Development Level

Tbio 153 | 10,625
Tdark 14 | 7,003
Tchem 11 | 1,890
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 5 | 633
decreased mean corpuscular hem... 3 | 34
abnormal sleep behavior 2 | 63
decreased NK T cell number 2 | 28
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased total body fat amoun... 2 | 186
hypoactivity 2 | 89
increased circulating chloride... 2 | 43
increased mean corpuscular hem... 2 | 93
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal eyelid aperture 1 | 3
abnormal iris morphology 1 | 12
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal thoracic cage shape 1 | 3
abnormal vertebrae morphology 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
enlarged heart 1 | 111
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased mean corpuscular vol... 1 | 91
increased urine magnesium leve... 1 | 1
preweaning lethality, incomple... 1 | 260

Disease

psoriasis 97 | 6,685
Cancer 92 | 2,346
Ankylosing spondylitis 72 | 138
ovarian cancer 67 | 8,484
diabetes mellitus 64 | 1,663
Arthritis 59 | 248
Hypersensitivity reaction type II disease 58 | 235
Acquired immunodeficiency syndrome 57 | 164
Uveitis 57 | 103
Behcet's disease 56 | 74
Juvenile rheumatoid arthritis 56 | 104
medulloblastoma, large-cell 56 | 6,234
osteosarcoma 54 | 7,933
Psoriatic arthritis 49 | 83
glioblastoma 49 | 5,572
Rheumatoid Arthritis 43 | 1,160
Stevens-Johnson syndrome 39 | 78
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
lung cancer 33 | 4,466
atypical teratoid / rhabdoid tumor 32 | 4,369
pilocytic astrocytoma 30 | 3,086
pediatric high grade glioma 26 | 2,712
Multiple Sclerosis 25 | 498
subependymal giant cell astrocytoma 24 | 2,287
Hemochromatosis 23 | 55
Kidney disease 23 | 396
Liver disease 23 | 219
invasive ductal carcinoma 23 | 2,950
Anemia 22 | 252
Hepatitis B 22 | 103
Leprosy 22 | 77
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
Primary immunodeficiency disease 21 | 52
Skin disease 21 | 65
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
Carcinoma 20 | 2,147
lung carcinoma 19 | 2,844
malignant mesothelioma 19 | 3,162
non-small cell lung cancer 19 | 2,798
oligodendroglioma 19 | 2,849
Pick disease 18 | 1,893
astrocytoma 18 | 1,493
Breast cancer 17 | 3,094
interstitial cystitis 17 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
juvenile dermatomyositis 16 | 1,189
pancreatic cancer 16 | 2,300
ulcerative colitis 16 | 2,087
Human immunodeficiency virus infectious disease 15 | 92
pre-eclampsia 15 | 67
tuberculosis 15 | 1,557
Multiple myeloma 14 | 1,327
breast carcinoma 14 | 1,614
ependymoma 14 | 2,514
posterior fossa group A ependymoma 14 | 1,511
primitive neuroectodermal tumor 14 | 3,031
adult high grade glioma 13 | 2,148
cutaneous lupus erythematosus 13 | 1,056
cystic fibrosis 13 | 1,665
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,875
lung adenocarcinoma 13 | 2,713
astrocytic glioma 12 | 2,241
dermatomyositis 12 | 933
pituitary cancer 12 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
primary Sjogren syndrome 11 | 789
group 3 medulloblastoma 10 | 2,254
medulloblastoma 10 | 1,524
sonic hedgehog group medulloblastoma 10 | 1,482
adrenocortical carcinoma 9 | 1,427
posterior fossa group B ependymoma 9 | 1,530
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 664
esophageal adenocarcinoma 8 | 737
primary pancreatic ductal adenocarcinoma 8 | 1,271
Duchenne muscular dystrophy 7 | 602
active Crohn's disease 7 | 918
atypical teratoid/rhabdoid tumor 7 | 1,095
fibroadenoma 7 | 557
mucosa-associated lymphoid tissue lymphoma 7 | 480
progressive supranuclear palsy 7 | 674
spina bifida 7 | 1,064
Intellectual disability 6 | 573
Schizophrenia 6 | 501
active ulcerative colitis 6 | 477
colon cancer 6 | 1,475
Amyotrophic Lateral Sclerosis 5 | 431
Down syndrome 5 | 548
IGA Glomerulonephritis 5 | 454
Neurodegenerative disease 5 | 383
Prostatic Neoplasms 5 | 471
acute quadriplegic myopathy 5 | 1,157
chronic rhinosinusitis 5 | 512
gastric carcinoma 5 | 832
inflammatory breast cancer 5 | 404
pancreatic carcinoma 5 | 567
tuberculosis and treatment for 6 months 5 | 686

Tissue

Digestive Tract 114 | 18,473
Endocrine System 114 | 18,512
Female tissues 114 | 18,647
Liver and Pancreas 114 | 18,136
Male tissues 114 | 17,969
Nervous System 114 | 18,561
Respiratory system 114 | 17,484
Urinary Tract 114 | 18,444
Blood and immune system 113 | 17,995
Cardiovascular System 113 | 17,958
Skin and soft tissues 108 | 18,115

Target Family

Non-IDG 150 | 11,971
Enzyme 17 | 4,146
Kinase 6 | 634
Ion Channel 4 | 341
Transporter 3 | 473
GPCR 1 | 406

Compartment GO Term

Early endosome membrane 181 | 181
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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