Development Level

Tbio 1,167 | 11,651
Tdark 249 | 6,593
Tchem 155 | 1,388
Tclin 67 | 612

Collection

RFA-RM-18-021 18 | 328
Kinase: IDG Consortium (Target... 15 | 125
Kinase: IDG Consortium (Comple... 7 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 140 | 979
preweaning lethality, incomple... 69 | 499
embryonic lethality prior to t... 41 | 278
abnormal embryo size 35 | 220
abnormal behavior 32 | 298
decreased body weight 28 | 161
decreased total body fat amoun... 24 | 207
embryonic lethality prior to o... 23 | 239
abnormal bone structure 22 | 187
male infertility 20 | 123
hyperactivity 19 | 148
increased circulating alkaline... 18 | 122
decreased body length 17 | 101
decreased bone mineral content 17 | 151
decreased lean body mass 17 | 135
decreased bone mineral density 16 | 126
embryonic growth retardation 16 | 106
increased total body fat amoun... 16 | 134
decreased grip strength 15 | 116
hypoactivity 15 | 132
increased lean body mass 15 | 172
cataract 14 | 92
decreased circulating serum al... 14 | 82
decreased vertical activity 14 | 208
edema 14 | 59
increased fasted circulating g... 14 | 76
prenatal lethality prior to he... 14 | 87
abnormal sleep behavior 13 | 70
short tibia 13 | 97
abnormal seminal vesicle morph... 12 | 114
enlarged heart 12 | 210
increased mean corpuscular hem... 12 | 96
increased or absent threshold ... 12 | 101
increased startle reflex 12 | 112
abnormal heart morphology 11 | 162
abnormal lens morphology 11 | 81
abnormal retina morphology 11 | 71
decreased circulating glucose ... 11 | 126
impaired glucose tolerance 11 | 75
improved glucose tolerance 11 | 79
increased mean corpuscular vol... 11 | 92
abnormal behavioral response t... 10 | 66
decreased circulating choleste... 10 | 93
decreased mean corpuscular vol... 10 | 79
increased blood urea nitrogen ... 10 | 48
increased bone mineral content 10 | 108
increased circulating HDL chol... 10 | 80
increased circulating chloride... 10 | 41
decreased startle reflex 9 | 75
increased bone mineral density 9 | 72
abnormal kidney morphology 8 | 65
decreased circulating HDL chol... 8 | 68
decreased circulating LDL chol... 8 | 38
decreased circulating calcium ... 8 | 36
decreased leukocyte cell numbe... 8 | 73
increased body length 8 | 32
increased hematocrit 8 | 46
pallor 8 | 34
abnormal coat-hair pigmentatio... 7 | 64
abnormal embryo turning 7 | 31
abnormal pericardium morpholog... 7 | 26
decreased blood urea nitrogen ... 7 | 51
decreased caudal vertebrae num... 7 | 53
decreased circulating insulin ... 7 | 76
decreased lymphocyte cell numb... 7 | 83
female infertility 7 | 60
increased circulating sodium l... 7 | 71
small superior vagus ganglion 7 | 74
tremors 7 | 39
abnormal craniofacial morpholo... 6 | 33
abnormal eye morphology 6 | 68
abnormal gait 6 | 69
cardiovascular system phenotyp... 6 | 36
convulsive seizures 6 | 13
decreased circulating alkaline... 6 | 46
decreased circulating total pr... 6 | 49
decreased red blood cell distr... 6 | 41
hemorrhage 6 | 23
increased circulating choleste... 6 | 66
increased heart weight 6 | 62
increased leukocyte cell numbe... 6 | 47
limb grasping 6 | 41
prolonged ST segment 6 | 36
small testis 6 | 58
thrombocytopenia 6 | 56
abnormal bone mineralization 5 | 38
abnormal cranium morphology 5 | 36
abnormal neural tube closure 5 | 46
abnormal placenta size 5 | 20
abnormal skin morphology 5 | 50
abnormal spleen morphology 5 | 55
decreased circulating alanine ... 5 | 47
decreased circulating amylase ... 5 | 28
decreased circulating free fat... 5 | 31
decreased circulating fructosa... 5 | 30
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
increased hemoglobin content 5 | 45
persistence of hyaloid vascula... 5 | 33
prolonged QT interval 5 | 38

