Development Level

Tbio 40 | 11,445
Tchem 8 | 1,598
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spinal cord morpholog... 1 | 9
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased fluid intake 1 | 3
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased body length 1 | 32
increased body weight 1 | 25
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
pale yolk sac 1 | 25
small testis 1 | 58

Disease

Carcinoma 38 | 11,493
ovarian cancer 34 | 8,520
lung cancer 28 | 4,740
osteosarcoma 27 | 7,950
medulloblastoma, large-cell 26 | 6,241
psoriasis 25 | 6,694
Cancer 24 | 2,499
group 3 medulloblastoma 23 | 4,104
malignant mesothelioma 22 | 3,232
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 20 | 5,112
primitive neuroectodermal tumor 20 | 3,035
Breast cancer 19 | 3,578
adult high grade glioma 18 | 3,801
non-small cell lung cancer 17 | 2,890
lung adenocarcinoma 16 | 2,716
invasive ductal carcinoma 15 | 2,951
Kidney cancer 13 | 2,613
colon cancer 12 | 1,478
Fanconi anemia 11 | 56
Intellectual disability 11 | 1,016
Rothmund-Thomson syndrome 11 | 19
Cockayne syndrome 10 | 60
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Bloom syndrome 9 | 29
Short stature 9 | 531
Small head 9 | 374
ductal carcinoma in situ 9 | 1,745
Autosomal recessive predisposition 8 | 1,442
Baller-Gerold syndrome 8 | 12
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Werner syndrome 8 | 29
adrenocortical carcinoma 8 | 1,428
ependymoma 8 | 4,679
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Multiple myeloma 7 | 1,332
Warsaw breakage syndrome 7 | 11
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
nasopharyngeal carcinoma 7 | 1,058
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Photosensitive trichothiodystrophy 6 | 30
Waldenstrons macroglobulinemia 6 | 765
diabetes mellitus 6 | 1,728
Breast Neoplasms 5 | 445
Cryptorchidism 5 | 296
Mammary Neoplasms 5 | 425
Nijmegen breakage syndrome 5 | 24
Xeroderma pigmentosum group D 5 | 33
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
juvenile dermatomyositis 5 | 1,187
oligodendroglioma 5 | 2,850
spina bifida 5 | 1,074
Astrocytoma, Pilocytic 4 | 3,081
Ataxia telangiectasia 4 | 34
Atopic dermatitis 4 | 952
Dental caries 4 | 164
Endometriosis 4 | 540
Liver cancer 4 | 604
Macrostomia 4 | 72
Microcephaly 4 | 166
Sparse scalp hair 4 | 42
Xeroderma pigmentosum 4 | 43
astrocytic glioma 4 | 2,597
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Acquired scoliosis 3 | 281
Anemia 3 | 365
Bilateral fifth finger clinodactyly 3 | 110
Congenital deafness 3 | 185
Curvature of little finger 3 | 110
Curvature of spine 3 | 282
Deafness 3 | 198
Delayed bone age 3 | 136
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Hearing Loss, Partial 3 | 185
Joint hyperflexibility 3 | 78
Large nose 3 | 23
Lung Neoplasms 3 | 232
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Recurrent respiratory infections 3 | 141
Seckel syndrome 3 | 34
Seizures 3 | 596
Strabismus 3 | 270
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
hearing impairment 3 | 199

Tissue

Blood and immune system 51 | 16,909
Cardiovascular System 51 | 15,192
Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Nervous System 51 | 16,725
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678

Target Family

Non-IDG 27 | 12,091
Enzyme 19 | 4,145
Epigenetic 3 | 242
Kinase 3 | 634
Transcription Factor 1 | 1,400

Compartment GO Term

DNA helicase complex 53 | 53
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
ATP-dependent DNA helicase Q1 RECQL Tbio Enzyme -1.87053 80.0 73
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Putative ATP-dependent RNA helicase DDX11-like protein 8 DDX11L8 Tdark Enzyme -1.05592 30.0 0
Nuclear factor related to kappa-B-binding protein NFRKB Tbio Non-IDG -0.80125 6.11 82
F-box DNA helicase 1 FBXO18 Tbio Enzyme -1.16507 17.7 87
DNA replication licensing factor MCM2 MCM2 Tbio Non-IDG -2.41622 246.0 777