Development Level

Tbio 146 | 11,651
Tchem 75 | 1,388
Tclin 38 | 612
Tdark 6 | 6,593

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 16 | 499
embryonic lethality prior to t... 8 | 278
embryonic lethality prior to o... 6 | 239
increased lymphocyte cell numb... 6 | 32
abnormal behavior 5 | 298
decreased vertical activity 5 | 208
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal seminal vesicle morph... 4 | 114
enlarged heart 4 | 210
increased total body fat amoun... 4 | 134
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased circulating insulin ... 3 | 76
decreased lean body mass 3 | 135
edema 3 | 59
hyperactivity 3 | 148
increased circulating choleste... 3 | 66
increased grip strength 3 | 41
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
male infertility 3 | 123
abnormal bone mineralization 2 | 38
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
absent startle reflex 2 | 24
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
female infertility 2 | 60
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased eosinophil cell numb... 2 | 11
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
premature death 2 | 5
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating serum al... 1 | 82
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
impaired righting response 1 | 26
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Cancer 181 | 2,499
ovarian cancer 176 | 8,520
Carcinoma 148 | 11,493
psoriasis 134 | 6,694
lung cancer 127 | 4,740
osteosarcoma 121 | 7,950
glioblastoma 115 | 5,792
diabetes mellitus 92 | 1,728
medulloblastoma, large-cell 85 | 6,241
atypical teratoid / rhabdoid tumor 84 | 5,112
Multiple myeloma 74 | 1,332
ependymoma 74 | 4,679
Breast cancer 69 | 3,578
malignant mesothelioma 68 | 3,232
adult high grade glioma 62 | 3,801
Alzheimer's disease 60 | 658
Schizophrenia 60 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
Vascular disease 58 | 319
non-small cell lung cancer 56 | 2,890
Astrocytoma, Pilocytic 55 | 3,081
Obesity 55 | 678
invasive ductal carcinoma 53 | 2,951
oligodendroglioma 53 | 2,850
pancreatic cancer 53 | 2,398
tuberculosis 52 | 2,010
ulcerative colitis 52 | 1,819
lung adenocarcinoma 50 | 2,716
lung carcinoma 50 | 2,843
Breast Neoplasms 49 | 445
Mammary Neoplasms 49 | 425
Kidney disease 48 | 430
group 3 medulloblastoma 48 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,989
Parkinson's disease 47 | 392
Prostatic Neoplasms 47 | 495
primitive neuroectodermal tumor 47 | 3,035
Neurodegenerative disease 46 | 414
subependymal giant cell astrocytoma 46 | 2,287
Arthritis 45 | 290
Toxic encephalopathy 44 | 141
Bipolar Disorder 43 | 666
Heart disease 43 | 306
Hypertension 43 | 396
Liver Cirrhosis, Experimental 43 | 769
astrocytoma 43 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,962
Depressive disorder 41 | 409
Rheumatoid arthritis 39 | 1,191
breast carcinoma 39 | 1,638
interstitial cystitis 39 | 2,312
astrocytic glioma 38 | 2,597
Asthma 37 | 385
colon cancer 37 | 1,478
cystic fibrosis 37 | 1,696
pituitary cancer 37 | 1,972
Autosomal recessive predisposition 36 | 1,442
Carcinoma, Hepatocellular 36 | 228
Kidney cancer 36 | 2,613
Liver carcinoma 36 | 240
Mental Depression 36 | 333
Multiple Sclerosis 35 | 540
group 4 medulloblastoma 35 | 1,855
Major Depressive Disorder 34 | 301
Cerebrovascular disease 33 | 238
Inflammatory bowel disease 33 | 151
Lung disease 33 | 142
Stomach Neoplasms 33 | 300
Liver disease 32 | 237
Hypertensive disease 31 | 292
Lung Neoplasms 31 | 232
Waldenstrons macroglobulinemia 31 | 765
acute quadriplegic myopathy 31 | 1,158
adrenocortical carcinoma 31 | 1,428
Hypersensitivity reaction type II disease 30 | 253
Neuropathy 30 | 261
cutaneous lupus erythematosus 30 | 1,057
hepatocellular carcinoma 30 | 547
Atherosclerosis 29 | 291
Endometriosis 29 | 540
HIV Infections 29 | 102
Epilepsy 28 | 792
Hyperglycemia 28 | 137
Unipolar Depression 28 | 250
dermatomyositis 28 | 966
Colonic Neoplasms 27 | 142
Anemia 26 | 365
Brain disease 26 | 96
Inflammation 26 | 120
Neoplasm Metastasis 26 | 168
Osteoporosis 26 | 363
Pick disease 26 | 1,894
juvenile dermatomyositis 26 | 1,187
Melanoma 25 | 711
ductal carcinoma in situ 25 | 1,745
Diarrhea 24 | 253
Eye disease 24 | 62
Reperfusion Injury 24 | 86
acute myeloid leukemia 24 | 783

Tissue

Endocrine System 256 | 18,159
Blood and immune system 255 | 16,909
Female tissues 255 | 17,400
Digestive Tract 254 | 17,369
Liver and Pancreas 253 | 16,750
Nervous System 253 | 16,725
Skin and soft tissues 253 | 17,230
Urinary Tract 253 | 16,678
Male tissues 251 | 17,142
Respiratory system 251 | 16,393
Cardiovascular System 246 | 15,192

Target Family

Non-IDG 123 | 12,091
Enzyme 94 | 4,145
Kinase 16 | 634
Transcription Factor 15 | 1,400
Nuclear Receptor 6 | 48
GPCR 5 | 408
Epigenetic 2 | 242
Ion Channel 2 | 344
Transporter 2 | 473

Compartment GO Term

Endopeptidase complex 265 | 265
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Chymotrypsin-like protease CTRL-1 CTRL Tchem Enzyme -3.14577 1283.5 150
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 Tbio Enzyme -1.71687 51.9 225