Development Level

Tbio 2,274 | 10,625
Tchem 686 | 1,890
Tdark 241 | 7,003
Tclin 151 | 602

Collection

Eligible Kinase Proteins 40 | 134
Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 175 | 633
embryonic lethality prior to t... 62 | 187
preweaning lethality, incomple... 53 | 260
embryonic lethality prior to o... 52 | 148
decreased lean body mass 51 | 195
abnormal behavior 49 | 226
decreased body weight 46 | 174
decreased bone mineral content 41 | 157
decreased total body fat amoun... 41 | 186
abnormal embryo size 37 | 112
decreased circulating choleste... 29 | 85
increased circulating alkaline... 29 | 119
decreased bone mineral density 28 | 126
abnormal bone structure 27 | 131
increased or absent threshold ... 27 | 128
abnormal retina morphology 26 | 100
decreased circulating glucose ... 26 | 121
decreased grip strength 26 | 123
decreased circulating HDL chol... 25 | 77
abnormal lens morphology 23 | 73
increased mean corpuscular hem... 23 | 93
decreased circulating triglyce... 22 | 83
hyperactivity 21 | 108
decreased body length 20 | 108
increased grip strength 20 | 83
abnormal bone mineralization 19 | 55
abnormal retinal pigmentation 18 | 61
decreased hemoglobin content 18 | 53
hypoactivity 18 | 89
increased lean body mass 18 | 107
decreased circulating insulin ... 17 | 75
decreased mean corpuscular vol... 17 | 50
decreased startle reflex 17 | 48
enlarged heart 17 | 111
increased mean corpuscular vol... 17 | 91
decreased circulating iron lev... 15 | 25
decreased fasted circulating g... 15 | 49
increased blood urea nitrogen ... 15 | 44
increased body weight 15 | 42
increased bone mineral density 15 | 52
increased circulating HDL chol... 15 | 63
increased heart weight 15 | 37
prenatal lethality prior to he... 15 | 64
abnormal coat/hair pigmentatio... 14 | 54
decreased T cell number 14 | 31
decreased circulating LDL chol... 14 | 37
decreased circulating alanine ... 14 | 53
decreased circulating serum al... 14 | 79
impaired glucose tolerance 14 | 52
increased bone mineral content 14 | 92
increased fasted circulating g... 14 | 68
decreased erythrocyte cell num... 13 | 43
decreased lumbar vertebrae num... 13 | 62
increased circulating choleste... 13 | 53
increased circulating sodium l... 13 | 71
decreased caudal vertebrae num... 12 | 49
decreased circulating free fat... 12 | 39
decreased mean corpuscular hem... 12 | 34
decreased prepulse inhibition 12 | 52
decreased rib number 12 | 59
enlarged lymph nodes 12 | 27
increased circulating chloride... 12 | 43
increased sacral vertebrae num... 12 | 62
thrombocytopenia 12 | 46
abnormal gait 11 | 51
abnormal neural tube closure 11 | 37
abnormal sleep behavior 11 | 63
decreased circulating alkaline... 11 | 41
decreased hematocrit 11 | 25
improved glucose tolerance 11 | 56
increased leukocyte cell numbe... 11 | 37
limb grasping 11 | 35
male infertility 11 | 62
short tibia 11 | 82
decreased circulating fructosa... 10 | 31
increased exploration in new e... 10 | 56
abnormal hindbrain development 9 | 24
abnormal midbrain development 9 | 22
cataract 9 | 26
decreased CD8-positive, alpha-... 9 | 26
decreased circulating calcium ... 9 | 33
decreased circulating creatini... 9 | 31
decreased heart weight 9 | 44
decreased leukocyte cell numbe... 9 | 54
decreased neutrophil cell numb... 9 | 37
embryonic growth retardation 9 | 28
increased circulating iron lev... 9 | 25
increased hemoglobin content 9 | 45
abnormal QRS complex 8 | 25
abnormal behavioral response t... 8 | 52
abnormal rib morphology 8 | 28
abnormal spleen morphology 8 | 36
anophthalmia 8 | 20
decreased circulating aspartat... 8 | 27
decreased eosinophil cell numb... 8 | 41
increased hematocrit 8 | 36
increased mean platelet volume 8 | 19
increased rib number 8 | 41
increased total body fat amoun... 8 | 57
small testis 8 | 37

