Development Level

Tbio 134 | 11,445
Tchem 40 | 1,598
Tclin 16 | 613
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
abnormal bone structure 10 | 187
preweaning lethality, incomple... 10 | 499
increased startle reflex 9 | 112
abnormal behavior 6 | 298
decreased bone mineral content 5 | 151
decreased total body fat amoun... 5 | 207
hypoactivity 5 | 132
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased lymphocyte cell numb... 4 | 83
increased heart weight 4 | 62
increased monocyte cell number 4 | 63
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
increased lean body mass 3 | 172
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating phosphat... 2 | 27
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased circulating sodium l... 2 | 71
increased hematocrit 2 | 46
increased mean corpuscular vol... 2 | 92
increased spleen weight 2 | 10
prenatal lethality prior to he... 2 | 87
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal hair growth 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 148 | 11,493
osteosarcoma 113 | 7,950
ovarian cancer 108 | 8,520
medulloblastoma, large-cell 88 | 6,241
glioblastoma 81 | 5,792
psoriasis 74 | 6,694
Cancer 71 | 2,499
atypical teratoid / rhabdoid tumor 69 | 5,112
lung cancer 66 | 4,740
ependymoma 65 | 4,679
adult high grade glioma 57 | 3,801
Breast cancer 54 | 3,578
Astrocytoma, Pilocytic 52 | 3,081
Kidney cancer 51 | 2,613
group 3 medulloblastoma 51 | 4,104
oligodendroglioma 51 | 2,850
lung carcinoma 47 | 2,843
invasive ductal carcinoma 45 | 2,951
pancreatic cancer 44 | 2,398
subependymal giant cell astrocytoma 44 | 2,287
primitive neuroectodermal tumor 43 | 3,035
malignant mesothelioma 42 | 3,232
non-small cell lung cancer 42 | 2,890
interstitial cystitis 40 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
Pick disease 34 | 1,894
astrocytic glioma 34 | 2,597
lung adenocarcinoma 34 | 2,716
tuberculosis 34 | 2,010
ulcerative colitis 34 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
pituitary cancer 31 | 1,972
group 4 medulloblastoma 29 | 1,855
juvenile dermatomyositis 27 | 1,187
breast carcinoma 26 | 1,638
ductal carcinoma in situ 25 | 1,745
Schizophrenia 24 | 1,160
colon cancer 24 | 1,478
Rheumatoid arthritis 23 | 1,191
diabetes mellitus 22 | 1,728
Autosomal recessive predisposition 21 | 1,442
Intellectual disability 20 | 1,016
astrocytoma 20 | 1,146
primary Sjogren syndrome 20 | 735
Obesity 19 | 678
Blastic phase chronic myeloid leukemia 18 | 58
Chronic Myelocytic Leukemia Accelerated Phase 18 | 59
Liver Cirrhosis, Experimental 18 | 769
spina bifida 18 | 1,074
Melanoma 17 | 711
Multiple myeloma 17 | 1,332
cutaneous lupus erythematosus 17 | 1,057
cystic fibrosis 17 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Chronic phase chronic myeloid leukemia 16 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 16 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 16 | 47
acute quadriplegic myopathy 16 | 1,158
primary pancreatic ductal adenocarcinoma 16 | 1,109
Epilepsy 14 | 792
Hypertension 14 | 396
Liver cancer 14 | 604
adrenocortical carcinoma 14 | 1,428
dermatomyositis 14 | 966
Bipolar Disorder 13 | 666
Duchenne muscular dystrophy 13 | 601
Skin cancer 13 | 469
esophageal adenocarcinoma 13 | 737
pediatric high grade glioma 13 | 1,064
Alzheimer's disease 12 | 658
Atopic dermatitis 12 | 952
Depressive disorder 12 | 409
Kidney disease 12 | 430
non primary Sjogren syndrome sicca 12 | 891
pancreatic carcinoma 12 | 562
Chronic Lymphocytic Leukemia 11 | 262
Down syndrome 11 | 499
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Prostatic Neoplasms 11 | 495
Asthma 10 | 385
Polycystic ovary syndrome 10 | 360
Stomach Neoplasms 10 | 300
mucosa-associated lymphoid tissue lymphoma 10 | 484
Adenoma 9 | 167
Anemia 9 | 365
Breast Neoplasms 9 | 445
Crohn's disease 9 | 321
Endometriosis 9 | 540
Hypertensive disease 9 | 292
Immune system cancer 9 | 140
Mammary Neoplasms 9 | 425
Waldenstrons macroglobulinemia 9 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
gastric carcinoma 9 | 807
urothelial carcinoma 9 | 318

Tissue

Endocrine System 190 | 18,159
Blood and immune system 187 | 16,909
Skin and soft tissues 187 | 17,230
Digestive Tract 186 | 17,369
Female tissues 186 | 17,400
Male tissues 184 | 17,142
Nervous System 184 | 16,725
Liver and Pancreas 183 | 16,750
Urinary Tract 182 | 16,678
Respiratory system 179 | 16,393
Cardiovascular System 175 | 15,192

Target Family

Non-IDG 112 | 12,091
Kinase 40 | 634
Enzyme 34 | 4,145
Ion Channel 4 | 344
GPCR 3 | 408
Transcription Factor 1 | 1,400

Compartment GO Term

Cytoplasmic side of plasma mem... 194 | 194
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Sorting nexin-18 SNX18 Tbio Non-IDG -0.76724 7.20 156
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394