Development Level

Tbio 4,545 | 11,651
Tdark 1,218 | 6,593
Tchem 712 | 1,388
Tclin 211 | 612

Collection

RFA-RM-18-021 89 | 328
Kinase: IDG Consortium (Target... 65 | 125
Kinase: IDG Consortium (Comple... 23 | 37
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 8 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 470 | 979
preweaning lethality, incomple... 221 | 499
embryonic lethality prior to t... 134 | 278
embryonic lethality prior to o... 122 | 239
abnormal behavior 116 | 298
abnormal embryo size 104 | 220
decreased total body fat amoun... 87 | 207
decreased body weight 81 | 161
abnormal bone structure 78 | 187
increased lean body mass 75 | 172
enlarged heart 69 | 210
decreased vertical activity 61 | 208
hyperactivity 60 | 148
abnormal heart morphology 59 | 162
decreased bone mineral content 59 | 151
increased total body fat amoun... 53 | 134
embryonic growth retardation 51 | 106
decreased bone mineral density 50 | 126
decreased lean body mass 50 | 135
increased startle reflex 50 | 112
decreased circulating glucose ... 49 | 126
male infertility 49 | 123
hypoactivity 48 | 132
decreased circulating choleste... 47 | 93
increased circulating alkaline... 47 | 122
increased mean corpuscular hem... 45 | 96
prenatal lethality prior to he... 45 | 87
decreased grip strength 44 | 116
abnormal lens morphology 42 | 81
cataract 42 | 92
decreased mean corpuscular vol... 41 | 79
increased bone mineral content 40 | 108
increased mean corpuscular vol... 40 | 92
decreased body length 39 | 101
increased or absent threshold ... 39 | 101
decreased lymphocyte cell numb... 38 | 83
short tibia 38 | 97
decreased prepulse inhibition 35 | 82
decreased circulating HDL chol... 34 | 68
decreased circulating triglyce... 34 | 79
impaired glucose tolerance 34 | 75
abnormal seminal vesicle morph... 33 | 114
decreased circulating insulin ... 33 | 76
decreased circulating serum al... 33 | 82
abnormal retina morphology 32 | 71
thrombocytopenia 32 | 56
improved glucose tolerance 31 | 79
increased heart weight 31 | 62
abnormal gait 30 | 69
increased bone mineral density 30 | 72
increased circulating HDL chol... 30 | 80
decreased hemoglobin content 29 | 68
decreased leukocyte cell numbe... 29 | 73
edema 29 | 59
decreased erythrocyte cell num... 27 | 62
decreased fasted circulating g... 27 | 65
increased fasted circulating g... 27 | 76
increased monocyte cell number 27 | 63
abnormal coat-hair pigmentatio... 26 | 64
abnormal sleep behavior 26 | 70
small superior vagus ganglion 26 | 74
abnormal eye morphology 25 | 68
decreased caudal vertebrae num... 25 | 53
decreased startle reflex 25 | 75
increased blood urea nitrogen ... 25 | 48
increased circulating choleste... 25 | 66
decreased circulating LDL chol... 24 | 38
decreased mean corpuscular hem... 24 | 50
increased circulating sodium l... 24 | 71
increased mean platelet volume 24 | 45
small testis 24 | 58
abnormal behavioral response t... 23 | 66
decreased hematocrit 23 | 46
decreased circulating iron lev... 22 | 32
increased neutrophil cell numb... 22 | 46
abnormal craniofacial morpholo... 21 | 33
anophthalmia 21 | 33
decreased circulating alanine ... 21 | 47
decreased circulating creatini... 21 | 39
decreased neutrophil cell numb... 21 | 42
increased hemoglobin content 21 | 45
abnormal kidney morphology 20 | 65
abnormal spleen morphology 20 | 55
decreased circulating aspartat... 20 | 34
hydrometra 20 | 53
increased circulating chloride... 20 | 41
increased hematocrit 20 | 46
abnormal bone mineralization 19 | 38
abnormal cranium morphology 19 | 36
female infertility 19 | 60
increased grip strength 19 | 41
increased leukocyte cell numbe... 19 | 47
abnormal neural tube closure 18 | 46
abnormal skin morphology 18 | 50
decreased blood urea nitrogen ... 18 | 51
decreased circulating total pr... 18 | 49
enlarged lymph nodes 18 | 37
enlarged spleen 17 | 41
increased mean corpuscular hem... 17 | 36
microphthalmia 17 | 26

