Development Level

Tbio 1,039 | 10,625
Tdark 261 | 7,003
Tchem 209 | 1,890
Tclin 59 | 602

Collection

Kinase: IDG Consortium (Targets) 12 | 125
Kinase: IDG Consortium (Complete/Control) 8 | 37
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 85 | 633
preweaning lethality, incomple... 38 | 260
decreased body weight 28 | 174
abnormal behavior 26 | 226
decreased bone mineral content 24 | 157
decreased lean body mass 24 | 195
embryonic lethality prior to t... 22 | 187
decreased total body fat amoun... 21 | 186
increased circulating alkaline... 20 | 119
increased or absent threshold ... 18 | 128
hyperactivity 17 | 108
decreased bone mineral density 16 | 126
abnormal embryo size 15 | 112
decreased grip strength 15 | 123
abnormal bone structure 14 | 131
increased mean corpuscular hem... 14 | 93
abnormal sleep behavior 12 | 63
decreased body length 12 | 108
embryonic lethality prior to o... 12 | 148
abnormal retina morphology 11 | 100
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 11 | 121
decreased circulating serum al... 11 | 79
increased lean body mass 11 | 107
abnormal lens morphology 10 | 73
decreased circulating HDL chol... 10 | 77
increased circulating HDL chol... 10 | 63
increased circulating chloride... 10 | 43
increased mean corpuscular vol... 10 | 91
abnormal coat-hair pigmentatio... 9 | 54
decreased mean corpuscular vol... 9 | 50
increased circulating choleste... 9 | 53
short tibia 9 | 82
hypoactivity 8 | 89
increased fasted circulating g... 8 | 68
abnormal behavioral response t... 7 | 52
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating free fat... 7 | 39
decreased circulating triglyce... 7 | 83
decreased lumbar vertebrae num... 7 | 62
improved glucose tolerance 7 | 56
increased exploration in new e... 7 | 56
increased grip strength 7 | 83
increased hematocrit 7 | 36
increased leukocyte cell numbe... 7 | 37
prenatal lethality prior to he... 7 | 64
abnormal bone mineralization 6 | 55
decreased circulating calcium ... 6 | 33
decreased startle reflex 6 | 48
increased blood urea nitrogen ... 6 | 44
increased body weight 6 | 42
increased bone mineral content 6 | 92
increased heart weight 6 | 37
increased hemoglobin content 6 | 45
increased mean corpuscular hem... 6 | 25
limb grasping 6 | 35
abnormal head morphology 5 | 10
abnormal humerus morphology 5 | 11
abnormal limb bud morphology 5 | 15
abnormal neural tube closure 5 | 37
absent pinna reflex 5 | 21
cardiovascular system phenotyp... 5 | 35
convulsive seizures 5 | 11
decreased blood urea nitrogen ... 5 | 31
decreased circulating insulin ... 5 | 75
decreased circulating total pr... 5 | 41
increased circulating LDL chol... 5 | 15
increased circulating iron lev... 5 | 25
increased circulating serum al... 5 | 25
increased circulating sodium l... 5 | 71
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
male infertility 5 | 62
thrombocytopenia 5 | 46
tremors 5 | 34
abnormal QRS complex 4 | 25
abnormal cranium morphology 4 | 32
abnormal embryo turning 4 | 15
abnormal gait 4 | 51
abnormal kidney morphology 4 | 30
decreased caudal vertebrae num... 4 | 49
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased circulating aspartat... 4 | 27
decreased circulating creatini... 4 | 31
decreased circulating fructosa... 4 | 31
decreased exploration in new e... 4 | 9
decreased heart weight 4 | 44
embryonic growth retardation 4 | 28
enlarged heart 4 | 111
hemorrhage 4 | 12
hydrops fetalis 4 | 22
impaired glucose tolerance 4 | 52
increased bone mineral density 4 | 52
increased circulating glucose ... 4 | 16
increased erythrocyte cell num... 4 | 26
persistence of hyaloid vascula... 4 | 22
straub tail 4 | 26
vertebral fusion 4 | 23

