Development Level

Tbio 2,530 | 10,625
Tdark 566 | 7,003
Tchem 480 | 1,890
Tclin 144 | 602

Collection

Eligible Kinase Proteins 20 | 134
Eligible Ion Channel Proteins 11 | 117
Eligible non-olfactory GPCR Proteins 4 | 145

IMPC Term

preweaning lethality, complete... 163 | 633
preweaning lethality, incomple... 62 | 260
decreased lean body mass 60 | 195
abnormal behavior 53 | 226
decreased total body fat amoun... 50 | 186
embryonic lethality prior to t... 50 | 187
decreased bone mineral content 48 | 157
decreased body weight 43 | 174
increased circulating alkaline... 35 | 119
decreased grip strength 34 | 123
decreased bone mineral density 33 | 126
abnormal bone structure 32 | 131
increased lean body mass 29 | 107
increased mean corpuscular hem... 29 | 93
embryonic lethality prior to o... 28 | 148
decreased circulating glucose ... 27 | 121
increased or absent threshold ... 26 | 128
abnormal embryo size 25 | 112
decreased body length 25 | 108
hypoactivity 25 | 89
hyperactivity 24 | 108
increased bone mineral content 24 | 92
abnormal lens morphology 23 | 73
abnormal retina morphology 23 | 100
decreased circulating HDL chol... 23 | 77
increased mean corpuscular vol... 23 | 91
decreased circulating choleste... 22 | 85
increased grip strength 20 | 83
short tibia 20 | 82
abnormal bone mineralization 19 | 55
abnormal retinal pigmentation 19 | 61
decreased circulating insulin ... 19 | 75
decreased circulating serum al... 19 | 79
decreased circulating triglyce... 19 | 83
enlarged heart 19 | 111
increased total body fat amoun... 19 | 57
decreased prepulse inhibition 18 | 52
increased circulating sodium l... 17 | 71
decreased circulating alanine ... 16 | 53
decreased mean corpuscular vol... 16 | 50
impaired glucose tolerance 16 | 52
abnormal sleep behavior 15 | 63
decreased fasted circulating g... 15 | 49
decreased hemoglobin content 15 | 53
increased bone mineral density 15 | 52
decreased circulating LDL chol... 14 | 37
increased fasted circulating g... 14 | 68
thrombocytopenia 14 | 46
cardiovascular system phenotyp... 13 | 35
decreased leukocyte cell numbe... 13 | 54
decreased lumbar vertebrae num... 13 | 62
decreased rib number 13 | 59
increased blood urea nitrogen ... 13 | 44
increased sacral vertebrae num... 13 | 62
limb grasping 13 | 35
abnormal behavioral response t... 12 | 52
abnormal gait 12 | 51
abnormal neural tube closure 12 | 37
decreased heart weight 12 | 44
decreased mean corpuscular hem... 12 | 34
increased circulating HDL chol... 12 | 63
increased circulating choleste... 12 | 53
increased heart weight 12 | 37
increased hemoglobin content 12 | 45
abnormal kidney morphology 11 | 30
male infertility 11 | 62
abnormal seminal vesicle morph... 10 | 47
decreased caudal vertebrae num... 10 | 49
decreased monocyte cell number 10 | 28
improved glucose tolerance 10 | 56
prenatal lethality prior to he... 10 | 64
abnormal coat/hair pigmentatio... 9 | 54
decreased NK T cell number 9 | 28
decreased circulating alkaline... 9 | 41
decreased eosinophil cell numb... 9 | 41
decreased startle reflex 9 | 48
increased circulating phosphat... 9 | 24
increased hematocrit 9 | 36
increased leukocyte cell numbe... 9 | 37
increased startle reflex 9 | 38
tremors 9 | 34
abnormal QRS complex 8 | 25
abnormal eye morphology 8 | 38
abnormal hindbrain development 8 | 24
abnormal limb bud morphology 8 | 15
decreased T cell number 8 | 31
decreased circulating aspartat... 8 | 27
decreased circulating calcium ... 8 | 33
decreased circulating fructosa... 8 | 31
decreased erythrocyte cell num... 8 | 43
decreased hematocrit 8 | 25
decreased vertical activity 8 | 22
hydrops fetalis 8 | 22
increased body weight 8 | 42
increased circulating calcium ... 8 | 32
increased circulating serum al... 8 | 25
increased mean corpuscular hem... 8 | 25
thrombocytosis 8 | 23
increased circulating chloride... 7 | 43
increased exploration in new e... 7 | 56

