Development Level

Tbio 1,374 | 10,625
Tdark 332 | 7,003
Tchem 272 | 1,890
Tclin 68 | 602

Collection

Eligible Kinase Proteins 15 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 98 | 633
preweaning lethality, incomple... 45 | 260
decreased body weight 32 | 174
decreased lean body mass 30 | 195
abnormal behavior 29 | 226
decreased total body fat amoun... 29 | 186
decreased bone mineral content 27 | 157
embryonic lethality prior to t... 24 | 187
increased or absent threshold ... 23 | 128
decreased grip strength 21 | 123
decreased bone mineral density 20 | 126
hyperactivity 20 | 108
increased circulating alkaline... 19 | 119
abnormal bone structure 17 | 131
abnormal embryo size 17 | 112
decreased body length 17 | 108
decreased circulating glucose ... 17 | 121
embryonic lethality prior to o... 17 | 148
decreased circulating choleste... 16 | 85
increased lean body mass 16 | 107
abnormal retina morphology 15 | 100
improved glucose tolerance 15 | 56
increased mean corpuscular hem... 15 | 93
increased mean corpuscular vol... 15 | 91
decreased circulating HDL chol... 14 | 77
abnormal lens morphology 12 | 73
abnormal sleep behavior 12 | 63
decreased mean corpuscular vol... 12 | 50
increased circulating chloride... 12 | 43
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating serum al... 11 | 79
increased body weight 11 | 42
increased circulating HDL chol... 11 | 63
decreased startle reflex 10 | 48
increased circulating choleste... 10 | 53
male infertility 10 | 62
abnormal behavioral response t... 9 | 52
decreased circulating triglyce... 9 | 83
hypoactivity 9 | 89
increased bone mineral content 9 | 92
increased fasted circulating g... 9 | 68
increased grip strength 9 | 83
increased heart weight 9 | 37
short tibia 9 | 82
decreased circulating alanine ... 8 | 53
increased blood urea nitrogen ... 8 | 44
increased exploration in new e... 8 | 56
increased leukocyte cell numbe... 8 | 37
limb grasping 8 | 35
abnormal bone mineralization 7 | 55
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating free fat... 7 | 39
decreased circulating insulin ... 7 | 75
decreased lumbar vertebrae num... 7 | 62
increased hematocrit 7 | 36
increased hemoglobin content 7 | 45
increased mean corpuscular hem... 7 | 25
prenatal lethality prior to he... 7 | 64
abnormal cranium morphology 6 | 32
absent pinna reflex 6 | 21
cardiovascular system phenotyp... 6 | 35
decreased blood urea nitrogen ... 6 | 31
decreased circulating aspartat... 6 | 27
decreased circulating calcium ... 6 | 33
decreased circulating total pr... 6 | 41
decreased heart weight 6 | 44
enlarged heart 6 | 111
increased circulating iron lev... 6 | 25
increased circulating sodium l... 6 | 71
increased rib number 6 | 41
thrombocytopenia 6 | 46
abnormal QRS complex 5 | 25
abnormal coat appearance 5 | 25
abnormal gait 5 | 51
abnormal head morphology 5 | 10
abnormal humerus morphology 5 | 11
abnormal kidney morphology 5 | 30
abnormal limb bud morphology 5 | 15
abnormal neural tube closure 5 | 37
abnormal retinal pigmentation 5 | 61
abnormal spleen morphology 5 | 36
convulsive seizures 5 | 11
decreased circulating alkaline... 5 | 41
decreased circulating amylase ... 5 | 24
decreased circulating iron lev... 5 | 25
decreased fasted circulating g... 5 | 49
decreased leukocyte cell numbe... 5 | 54
decreased rib number 5 | 59
impaired glucose tolerance 5 | 52
increased bone mineral density 5 | 52
increased circulating LDL chol... 5 | 15
increased circulating serum al... 5 | 25
increased heart rate 5 | 17
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
tremors 5 | 34
abnormal optic disc morphology 4 | 10
decreased prepulse inhibition 4 | 52
increased erythrocyte cell num... 4 | 26

