Development Level

Tbio 173 | 10,625
Tchem 30 | 1,890
Tdark 8 | 7,003
Tclin 5 | 602

Collection

Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 10 | 633
decreased grip strength 5 | 123
embryonic lethality prior to t... 5 | 187
abnormal behavior 4 | 226
cardiovascular system phenotyp... 4 | 35
decreased total body fat amoun... 4 | 186
abnormal lens morphology 3 | 73
abnormal limb bud morphology 3 | 15
abnormal sleep behavior 3 | 63
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
decreased mean corpuscular vol... 3 | 50
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal embryo size 2 | 112
abnormal facial morphology 2 | 9
abnormal limb morphology 2 | 7
abnormal pericardium morpholog... 2 | 11
anophthalmia 2 | 20
cleft palate 2 | 6
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
edema 2 | 11
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
facial cleft 2 | 3
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
polydactyly 2 | 22
preweaning lethality, incomple... 2 | 260
abnormal digit morphology 1 | 13
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal kidney morphology 1 | 30
abnormal posture 1 | 5
abnormal retinal blood vessel ... 1 | 18
abnormal seminal vesicle morph... 1 | 47
absent pinna reflex 1 | 21
cataract 1 | 26
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased cardiac muscle contr... 1 | 5
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
hydrometra 1 | 13
hyperactivity 1 | 108
impaired righting response 1 | 19
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased spleen weight 1 | 3
increased startle reflex 1 | 38
microphthalmia 1 | 15
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
stereotypic behavior 1 | 3
tremors 1 | 34
trunk curl 1 | 15

Disease

psoriasis 120 | 6,685
Cancer 103 | 2,346
diabetes mellitus 84 | 1,663
ovarian cancer 81 | 8,484
Ankylosing spondylitis 71 | 138
osteosarcoma 66 | 7,933
Hypersensitivity reaction type II disease 65 | 235
glioblastoma 65 | 5,572
Juvenile rheumatoid arthritis 61 | 104
Arthritis 60 | 248
lung carcinoma 59 | 2,844
Acquired immunodeficiency syndrome 57 | 164
Uveitis 57 | 103
Behcet's disease 56 | 74
medulloblastoma, large-cell 56 | 6,234
Rheumatoid Arthritis 55 | 1,160
Psoriatic arthritis 52 | 83
lung cancer 51 | 4,466
pilocytic astrocytoma 46 | 3,086
atypical teratoid / rhabdoid tumor 43 | 4,369
Stevens-Johnson syndrome 38 | 78
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
invasive ductal carcinoma 35 | 2,950
pediatric high grade glioma 34 | 2,712
subependymal giant cell astrocytoma 34 | 2,287
Multiple Sclerosis 32 | 498
Kidney disease 30 | 396
interstitial cystitis 30 | 2,299
malignant mesothelioma 29 | 3,162
non-small cell lung cancer 29 | 2,798
primitive neuroectodermal tumor 29 | 3,031
Leprosy 28 | 77
Liver disease 28 | 219
astrocytoma 28 | 1,493
posterior fossa group A ependymoma 28 | 1,511
Breast cancer 27 | 3,094
ulcerative colitis 27 | 2,087
pancreatic cancer 26 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
lung adenocarcinoma 25 | 2,713
Anemia 24 | 252
oligodendroglioma 24 | 2,849
Hemochromatosis 23 | 55
Hepatitis B 23 | 103
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
ependymoma 22 | 2,514
Primary immunodeficiency disease 21 | 52
Skin disease 21 | 65
breast carcinoma 21 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
juvenile dermatomyositis 21 | 1,189
tuberculosis 21 | 1,557
cutaneous lupus erythematosus 20 | 1,056
Carcinoma 18 | 2,147
Pick disease 18 | 1,893
cystic fibrosis 18 | 1,665
pituitary cancer 18 | 1,972
Human immunodeficiency virus infectious disease 17 | 92
astrocytic glioma 17 | 2,241
ductal carcinoma in situ 17 | 1,745
primary pancreatic ductal adenocarcinoma 17 | 1,271
Multiple myeloma 16 | 1,327
adrenocortical carcinoma 16 | 1,427
adult high grade glioma 16 | 2,148
group 3 medulloblastoma 16 | 2,254
medulloblastoma 16 | 1,524
pre-eclampsia 16 | 67
group 4 medulloblastoma 15 | 1,875
primary Sjogren syndrome 15 | 789
dermatomyositis 14 | 933
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Duchenne muscular dystrophy 13 | 602
colon cancer 13 | 1,475
Alzheimer's disease 12 | 644
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 832
Atherosclerosis 11 | 275
active Crohn's disease 11 | 918
mucosa-associated lymphoid tissue lymphoma 11 | 480
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
Prostatic Neoplasms 10 | 471
Schizophrenia 10 | 501
spina bifida 10 | 1,064
fibroadenoma 9 | 557
IGA Glomerulonephritis 8 | 454
sarcoidosis 8 | 358
Becker muscular dystrophy 7 | 187
Down syndrome 7 | 548
HIV Infections 7 | 100
Intellectual disability 7 | 573
Neurodegenerative disease 7 | 383
acute myeloid leukemia 7 | 780
atypical teratoid/rhabdoid tumor 7 | 1,095
glioblastoma multiforme 7 | 347
head and neck cancer and chronic obstructive pulmonary disease 7 | 237
non-small cell lung carcinoma 7 | 413
limb girdle muscular dystrophy 2I 6 | 56

Tissue

Digestive Tract 153 | 18,473
Endocrine System 153 | 18,512
Female tissues 153 | 18,647
Liver and Pancreas 153 | 18,136
Nervous System 153 | 18,561
Urinary Tract 153 | 18,444
Cardiovascular System 152 | 17,958
Blood and immune system 151 | 17,995
Male tissues 151 | 17,969
Respiratory system 151 | 17,484
Skin and soft tissues 145 | 18,115

Target Family

Non-IDG 156 | 11,971
Enzyme 37 | 4,146
Ion Channel 9 | 341
Kinase 7 | 634
GPCR 5 | 406
Transporter 2 | 473

Compartment GO Term

Endocytic vesicle membrane 216 | 216
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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