Disease

ovarian cancer 2,005 | 8,492
osteosarcoma 1,728 | 7,933
psoriasis 1,455 | 6,685
medulloblastoma, large-cell 1,374 | 6,234
glioblastoma 1,348 | 5,572
lung cancer 1,054 | 4,473
atypical teratoid / rhabdoid tumor 1,002 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 835 | 3,289
pilocytic astrocytoma 818 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 744 | 2,956
invasive ductal carcinoma 744 | 2,950
malignant mesothelioma 743 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 736 | 2,988
Breast cancer 715 | 3,099
Cancer 692 | 2,346
pediatric high grade glioma 683 | 2,712
lung carcinoma 675 | 2,844
oligodendroglioma 668 | 2,849
lung adenocarcinoma 643 | 2,714
pancreatic cancer 643 | 2,300
non-small cell lung cancer 640 | 2,798
primitive neuroectodermal tumor 633 | 3,031
ependymoma 549 | 2,514
subependymal giant cell astrocytoma 543 | 2,287
interstitial cystitis 529 | 2,299
ulcerative colitis 519 | 2,087
diabetes mellitus 505 | 1,663
Pick disease 489 | 1,893
pituitary cancer 484 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 473 | 1,795
astrocytic glioma 464 | 2,241
Carcinoma 453 | 2,147
adult high grade glioma 445 | 2,148
ductal carcinoma in situ 436 | 1,745
group 4 medulloblastoma 435 | 1,875
group 3 medulloblastoma 432 | 2,254
astrocytoma 425 | 1,493
cystic fibrosis 421 | 1,670
tuberculosis 398 | 1,563
breast carcinoma 395 | 1,614
posterior fossa group A ependymoma 395 | 1,511
Multiple myeloma 389 | 1,328
primary pancreatic ductal adenocarcinoma 359 | 1,271
adrenocortical carcinoma 335 | 1,427
colon cancer 335 | 1,475
juvenile dermatomyositis 332 | 1,189
medulloblastoma 329 | 1,524
Rheumatoid Arthritis 313 | 1,171
posterior fossa group B ependymoma 312 | 1,530
sonic hedgehog group medulloblastoma 303 | 1,482
acute quadriplegic myopathy 293 | 1,157
dermatomyositis 293 | 967
active Crohn's disease 285 | 918
cutaneous lupus erythematosus 247 | 1,056
atypical teratoid/rhabdoid tumor 235 | 1,095
spina bifida 230 | 1,064
esophageal adenocarcinoma 229 | 737
Alzheimer's disease 227 | 644
nasopharyngeal carcinoma 226 | 1,056
gastric carcinoma 219 | 832
non primary Sjogren syndrome sicca 212 | 840
Atopic dermatitis 204 | 944
Obesity 199 | 616
primary Sjogren syndrome 191 | 789
Waldenstrons macroglobulinemia 187 | 765
Duchenne muscular dystrophy 186 | 602
aldosterone-producing adenoma 174 | 664
Kidney disease 172 | 397
Down syndrome 170 | 548
Neurodegenerative disease 169 | 383
pancreatic carcinoma 169 | 567
acute myeloid leukemia 166 | 785
Prostatic Neoplasms 164 | 471
progressive supranuclear palsy 161 | 674
tuberculosis and treatment for 6 months 158 | 686
Schizophrenia 151 | 503
Multiple Sclerosis 148 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 145 | 499
fibroadenoma 145 | 557
Arthritis 140 | 248
hepatocellular carcinoma 138 | 550
Intellectual disability 136 | 573
IGA Glomerulonephritis 135 | 454
active ulcerative colitis 132 | 477
mucosa-associated lymphoid tissue lymphoma 132 | 480
Parkinson's disease 130 | 364
Atherosclerosis 126 | 275
Amyotrophic Lateral Sclerosis 124 | 432
Hypersensitivity reaction type II disease 123 | 235
Hypertension 122 | 293
Heart disease 121 | 279
Endometriosis 118 | 535
Liver disease 116 | 219
Cerebrovascular disease 111 | 231
Asthma 110 | 349
Mammary Neoplasms 110 | 410
Vascular disease 107 | 281
gastric cancer 107 | 436
hereditary spastic paraplegia 105 | 313
Coronary artery disease 104 | 240

Tissue

Nervous System 3,589 | 18,561
Female tissues 3,586 | 18,647
Endocrine System 3,575 | 18,512
Digestive Tract 3,574 | 18,473
Urinary Tract 3,573 | 18,444
Liver and Pancreas 3,567 | 18,136
Blood and immune system 3,562 | 17,995
Male tissues 3,544 | 17,969
Skin and soft tissues 3,541 | 18,115
Cardiovascular System 3,540 | 17,958
Respiratory system 3,508 | 17,484

Target Family

Non-IDG 2,153 | 11,969
Enzyme 1,117 | 4,146
Kinase 128 | 634
Transporter 117 | 473
Transcription Factor 67 | 1,400
Ion Channel 65 | 341
GPCR 47 | 408
Epigenetic 18 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38
oGPCR 1 | 421

Compartment GO Term

Endomembrane system 3,720 | 3,720
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Thioredoxin reductase 3 TXNRD3 Tchem Enzyme -1.69637 55.1 0
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.62300 6.27 55