Development Level

Tbio 1,373 | 10,625
Tdark 332 | 7,003
Tchem 272 | 1,890
Tclin 68 | 602

Collection

Eligible Kinase Proteins 15 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 98 | 633
preweaning lethality, incomple... 45 | 260
decreased body weight 32 | 174
decreased lean body mass 30 | 195
abnormal behavior 29 | 226
decreased total body fat amoun... 29 | 186
decreased bone mineral content 27 | 157
embryonic lethality prior to t... 24 | 187
increased or absent threshold ... 23 | 128
decreased grip strength 21 | 123
decreased bone mineral density 20 | 126
hyperactivity 20 | 108
increased circulating alkaline... 19 | 119
abnormal bone structure 17 | 131
abnormal embryo size 17 | 112
decreased body length 17 | 108
decreased circulating glucose ... 17 | 121
embryonic lethality prior to o... 17 | 148
decreased circulating choleste... 16 | 85
increased lean body mass 16 | 107
abnormal retina morphology 15 | 100
improved glucose tolerance 15 | 56
increased mean corpuscular hem... 15 | 93
increased mean corpuscular vol... 15 | 91
decreased circulating HDL chol... 14 | 77
abnormal lens morphology 12 | 73
abnormal sleep behavior 12 | 63
decreased mean corpuscular vol... 12 | 50
increased circulating chloride... 12 | 43
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating serum al... 11 | 79
increased body weight 11 | 42
increased circulating HDL chol... 11 | 63
decreased startle reflex 10 | 48
increased circulating choleste... 10 | 53
male infertility 10 | 62
abnormal behavioral response t... 9 | 52
decreased circulating triglyce... 9 | 83
hypoactivity 9 | 89
increased bone mineral content 9 | 92
increased fasted circulating g... 9 | 68
increased grip strength 9 | 83
increased heart weight 9 | 37
short tibia 9 | 82
decreased circulating alanine ... 8 | 53
increased blood urea nitrogen ... 8 | 44
increased exploration in new e... 8 | 56
increased leukocyte cell numbe... 8 | 37
limb grasping 8 | 35
abnormal bone mineralization 7 | 55
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating free fat... 7 | 39
decreased circulating insulin ... 7 | 75
decreased lumbar vertebrae num... 7 | 62
increased hematocrit 7 | 36
increased hemoglobin content 7 | 45
increased mean corpuscular hem... 7 | 25
prenatal lethality prior to he... 7 | 64
abnormal cranium morphology 6 | 32
absent pinna reflex 6 | 21
cardiovascular system phenotyp... 6 | 35
decreased blood urea nitrogen ... 6 | 31
decreased circulating aspartat... 6 | 27
decreased circulating calcium ... 6 | 33
decreased circulating total pr... 6 | 41
decreased heart weight 6 | 44
enlarged heart 6 | 111
increased circulating iron lev... 6 | 25
increased circulating sodium l... 6 | 71
increased rib number 6 | 41
thrombocytopenia 6 | 46
abnormal QRS complex 5 | 25
abnormal coat appearance 5 | 25
abnormal gait 5 | 51
abnormal head morphology 5 | 10
abnormal humerus morphology 5 | 11
abnormal kidney morphology 5 | 30
abnormal limb bud morphology 5 | 15
abnormal neural tube closure 5 | 37
abnormal retinal pigmentation 5 | 61
abnormal spleen morphology 5 | 36
convulsive seizures 5 | 11
decreased circulating alkaline... 5 | 41
decreased circulating amylase ... 5 | 24
decreased circulating iron lev... 5 | 25
decreased fasted circulating g... 5 | 49
decreased leukocyte cell numbe... 5 | 54
decreased rib number 5 | 59
impaired glucose tolerance 5 | 52
increased bone mineral density 5 | 52
increased circulating LDL chol... 5 | 15
increased circulating serum al... 5 | 25
increased heart rate 5 | 17
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
tremors 5 | 34
abnormal optic disc morphology 4 | 10
decreased prepulse inhibition 4 | 52
increased erythrocyte cell num... 4 | 26

