Development Level

Tbio 1,430 | 11,178
Tdark 316 | 6,569
Tchem 265 | 1,885
Tclin 73 | 612

Collection

Kinase: IDG Consortium (Target... 18 | 125
Kinase: IDG Consortium (Comple... 11 | 37
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 157 | 979
preweaning lethality, incomple... 84 | 499
embryonic lethality prior to t... 44 | 278
abnormal behavior 43 | 298
abnormal embryo size 36 | 220
decreased body weight 32 | 161
decreased total body fat amoun... 30 | 207
embryonic lethality prior to o... 30 | 239
male infertility 27 | 123
abnormal bone structure 25 | 187
hyperactivity 24 | 148
increased lean body mass 23 | 172
decreased bone mineral content 22 | 151
decreased circulating glucose ... 19 | 126
decreased lean body mass 19 | 135
enlarged heart 19 | 210
hypoactivity 19 | 132
increased circulating alkaline... 19 | 122
increased total body fat amoun... 19 | 134
cataract 18 | 92
decreased grip strength 18 | 116
improved glucose tolerance 18 | 79
decreased body length 17 | 101
decreased bone mineral density 17 | 126
decreased vertical activity 17 | 208
increased mean corpuscular vol... 17 | 92
increased startle reflex 17 | 112
abnormal behavioral response t... 16 | 66
abnormal heart morphology 16 | 162
abnormal seminal vesicle morph... 15 | 114
embryonic growth retardation 15 | 106
increased fasted circulating g... 15 | 76
increased or absent threshold ... 15 | 101
abnormal retina morphology 14 | 71
abnormal sleep behavior 14 | 70
decreased circulating choleste... 14 | 93
decreased mean corpuscular vol... 14 | 79
edema 14 | 59
prenatal lethality prior to he... 14 | 87
abnormal lens morphology 13 | 81
decreased circulating serum al... 13 | 82
decreased startle reflex 13 | 75
impaired glucose tolerance 13 | 75
increased bone mineral content 13 | 108
increased mean corpuscular hem... 13 | 96
abnormal coat-hair pigmentatio... 12 | 64
increased circulating chloride... 12 | 41
short tibia 12 | 97
increased blood urea nitrogen ... 11 | 48
increased circulating sodium l... 11 | 71
small superior vagus ganglion 11 | 74
abnormal kidney morphology 10 | 65
decreased circulating HDL chol... 10 | 68
increased bone mineral density 10 | 72
increased circulating HDL chol... 10 | 80
increased heart weight 10 | 62
small testis 10 | 58
abnormal skin morphology 9 | 50
decreased circulating LDL chol... 9 | 38
decreased circulating alanine ... 9 | 47
decreased circulating insulin ... 9 | 76
decreased leukocyte cell numbe... 9 | 73
pallor 9 | 34
abnormal eye morphology 8 | 68
abnormal spleen morphology 8 | 55
decreased blood urea nitrogen ... 8 | 51
decreased caudal vertebrae num... 8 | 53
decreased circulating calcium ... 8 | 36
decreased fasted circulating g... 8 | 65
decreased lymphocyte cell numb... 8 | 83
decreased red blood cell distr... 8 | 41
female infertility 8 | 60
increased body length 8 | 32
increased hematocrit 8 | 46
limb grasping 8 | 41
thrombocytopenia 8 | 56
abnormal embryo turning 7 | 31
abnormal gait 7 | 69
abnormal pericardium morpholog... 7 | 26
abnormal testis morphology 7 | 43
cardiovascular system phenotyp... 7 | 36
convulsive seizures 7 | 13
decreased circulating alkaline... 7 | 46
decreased circulating total pr... 7 | 49
decreased circulating triglyce... 7 | 79
decreased erythrocyte cell num... 7 | 62
increased circulating choleste... 7 | 66
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 47
abnormal bone mineralization 6 | 38
abnormal craniofacial morpholo... 6 | 33
decreased circulating amylase ... 6 | 28
decreased circulating aspartat... 6 | 34
decreased circulating free fat... 6 | 31
decreased mean corpuscular hem... 6 | 50
increased body weight 6 | 25
increased monocyte cell number 6 | 63
persistence of hyaloid vascula... 6 | 33
prenatal lethality 6 | 28
tremors 6 | 39

