocytic glioma 208 | 2,241
posterior fossa group A ependymoma 208 | 1,511
astrocytoma 200 | 1,493
group 3 medulloblastoma 197 | 2,254
tuberculosis 196 | 1,563
Carcinoma 192 | 2,147
Rheumatoid Arthritis 180 | 1,171
active Crohn's disease 170 | 918
primary pancreatic ductal adenocarcinoma 169 | 1,271
adrenocortical carcinoma 162 | 1,427
juvenile dermatomyositis 156 | 1,189
acute quadriplegic myopathy 154 | 1,157
colon cancer 154 | 1,475
medulloblastoma 153 | 1,524
dermatomyositis 145 | 967
sonic hedgehog group medulloblastoma 143 | 1,482
posterior fossa group B ependymoma 123 | 1,530
esophageal adenocarcinoma 118 | 737
cutaneous lupus erythematosus 114 | 1,056
Alzheimer's disease 110 | 644
Obesity 108 | 616
atypical teratoid/rhabdoid tumor 107 | 1,095
gastric carcinoma 105 | 832
nasopharyngeal carcinoma 102 | 1,056
non primary Sjogren syndrome sicca 101 | 840
Atopic dermatitis 100 | 944
Neurodegenerative disease 100 | 383
spina bifida 99 | 1,064
Kidney disease 97 | 397
Duchenne muscular dystrophy 96 | 602
Prostatic Neoplasms 96 | 471
Arthritis 93 | 248
pancreatic carcinoma 92 | 567
primary Sjogren syndrome 89 | 789
Down syndrome 85 | 548
Waldenstrons macroglobulinemia 85 | 765
Ankylosing spondylitis 84 | 138
Hypersensitivity reaction type II disease 84 | 235
acute myeloid leukemia 83 | 785
progressive supranuclear palsy 82 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 78 | 499
Multiple Sclerosis 76 | 498
fibroadenoma 76 | 557
Hypertension 75 | 293
aldosterone-producing adenoma 75 | 664
Acquired immunodeficiency syndrome 74 | 164
Liver disease 74 | 219
Schizophrenia 74 | 503
Heart disease 72 | 279
Intellectual disability 72 | 573
hepatocellular carcinoma 72 | 550
Atherosclerosis 71 | 275
IGA Glomerulonephritis 71 | 454
tuberculosis and treatment for 6 months 69 | 686
Juvenile rheumatoid arthritis 68 | 105
Vascular disease 67 | 281
Endometriosis 64 | 535
active ulcerative colitis 63 | 477
Anemia 62 | 252
Parkinson's disease 61 | 364
Uveitis 61 | 103
Cerebrovascular disease 60 | 231
Mammary Neoplasms 60 | 410
mucosa-associated lymphoid tissue lymphoma 59 | 480

Tissue

Nervous System 1,779 | 18,561
Female tissues 1,777 | 18,647
Blood and immune system 1,769 | 17,995
Digestive Tract 1,767 | 18,473
Urinary Tract 1,767 | 18,444
Liver and Pancreas 1,766 | 18,136
Endocrine System 1,763 | 18,512
Male tissues 1,751 | 17,969
Cardiovascular System 1,747 | 17,958
Skin and soft tissues 1,746 | 18,115
Respiratory system 1,735 | 17,484

Target Family

Non-IDG 1,048 | 11,969
Enzyme 632 | 4,146
Transporter 54 | 473
Kinase 47 | 634
Ion Channel 43 | 341
Transcription Factor 32 | 1,400
GPCR 14 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Endoplasmic reticulum 1,872 | 1,872
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Thioredoxin reductase 3 TXNRD3 Tchem Enzyme -1.69637 55.1 0
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.62300 6.27 55
FK506-binding protein-like FKBPL Tbio Non-IDG -1.37535 26.7 129
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Retinoic acid early transcript 1G protein RAET1G Tbio Non-IDG -0.73392 5.37 19
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Noelin OLFM1 Tbio Non-IDG -1.26710 24.7 286
Palmitoyltransferase ZDHHC2 ZDHHC2 Tbio Enzyme -1.85412 69.1 64