Development Level

Tbio 3,792 | 10,625
Tdark 1,163 | 7,003
Tchem 886 | 1,890
Tclin 194 | 602

Collection

Kinase: IDG Consortium (Targets) 64 | 125
Kinase: IDG Consortium (Complete/Control) 19 | 37
Ion Channel: IDG Consortium (Targets) 14 | 102
GPCR: IDG Consortium (Targets) 6 | 128
GPCR: IDG Consortium (Complete/Control) 3 | 24

IMPC Phenotype

preweaning lethality, complete... 273 | 633
preweaning lethality, incomple... 114 | 260
embryonic lethality prior to t... 93 | 187
abnormal behavior 86 | 226
decreased lean body mass 80 | 195
decreased total body fat amoun... 77 | 186
decreased body weight 76 | 174
embryonic lethality prior to o... 76 | 148
decreased bone mineral content 60 | 157
abnormal bone structure 52 | 131
decreased bone mineral density 51 | 126
abnormal embryo size 50 | 112
increased or absent threshold ... 50 | 128
increased circulating alkaline... 48 | 119
decreased circulating glucose ... 46 | 121
decreased body length 42 | 108
decreased grip strength 42 | 123
increased lean body mass 42 | 107
abnormal retina morphology 39 | 100
increased mean corpuscular hem... 39 | 93
decreased circulating choleste... 37 | 85
decreased circulating HDL chol... 35 | 77
hyperactivity 34 | 108
decreased circulating insulin ... 31 | 75
enlarged heart 31 | 111
increased mean corpuscular vol... 31 | 91
abnormal lens morphology 30 | 73
decreased circulating triglyce... 30 | 83
increased bone mineral content 30 | 92
increased grip strength 29 | 83
decreased circulating serum al... 28 | 79
hypoactivity 28 | 89
short tibia 27 | 82
abnormal retinal pigmentation 26 | 61
decreased mean corpuscular vol... 26 | 50
increased circulating HDL chol... 26 | 63
prenatal lethality prior to he... 26 | 64
thrombocytopenia 25 | 46
abnormal bone mineralization 24 | 55
abnormal coat-hair pigmentatio... 24 | 54
decreased lumbar vertebrae num... 24 | 62
male infertility 24 | 62
impaired glucose tolerance 23 | 52
increased body weight 23 | 42
increased bone mineral density 23 | 52
abnormal sleep behavior 22 | 63
decreased circulating alanine ... 22 | 53
decreased hemoglobin content 22 | 53
decreased rib number 22 | 59
improved glucose tolerance 22 | 56
increased circulating choleste... 22 | 53
decreased startle reflex 21 | 48
increased sacral vertebrae num... 21 | 62
abnormal behavioral response t... 20 | 52
abnormal gait 20 | 51
decreased circulating LDL chol... 20 | 37
decreased erythrocyte cell num... 20 | 43
decreased fasted circulating g... 20 | 49
decreased mean corpuscular hem... 20 | 34
increased blood urea nitrogen ... 20 | 44
increased circulating sodium l... 20 | 71
increased fasted circulating g... 20 | 68
decreased T cell number 19 | 31
decreased caudal vertebrae num... 19 | 49
increased circulating chloride... 19 | 43
decreased circulating iron lev... 18 | 25
decreased prepulse inhibition 18 | 52
increased heart weight 18 | 37
increased total body fat amoun... 18 | 57
abnormal cranium morphology 17 | 32
decreased circulating alkaline... 17 | 41
decreased heart weight 17 | 44
increased exploration in new e... 17 | 56
increased hemoglobin content 17 | 45
increased rib number 17 | 41
abnormal neural tube closure 16 | 37
decreased leukocyte cell numbe... 16 | 54
decreased neutrophil cell numb... 16 | 37
enlarged lymph nodes 16 | 27
increased hematocrit 16 | 36
increased leukocyte cell numbe... 16 | 37
decreased circulating creatini... 15 | 31
tremors 15 | 34
abnormal heart morphology 14 | 51
decreased circulating calcium ... 14 | 33
decreased circulating free fat... 14 | 39
decreased circulating fructosa... 14 | 31
decreased eosinophil cell numb... 14 | 41
increased monocyte cell number 14 | 27
limb grasping 14 | 35
abnormal rib morphology 13 | 28
abnormal spleen morphology 13 | 36
decreased CD4-positive, CD25-p... 13 | 24
decreased CD8-positive, alpha-... 13 | 26
decreased circulating aspartat... 13 | 27
decreased monocyte cell number 13 | 28
small testis 13 | 37
anophthalmia 12 | 20
increased circulating iron lev... 12 | 25
increased erythrocyte cell num... 12 | 26