Disease

Carcinoma 1,153 | 11,493
ovarian cancer 853 | 8,520
osteosarcoma 744 | 7,950
psoriasis 674 | 6,694
medulloblastoma, large-cell 646 | 6,241
glioblastoma 644 | 5,792
ependymoma 580 | 4,679
atypical teratoid / rhabdoid tumor 579 | 5,112
lung cancer 534 | 4,740
Breast cancer 476 | 3,578
group 3 medulloblastoma 475 | 4,104
Cancer 434 | 2,499
adult high grade glioma 421 | 3,801
malignant mesothelioma 397 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 367 | 3,291
primitive neuroectodermal tumor 366 | 3,035
Kidney cancer 355 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 355 | 2,989
non-small cell lung cancer 346 | 2,890
invasive ductal carcinoma 340 | 2,951
oligodendroglioma 330 | 2,850
Astrocytoma, Pilocytic 328 | 3,081
lung adenocarcinoma 315 | 2,716
pancreatic cancer 307 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 301 | 2,955
lung carcinoma 278 | 2,843
astrocytic glioma 271 | 2,597
subependymal giant cell astrocytoma 248 | 2,287
ductal carcinoma in situ 232 | 1,745
breast carcinoma 231 | 1,638
diabetes mellitus 221 | 1,728
Pick disease 220 | 1,894
interstitial cystitis 220 | 2,312
colon cancer 215 | 1,478
Autosomal recessive predisposition 207 | 1,442
adrenocortical carcinoma 204 | 1,428
ulcerative colitis 192 | 1,819
pituitary cancer 191 | 1,972
group 4 medulloblastoma 186 | 1,855
Schizophrenia 184 | 1,160
nasopharyngeal carcinoma 180 | 1,058
Intellectual disability 179 | 1,016
tuberculosis 167 | 2,010
cystic fibrosis 162 | 1,696
acute quadriplegic myopathy 158 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 154 | 1,962
primary pancreatic ductal adenocarcinoma 144 | 1,109
Multiple myeloma 140 | 1,332
juvenile dermatomyositis 137 | 1,187
astrocytoma 133 | 1,146
Alzheimer's disease 126 | 658
Rheumatoid arthritis 125 | 1,191
dermatomyositis 123 | 966
Atopic dermatitis 122 | 952
Endometriosis 122 | 540
Dull intelligence 121 | 645
Low intelligence 121 | 645
Mental Retardation 121 | 645
Mental deficiency 121 | 645
Poor school performance 121 | 645
Obesity 116 | 678
pediatric high grade glioma 116 | 1,064
spina bifida 113 | 1,074
Liver Cirrhosis, Experimental 111 | 769
Cognitive delay 108 | 608
Global developmental delay 108 | 608
Mental and motor retardation 108 | 608
Epilepsy 106 | 792
Short stature 106 | 531
Duchenne muscular dystrophy 104 | 601
Kidney disease 104 | 430
Melanoma 104 | 711
Liver cancer 102 | 604
cutaneous lupus erythematosus 100 | 1,057
Bipolar Disorder 99 | 666
Waldenstrons macroglobulinemia 99 | 765
chronic rhinosinusitis 97 | 512
Breast Neoplasms 94 | 445
Neurodegenerative disease 94 | 414
esophageal adenocarcinoma 94 | 737
Down syndrome 92 | 499
Heart disease 92 | 306
Mammary Neoplasms 92 | 425
gastric carcinoma 92 | 807
Amyotrophic lateral sclerosis 91 | 451
Seizures 90 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 87 | 510
non primary Sjogren syndrome sicca 87 | 891
Hypertension 86 | 396
Small head 84 | 374
progressive supranuclear palsy 82 | 676
Cerebrovascular disease 81 | 238
acute myeloid leukemia 81 | 783
Depressive disorder 79 | 409
Vascular disease 78 | 319
active Crohn's disease 78 | 922
Prostatic Neoplasms 76 | 495
Stomach Neoplasms 76 | 300
medulloblastoma 76 | 720
Muscle hypotonia 74 | 571

Tissue

Endocrine System 1,575 | 18,159
Skin and soft tissues 1,552 | 17,230
Female tissues 1,548 | 17,400
Digestive Tract 1,539 | 17,369
Male tissues 1,528 | 17,142
Blood and immune system 1,520 | 16,909
Urinary Tract 1,503 | 16,678
Liver and Pancreas 1,502 | 16,750
Nervous System 1,501 | 16,725
Respiratory system 1,488 | 16,393
Cardiovascular System 1,410 | 15,192

Target Family

Non-IDG 1,222 | 12,091
Enzyme 221 | 4,145
Kinase 96 | 634
Transcription Factor 56 | 1,400
Epigenetic 14 | 242
Transporter 9 | 473
GPCR 8 | 408
Ion Channel 6 | 344
Nuclear Receptor 5 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeletal part 1,638 | 1,638
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
RBPJ-interacting and tubulin-associated protein 1 RITA1 Tbio Non-IDG -0.85891 6.79 61
Cilia- and flagella-associated protein 74 CFAP74 Tdark Non-IDG 0.38 0.16 21
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106