Development Level

Tbio 128 | 10,625
Tchem 49 | 1,890
Tclin 16 | 602
Tdark 6 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 3 | 102
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 633
abnormal bone structure 6 | 131
decreased total body fat amoun... 6 | 186
abnormal behavior 5 | 226
abnormal bone mineralization 5 | 55
decreased bone mineral content 5 | 157
decreased body weight 4 | 174
increased heart weight 4 | 37
preweaning lethality, incomple... 4 | 260
decreased NK T cell number 3 | 28
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
hypoactivity 3 | 89
increased circulating phosphat... 3 | 24
increased lean body mass 3 | 107
abnormal QRS complex 2 | 25
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating phosphat... 2 | 15
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased prepulse inhibition 2 | 52
enlarged spleen 2 | 26
impaired righting response 2 | 19
increased CD4-positive, alpha ... 2 | 15
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating potassiu... 2 | 31
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
thrombocytopenia 2 | 46
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal kidney morphology 1 | 30
abnormal rib morphology 1 | 28
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased circulating potassiu... 1 | 17
decreased dendritic cell numbe... 1 | 3
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased kidney weight 1 | 7
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
edema 1 | 11
hyperactivity 1 | 108
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
male infertility 1 | 62
polydactyly 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
small testis 1 | 37
sparse hair 1 | 6
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 115 | 7,933
ovarian cancer 111 | 8,491
medulloblastoma, large-cell 90 | 6,234
glioblastoma 77 | 5,572
psoriasis 73 | 6,685
Cancer 72 | 2,346
atypical teratoid / rhabdoid tumor 63 | 4,369
pilocytic astrocytoma 57 | 3,086
lung cancer 56 | 4,473
Breast cancer 53 | 3,098
oligodendroglioma 53 | 2,849
invasive ductal carcinoma 48 | 2,950
lung carcinoma 45 | 2,844
subependymal giant cell astrocytoma 45 | 2,287
primitive neuroectodermal tumor 44 | 3,031
non-small cell lung cancer 43 | 2,798
pancreatic cancer 42 | 2,300
Carcinoma 40 | 2,147
malignant mesothelioma 40 | 3,163
interstitial cystitis 39 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
ulcerative colitis 38 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,289
Pick disease 36 | 1,893
lung adenocarcinoma 36 | 2,714
adult high grade glioma 35 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
pediatric high grade glioma 34 | 2,712
ependymoma 33 | 2,514
medulloblastoma 31 | 1,524
astrocytic glioma 30 | 2,241
juvenile dermatomyositis 30 | 1,189
pituitary cancer 30 | 1,972
group 4 medulloblastoma 28 | 1,875
tuberculosis 27 | 1,563
astrocytoma 26 | 1,493
colon cancer 24 | 1,475
ductal carcinoma in situ 24 | 1,745
posterior fossa group A ependymoma 24 | 1,511
Rheumatoid Arthritis 23 | 1,170
breast carcinoma 23 | 1,614
group 3 medulloblastoma 23 | 2,254
diabetes mellitus 22 | 1,663
acute quadriplegic myopathy 20 | 1,157
primary Sjogren syndrome 20 | 788
cystic fibrosis 19 | 1,670
Blastic phase chronic myeloid leukemia 18 | 58
Chronic Myelocytic Leukemia Accelerated Phase 18 | 59
Multiple myeloma 18 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
Alzheimer's disease 17 | 644
Obesity 17 | 616
cutaneous lupus erythematosus 17 | 1,056
posterior fossa group B ependymoma 17 | 1,530
Chronic phase chronic myeloid leukemia 16 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 16 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 16 | 47
primary pancreatic ductal adenocarcinoma 16 | 1,271
spina bifida 16 | 1,064
dermatomyositis 15 | 966
Intellectual disability 14 | 573
adrenocortical carcinoma 14 | 1,427
Duchenne muscular dystrophy 13 | 602
IGA Glomerulonephritis 13 | 454
Kidney disease 13 | 397
Schizophrenia 13 | 503
esophageal adenocarcinoma 12 | 737
Atopic dermatitis 11 | 944
Crohn's disease 11 | 304
Down syndrome 11 | 548
Epilepsy 11 | 346
Prostatic Neoplasms 11 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
mucosa-associated lymphoid tissue lymphoma 11 | 480
non primary Sjogren syndrome sicca 11 | 840
pancreatic carcinoma 11 | 567
Endometriosis 10 | 535
Parkinson's disease 10 | 364
Polycystic Ovary Syndrome 10 | 334
Stomach Neoplasms 10 | 282
Waldenstrons macroglobulinemia 10 | 764
Adenoma 9 | 165
Asthma 9 | 349
Hypertension 9 | 293
Melanoma 9 | 261
gastric carcinoma 9 | 832
sonic hedgehog group medulloblastoma 9 | 1,482
Amyotrophic Lateral Sclerosis 8 | 432
Mammary Neoplasms 8 | 410
active Crohn's disease 8 | 918
atypical teratoid/rhabdoid tumor 8 | 1,095
chronic lymphocytic leukemia 8 | 244
gastric cancer 8 | 436
hepatocellular carcinoma 8 | 550
progressive supranuclear palsy 8 | 674
urothelial carcinoma 8 | 318
Hypertensive disease 7 | 193
Multiple Sclerosis 7 | 498
acute myeloid leukemia 7 | 785
chronic lymphosyte leukemia 7 | 232

Tissue

Digestive Tract 197 | 18,472
Endocrine System 197 | 18,511
Liver and Pancreas 197 | 18,135
Nervous System 197 | 18,560
Urinary Tract 197 | 18,443
Blood and immune system 196 | 17,994
Cardiovascular System 196 | 17,957
Female tissues 196 | 18,646
Male tissues 195 | 17,968
Skin and soft tissues 194 | 18,114
Respiratory system 193 | 17,483

Target Family

Non-IDG 110 | 11,969
Kinase 41 | 634
Enzyme 40 | 4,146
Ion Channel 5 | 341
GPCR 3 | 408

Compartment GO Term

Cytoplasmic side of membrane 199 | 199
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.84299 53.1 358
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.84249 72.2 131
Rho guanine nucleotide exchange factor 25 ARHGEF25 Tbio Non-IDG -1.42716 30.4 46
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Guanine nucleotide-binding protein subunit beta-like protein 1 GNB1L Tbio Non-IDG -1.88405 75.6 53
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.56782 368.4 441
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46
Cyclin-dependent kinase 16 CDK16 Tchem Kinase -1.43415 32.3 122