Disease

ovarian cancer 1,091 | 8,492
osteosarcoma 968 | 7,933
psoriasis 856 | 6,685
glioblastoma 822 | 5,572
medulloblastoma, large-cell 822 | 6,234
lung cancer 656 | 4,473
atypical teratoid / rhabdoid tumor 619 | 4,369
Breast cancer 504 | 3,099
malignant mesothelioma 499 | 3,163
Cancer 484 | 2,346
primitive neuroectodermal tumor 478 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 465 | 3,289
invasive ductal carcinoma 455 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 447 | 2,988
pediatric high grade glioma 438 | 2,712
pilocytic astrocytoma 437 | 3,086
non-small cell lung cancer 435 | 2,798
oligodendroglioma 427 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 398 | 2,956
lung adenocarcinoma 388 | 2,714
pancreatic cancer 387 | 2,300
Carcinoma 376 | 2,147
lung carcinoma 366 | 2,844
ependymoma 348 | 2,514
subependymal giant cell astrocytoma 330 | 2,287
group 3 medulloblastoma 321 | 2,254
astrocytic glioma 299 | 2,241
ductal carcinoma in situ 297 | 1,745
interstitial cystitis 297 | 2,299
Pick disease 284 | 1,893
ulcerative colitis 273 | 2,087
breast carcinoma 272 | 1,614
colon cancer 269 | 1,475
posterior fossa group B ependymoma 267 | 1,530
adult high grade glioma 263 | 2,148
pituitary cancer 253 | 1,972
diabetes mellitus 250 | 1,663
group 4 medulloblastoma 250 | 1,875
adrenocortical carcinoma 244 | 1,427
astrocytoma 227 | 1,493
posterior fossa group A ependymoma 221 | 1,511
cystic fibrosis 214 | 1,670
primary pancreatic ductal adenocarcinoma 213 | 1,271
sonic hedgehog group medulloblastoma 213 | 1,482
tuberculosis 209 | 1,563
medulloblastoma 207 | 1,524
nasopharyngeal carcinoma 204 | 1,056
acute quadriplegic myopathy 195 | 1,157
atypical teratoid/rhabdoid tumor 186 | 1,095
juvenile dermatomyositis 182 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 174 | 1,795
spina bifida 169 | 1,064
Multiple myeloma 163 | 1,328
dermatomyositis 158 | 967
Rheumatoid Arthritis 153 | 1,171
Atopic dermatitis 151 | 944
Alzheimer's disease 135 | 644
Waldenstrons macroglobulinemia 135 | 765
cutaneous lupus erythematosus 130 | 1,056
Endometriosis 129 | 535
Duchenne muscular dystrophy 128 | 602
gastric carcinoma 127 | 832
esophageal adenocarcinoma 124 | 737
Intellectual disability 115 | 573
Obesity 115 | 616
Down syndrome 106 | 548
Kidney disease 105 | 397
non primary Sjogren syndrome sicca 105 | 840
active Crohn's disease 104 | 918
Mammary Neoplasms 103 | 410
progressive supranuclear palsy 103 | 674
Amyotrophic Lateral Sclerosis 102 | 432
Neurodegenerative disease 102 | 383
acute myeloid leukemia 102 | 785
chronic rhinosinusitis 99 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 98 | 499
primary Sjogren syndrome 97 | 789
Heart disease 94 | 279
Schizophrenia 89 | 503
Cerebrovascular disease 88 | 231
tuberculosis and treatment for 6 months 88 | 686
pancreatic carcinoma 85 | 567
Parkinson's disease 83 | 364
IGA Glomerulonephritis 82 | 454
hepatocellular carcinoma 82 | 550
Vascular disease 81 | 281
fibroadenoma 80 | 557
Prostatic Neoplasms 79 | 471
aldosterone-producing adenoma 79 | 664
gastric cancer 78 | 436
Hypertension 77 | 293
Multiple Sclerosis 73 | 498
non-small cell lung carcinoma 72 | 413
Neuropathy 71 | 210
Stomach Neoplasms 71 | 282
active ulcerative colitis 68 | 477
mucosa-associated lymphoid tissue lymphoma 66 | 480
Osteoporosis 65 | 259
Asthma 64 | 349
Toxic encephalopathy 62 | 131

Tissue

Female tissues 2,008 | 18,647
Nervous System 2,003 | 18,561
Endocrine System 2,001 | 18,512
Digestive Tract 1,999 | 18,473
Urinary Tract 1,990 | 18,444
Liver and Pancreas 1,988 | 18,136
Male tissues 1,984 | 17,969
Cardiovascular System 1,982 | 17,958
Blood and immune system 1,981 | 17,995
Skin and soft tissues 1,980 | 18,115
Respiratory system 1,955 | 17,484

Target Family

Non-IDG 1,502 | 11,969
Enzyme 297 | 4,146
Kinase 126 | 634
Transcription Factor 68 | 1,400
Epigenetic 14 | 242
Transporter 13 | 473
Ion Channel 10 | 341
GPCR 8 | 408
Nuclear Receptor 7 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeleton 2,046 | 2,046
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
MARVEL domain-containing protein 1 MARVELD1 Tbio Non-IDG -1.56013 36.2 57
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165
Synapsin-1 SYN1 Tbio Non-IDG -2.85684 687.9 716
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Lamin tail domain-containing protein 1 LMNTD1 Tdark Non-IDG 0.00000 1.11 56
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -0.87211 7.62 129
Small kinetochore-associated protein KNSTRN Tbio Non-IDG -1.24054 16.5 27