Development Level

Tbio 1,497 | 11,445
Tdark 318 | 6,588
Tchem 216 | 1,598
Tclin 77 | 613

Collection

RFA-RM-18-021 24 | 328
Kinase: IDG Consortium (Target... 18 | 125
Kinase: IDG Consortium (Comple... 11 | 37
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 158 | 979
preweaning lethality, incomple... 86 | 499
embryonic lethality prior to t... 45 | 278
abnormal behavior 43 | 298
abnormal embryo size 38 | 220
decreased body weight 33 | 161
decreased total body fat amoun... 31 | 207
embryonic lethality prior to o... 30 | 239
male infertility 27 | 123
abnormal bone structure 25 | 187
hyperactivity 24 | 148
increased lean body mass 23 | 172
decreased bone mineral content 22 | 151
decreased lean body mass 20 | 135
decreased circulating glucose ... 19 | 126
decreased grip strength 19 | 116
enlarged heart 19 | 210
hypoactivity 19 | 132
increased circulating alkaline... 19 | 122
increased total body fat amoun... 19 | 134
cataract 18 | 92
decreased bone mineral density 18 | 126
decreased vertical activity 18 | 208
improved glucose tolerance 18 | 79
decreased body length 17 | 101
increased mean corpuscular vol... 17 | 92
increased startle reflex 17 | 112
abnormal behavioral response t... 16 | 66
abnormal heart morphology 16 | 162
abnormal seminal vesicle morph... 16 | 114
embryonic growth retardation 16 | 106
abnormal retina morphology 15 | 71
abnormal sleep behavior 15 | 70
increased fasted circulating g... 15 | 76
increased or absent threshold ... 15 | 101
decreased circulating choleste... 14 | 93
decreased mean corpuscular vol... 14 | 79
edema 14 | 59
increased mean corpuscular hem... 14 | 96
prenatal lethality prior to he... 14 | 87
abnormal lens morphology 13 | 81
decreased circulating serum al... 13 | 82
decreased startle reflex 13 | 75
impaired glucose tolerance 13 | 75
increased bone mineral content 13 | 108
short tibia 13 | 97
abnormal coat-hair pigmentatio... 12 | 64
increased blood urea nitrogen ... 12 | 48
increased circulating chloride... 12 | 41
increased circulating sodium l... 11 | 71
small superior vagus ganglion 11 | 74
abnormal kidney morphology 10 | 65
decreased circulating HDL chol... 10 | 68
increased bone mineral density 10 | 72
increased circulating HDL chol... 10 | 80
increased heart weight 10 | 62
small testis 10 | 58
abnormal skin morphology 9 | 50
decreased circulating LDL chol... 9 | 38
decreased circulating alanine ... 9 | 47
decreased circulating insulin ... 9 | 76
decreased fasted circulating g... 9 | 65
decreased leukocyte cell numbe... 9 | 73
pallor 9 | 34
abnormal eye morphology 8 | 68
abnormal gait 8 | 69
abnormal spleen morphology 8 | 55
decreased blood urea nitrogen ... 8 | 51
decreased caudal vertebrae num... 8 | 53
decreased circulating calcium ... 8 | 36
decreased lymphocyte cell numb... 8 | 83
decreased red blood cell distr... 8 | 41
female infertility 8 | 60
increased body length 8 | 32
increased hematocrit 8 | 46
limb grasping 8 | 41
thrombocytopenia 8 | 56
abnormal embryo turning 7 | 31
abnormal pericardium morpholog... 7 | 26
abnormal testis morphology 7 | 43
cardiovascular system phenotyp... 7 | 36
convulsive seizures 7 | 13
decreased circulating alkaline... 7 | 46
decreased circulating aspartat... 7 | 34
decreased circulating total pr... 7 | 49
decreased circulating triglyce... 7 | 79
decreased erythrocyte cell num... 7 | 62
increased circulating choleste... 7 | 66
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 47
tremors 7 | 39
abnormal bone mineralization 6 | 38
abnormal craniofacial morpholo... 6 | 33
decreased circulating amylase ... 6 | 28
decreased circulating free fat... 6 | 31
decreased mean corpuscular hem... 6 | 50
increased body weight 6 | 25
increased monocyte cell number 6 | 63
persistence of hyaloid vascula... 6 | 33
prolonged ST segment 6 | 36

