Development Level

Tbio 38 | 10,625
Tchem 6 | 1,890
Tdark 6 | 7,003

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 3 | 187
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating glucose ... 1 | 121
decreased lymphocyte cell numb... 1 | 9
hypoactivity 1 | 89
increased body length 1 | 20
increased body weight 1 | 42
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased heart weight 1 | 37
increased neutrophil cell numb... 1 | 15
male infertility 1 | 62
pale yolk sac 1 | 12
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
straub tail 1 | 26

Disease

ovarian cancer 30 | 8,491
lung cancer 25 | 4,473
Cancer 23 | 2,346
osteosarcoma 23 | 7,933
medulloblastoma, large-cell 22 | 6,234
psoriasis 22 | 6,685
malignant mesothelioma 19 | 3,163
glioblastoma 18 | 5,572
primitive neuroectodermal tumor 17 | 3,031
atypical teratoid / rhabdoid tumor 16 | 4,369
non-small cell lung cancer 14 | 2,798
Breast cancer 13 | 3,098
Carcinoma 13 | 2,147
group 3 medulloblastoma 13 | 2,254
lung adenocarcinoma 13 | 2,714
Cockayne syndrome 12 | 54
Rothmund-Thomson syndrome 12 | 22
invasive ductal carcinoma 12 | 2,950
pediatric high grade glioma 11 | 2,712
Baller-Gerold syndrome 10 | 14
colon cancer 10 | 1,475
Bloom syndrome 9 | 30
Fanconi's anemia 9 | 50
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
Werner syndrome 8 | 29
adrenocortical carcinoma 8 | 1,427
Intellectual disability 7 | 573
Photosensitive trichothiodystrophy 7 | 24
Warsaw breakage syndrome 7 | 12
ductal carcinoma in situ 7 | 1,745
nasopharyngeal carcinoma 7 | 1,056
posterior fossa group A ependymoma 7 | 1,511
sonic hedgehog group medulloblastoma 7 | 1,482
Multiple myeloma 6 | 1,327
Xeroderma pigmentosum 6 | 41
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
Nijmegen breakage syndrome 5 | 23
Waldenstrons macroglobulinemia 5 | 764
adult high grade glioma 5 | 2,148
juvenile dermatomyositis 5 | 1,189
oligodendroglioma 5 | 2,849
Atopic dermatitis 4 | 944
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Mammary Neoplasms 4 | 410
Microcephaly 4 | 149
Peripheral Neuropathy 4 | 303
acute myeloid leukemia 4 | 785
astrocytic glioma 4 | 2,241
breast carcinoma 4 | 1,614
spina bifida 4 | 1,064
Alpha thalassemia 3 | 10
Anemia 3 | 252
Ataxia telangiectasia 3 | 32
Breast Cancer, Familial 3 | 12
Fanconi Anemia 3 | 22
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
Malignant neoplasm of breast 3 | 63
Malignant neoplasm of lung 3 | 16
Pick disease 3 | 1,893
RAPADILINO syndrome 3 | 7
Roberts syndrome 3 | 16
Schimke immuno-osseous dysplasia 3 | 9
Seckel syndrome 3 | 35
acute quadriplegic myopathy 3 | 1,157
astrocytoma 3 | 1,493
atypical teratoid/rhabdoid tumor 3 | 1,095
group 4 medulloblastoma 3 | 1,875
medulloblastoma 3 | 1,524
non primary Sjogren syndrome sicca 3 | 840
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
ulcerative colitis 3 | 2,087
Adenoid Cystic Carcinoma 2 | 99
Chronic progressive external ophthalmoplegia 2 | 18
Cleft palate 2 | 125
Coffin-Siris syndrome 2 | 17
Colorectal Neoplasms 2 | 217
Disease Progression 2 | 125
HIV Infections 2 | 99
Leishmaniasis 2 | 49
Meier-Gorlin syndrome 2 | 12
Neoplastic Syndromes, Hereditary 2 | 48
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Prostate cancer 2 | 172
Prostatic Neoplasms 2 | 471
Stomach Neoplasms 2 | 282
aldosterone-producing adenoma 2 | 664
ependymoma 2 | 2,514
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 550
hereditary spastic paraplegia 2 | 313
inflammatory breast cancer 2 | 404
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
pilocytic astrocytoma 2 | 3,086
pituitary cancer 2 | 1,972
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 48 | 17,994
Cardiovascular System 48 | 17,957
Digestive Tract 48 | 18,472
Endocrine System 48 | 18,511
Female tissues 48 | 18,646
Liver and Pancreas 48 | 18,135
Male tissues 48 | 17,968
Nervous System 48 | 18,560
Respiratory system 48 | 17,483
Skin and soft tissues 48 | 18,114
Urinary Tract 48 | 18,443

Target Family

Non-IDG 26 | 11,969
Enzyme 18 | 4,146
Kinase 3 | 634
Epigenetic 2 | 242
Transcription Factor 1 | 1,400

Compartment GO Term

DNA helicase complex 50 | 50
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Twinkle protein, mitochondrial TWNK Tbio Non-IDG -2.15938 144.6 127
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.63144 224.5 73
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.80154 73.3 194
INO80 complex subunit B INO80B Tdark Non-IDG -1.09962 12.3 46
INO80 complex subunit C INO80C Tdark Non-IDG 0.00000 16
Protein MCM10 homolog MCM10 Tbio Non-IDG -1.62619 49.9 70
DNA repair protein RAD51 homolog 1 RAD51 Tchem Non-IDG -3.80958 5951.5 520
Histone H2A.Z H2AFZ Tbio Non-IDG -2.48248 304.4 245
DNA replication factor Cdt1 CDT1 Tbio Non-IDG -2.17234 139.2 105
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.08011 105.8 227