Disease

ovarian cancer 1,886 | 8,484
osteosarcoma 1,605 | 7,933
psoriasis 1,432 | 6,685
medulloblastoma, large-cell 1,314 | 6,234
glioblastoma 1,234 | 5,572
lung cancer 1,145 | 4,466
atypical teratoid / rhabdoid tumor 905 | 4,369
Cancer 847 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 751 | 3,289
malignant mesothelioma 720 | 3,162
Breast cancer 693 | 3,094
invasive ductal carcinoma 683 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 661 | 2,988
primitive neuroectodermal tumor 660 | 3,031
non-small cell lung cancer 649 | 2,798
pilocytic astrocytoma 635 | 3,086
oligodendroglioma 624 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 620 | 2,956
lung adenocarcinoma 607 | 2,713
pediatric high grade glioma 602 | 2,712
lung carcinoma 581 | 2,844
subependymal giant cell astrocytoma 548 | 2,287
pancreatic cancer 543 | 2,300
ependymoma 521 | 2,514
ulcerative colitis 490 | 2,087
astrocytic glioma 478 | 2,241
diabetes mellitus 465 | 1,663
group 3 medulloblastoma 459 | 2,254
Multiple myeloma 444 | 1,327
Carcinoma 437 | 2,147
interstitial cystitis 435 | 2,299
Pick disease 433 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 420 | 1,795
adult high grade glioma 414 | 2,148
breast carcinoma 393 | 1,614
ductal carcinoma in situ 393 | 1,745
group 4 medulloblastoma 393 | 1,875
astrocytoma 389 | 1,493
colon cancer 388 | 1,475
tuberculosis 387 | 1,557
pituitary cancer 353 | 1,972
acute quadriplegic myopathy 344 | 1,157
cystic fibrosis 338 | 1,665
medulloblastoma 338 | 1,524
adrenocortical carcinoma 320 | 1,427
sonic hedgehog group medulloblastoma 317 | 1,482
posterior fossa group A ependymoma 315 | 1,511
juvenile dermatomyositis 303 | 1,189
Rheumatoid Arthritis 299 | 1,160
dermatomyositis 294 | 933
Waldenstrons macroglobulinemia 293 | 765
primary pancreatic ductal adenocarcinoma 273 | 1,271
posterior fossa group B ependymoma 252 | 1,530
cutaneous lupus erythematosus 250 | 1,056
atypical teratoid/rhabdoid tumor 233 | 1,095
spina bifida 222 | 1,064
Atopic dermatitis 221 | 944
Obesity 213 | 616
nasopharyngeal carcinoma 213 | 1,056
active Crohn's disease 202 | 918
acute myeloid leukemia 200 | 780
primary Sjogren syndrome 197 | 789
Alzheimer's disease 191 | 644
esophageal adenocarcinoma 189 | 737
gastric carcinoma 176 | 832
Intellectual disability 170 | 573
non primary Sjogren syndrome sicca 169 | 840
Kidney disease 167 | 396
Prostatic Neoplasms 166 | 471
tuberculosis and treatment for 6 months 157 | 686
Neurodegenerative disease 151 | 383
Endometriosis 149 | 535
pancreatic carcinoma 147 | 567
Mammary Neoplasms 145 | 410
hepatocellular carcinoma 143 | 532
IGA Glomerulonephritis 141 | 454
aldosterone-producing adenoma 140 | 664
Amyotrophic Lateral Sclerosis 139 | 431
Duchenne muscular dystrophy 138 | 602
Schizophrenia 136 | 501
Multiple Sclerosis 129 | 498
Down syndrome 127 | 548
progressive supranuclear palsy 127 | 674
Vascular disease 126 | 281
Hypertension 122 | 287
Parkinson's disease 119 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 119 | 499
Asthma 118 | 349
Liver carcinoma 118 | 217
Stomach Neoplasms 118 | 282
mucosa-associated lymphoid tissue lymphoma 117 | 480
Anemia 112 | 252
Heart disease 112 | 279
Atherosclerosis 110 | 275
fibroadenoma 110 | 557
gastric cancer 108 | 430
Cerebrovascular disease 104 | 231
hereditary spastic paraplegia 104 | 313
sarcoidosis 104 | 358
Polycystic Ovary Syndrome 103 | 332

Tissue

Nervous System 3,309 | 18,561
Digestive Tract 3,308 | 18,473
Female tissues 3,305 | 18,647
Blood and immune system 3,301 | 17,995
Urinary Tract 3,299 | 18,444
Endocrine System 3,298 | 18,512
Liver and Pancreas 3,298 | 18,136
Male tissues 3,294 | 17,969
Cardiovascular System 3,290 | 17,958
Skin and soft tissues 3,274 | 18,115
Respiratory system 3,271 | 17,484

Target Family

Non-IDG 1,768 | 11,971
Enzyme 1,130 | 4,146
Kinase 305 | 634
Transcription Factor 78 | 1,400
Epigenetic 26 | 242
Ion Channel 18 | 341
Transporter 15 | 473
Nuclear Receptor 6 | 48
GPCR 3 | 406
TF/Epigenetic 3 | 38

Compartment GO Term

Cytosol 3,352 | 3,352
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345