Development Level

Tbio 1,517 | 11,178
Tchem 308 | 1,885
Tdark 213 | 6,569
Tclin 120 | 612

Collection

Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 8 | 126
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 123 | 979
preweaning lethality, incomple... 64 | 499
abnormal behavior 42 | 298
embryonic lethality prior to t... 40 | 278
embryonic lethality prior to o... 32 | 239
decreased total body fat amoun... 30 | 207
abnormal embryo size 28 | 220
decreased vertical activity 27 | 208
hypoactivity 24 | 132
abnormal bone structure 23 | 187
decreased bone mineral content 23 | 151
decreased grip strength 22 | 116
increased lean body mass 22 | 172
short tibia 22 | 97
increased circulating alkaline... 21 | 122
enlarged heart 20 | 210
increased total body fat amoun... 20 | 134
abnormal seminal vesicle morph... 19 | 114
hyperactivity 18 | 148
decreased body weight 17 | 161
increased startle reflex 17 | 112
decreased circulating choleste... 16 | 93
edema 16 | 59
increased bone mineral content 16 | 108
abnormal retina morphology 15 | 71
decreased bone mineral density 15 | 126
decreased circulating serum al... 15 | 82
cataract 14 | 92
decreased circulating HDL chol... 14 | 68
decreased circulating glucose ... 14 | 126
decreased circulating insulin ... 14 | 76
decreased mean corpuscular hem... 14 | 50
increased mean corpuscular vol... 14 | 92
abnormal sleep behavior 13 | 70
decreased lean body mass 13 | 135
embryonic growth retardation 13 | 106
impaired glucose tolerance 13 | 75
increased circulating sodium l... 13 | 71
increased heart weight 13 | 62
increased or absent threshold ... 13 | 101
abnormal heart morphology 12 | 162
abnormal kidney morphology 12 | 65
abnormal lens morphology 12 | 81
decreased prepulse inhibition 12 | 82
improved glucose tolerance 12 | 79
increased bone mineral density 12 | 72
decreased lymphocyte cell numb... 11 | 83
increased circulating chloride... 11 | 41
abnormal behavioral response t... 10 | 66
abnormal coat-hair pigmentatio... 10 | 64
decreased fasted circulating g... 10 | 65
decreased mean corpuscular vol... 10 | 79
decreased startle reflex 10 | 75
enlarged lymph nodes 10 | 37
increased fasted circulating g... 10 | 76
increased leukocyte cell numbe... 10 | 47
increased mean corpuscular hem... 10 | 96
prolonged QT interval 10 | 38
tremors 10 | 39
decreased circulating LDL chol... 9 | 38
decreased circulating alkaline... 9 | 46
decreased leukocyte cell numbe... 9 | 73
abnormal gait 8 | 69
cardiovascular system phenotyp... 8 | 36
decreased circulating total pr... 8 | 49
decreased circulating triglyce... 8 | 79
increased circulating choleste... 8 | 66
increased circulating triglyce... 8 | 42
increased hematocrit 8 | 46
limb grasping 8 | 41
small superior vagus ganglion 8 | 74
abnormal eye morphology 7 | 68
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
decreased hemoglobin content 7 | 68
increased body weight 7 | 25
increased circulating HDL chol... 7 | 80
increased neutrophil cell numb... 7 | 46
prenatal lethality 7 | 28
prenatal lethality prior to he... 7 | 87
prolonged ST segment 7 | 36
thrombocytosis 7 | 27
abnormal craniofacial morpholo... 6 | 33
decreased mean corpuscular hem... 6 | 31
decreased threshold for audito... 6 | 26
enlarged spleen 6 | 41
increased circulating free fat... 6 | 20
increased hemoglobin content 6 | 45
increased red blood cell distr... 6 | 34
male infertility 6 | 123
small testis 6 | 58
abnormal locomotor behavior 5 | 24
anophthalmia 5 | 33
increased circulating calcium ... 5 | 34
increased circulating potassiu... 5 | 29
increased circulating serum al... 5 | 22
increased circulating total pr... 5 | 28
increased monocyte cell number 5 | 63
increased prepulse inhibition 5 | 32
pallor 5 | 34