Disease

ovarian cancer 817 | 8,491
osteosarcoma 713 | 7,933
psoriasis 665 | 6,685
medulloblastoma, large-cell 623 | 6,234
glioblastoma 614 | 5,572
lung cancer 496 | 4,473
atypical teratoid / rhabdoid tumor 452 | 4,369
Cancer 404 | 2,346
Breast cancer 395 | 3,098
malignant mesothelioma 374 | 3,163
primitive neuroectodermal tumor 359 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 348 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 340 | 2,988
pediatric high grade glioma 332 | 2,712
invasive ductal carcinoma 329 | 2,950
non-small cell lung cancer 323 | 2,798
oligodendroglioma 319 | 2,849
pilocytic astrocytoma 316 | 3,086
lung adenocarcinoma 302 | 2,714
Carcinoma 293 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 289 | 2,956
pancreatic cancer 284 | 2,300
lung carcinoma 262 | 2,844
ependymoma 259 | 2,514
group 3 medulloblastoma 259 | 2,254
subependymal giant cell astrocytoma 244 | 2,287
posterior fossa group B ependymoma 229 | 1,530
ductal carcinoma in situ 224 | 1,745
astrocytic glioma 218 | 2,241
Pick disease 214 | 1,893
breast carcinoma 212 | 1,614
colon cancer 212 | 1,475
interstitial cystitis 205 | 2,299
ulcerative colitis 205 | 2,087
diabetes mellitus 202 | 1,663
adrenocortical carcinoma 196 | 1,427
adult high grade glioma 192 | 2,148
group 4 medulloblastoma 185 | 1,875
pituitary cancer 185 | 1,972
astrocytoma 173 | 1,493
nasopharyngeal carcinoma 167 | 1,056
posterior fossa group A ependymoma 165 | 1,511
primary pancreatic ductal adenocarcinoma 155 | 1,271
medulloblastoma 154 | 1,524
cystic fibrosis 153 | 1,670
sonic hedgehog group medulloblastoma 153 | 1,482
acute quadriplegic myopathy 152 | 1,157
atypical teratoid/rhabdoid tumor 149 | 1,095
tuberculosis 147 | 1,563
Multiple myeloma 136 | 1,327
juvenile dermatomyositis 134 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 130 | 1,795
Endometriosis 118 | 535
Atopic dermatitis 117 | 944
Alzheimer's disease 116 | 644
Rheumatoid Arthritis 115 | 1,170
dermatomyositis 114 | 966
spina bifida 104 | 1,064
Duchenne muscular dystrophy 100 | 602
Waldenstrons macroglobulinemia 100 | 764
Intellectual disability 98 | 573
Obesity 97 | 616
Kidney disease 96 | 397
gastric carcinoma 94 | 832
cutaneous lupus erythematosus 91 | 1,056
Down syndrome 90 | 548
esophageal adenocarcinoma 88 | 737
chronic rhinosinusitis 86 | 512
Mammary Neoplasms 85 | 410
Neurodegenerative disease 85 | 383
Amyotrophic Lateral Sclerosis 84 | 432
Heart disease 82 | 279
acute myeloid leukemia 82 | 785
non primary Sjogren syndrome sicca 82 | 840
progressive supranuclear palsy 80 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 79 | 499
Cerebrovascular disease 78 | 231
Vascular disease 74 | 281
IGA Glomerulonephritis 73 | 454
Prostatic Neoplasms 72 | 471
active Crohn's disease 72 | 918
Hypertension 71 | 293
Parkinson's disease 71 | 364
Schizophrenia 69 | 503
primary Sjogren syndrome 69 | 788
pancreatic carcinoma 68 | 567
Stomach Neoplasms 64 | 282
non-small cell lung carcinoma 63 | 413
Neuropathy 62 | 210
hepatocellular carcinoma 62 | 550
Toxic encephalopathy 61 | 131
fibroadenoma 61 | 557
gastric cancer 61 | 436
tuberculosis and treatment for 6 months 61 | 686
Osteoporosis 60 | 259
Multiple Sclerosis 58 | 498
aldosterone-producing adenoma 58 | 664
Asthma 57 | 349
Liver disease 56 | 219
Liver carcinoma 53 | 217

Tissue

Female tissues 1,537 | 18,646
Nervous System 1,531 | 18,560
Endocrine System 1,530 | 18,511
Digestive Tract 1,527 | 18,472
Urinary Tract 1,520 | 18,443
Liver and Pancreas 1,518 | 18,135
Male tissues 1,515 | 17,968
Skin and soft tissues 1,514 | 18,114
Blood and immune system 1,512 | 17,994
Cardiovascular System 1,512 | 17,957
Respiratory system 1,494 | 17,483

Target Family

Non-IDG 1,175 | 11,969
Enzyme 211 | 4,146
Kinase 92 | 634
Transcription Factor 52 | 1,400
Epigenetic 13 | 242
Transporter 9 | 473
GPCR 7 | 408
Ion Channel 4 | 341
Nuclear Receptor 4 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeletal part 1,568 | 1,568
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
HAUS augmin-like complex subunit 8 HAUS8 Tbio Non-IDG 1.00 0.07 117
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
Rotatin RTTN Tdark Non-IDG -0.83847 8.10 9
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.24310 169.4 383
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67051 512.2 639
CD40 ligand CD40LG Tchem Non-IDG -4.56976 36580.5 1095
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306