Development Level

Tbio 883 | 10,625
Tchem 177 | 1,890
Tdark 134 | 7,003
Tclin 61 | 602

Collection

Eligible Ion Channel Proteins 7 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 5 | 145

IMPC Term

preweaning lethality, complete... 55 | 633
abnormal behavior 23 | 226
decreased grip strength 20 | 123
embryonic lethality prior to t... 19 | 187
preweaning lethality, incomple... 18 | 260
decreased total body fat amoun... 17 | 186
increased or absent threshold ... 17 | 128
decreased bone mineral content 13 | 157
decreased lean body mass 13 | 195
abnormal bone structure 12 | 131
abnormal embryo size 12 | 112
decreased circulating HDL chol... 12 | 77
decreased circulating choleste... 11 | 85
embryonic lethality prior to o... 11 | 148
enlarged heart 11 | 111
increased circulating alkaline... 11 | 119
short tibia 11 | 82
decreased body length 9 | 108
decreased body weight 9 | 174
decreased circulating glucose ... 9 | 121
decreased fasted circulating g... 9 | 49
hypoactivity 9 | 89
increased circulating sodium l... 9 | 71
increased grip strength 9 | 83
abnormal coat/hair pigmentatio... 8 | 54
abnormal lens morphology 8 | 73
decreased circulating serum al... 8 | 79
decreased mean corpuscular vol... 8 | 50
increased mean corpuscular hem... 8 | 93
increased total body fat amoun... 8 | 57
abnormal retina morphology 7 | 100
abnormal sleep behavior 7 | 63
decreased circulating LDL chol... 7 | 37
decreased circulating insulin ... 7 | 75
decreased mean corpuscular hem... 7 | 34
hyperactivity 7 | 108
increased bone mineral content 7 | 92
increased circulating HDL chol... 7 | 63
increased hematocrit 7 | 36
abnormal retinal pigmentation 6 | 61
cardiovascular system phenotyp... 6 | 35
decreased bone mineral density 6 | 126
decreased prepulse inhibition 6 | 52
increased body weight 6 | 42
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
tremors 6 | 34
abnormal QRS complex 5 | 25
abnormal bone mineralization 5 | 55
abnormal kidney morphology 5 | 30
abnormal seminal vesicle morph... 5 | 47
cataract 5 | 26
decreased mean corpuscular hem... 5 | 19
decreased startle reflex 5 | 48
decreased vertical activity 5 | 22
hydrops fetalis 5 | 22
impaired glucose tolerance 5 | 52
improved glucose tolerance 5 | 56
increased blood urea nitrogen ... 5 | 44
increased circulating choleste... 5 | 53
increased mean corpuscular hem... 5 | 25
male infertility 5 | 62
prenatal lethality prior to he... 5 | 64
thrombocytopenia 5 | 46
abnormal behavioral response t... 4 | 52
abnormal epididymis morphology 4 | 31
abnormal eye morphology 4 | 38
abnormal facial morphology 4 | 9
abnormal limb bud morphology 4 | 15
abnormal limb morphology 4 | 7
abnormal locomotor activation 4 | 26
abnormal neural tube closure 4 | 37
abnormal retinal blood vessel ... 4 | 18
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased hemoglobin content 4 | 53
decreased leukocyte cell numbe... 4 | 54
increased circulating chloride... 4 | 43
increased fasted circulating g... 4 | 68
increased heart weight 4 | 37
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
abnormal body wall morphology 3 | 7
abnormal tail movements 3 | 12
abnormal tooth morphology 3 | 24
anophthalmia 3 | 20
decreased caudal vertebrae num... 3 | 49
decreased circulating bilirubi... 3 | 14
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased eosinophil cell numb... 3 | 41
decreased heart weight 3 | 44
decreased neutrophil cell numb... 3 | 37
increased bone mineral density 3 | 52
increased circulating free fat... 3 | 17
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased prepulse inhibition 3 | 21
persistence of hyaloid vascula... 3 | 22

