Development Level

Tbio 25 | 11,445
Tdark 12 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 3 | 499
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased total body fat amoun... 2 | 134
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal spine curvature 1 | 9
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased eosinophil cell numb... 1 | 11
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

ovarian cancer 29 | 8,520
osteosarcoma 21 | 7,950
psoriasis 16 | 6,694
medulloblastoma, large-cell 15 | 6,241
Carcinoma 14 | 11,493
atypical teratoid / rhabdoid tumor 14 | 5,112
glioblastoma 13 | 5,792
lung cancer 13 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Breast cancer 10 | 3,578
ependymoma 10 | 4,679
Multiple myeloma 8 | 1,332
primitive neuroectodermal tumor 7 | 3,035
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Neurodegenerative disease 5 | 414
Obesity 5 | 678
group 4 medulloblastoma 5 | 1,855
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Down syndrome 4 | 499
Pick disease 4 | 1,894
astrocytic glioma 4 | 2,597
chronic rhinosinusitis 4 | 512
diabetes mellitus 4 | 1,728
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung cancer 4 | 2,890
Byzanthine arch palate 3 | 194
Cancer 3 | 2,499
Cerebral atrophy 3 | 178
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Dull intelligence 3 | 645
Hypoplastic mandible condyle 3 | 275
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Poor school performance 3 | 645
Seizures 3 | 596
Strabismus 3 | 270
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
gastric cancer 3 | 459
hereditary spastic paraplegia 3 | 318
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Absent speech 2 | 43
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Anemia 2 | 365
Bulging forehead 2 | 66
Carcinoma, Hepatocellular 2 | 228
Cognitive delay 2 | 608
Congenital muscular dystrophy 2 | 29
Curvature of spine 2 | 282
Death in early childhood 2 | 82
Death in infancy 2 | 82
Degenerative brain disorder 2 | 100
Duchenne muscular dystrophy 2 | 601
Frontal bossing 2 | 157
Global developmental delay 2 | 608
Hyperreflexia 2 | 209
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Mental and motor retardation 2 | 608
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Neuronal loss 2 | 25
Polycystic ovary syndrome 2 | 360
Prominent forehead 2 | 66
Skeletal muscle atrophy 2 | 139
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
hepatocellular carcinoma 2 | 547
muscle degeneration 2 | 139
nonverbal 2 | 43
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819

Tissue

Digestive Tract 38 | 17,369
Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678

Target Family

Non-IDG 27 | 12,091
Enzyme 10 | 4,145
Transcription Factor 1 | 1,400

Compartment GO Term

ER membrane protein complex 38 | 38
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
ER membrane protein complex subunit 10 EMC10 Tbio Non-IDG -1.41680 25.5 60
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIGY Tdark Enzyme -0.25795 2.85 56
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Cytoskeleton-associated protein 4 CKAP4 Tbio Non-IDG -1.45279 28.4 190
ER membrane protein complex subunit 8 EMC8 Tdark Non-IDG 0.06 0.41 160
Selenoprotein K SELENOK Tbio Non-IDG -1.39537 26.6 0
Insulin-induced gene 1 protein INSIG1 Tbio Non-IDG -2.29727 186.9 147