Disease

Carcinoma 1,350 | 11,192
ovarian cancer 1,137 | 8,297
osteosarcoma 1,046 | 7,766
psoriasis 887 | 6,514
glioblastoma 841 | 5,635
medulloblastoma, large-cell 801 | 6,086
atypical teratoid / rhabdoid tumor 668 | 4,971
lung cancer 663 | 4,607
ependymoma 612 | 4,559
Cancer 545 | 2,388
adult high grade glioma 527 | 3,701
Astrocytoma, Pilocytic 510 | 3,006
lung carcinoma 472 | 2,755
malignant mesothelioma 468 | 3,135
Breast cancer 449 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 447 | 3,204
invasive ductal carcinoma 428 | 2,867
group 3 medulloblastoma 423 | 4,002
intraductal papillary-mucinous adenoma (IPMA) 417 | 2,872
non-small cell lung cancer 412 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 404 | 2,902
tuberculosis 398 | 1,963
lung adenocarcinoma 396 | 2,627
oligodendroglioma 395 | 2,768
diabetes mellitus 387 | 1,683
pancreatic cancer 379 | 2,322
interstitial cystitis 363 | 2,237
subependymal giant cell astrocytoma 361 | 2,230
astrocytic glioma 360 | 2,530
primitive neuroectodermal tumor 352 | 2,957
Kidney cancer 349 | 2,548
ulcerative colitis 302 | 1,765
pancreatic ductal adenocarcinoma liver metastasis 292 | 1,911
Pick disease 271 | 1,856
Autosomal recessive predisposition 255 | 1,407
Schizophrenia 246 | 1,136
cystic fibrosis 246 | 1,629
Multiple myeloma 245 | 1,296
group 4 medulloblastoma 243 | 1,806
pituitary cancer 242 | 1,915
ductal carcinoma in situ 238 | 1,686
Rheumatoid arthritis 232 | 1,156
breast carcinoma 227 | 1,589
juvenile dermatomyositis 218 | 1,147
dermatomyositis 217 | 941
cutaneous lupus erythematosus 212 | 1,016
astrocytoma 202 | 1,113
colon cancer 197 | 1,428
primary pancreatic ductal adenocarcinoma 189 | 1,071
acute quadriplegic myopathy 185 | 1,133
adrenocortical carcinoma 175 | 1,385
Liver Cirrhosis, Experimental 168 | 733
Intellectual disability 165 | 998
Alzheimer's disease 163 | 640
Waldenstrons macroglobulinemia 154 | 742
Epilepsy 152 | 775
pediatric high grade glioma 152 | 1,035
Bipolar Disorder 148 | 646
esophageal adenocarcinoma 147 | 696
gastric carcinoma 147 | 781
spina bifida 144 | 1,053
mucosa-associated lymphoid tissue lymphoma 143 | 473
Arthritis 140 | 276
Kidney disease 140 | 411
active Crohn's disease 136 | 882
primary Sjogren syndrome 134 | 710
Duchenne muscular dystrophy 130 | 587
nasopharyngeal carcinoma 129 | 1,024
Multiple Sclerosis 128 | 527
Obesity 127 | 655
Neurodegenerative disease 121 | 402
non primary Sjogren syndrome sicca 120 | 861
Hypersensitivity reaction type II disease 119 | 245
Atopic dermatitis 118 | 915
Seizures 118 | 584
Hypertension 112 | 372
active ulcerative colitis 112 | 736
Melanoma 108 | 689
Dull intelligence 106 | 634
Low intelligence 106 | 634
Mental Retardation 106 | 634
Mental deficiency 106 | 634
Poor school performance 106 | 634
Depressive disorder 105 | 401
Down syndrome 104 | 480
Prostatic Neoplasms 104 | 472
pancreatic carcinoma 104 | 555
Parkinson's disease 97 | 378
Anemia 95 | 353
Atherosclerosis 95 | 276
acute myeloid leukemia 95 | 760
Liver cancer 93 | 589
Asthma 90 | 370
Liver disease 89 | 227
hepatocellular carcinoma 89 | 536
Cognitive delay 88 | 596
Global developmental delay 88 | 596
Mental and motor retardation 88 | 596
aldosterone-producing adenoma 88 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 88 | 492

Tissue

Endocrine System 2,027 | 18,159
Digestive Tract 2,006 | 17,369
Female tissues 2,001 | 17,400
Skin and soft tissues 1,988 | 17,230
Male tissues 1,974 | 17,142
Liver and Pancreas 1,973 | 16,750
Blood and immune system 1,966 | 16,909
Urinary Tract 1,959 | 16,678
Nervous System 1,947 | 16,725
Respiratory system 1,939 | 16,393
Cardiovascular System 1,824 | 15,192

Target Family

Non-IDG 1,430 | 12,091
Enzyme 439 | 4,145
Kinase 91 | 634
Transporter 69 | 473
GPCR 58 | 408
Ion Channel 51 | 344
Transcription Factor 11 | 1,400
oGPCR 5 | 421
Epigenetic 3 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Cytoplasmic vesicle 2,158 | 2,158
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847