Development Level

Tbio 3,039 | 11,445
Tdark 544 | 6,588
Tchem 486 | 1,598
Tclin 168 | 613

Collection

RFA-RM-18-021 38 | 328
Kinase: IDG Consortium (Target... 19 | 125
Ion Channel: IDG Consortium (T... 14 | 99
GPCR: IDG Consortium (Complete... 6 | 25
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 262 | 979
preweaning lethality, incomple... 135 | 499
embryonic lethality prior to t... 82 | 278
abnormal behavior 66 | 298
abnormal embryo size 62 | 220
embryonic lethality prior to o... 61 | 239
decreased total body fat amoun... 58 | 207
abnormal bone structure 48 | 187
decreased bone mineral content 47 | 151
decreased vertical activity 44 | 208
increased lean body mass 44 | 172
increased total body fat amoun... 44 | 134
decreased body weight 43 | 161
enlarged heart 43 | 210
hypoactivity 43 | 132
decreased lean body mass 40 | 135
increased startle reflex 39 | 112
increased circulating alkaline... 37 | 122
abnormal seminal vesicle morph... 35 | 114
hyperactivity 35 | 148
decreased grip strength 33 | 116
abnormal heart morphology 31 | 162
short tibia 31 | 97
decreased circulating glucose ... 30 | 126
embryonic growth retardation 30 | 106
decreased circulating serum al... 29 | 82
decreased bone mineral density 28 | 126
increased bone mineral content 28 | 108
increased mean corpuscular vol... 28 | 92
cataract 26 | 92
decreased circulating choleste... 26 | 93
edema 26 | 59
impaired glucose tolerance 25 | 75
decreased circulating HDL chol... 24 | 68
increased mean corpuscular hem... 24 | 96
abnormal lens morphology 23 | 81
decreased lymphocyte cell numb... 23 | 83
abnormal kidney morphology 22 | 65
decreased circulating triglyce... 22 | 79
decreased mean corpuscular vol... 22 | 79
increased fasted circulating g... 22 | 76
abnormal retina morphology 21 | 71
decreased hemoglobin content 21 | 68
increased bone mineral density 21 | 72
increased or absent threshold ... 21 | 101
decreased body length 20 | 101
improved glucose tolerance 20 | 79
increased circulating sodium l... 20 | 71
increased heart weight 20 | 62
abnormal eye morphology 19 | 68
abnormal sleep behavior 19 | 70
decreased mean corpuscular hem... 19 | 50
male infertility 19 | 123
decreased circulating insulin ... 18 | 76
decreased fasted circulating g... 18 | 65
decreased prepulse inhibition 18 | 82
increased monocyte cell number 18 | 63
increased leukocyte cell numbe... 17 | 47
thrombocytopenia 17 | 56
abnormal gait 16 | 69
decreased leukocyte cell numbe... 16 | 73
increased circulating HDL chol... 16 | 80
increased circulating triglyce... 16 | 42
small superior vagus ganglion 16 | 74
abnormal neural tube closure 15 | 46
decreased circulating LDL chol... 15 | 38
decreased circulating alkaline... 15 | 46
decreased circulating total pr... 15 | 49
increased blood urea nitrogen ... 15 | 48
increased circulating choleste... 15 | 66
abnormal behavioral response t... 14 | 66
abnormal coat-hair pigmentatio... 14 | 64
decreased startle reflex 14 | 75
decreased caudal vertebrae num... 13 | 53
decreased circulating alanine ... 13 | 47
decreased circulating creatini... 13 | 39
decreased erythrocyte cell num... 13 | 62
decreased hematocrit 13 | 46
hydrometra 13 | 53
increased circulating creatini... 13 | 38
increased neutrophil cell numb... 13 | 46
increased red blood cell distr... 13 | 34
limb grasping 13 | 41
prolonged ST segment 13 | 36
tremors 13 | 39
abnormal testis morphology 12 | 43
decreased blood urea nitrogen ... 12 | 51
increased circulating chloride... 12 | 41
prolonged QT interval 12 | 38
small testis 12 | 58
decreased circulating calcium ... 11 | 36
decreased heart weight 11 | 27
increased circulating phosphat... 11 | 26
increased grip strength 11 | 41
increased mean corpuscular hem... 11 | 36
increased mean platelet volume 11 | 45
prenatal lethality prior to he... 11 | 87
decreased circulating aspartat... 10 | 34
decreased circulating fructosa... 10 | 30
increased hematocrit 10 | 46