Disease

Carcinoma 1,483 | 11,192
ovarian cancer 1,104 | 8,297
osteosarcoma 981 | 7,766
psoriasis 857 | 6,514
glioblastoma 849 | 5,635
medulloblastoma, large-cell 824 | 6,086
atypical teratoid / rhabdoid tumor 743 | 4,971
ependymoma 723 | 4,559
lung cancer 672 | 4,607
group 3 medulloblastoma 602 | 4,002
Breast cancer 580 | 3,469
adult high grade glioma 553 | 3,701
malignant mesothelioma 508 | 3,135
Cancer 501 | 2,388
primitive neuroectodermal tumor 472 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 471 | 3,204
Kidney cancer 455 | 2,548
invasive ductal carcinoma 455 | 2,867
Astrocytoma, Pilocytic 449 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 448 | 2,902
non-small cell lung cancer 443 | 2,799
oligodendroglioma 433 | 2,768
intraductal papillary-mucinous adenoma (IPMA) 404 | 2,872
pancreatic cancer 404 | 2,322
lung adenocarcinoma 385 | 2,627
lung carcinoma 371 | 2,755
astrocytic glioma 353 | 2,530
subependymal giant cell astrocytoma 332 | 2,230
interstitial cystitis 307 | 2,237
ductal carcinoma in situ 295 | 1,686
Pick disease 284 | 1,856
breast carcinoma 283 | 1,589
diabetes mellitus 267 | 1,683
colon cancer 263 | 1,428
pituitary cancer 261 | 1,915
ulcerative colitis 253 | 1,765
tuberculosis 249 | 1,963
Autosomal recessive predisposition 248 | 1,407
adrenocortical carcinoma 241 | 1,385
group 4 medulloblastoma 235 | 1,806
cystic fibrosis 217 | 1,629
Schizophrenia 215 | 1,136
nasopharyngeal carcinoma 208 | 1,024
pancreatic ductal adenocarcinoma liver metastasis 207 | 1,911
Intellectual disability 205 | 998
acute quadriplegic myopathy 196 | 1,133
primary pancreatic ductal adenocarcinoma 185 | 1,071
juvenile dermatomyositis 184 | 1,147
astrocytoma 173 | 1,113
spina bifida 172 | 1,053
Multiple myeloma 162 | 1,296
dermatomyositis 159 | 941
pediatric high grade glioma 158 | 1,035
Atopic dermatitis 155 | 915
Rheumatoid arthritis 155 | 1,156
Alzheimer's disease 141 | 640
Dull intelligence 137 | 634
Low intelligence 137 | 634
Mental Retardation 137 | 634
Mental deficiency 137 | 634
Poor school performance 137 | 634
cutaneous lupus erythematosus 137 | 1,016
Liver Cirrhosis, Experimental 134 | 733
Duchenne muscular dystrophy 132 | 587
Melanoma 130 | 689
Liver cancer 129 | 589
Waldenstrons macroglobulinemia 128 | 742
Endometriosis 126 | 521
Obesity 125 | 655
esophageal adenocarcinoma 124 | 696
Cognitive delay 122 | 596
Global developmental delay 122 | 596
Mental and motor retardation 122 | 596
gastric carcinoma 120 | 781
Bipolar Disorder 117 | 646
Epilepsy 114 | 775
Short stature 113 | 514
non primary Sjogren syndrome sicca 111 | 861
Kidney disease 109 | 411
active Crohn's disease 109 | 882
chronic rhinosinusitis 109 | 505
Amyotrophic lateral sclerosis 107 | 437
Breast Neoplasms 106 | 423
Neurodegenerative disease 105 | 402
Mammary Neoplasms 104 | 403
autosomal dominant Emery-Dreifuss muscular dystrophy 104 | 492
Down syndrome 101 | 480
acute myeloid leukemia 101 | 760
Seizures 99 | 584
progressive supranuclear palsy 98 | 656
Heart disease 96 | 288
Hypertension 95 | 372
primary Sjogren syndrome 95 | 710
medulloblastoma 93 | 702
Skin cancer 92 | 451
Muscle hypotonia 90 | 562
Small head 88 | 366
active ulcerative colitis 88 | 736
Cerebrovascular disease 86 | 223
aldosterone-producing adenoma 85 | 646

Tissue

Endocrine System 2,016 | 18,159
Skin and soft tissues 1,980 | 17,230
Female tissues 1,977 | 17,400
Digestive Tract 1,967 | 17,369
Male tissues 1,956 | 17,142
Blood and immune system 1,945 | 16,909
Urinary Tract 1,926 | 16,678
Nervous System 1,925 | 16,725
Liver and Pancreas 1,922 | 16,750
Respiratory system 1,903 | 16,393
Cardiovascular System 1,807 | 15,192

Target Family

Non-IDG 1,539 | 12,091
Enzyme 288 | 4,145
Kinase 130 | 634
Transcription Factor 63 | 1,400
Epigenetic 16 | 242
Transporter 15 | 473
Ion Channel 14 | 344
GPCR 9 | 408
Nuclear Receptor 9 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeleton 2,084 | 2,084
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Mitogen-activated protein kinase-binding protein 1 MAPKBP1 Tbio Enzyme -0.46630 4.01 51
Protein KIAA0556 KIAA0556 Tdark Non-IDG -0.22617 2.09 22
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Protein monoglycylase TTLL8 TTLL8 Tdark Enzyme -0.12494 0.88 19
Cilia- and flagella-associated protein 251 WDR66 Tbio Non-IDG -0.15127 1.56 72
Disks large-associated protein 2 DLGAP2 Tbio Non-IDG -1.34061 22.6 54
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159
Keratin, type I cytoskeletal 17 KRT17 Tbio Non-IDG -2.43909 265.8 711