Development Level

Tbio 1,039 | 10,625
Tdark 261 | 7,003
Tchem 208 | 1,890
Tclin 59 | 602

Collection

Eligible Kinase Proteins 12 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 85 | 633
preweaning lethality, incomple... 38 | 260
decreased body weight 28 | 174
abnormal behavior 26 | 226
decreased bone mineral content 24 | 157
decreased lean body mass 24 | 195
embryonic lethality prior to t... 22 | 187
decreased total body fat amoun... 21 | 186
increased circulating alkaline... 20 | 119
increased or absent threshold ... 18 | 128
hyperactivity 17 | 108
decreased bone mineral density 16 | 126
abnormal embryo size 15 | 112
decreased grip strength 15 | 123
abnormal bone structure 14 | 131
increased mean corpuscular hem... 14 | 93
abnormal sleep behavior 12 | 63
decreased body length 12 | 108
embryonic lethality prior to o... 12 | 148
abnormal retina morphology 11 | 100
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 11 | 121
decreased circulating serum al... 11 | 79
increased lean body mass 11 | 107
abnormal lens morphology 10 | 73
decreased circulating HDL chol... 10 | 77
increased circulating HDL chol... 10 | 63
increased circulating chloride... 10 | 43
increased mean corpuscular vol... 10 | 91
abnormal coat/hair pigmentatio... 9 | 54
decreased mean corpuscular vol... 9 | 50
increased circulating choleste... 9 | 53
short tibia 9 | 82
hypoactivity 8 | 89
increased fasted circulating g... 8 | 68
abnormal behavioral response t... 7 | 52
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating free fat... 7 | 39
decreased circulating triglyce... 7 | 83
decreased lumbar vertebrae num... 7 | 62
improved glucose tolerance 7 | 56
increased exploration in new e... 7 | 56
increased grip strength 7 | 83
increased hematocrit 7 | 36
increased leukocyte cell numbe... 7 | 37
prenatal lethality prior to he... 7 | 64
abnormal bone mineralization 6 | 55
decreased circulating calcium ... 6 | 33
decreased startle reflex 6 | 48
increased blood urea nitrogen ... 6 | 44
increased body weight 6 | 42
increased bone mineral content 6 | 92
increased heart weight 6 | 37
increased hemoglobin content 6 | 45
increased mean corpuscular hem... 6 | 25
limb grasping 6 | 35
abnormal head morphology 5 | 10
abnormal humerus morphology 5 | 11
abnormal limb bud morphology 5 | 15
abnormal neural tube closure 5 | 37
absent pinna reflex 5 | 21
cardiovascular system phenotyp... 5 | 35
convulsive seizures 5 | 11
decreased blood urea nitrogen ... 5 | 31
decreased circulating insulin ... 5 | 75
decreased circulating total pr... 5 | 41
increased circulating LDL chol... 5 | 15
increased circulating iron lev... 5 | 25
increased circulating serum al... 5 | 25
increased circulating sodium l... 5 | 71
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
male infertility 5 | 62
thrombocytopenia 5 | 46
tremors 5 | 34
abnormal QRS complex 4 | 25
abnormal cranium morphology 4 | 32
abnormal embryo turning 4 | 15
abnormal gait 4 | 51
abnormal kidney morphology 4 | 30
decreased caudal vertebrae num... 4 | 49
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased circulating aspartat... 4 | 27
decreased circulating creatini... 4 | 31
decreased circulating fructosa... 4 | 31
decreased exploration in new e... 4 | 9
decreased heart weight 4 | 44
embryonic growth retardation 4 | 28
enlarged heart 4 | 111
hemorrhage 4 | 12
hydrops fetalis 4 | 22
impaired glucose tolerance 4 | 52
increased bone mineral density 4 | 52
increased circulating glucose ... 4 | 16
increased erythrocyte cell num... 4 | 26
persistence of hyaloid vascula... 4 | 22
straub tail 4 | 26
vertebral fusion 4 | 23

