Development Level

Tbio 236 | 10,625
Tchem 49 | 1,890
Tclin 12 | 602
Tdark 11 | 7,003

Collection

Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 16 | 633
decreased grip strength 7 | 123
increased circulating alkaline... 7 | 119
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
short tibia 5 | 82
abnormal behavior 4 | 226
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
cardiovascular system phenotyp... 4 | 35
decreased bone mineral content 4 | 157
decreased lean body mass 4 | 195
decreased mean corpuscular vol... 4 | 50
abnormal embryo size 3 | 112
abnormal eye morphology 3 | 38
abnormal limb bud morphology 3 | 15
abnormal sleep behavior 3 | 63
decreased body length 3 | 108
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased grip strength 3 | 83
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
tremors 3 | 34
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal craniofacial morpholo... 2 | 12
abnormal facial morphology 2 | 9
abnormal heart left ventricle ... 2 | 20
abnormal limb morphology 2 | 7
abnormal locomotor activation 2 | 26
abnormal pericardium morpholog... 2 | 11
abnormal posture 2 | 5
abnormal retina morphology 2 | 100
abnormal tooth morphology 2 | 24
anophthalmia 2 | 20
cataract 2 | 26
cleft palate 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating alkaline... 2 | 41
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased pulmonary respirator... 2 | 4
edema 2 | 11
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged stomach 2 | 2
facial cleft 2 | 3
hydrops fetalis 2 | 22
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating free fat... 2 | 17
increased circulating phosphat... 2 | 24
increased circulating potassiu... 2 | 31
increased hematocrit 2 | 36
lethargy 2 | 5
polydactyly 2 | 22
small thymus 2 | 11
abnormal coat appearance 1 | 25
abnormal embryo turning 1 | 15
abnormal kidney morphology 1 | 30
abnormal retinal pigmentation 1 | 61
absent pinna reflex 1 | 21
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating sodium l... 1 | 18
decreased exploration in new e... 1 | 9
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
impaired righting response 1 | 19
increased body weight 1 | 42
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased circulating triglyce... 1 | 24
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
stereotypic behavior 1 | 3
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

psoriasis 165 | 6,685
Cancer 137 | 2,346
ovarian cancer 133 | 8,484
osteosarcoma 113 | 7,933
diabetes mellitus 104 | 1,663
glioblastoma 100 | 5,572
medulloblastoma, large-cell 92 | 6,234
lung carcinoma 83 | 2,844
lung cancer 82 | 4,466
Rheumatoid Arthritis 76 | 1,160
Ankylosing spondylitis 72 | 138
Hypersensitivity reaction type II disease 70 | 235
Arthritis 69 | 248
pilocytic astrocytoma 64 | 3,086
Juvenile rheumatoid arthritis 62 | 104
Uveitis 60 | 103
atypical teratoid / rhabdoid tumor 60 | 4,369
invasive ductal carcinoma 60 | 2,950
non-small cell lung cancer 59 | 2,798
Acquired immunodeficiency syndrome 58 | 164
Behcet's disease 56 | 74
Psoriatic arthritis 53 | 83
malignant mesothelioma 52 | 3,162
lung adenocarcinoma 50 | 2,713
pediatric high grade glioma 49 | 2,712
pancreatic cancer 47 | 2,300
interstitial cystitis 46 | 2,299
subependymal giant cell astrocytoma 46 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
tuberculosis 45 | 1,557
Kidney disease 44 | 396
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
ulcerative colitis 42 | 2,087
Breast cancer 41 | 3,094
oligodendroglioma 40 | 2,849
Liver disease 38 | 219
Multiple Sclerosis 38 | 498
Stevens-Johnson syndrome 38 | 78
astrocytoma 38 | 1,493
primitive neuroectodermal tumor 38 | 3,031
Carcinoma 37 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,289
juvenile dermatomyositis 37 | 1,189
Anemia 36 | 252
Retinal vasculitis 36 | 36
Takayasu's arteritis 36 | 52
Congenital adrenal hyperplasia 35 | 74
posterior fossa group A ependymoma 35 | 1,511
breast carcinoma 34 | 1,614
ependymoma 33 | 2,514
cutaneous lupus erythematosus 32 | 1,056
Hepatitis B 30 | 103
Hemochromatosis 29 | 55
Leprosy 29 | 77
Multiple myeloma 29 | 1,327
Pick disease 29 | 1,893
adult high grade glioma 27 | 2,148
cystic fibrosis 27 | 1,665
colon cancer 26 | 1,475
pituitary cancer 26 | 1,972
primary pancreatic ductal adenocarcinoma 26 | 1,271
astrocytic glioma 25 | 2,241
ductal carcinoma in situ 25 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
acute quadriplegic myopathy 24 | 1,157
group 4 medulloblastoma 24 | 1,875
primary Sjogren syndrome 24 | 789
dermatomyositis 23 | 933
Alzheimer's disease 22 | 644
Primary immunodeficiency disease 22 | 52
adrenocortical carcinoma 22 | 1,427
group 3 medulloblastoma 22 | 2,254
mucosa-associated lymphoid tissue lymphoma 22 | 480
Human immunodeficiency virus infectious disease 21 | 92
Skin disease 21 | 65
esophageal adenocarcinoma 21 | 737
medulloblastoma 21 | 1,524
Atherosclerosis 20 | 275
Duchenne muscular dystrophy 20 | 602
gastric carcinoma 20 | 832
Schizophrenia 18 | 501
Asthma 16 | 349
Atopic dermatitis 16 | 944
acute myeloid leukemia 16 | 780
nasopharyngeal carcinoma 16 | 1,056
pancreatic carcinoma 16 | 567
pre-eclampsia 16 | 67
sonic hedgehog group medulloblastoma 16 | 1,482
spina bifida 16 | 1,064
Vascular disease 15 | 281
posterior fossa group B ependymoma 15 | 1,530
Hypertension 14 | 287
Intellectual disability 14 | 573
Neurodegenerative disease 14 | 383
Obesity 14 | 616
Prostatic Neoplasms 14 | 471
active Crohn's disease 14 | 918
Coronary artery disease 13 | 240
Down syndrome 13 | 548
gastric cancer 12 | 430

Tissue

Liver and Pancreas 242 | 18,136
Nervous System 242 | 18,561
Digestive Tract 241 | 18,473
Female tissues 241 | 18,647
Urinary Tract 241 | 18,444
Endocrine System 240 | 18,512
Blood and immune system 239 | 17,995
Cardiovascular System 239 | 17,958
Male tissues 239 | 17,969
Respiratory system 237 | 17,484
Skin and soft tissues 231 | 18,115

Target Family

Non-IDG 222 | 11,971
Enzyme 56 | 4,146
Ion Channel 10 | 341
Kinase 8 | 634
Transporter 6 | 473
GPCR 5 | 406
Transcription Factor 1 | 1,400

Compartment GO Term

Endocytic vesicle 308 | 308
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
HLA class I histocompatibility antigen, Cw-15 alpha chain HLA-C Tbio Non-IDG 777.4 0