Disease

ovarian cancer 618 | 8,492
osteosarcoma 555 | 7,933
psoriasis 520 | 6,685
glioblastoma 486 | 5,572
medulloblastoma, large-cell 469 | 6,234
atypical teratoid / rhabdoid tumor 362 | 4,369
lung cancer 345 | 4,473
Cancer 342 | 2,346
pilocytic astrocytoma 326 | 3,086
lung carcinoma 293 | 2,844
pediatric high grade glioma 261 | 2,712
invasive ductal carcinoma 258 | 2,950
diabetes mellitus 255 | 1,663
malignant mesothelioma 254 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 251 | 3,289
oligodendroglioma 250 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 249 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 244 | 2,988
lung adenocarcinoma 233 | 2,714
pancreatic cancer 227 | 2,300
primitive neuroectodermal tumor 227 | 3,031
Breast cancer 219 | 3,099
non-small cell lung cancer 215 | 2,798
subependymal giant cell astrocytoma 205 | 2,287
ependymoma 197 | 2,514
interstitial cystitis 187 | 2,299
ulcerative colitis 179 | 2,087
astrocytoma 176 | 1,493
Carcinoma 172 | 2,147
Pick disease 167 | 1,893
astrocytic glioma 165 | 2,241
pituitary cancer 158 | 1,972
posterior fossa group A ependymoma 155 | 1,511
tuberculosis 153 | 1,563
pancreatic ductal adenocarcinoma liver metastasis 147 | 1,795
adult high grade glioma 146 | 2,148
Rheumatoid Arthritis 144 | 1,171
cystic fibrosis 143 | 1,670
ductal carcinoma in situ 143 | 1,745
group 4 medulloblastoma 141 | 1,875
Multiple myeloma 138 | 1,328
dermatomyositis 131 | 967
breast carcinoma 128 | 1,614
primary pancreatic ductal adenocarcinoma 127 | 1,271
medulloblastoma 122 | 1,524
group 3 medulloblastoma 118 | 2,254
juvenile dermatomyositis 117 | 1,189
posterior fossa group B ependymoma 117 | 1,530
colon cancer 113 | 1,475
acute quadriplegic myopathy 110 | 1,157
Alzheimer's disease 109 | 644
sonic hedgehog group medulloblastoma 109 | 1,482
cutaneous lupus erythematosus 106 | 1,056
adrenocortical carcinoma 104 | 1,427
Arthritis 102 | 248
gastric carcinoma 99 | 832
Kidney disease 98 | 397
Hypersensitivity reaction type II disease 91 | 235
atypical teratoid/rhabdoid tumor 89 | 1,095
esophageal adenocarcinoma 86 | 737
spina bifida 84 | 1,064
Waldenstrons macroglobulinemia 83 | 765
Duchenne muscular dystrophy 82 | 602
Schizophrenia 80 | 503
Obesity 78 | 616
mucosa-associated lymphoid tissue lymphoma 75 | 480
Ankylosing spondylitis 74 | 138
active Crohn's disease 74 | 918
Multiple Sclerosis 72 | 498
Neurodegenerative disease 71 | 383
nasopharyngeal carcinoma 68 | 1,056
Parkinson's disease 67 | 364
Acquired immunodeficiency syndrome 66 | 164
Atopic dermatitis 66 | 944
Uveitis 66 | 103
Down syndrome 65 | 548
Liver disease 65 | 219
pancreatic carcinoma 65 | 567
Juvenile rheumatoid arthritis 64 | 105
Atherosclerosis 62 | 275
Human immunodeficiency virus infectious disease 61 | 129
Anemia 60 | 252
Hypertension 60 | 293
Prostatic Neoplasms 60 | 471
non primary Sjogren syndrome sicca 60 | 840
primary Sjogren syndrome 60 | 789
Behcet's disease 57 | 74
Epilepsy 56 | 346
Stevens-Johnson syndrome 55 | 91
Dermatitis 54 | 141
Psoriatic arthritis 54 | 85
Vascular disease 54 | 281
Cerebrovascular disease 53 | 231
aldosterone-producing adenoma 53 | 664
Asthma 52 | 349
fibroadenoma 52 | 557
acute myeloid leukemia 51 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 51 | 499
Amyotrophic Lateral Sclerosis 50 | 432
hepatocellular carcinoma 49 | 550

Tissue

Nervous System 1,172 | 18,561
Endocrine System 1,171 | 18,512
Digestive Tract 1,169 | 18,473
Female tissues 1,169 | 18,647
Liver and Pancreas 1,165 | 18,136
Urinary Tract 1,165 | 18,444
Blood and immune system 1,157 | 17,995
Cardiovascular System 1,157 | 17,958
Male tissues 1,154 | 17,969
Skin and soft tissues 1,154 | 18,115
Respiratory system 1,144 | 17,484

Target Family

Non-IDG 855 | 11,969
Enzyme 256 | 4,146
Transporter 39 | 473
Kinase 37 | 634
Ion Channel 36 | 341
GPCR 24 | 408
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Cytoplasmic vesicle 1,255 | 1,255
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35
Synapsin-1 SYN1 Tbio Non-IDG -2.85684 687.9 716
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.89144 80.2 134
ATP-binding cassette sub-family A member 3 ABCA3 Tbio Transporter -2.22245 177.7 29
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.79022 8.54 95
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.72093 48.8 66