Disease

Carcinoma 1,502 | 11,493
ovarian cancer 1,120 | 8,520
osteosarcoma 993 | 7,950
psoriasis 869 | 6,694
glioblastoma 862 | 5,792
medulloblastoma, large-cell 834 | 6,241
atypical teratoid / rhabdoid tumor 754 | 5,112
ependymoma 733 | 4,679
lung cancer 686 | 4,740
group 3 medulloblastoma 612 | 4,104
Breast cancer 595 | 3,578
adult high grade glioma 559 | 3,801
Cancer 518 | 2,499
malignant mesothelioma 517 | 3,232
primitive neuroectodermal tumor 481 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 479 | 3,291
Kidney cancer 463 | 2,613
invasive ductal carcinoma 463 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 458 | 2,989
Astrocytoma, Pilocytic 454 | 3,081
non-small cell lung cancer 454 | 2,890
oligodendroglioma 439 | 2,850
pancreatic cancer 412 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 407 | 2,955
lung adenocarcinoma 396 | 2,716
lung carcinoma 380 | 2,843
astrocytic glioma 357 | 2,597
subependymal giant cell astrocytoma 338 | 2,287
interstitial cystitis 310 | 2,312
ductal carcinoma in situ 303 | 1,745
breast carcinoma 290 | 1,638
Pick disease 287 | 1,894
diabetes mellitus 275 | 1,728
colon cancer 272 | 1,478
pituitary cancer 263 | 1,972
ulcerative colitis 259 | 1,819
Autosomal recessive predisposition 255 | 1,442
tuberculosis 254 | 2,010
adrenocortical carcinoma 245 | 1,428
group 4 medulloblastoma 237 | 1,855
cystic fibrosis 223 | 1,696
Schizophrenia 221 | 1,160
nasopharyngeal carcinoma 212 | 1,058
Intellectual disability 210 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 208 | 1,962
acute quadriplegic myopathy 200 | 1,158
primary pancreatic ductal adenocarcinoma 190 | 1,109
juvenile dermatomyositis 188 | 1,187
astrocytoma 177 | 1,146
spina bifida 172 | 1,074
Multiple myeloma 165 | 1,332
dermatomyositis 162 | 966
pediatric high grade glioma 160 | 1,064
Atopic dermatitis 159 | 952
Rheumatoid arthritis 159 | 1,191
Alzheimer's disease 146 | 658
Liver Cirrhosis, Experimental 143 | 769
Dull intelligence 140 | 645
Low intelligence 140 | 645
Mental Retardation 140 | 645
Mental deficiency 140 | 645
Poor school performance 140 | 645
cutaneous lupus erythematosus 140 | 1,057
Duchenne muscular dystrophy 134 | 601
Endometriosis 133 | 540
Liver cancer 133 | 604
Melanoma 132 | 711
Obesity 131 | 678
Waldenstrons macroglobulinemia 131 | 765
esophageal adenocarcinoma 127 | 737
Cognitive delay 125 | 608
Global developmental delay 125 | 608
Mental and motor retardation 125 | 608
gastric carcinoma 122 | 807
Bipolar Disorder 120 | 666
Epilepsy 118 | 792
Short stature 117 | 531
Kidney disease 116 | 430
Breast Neoplasms 114 | 445
Mammary Neoplasms 112 | 425
non primary Sjogren syndrome sicca 112 | 891
active Crohn's disease 111 | 922
Neurodegenerative disease 109 | 414
chronic rhinosinusitis 109 | 512
Amyotrophic lateral sclerosis 108 | 451
autosomal dominant Emery-Dreifuss muscular dystrophy 107 | 510
Down syndrome 105 | 499
Heart disease 103 | 306
Seizures 103 | 596
acute myeloid leukemia 103 | 783
Hypertension 102 | 396
progressive supranuclear palsy 99 | 676
primary Sjogren syndrome 98 | 735
Skin cancer 94 | 469
medulloblastoma 94 | 720
Muscle hypotonia 93 | 571
Cerebrovascular disease 91 | 238
Depressive disorder 90 | 409
Small head 90 | 374
active ulcerative colitis 90 | 764

Tissue

Endocrine System 2,039 | 18,159
Skin and soft tissues 2,003 | 17,230
Female tissues 2,000 | 17,400
Digestive Tract 1,990 | 17,369
Male tissues 1,979 | 17,142
Blood and immune system 1,968 | 16,909
Nervous System 1,949 | 16,725
Urinary Tract 1,949 | 16,678
Liver and Pancreas 1,945 | 16,750
Respiratory system 1,926 | 16,393
Cardiovascular System 1,830 | 15,192

Target Family

Non-IDG 1,546 | 12,091
Enzyme 299 | 4,145
Kinase 130 | 634
Transcription Factor 69 | 1,400
Epigenetic 16 | 242
Transporter 15 | 473
Ion Channel 14 | 344
GPCR 9 | 408
Nuclear Receptor 9 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeleton 2,108 | 2,108
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Nck-associated protein 5-like NCKAP5L Tdark Non-IDG -0.22123 2.83 11
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221