Disease

ovarian cancer 814 | 8,484
osteosarcoma 712 | 7,933
psoriasis 665 | 6,685
medulloblastoma, large-cell 622 | 6,234
glioblastoma 613 | 5,572
lung cancer 494 | 4,466
atypical teratoid / rhabdoid tumor 452 | 4,369
Cancer 403 | 2,346
Breast cancer 394 | 3,094
malignant mesothelioma 373 | 3,162
primitive neuroectodermal tumor 358 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 348 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 340 | 2,988
pediatric high grade glioma 332 | 2,712
invasive ductal carcinoma 329 | 2,950
non-small cell lung cancer 323 | 2,798
oligodendroglioma 318 | 2,849
pilocytic astrocytoma 315 | 3,086
lung adenocarcinoma 302 | 2,713
Carcinoma 293 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 289 | 2,956
pancreatic cancer 284 | 2,300
lung carcinoma 261 | 2,844
group 3 medulloblastoma 259 | 2,254
ependymoma 258 | 2,514
subependymal giant cell astrocytoma 243 | 2,287
posterior fossa group B ependymoma 229 | 1,530
ductal carcinoma in situ 224 | 1,745
astrocytic glioma 218 | 2,241
Pick disease 213 | 1,893
breast carcinoma 212 | 1,614
colon cancer 212 | 1,475
interstitial cystitis 205 | 2,299
ulcerative colitis 205 | 2,087
diabetes mellitus 202 | 1,663
adrenocortical carcinoma 196 | 1,427
adult high grade glioma 191 | 2,148
pituitary cancer 185 | 1,972
group 4 medulloblastoma 184 | 1,875
astrocytoma 172 | 1,493
nasopharyngeal carcinoma 167 | 1,056
posterior fossa group A ependymoma 165 | 1,511
primary pancreatic ductal adenocarcinoma 155 | 1,271
medulloblastoma 154 | 1,524
cystic fibrosis 153 | 1,665
sonic hedgehog group medulloblastoma 153 | 1,482
acute quadriplegic myopathy 152 | 1,157
atypical teratoid/rhabdoid tumor 148 | 1,095
tuberculosis 147 | 1,557
Multiple myeloma 136 | 1,327
juvenile dermatomyositis 134 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 130 | 1,795
Endometriosis 118 | 535
Atopic dermatitis 117 | 944
Alzheimer's disease 115 | 644
Rheumatoid Arthritis 115 | 1,160
dermatomyositis 114 | 933
spina bifida 104 | 1,064
Duchenne muscular dystrophy 100 | 602
Waldenstrons macroglobulinemia 100 | 765
Intellectual disability 98 | 573
Obesity 97 | 616
Kidney disease 96 | 396
gastric carcinoma 94 | 832
cutaneous lupus erythematosus 91 | 1,056
Down syndrome 90 | 548
esophageal adenocarcinoma 88 | 737
chronic rhinosinusitis 86 | 512
Mammary Neoplasms 85 | 410
Neurodegenerative disease 85 | 383
Amyotrophic Lateral Sclerosis 83 | 431
Heart disease 82 | 279
non primary Sjogren syndrome sicca 82 | 840
acute myeloid leukemia 81 | 780
progressive supranuclear palsy 80 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 79 | 499
Cerebrovascular disease 78 | 231
IGA Glomerulonephritis 73 | 454
Vascular disease 73 | 281
Prostatic Neoplasms 72 | 471
active Crohn's disease 72 | 918
Parkinson's disease 71 | 364
Hypertension 70 | 287
Schizophrenia 69 | 501
primary Sjogren syndrome 69 | 789
pancreatic carcinoma 68 | 567
Stomach Neoplasms 64 | 282
non-small cell lung carcinoma 63 | 413
Neuropathy 62 | 210
Toxic encephalopathy 61 | 131
fibroadenoma 61 | 557
tuberculosis and treatment for 6 months 61 | 686
Osteoporosis 59 | 257
gastric cancer 59 | 430
Multiple Sclerosis 58 | 498
aldosterone-producing adenoma 58 | 664
Asthma 57 | 349
Liver disease 56 | 219
Liver carcinoma 53 | 217
hepatocellular carcinoma 53 | 532

Tissue

Female tissues 1,536 | 18,647
Nervous System 1,530 | 18,561
Endocrine System 1,529 | 18,512
Digestive Tract 1,526 | 18,473
Urinary Tract 1,519 | 18,444
Liver and Pancreas 1,517 | 18,136
Male tissues 1,514 | 17,969
Skin and soft tissues 1,513 | 18,115
Blood and immune system 1,511 | 17,995
Cardiovascular System 1,511 | 17,958
Respiratory system 1,493 | 17,484

Target Family

Non-IDG 1,175 | 11,971
Enzyme 211 | 4,146
Kinase 91 | 634
Transcription Factor 52 | 1,400
Epigenetic 13 | 242
Transporter 9 | 473
GPCR 7 | 406
Ion Channel 4 | 341
Nuclear Receptor 4 | 48
oGPCR 1 | 421

Compartment GO Term

Cytoskeletal part 1,567 | 1,567
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303