Disease

ovarian cancer 1,087 | 8,484
osteosarcoma 967 | 7,933
psoriasis 855 | 6,685
medulloblastoma, large-cell 822 | 6,234
glioblastoma 821 | 5,572
lung cancer 653 | 4,466
atypical teratoid / rhabdoid tumor 618 | 4,369
Breast cancer 501 | 3,094
malignant mesothelioma 498 | 3,162
Cancer 483 | 2,346
primitive neuroectodermal tumor 477 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 465 | 3,289
invasive ductal carcinoma 454 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 446 | 2,988
pediatric high grade glioma 438 | 2,712
pilocytic astrocytoma 436 | 3,086
non-small cell lung cancer 434 | 2,798
oligodendroglioma 427 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 397 | 2,956
lung adenocarcinoma 387 | 2,713
pancreatic cancer 386 | 2,300
Carcinoma 376 | 2,147
lung carcinoma 365 | 2,844
ependymoma 348 | 2,514
subependymal giant cell astrocytoma 330 | 2,287
group 3 medulloblastoma 321 | 2,254
astrocytic glioma 299 | 2,241
ductal carcinoma in situ 296 | 1,745
interstitial cystitis 296 | 2,299
Pick disease 284 | 1,893
ulcerative colitis 273 | 2,087
breast carcinoma 271 | 1,614
colon cancer 269 | 1,475
posterior fossa group B ependymoma 267 | 1,530
adult high grade glioma 262 | 2,148
pituitary cancer 253 | 1,972
group 4 medulloblastoma 250 | 1,875
diabetes mellitus 249 | 1,663
adrenocortical carcinoma 244 | 1,427
astrocytoma 227 | 1,493
posterior fossa group A ependymoma 220 | 1,511
cystic fibrosis 214 | 1,665
primary pancreatic ductal adenocarcinoma 213 | 1,271
sonic hedgehog group medulloblastoma 213 | 1,482
tuberculosis 208 | 1,557
medulloblastoma 206 | 1,524
nasopharyngeal carcinoma 204 | 1,056
acute quadriplegic myopathy 195 | 1,157
atypical teratoid/rhabdoid tumor 186 | 1,095
juvenile dermatomyositis 181 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 174 | 1,795
spina bifida 169 | 1,064
Multiple myeloma 163 | 1,327
dermatomyositis 157 | 933
Rheumatoid Arthritis 153 | 1,160
Atopic dermatitis 151 | 944
Alzheimer's disease 135 | 644
Waldenstrons macroglobulinemia 134 | 765
Endometriosis 129 | 535
cutaneous lupus erythematosus 129 | 1,056
Duchenne muscular dystrophy 127 | 602
gastric carcinoma 127 | 832
esophageal adenocarcinoma 123 | 737
Intellectual disability 115 | 573
Obesity 115 | 616
Down syndrome 106 | 548
non primary Sjogren syndrome sicca 104 | 840
Kidney disease 103 | 396
Mammary Neoplasms 103 | 410
active Crohn's disease 103 | 918
progressive supranuclear palsy 103 | 674
Neurodegenerative disease 102 | 383
Amyotrophic Lateral Sclerosis 101 | 431
acute myeloid leukemia 101 | 780
chronic rhinosinusitis 98 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 97 | 499
primary Sjogren syndrome 97 | 789
Heart disease 94 | 279
Cerebrovascular disease 88 | 231
Schizophrenia 88 | 501
tuberculosis and treatment for 6 months 88 | 686
pancreatic carcinoma 85 | 567
Parkinson's disease 83 | 364
IGA Glomerulonephritis 82 | 454
Vascular disease 81 | 281
fibroadenoma 80 | 557
Prostatic Neoplasms 79 | 471
aldosterone-producing adenoma 79 | 664
Hypertension 76 | 287
gastric cancer 76 | 430
Multiple Sclerosis 73 | 498
hepatocellular carcinoma 73 | 532
non-small cell lung carcinoma 72 | 413
Neuropathy 71 | 210
Stomach Neoplasms 71 | 282
active ulcerative colitis 67 | 477
mucosa-associated lymphoid tissue lymphoma 66 | 480
Asthma 64 | 349
Osteoporosis 64 | 257
Toxic encephalopathy 62 | 131

Tissue

Female tissues 2,007 | 18,647
Nervous System 2,002 | 18,561
Endocrine System 2,000 | 18,512
Digestive Tract 1,998 | 18,473
Urinary Tract 1,989 | 18,444
Liver and Pancreas 1,987 | 18,136
Male tissues 1,983 | 17,969
Cardiovascular System 1,981 | 17,958
Blood and immune system 1,980 | 17,995
Skin and soft tissues 1,979 | 18,115
Respiratory system 1,954 | 17,484

Target Family

Non-IDG 1,502 | 11,971
Enzyme 296 | 4,146
Kinase 126 | 634
Transcription Factor 68 | 1,400
Epigenetic 14 | 242
Transporter 13 | 473
Ion Channel 10 | 341
GPCR 8 | 406
Nuclear Receptor 7 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeleton 2,045 | 2,045
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303