Disease

ovarian cancer 3,321 | 8,491
osteosarcoma 2,870 | 7,933
medulloblastoma, large-cell 2,313 | 6,234
psoriasis 2,304 | 6,685
glioblastoma 2,113 | 5,572
lung cancer 1,870 | 4,473
atypical teratoid / rhabdoid tumor 1,623 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,292 | 3,289
malignant mesothelioma 1,280 | 3,163
Breast cancer 1,201 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 1,179 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,168 | 2,956
invasive ductal carcinoma 1,159 | 2,950
primitive neuroectodermal tumor 1,145 | 3,031
pilocytic astrocytoma 1,129 | 3,086
Cancer 1,100 | 2,346
oligodendroglioma 1,078 | 2,849
non-small cell lung cancer 1,067 | 2,798
pediatric high grade glioma 1,049 | 2,712
lung carcinoma 1,014 | 2,844
lung adenocarcinoma 982 | 2,714
ependymoma 942 | 2,514
subependymal giant cell astrocytoma 919 | 2,287
pancreatic cancer 902 | 2,300
astrocytic glioma 853 | 2,241
group 3 medulloblastoma 812 | 2,254
Carcinoma 784 | 2,147
ulcerative colitis 776 | 2,087
interstitial cystitis 767 | 2,299
Pick disease 753 | 1,893
adult high grade glioma 751 | 2,148
group 4 medulloblastoma 725 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 689 | 1,795
ductal carcinoma in situ 653 | 1,745
pituitary cancer 652 | 1,972
diabetes mellitus 643 | 1,663
astrocytoma 634 | 1,493
breast carcinoma 628 | 1,614
cystic fibrosis 625 | 1,670
tuberculosis 621 | 1,563
Multiple myeloma 620 | 1,327
colon cancer 597 | 1,475
medulloblastoma 578 | 1,524
adrenocortical carcinoma 559 | 1,427
acute quadriplegic myopathy 548 | 1,157
posterior fossa group A ependymoma 544 | 1,511
sonic hedgehog group medulloblastoma 544 | 1,482
posterior fossa group B ependymoma 517 | 1,530
juvenile dermatomyositis 513 | 1,189
primary pancreatic ductal adenocarcinoma 494 | 1,271
Rheumatoid Arthritis 467 | 1,170
spina bifida 451 | 1,064
dermatomyositis 448 | 966
atypical teratoid/rhabdoid tumor 404 | 1,095
Waldenstrons macroglobulinemia 388 | 764
cutaneous lupus erythematosus 383 | 1,056
nasopharyngeal carcinoma 379 | 1,056
Atopic dermatitis 350 | 944
acute myeloid leukemia 349 | 785
active Crohn's disease 319 | 918
esophageal adenocarcinoma 316 | 737
gastric carcinoma 316 | 832
primary Sjogren syndrome 302 | 788
non primary Sjogren syndrome sicca 293 | 840
tuberculosis and treatment for 6 months 290 | 686
Alzheimer's disease 273 | 644
Obesity 258 | 616
aldosterone-producing adenoma 256 | 664
Intellectual disability 252 | 573
progressive supranuclear palsy 251 | 674
Duchenne muscular dystrophy 235 | 602
pancreatic carcinoma 231 | 567
hepatocellular carcinoma 230 | 550
Endometriosis 223 | 535
Prostatic Neoplasms 222 | 471
Amyotrophic Lateral Sclerosis 220 | 432
Down syndrome 213 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 210 | 499
IGA Glomerulonephritis 206 | 454
Schizophrenia 196 | 503
Kidney disease 194 | 397
Neurodegenerative disease 193 | 383
Mammary Neoplasms 192 | 410
fibroadenoma 190 | 557
Multiple Sclerosis 176 | 498
gastric cancer 175 | 436
mucosa-associated lymphoid tissue lymphoma 172 | 480
chronic rhinosinusitis 169 | 512
sarcoidosis 161 | 368
Parkinson's disease 160 | 364
hereditary spastic paraplegia 155 | 313
active ulcerative colitis 154 | 477
Polycystic Ovary Syndrome 152 | 334
non-small cell lung carcinoma 151 | 413
Vascular disease 148 | 281
inflammatory breast cancer 148 | 404
Stomach Neoplasms 147 | 282
tuberculosis and treatment for 3 months 146 | 327
glioblastoma multiforme 141 | 347
Hypertension 140 | 293

Tissue

Nervous System 5,970 | 18,560
Female tissues 5,968 | 18,646
Digestive Tract 5,965 | 18,472
Liver and Pancreas 5,953 | 18,135
Blood and immune system 5,951 | 17,994
Endocrine System 5,950 | 18,511
Urinary Tract 5,950 | 18,443
Male tissues 5,946 | 17,968
Cardiovascular System 5,936 | 17,957
Skin and soft tissues 5,905 | 18,114
Respiratory system 5,891 | 17,483

Target Family

Non-IDG 3,509 | 11,969
Enzyme 1,619 | 4,146
Kinase 398 | 634
Transcription Factor 280 | 1,400
Transporter 68 | 473
Epigenetic 66 | 242
Ion Channel 53 | 341
GPCR 23 | 408
Nuclear Receptor 11 | 48
TF/Epigenetic 8 | 38

Compartment GO Term

Cytosol 6,035 | 6,035
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173