Disease

Carcinoma 2,702 | 11,493
ovarian cancer 2,273 | 8,520
osteosarcoma 2,000 | 7,950
psoriasis 1,676 | 6,694
glioblastoma 1,572 | 5,792
medulloblastoma, large-cell 1,525 | 6,241
atypical teratoid / rhabdoid tumor 1,285 | 5,112
lung cancer 1,274 | 4,740
ependymoma 1,172 | 4,679
adult high grade glioma 956 | 3,801
Breast cancer 936 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 936 | 3,291
Astrocytoma, Pilocytic 922 | 3,081
group 3 medulloblastoma 891 | 4,104
malignant mesothelioma 877 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 842 | 2,955
Cancer 836 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 831 | 2,989
invasive ductal carcinoma 829 | 2,951
non-small cell lung cancer 790 | 2,890
lung carcinoma 783 | 2,843
pancreatic cancer 752 | 2,398
lung adenocarcinoma 741 | 2,716
oligodendroglioma 725 | 2,850
primitive neuroectodermal tumor 682 | 3,035
tuberculosis 642 | 2,010
astrocytic glioma 636 | 2,597
interstitial cystitis 633 | 2,312
Kidney cancer 629 | 2,613
subependymal giant cell astrocytoma 625 | 2,287
diabetes mellitus 610 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 595 | 1,962
Pick disease 527 | 1,894
ulcerative colitis 526 | 1,819
pituitary cancer 521 | 1,972
group 4 medulloblastoma 499 | 1,855
cystic fibrosis 484 | 1,696
ductal carcinoma in situ 472 | 1,745
Autosomal recessive predisposition 463 | 1,442
breast carcinoma 458 | 1,638
Multiple myeloma 444 | 1,332
juvenile dermatomyositis 387 | 1,187
adrenocortical carcinoma 382 | 1,428
colon cancer 381 | 1,478
astrocytoma 360 | 1,146
primary pancreatic ductal adenocarcinoma 360 | 1,109
Rheumatoid arthritis 359 | 1,191
Schizophrenia 352 | 1,160
acute quadriplegic myopathy 350 | 1,158
dermatomyositis 347 | 966
cutaneous lupus erythematosus 315 | 1,057
active Crohn's disease 308 | 922
pediatric high grade glioma 308 | 1,064
Liver Cirrhosis, Experimental 282 | 769
esophageal adenocarcinoma 272 | 737
nasopharyngeal carcinoma 270 | 1,058
Intellectual disability 269 | 1,016
Alzheimer's disease 258 | 658
gastric carcinoma 254 | 807
non primary Sjogren syndrome sicca 254 | 891
spina bifida 253 | 1,074
Epilepsy 250 | 792
Atopic dermatitis 246 | 952
Waldenstrons macroglobulinemia 245 | 765
active ulcerative colitis 241 | 764
Obesity 240 | 678
Duchenne muscular dystrophy 226 | 601
primary Sjogren syndrome 210 | 735
Kidney disease 208 | 430
Seizures 202 | 596
Bipolar Disorder 198 | 666
mucosa-associated lymphoid tissue lymphoma 193 | 484
Prostatic Neoplasms 190 | 495
Melanoma 188 | 711
acute myeloid leukemia 188 | 783
aldosterone-producing adenoma 187 | 665
Neurodegenerative disease 185 | 414
Hypertension 184 | 396
pancreatic carcinoma 182 | 562
Multiple Sclerosis 181 | 540
Dull intelligence 180 | 645
Low intelligence 180 | 645
Mental Retardation 180 | 645
Mental deficiency 180 | 645
Poor school performance 180 | 645
Arthritis 178 | 290
Down syndrome 177 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 177 | 510
progressive supranuclear palsy 170 | 676
Short stature 166 | 531
Liver cancer 163 | 604
hepatocellular carcinoma 160 | 547
Cognitive delay 159 | 608
Global developmental delay 159 | 608
Mental and motor retardation 159 | 608
Muscle hypotonia 159 | 571
medulloblastoma 157 | 720
fibroadenoma 156 | 559
Amyotrophic lateral sclerosis 150 | 451
Anemia 149 | 365

Tissue

Endocrine System 4,026 | 18,159
Digestive Tract 3,987 | 17,369
Female tissues 3,975 | 17,400
Skin and soft tissues 3,956 | 17,230
Male tissues 3,924 | 17,142
Liver and Pancreas 3,920 | 16,750
Blood and immune system 3,901 | 16,909
Urinary Tract 3,892 | 16,678
Nervous System 3,864 | 16,725
Respiratory system 3,838 | 16,393
Cardiovascular System 3,616 | 15,192

Target Family

Non-IDG 2,459 | 12,091
Enzyme 1,269 | 4,145
Kinase 146 | 634
Transporter 127 | 473
Ion Channel 74 | 344
Transcription Factor 70 | 1,400
GPCR 60 | 408
Epigenetic 21 | 242
oGPCR 5 | 421
Nuclear Receptor 3 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Endomembrane system 4,237 | 4,237
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Zona pellucida-binding protein 1 ZPBP Tdark Non-IDG -1.44041 27.1 43
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86