Development Level

Tbio 93 | 11,651
Tdark 13 | 6,593
Tchem 3 | 1,388

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
decreased leukocyte cell numbe... 2 | 73
decreased red blood cell distr... 2 | 41
decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
increased circulating magnesiu... 2 | 10
increased circulating potassiu... 2 | 29
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal maxilla morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
short tibia 1 | 97
small superior vagus ganglion 1 | 74
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 64 | 11,493
ovarian cancer 58 | 8,520
osteosarcoma 49 | 7,950
lung cancer 32 | 4,740
psoriasis 27 | 6,694
Kidney cancer 22 | 2,613
malignant mesothelioma 20 | 3,232
medulloblastoma, large-cell 20 | 6,241
glioblastoma 19 | 5,792
group 3 medulloblastoma 19 | 4,104
Cockayne syndrome 16 | 60
Multiple myeloma 16 | 1,332
atypical teratoid / rhabdoid tumor 15 | 5,112
oligodendroglioma 15 | 2,850
Breast cancer 14 | 3,578
ependymoma 14 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Cancer 12 | 2,499
Photosensitive trichothiodystrophy 12 | 30
astrocytic glioma 12 | 2,597
Intellectual disability 11 | 1,016
Xeroderma pigmentosum group B 11 | 20
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
primitive neuroectodermal tumor 9 | 3,035
Autosomal recessive predisposition 8 | 1,442
Pick disease 8 | 1,894
Waldenstrons macroglobulinemia 8 | 765
acute myeloid leukemia 8 | 783
diabetes mellitus 8 | 1,728
tuberculosis 8 | 2,010
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
group 4 medulloblastoma 7 | 1,855
invasive ductal carcinoma 7 | 2,951
Cognitive delay 6 | 608
Cryptorchidism 6 | 296
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Liver cancer 6 | 604
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Muscle Spasticity 6 | 195
Short stature 6 | 531
Small head 6 | 374
Strabismus 6 | 270
Xeroderma pigmentosum 6 | 43
Xeroderma pigmentosum group D 6 | 33
aldosterone-producing adenoma 6 | 665
astrocytoma 6 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Cataract 5 | 297
Cerebellar Ataxia 5 | 304
Epidermodysplasia verruciformis 5 | 21
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Impaired cognition 5 | 96
Lens Opacities 5 | 231
Mental impairment 5 | 95
Optic Atrophy 5 | 242
Pediatric failure to thrive 5 | 365
Seizures 5 | 596
Sensorineural Hearing Loss (disorder) 5 | 284
Spinocerebellar ataxia type 7 5 | 13
cystic fibrosis 5 | 1,696
hepatocellular carcinoma 5 | 547
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Developmental regression 4 | 95
Electroencephalogram abnormal 4 | 101
Feeding difficulties in infancy 4 | 175
Fetal Growth Retardation 4 | 189
Hyperreflexia 4 | 209
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Loss of developmental milestones 4 | 95
Melanoma 4 | 711
Nystagmus 4 | 317
Psychomotor regression in infants 4 | 95
Psychomotor regression, progressive 4 | 95
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
acute quadriplegic myopathy 4 | 1,158
ductal carcinoma in situ 4 | 1,745
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung cancer 4 | 2,890
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
tuberculosis and treatment for 3 months 4 | 179

Tissue

Endocrine System 107 | 18,159
Blood and immune system 106 | 16,909
Digestive Tract 106 | 17,369
Female tissues 106 | 17,400
Liver and Pancreas 106 | 16,750
Male tissues 106 | 17,142
Respiratory system 106 | 16,393
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Cardiovascular System 105 | 15,192
Nervous System 105 | 16,725

Target Family

Non-IDG 63 | 12,091
Enzyme 37 | 4,145
Epigenetic 6 | 242
Kinase 3 | 634

Compartment GO Term

DNA-directed RNA polymerase II... 109 | 109
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
SET domain-containing protein 5 SETD5 Tbio Epigenetic -0.91515 9.39 43
Mediator of RNA polymerase II transcription subunit 18 MED18 Tbio Enzyme -1.00423 10.4 161
Integrator complex subunit 6 INTS6 Tbio Non-IDG -2.07240 118.9 80
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
Mediator of RNA polymerase II transcription subunit 10 MED10 Tdark Enzyme -1.38171 24.0 16
RNA polymerase-associated protein LEO1 LEO1 Tbio Enzyme -2.07251 114.4 293
Integrator complex subunit 10 INTS10 Tdark Non-IDG -0.67290 3.96 116
MMS19 nucleotide excision repair protein homolog MMS19 Tbio Non-IDG -1.66416 46.5 122
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213