Development Level

Tbio 49 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased fasted circulating g... 3 | 65
abnormal embryo size 2 | 220
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased bone mineral density 2 | 72
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total retina thickne... 1 | 4
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16

Disease

Carcinoma 46 | 11,493
ovarian cancer 34 | 8,520
Breast cancer 28 | 3,578
osteosarcoma 28 | 7,950
psoriasis 28 | 6,694
Cancer 27 | 2,499
esophageal adenocarcinoma 21 | 737
interstitial cystitis 20 | 2,312
lung cancer 20 | 4,740
malignant mesothelioma 20 | 3,232
non-small cell lung cancer 20 | 2,890
Kidney cancer 19 | 2,613
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 18 | 4,679
glioblastoma 18 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
pancreatic cancer 18 | 2,398
cystic fibrosis 17 | 1,696
lung adenocarcinoma 15 | 2,716
medulloblastoma, large-cell 15 | 6,241
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
spina bifida 14 | 1,074
Autosomal recessive predisposition 13 | 1,442
breast carcinoma 13 | 1,638
primitive neuroectodermal tumor 12 | 3,035
Palmoplantar keratosis 11 | 74
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
invasive ductal carcinoma 11 | 2,951
lung carcinoma 11 | 2,843
nasopharyngeal carcinoma 11 | 1,058
Melanoma 10 | 711
Skin cancer 10 | 469
adult high grade glioma 10 | 3,801
oligodendroglioma 10 | 2,850
pituitary cancer 10 | 1,972
Cardiomyopathy 9 | 116
Dermatitis 9 | 157
Hypotrichosis 9 | 47
astrocytic glioma 9 | 2,597
group 4 medulloblastoma 9 | 1,855
Arrhythmogenic right ventricular cardiomyopathy 8 | 30
Astrocytoma, Pilocytic 8 | 3,081
Atopic dermatitis 8 | 952
Bullous pemphigoid 8 | 18
Liver cancer 8 | 604
Pemphigus 8 | 23
ductal carcinoma in situ 8 | 1,745
Alopecia 7 | 115
Breast Neoplasms 7 | 445
Epidermolysis bullosa 7 | 21
Keratosis 7 | 37
Netherton syndrome 7 | 15
Pick disease 7 | 1,894
Prostatic Neoplasms 7 | 495
Squamous cell carcinoma 7 | 129
colon cancer 7 | 1,478
diabetes mellitus 7 | 1,728
group 3 medulloblastoma 7 | 4,104
periodontitis 7 | 293
ulcerative colitis 7 | 1,819
Abnormal blistering of the skin 6 | 54
Adenoma 6 | 167
Blister of skin 6 | 54
Carcinoma, Squamous Cell 6 | 110
Congenital ichthyosiform erythroderma 6 | 28
Dilated cardiomyopathy 6 | 56
Dystrophia unguium 6 | 53
Erythema 6 | 58
Flushing 6 | 60
Mammary Neoplasms 6 | 425
Rheumatoid arthritis 6 | 1,191
Ritter's disease 6 | 10
Skin bulla 6 | 54
acute quadriplegic myopathy 6 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
subependymal giant cell astrocytoma 6 | 2,287
Cardiomyopathy, right ventricular 5 | 7
Epidermolytic hyperkeratosis 5 | 14
Failure to gain weight 5 | 365
Ichthyosis vulgaris 5 | 11
Liver disease 5 | 237
Nail Diseases 5 | 24
Nail abnormality 5 | 22
Nail dysplasia 5 | 52
Pediatric failure to thrive 5 | 365
Skin Neoplasms 5 | 69
Skin disease 5 | 66
Sudden Cardiac Death 5 | 29
acute myeloid leukemia 5 | 783
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Cerebrovascular disease 4 | 238
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
mucosa-associated lymphoid tissue lymphoma 4 | 484
urothelial carcinoma 4 | 318

Tissue

Skin and soft tissues 50 | 17,230
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Blood and immune system 48 | 16,909
Male tissues 48 | 17,142
Nervous System 47 | 16,725
Urinary Tract 46 | 16,678
Respiratory system 44 | 16,393
Liver and Pancreas 42 | 16,750
Cardiovascular System 39 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 5 | 4,145

Compartment GO Term

Desmosome 52 | 52
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.34455 143.0 113
Complement receptor type 1 CR1 Tbio Non-IDG -3.36509 2362.6 700
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Cadherin-17 CDH17 Tbio Non-IDG -3.38219 2005.5 312
Plakophilin-1 PKP1 Tbio Non-IDG -1.86062 76.3 103
Collagen alpha-1(XVII) chain COL17A1 Tbio Non-IDG -2.75473 576.3 123
Cadherin-2 CDH2 Tbio Non-IDG -3.19431 1382.9 993