Disease

Carcinoma 4,256 | 11,493
ovarian cancer 3,607 | 8,520
osteosarcoma 3,142 | 7,950
psoriasis 2,584 | 6,694
medulloblastoma, large-cell 2,505 | 6,241
glioblastoma 2,364 | 5,792
lung cancer 2,092 | 4,740
atypical teratoid / rhabdoid tumor 2,044 | 5,112
ependymoma 1,817 | 4,679
group 3 medulloblastoma 1,612 | 4,104
adult high grade glioma 1,522 | 3,801
Breast cancer 1,471 | 3,578
malignant mesothelioma 1,405 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,385 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 1,266 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,250 | 2,955
invasive ductal carcinoma 1,248 | 2,951
Cancer 1,247 | 2,499
primitive neuroectodermal tumor 1,233 | 3,035
Astrocytoma, Pilocytic 1,206 | 3,081
non-small cell lung cancer 1,183 | 2,890
oligodendroglioma 1,154 | 2,850
lung carcinoma 1,083 | 2,843
Kidney cancer 1,063 | 2,613
astrocytic glioma 1,062 | 2,597
lung adenocarcinoma 1,048 | 2,716
pancreatic cancer 1,001 | 2,398
subependymal giant cell astrocytoma 998 | 2,287
tuberculosis 838 | 2,010
interstitial cystitis 837 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 817 | 1,962
Pick disease 814 | 1,894
group 4 medulloblastoma 776 | 1,855
diabetes mellitus 764 | 1,728
ulcerative colitis 723 | 1,819
pituitary cancer 705 | 1,972
ductal carcinoma in situ 697 | 1,745
cystic fibrosis 685 | 1,696
breast carcinoma 683 | 1,638
Multiple myeloma 661 | 1,332
colon cancer 629 | 1,478
Autosomal recessive predisposition 604 | 1,442
adrenocortical carcinoma 594 | 1,428
acute quadriplegic myopathy 588 | 1,158
juvenile dermatomyositis 566 | 1,187
astrocytoma 540 | 1,146
Rheumatoid arthritis 522 | 1,191
Schizophrenia 501 | 1,160
spina bifida 493 | 1,074
dermatomyositis 487 | 966
Intellectual disability 474 | 1,016
primary pancreatic ductal adenocarcinoma 456 | 1,109
pediatric high grade glioma 429 | 1,064
cutaneous lupus erythematosus 425 | 1,057
nasopharyngeal carcinoma 421 | 1,058
Waldenstrons macroglobulinemia 417 | 765
Atopic dermatitis 412 | 952
acute myeloid leukemia 368 | 783
Liver Cirrhosis, Experimental 358 | 769
esophageal adenocarcinoma 355 | 737
non primary Sjogren syndrome sicca 351 | 891
active Crohn's disease 348 | 922
gastric carcinoma 331 | 807
Epilepsy 324 | 792
primary Sjogren syndrome 308 | 735
Alzheimer's disease 297 | 658
Obesity 297 | 678
active ulcerative colitis 291 | 764
Bipolar Disorder 288 | 666
medulloblastoma 288 | 720
Dull intelligence 284 | 645
Low intelligence 284 | 645
Mental Retardation 284 | 645
Mental deficiency 284 | 645
Poor school performance 284 | 645
Cognitive delay 283 | 608
Global developmental delay 283 | 608
Mental and motor retardation 283 | 608
aldosterone-producing adenoma 277 | 665
progressive supranuclear palsy 269 | 676
Seizures 265 | 596
Melanoma 257 | 711
Duchenne muscular dystrophy 255 | 601
Prostatic Neoplasms 249 | 495
pancreatic carcinoma 242 | 562
Endometriosis 241 | 540
Amyotrophic lateral sclerosis 239 | 451
hepatocellular carcinoma 239 | 547
Short stature 238 | 531
Liver cancer 234 | 604
Muscle hypotonia 234 | 571
autosomal dominant Emery-Dreifuss muscular dystrophy 234 | 510
Breast Neoplasms 226 | 445
Neurodegenerative disease 221 | 414
Kidney disease 217 | 430
Mammary Neoplasms 213 | 425
Multiple Sclerosis 212 | 540
Down syndrome 211 | 499
Anemia 207 | 365
Hypertension 204 | 396

Tissue

Endocrine System 6,505 | 18,159
Digestive Tract 6,447 | 17,369
Female tissues 6,447 | 17,400
Skin and soft tissues 6,438 | 17,230
Male tissues 6,389 | 17,142
Blood and immune system 6,376 | 16,909
Liver and Pancreas 6,360 | 16,750
Urinary Tract 6,342 | 16,678
Nervous System 6,323 | 16,725
Respiratory system 6,281 | 16,393
Cardiovascular System 6,071 | 15,192

Target Family

Non-IDG 3,954 | 12,091
Enzyme 1,738 | 4,145
Kinase 409 | 634
Transcription Factor 324 | 1,400
Epigenetic 81 | 242
Transporter 70 | 473
Ion Channel 58 | 344
GPCR 27 | 408
Nuclear Receptor 13 | 48
TF/Epigenetic 12 | 38

Compartment GO Term

Cytosol 6,686 | 6,686
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134