Development Level

Tbio 6,568 | 11,445
Tdark 1,257 | 6,588
Tchem 1,047 | 1,598
Tclin 375 | 613

Collection

RFA-RM-18-021 103 | 328
Kinase: IDG Consortium (Target... 66 | 125
Ion Channel: IDG Consortium (T... 25 | 99
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Targets) 14 | 126
GPCR: IDG Consortium (Complete... 7 | 25

IMPC Phenotype

preweaning lethality, complete... 663 | 979
preweaning lethality, incomple... 282 | 499
embryonic lethality prior to t... 201 | 278
embryonic lethality prior to o... 173 | 239
abnormal behavior 156 | 298
abnormal embryo size 146 | 220
decreased total body fat amoun... 123 | 207
abnormal bone structure 104 | 187
decreased body weight 103 | 161
increased lean body mass 102 | 172
decreased vertical activity 95 | 208
decreased bone mineral content 94 | 151
enlarged heart 93 | 210
increased total body fat amoun... 87 | 134
decreased lean body mass 82 | 135
hyperactivity 79 | 148
increased startle reflex 78 | 112
embryonic growth retardation 77 | 106
hypoactivity 77 | 132
decreased grip strength 72 | 116
abnormal heart morphology 70 | 162
increased circulating alkaline... 70 | 122
decreased bone mineral density 68 | 126
decreased circulating glucose ... 67 | 126
decreased circulating choleste... 63 | 93
cataract 59 | 92
increased mean corpuscular vol... 59 | 92
increased mean corpuscular hem... 58 | 96
abnormal seminal vesicle morph... 57 | 114
increased bone mineral content 56 | 108
male infertility 56 | 123
increased or absent threshold ... 55 | 101
prenatal lethality prior to he... 55 | 87
decreased mean corpuscular vol... 54 | 79
short tibia 54 | 97
abnormal lens morphology 53 | 81
decreased body length 51 | 101
decreased lymphocyte cell numb... 51 | 83
decreased circulating serum al... 50 | 82
decreased circulating HDL chol... 48 | 68
decreased circulating triglyce... 48 | 79
impaired glucose tolerance 48 | 75
improved glucose tolerance 47 | 79
increased bone mineral density 47 | 72
decreased prepulse inhibition 46 | 82
abnormal retina morphology 45 | 71
increased fasted circulating g... 45 | 76
edema 44 | 59
increased heart weight 44 | 62
abnormal sleep behavior 43 | 70
decreased circulating insulin ... 43 | 76
abnormal gait 41 | 69
decreased hemoglobin content 41 | 68
decreased fasted circulating g... 40 | 65
decreased leukocyte cell numbe... 40 | 73
increased circulating sodium l... 40 | 71
thrombocytopenia 40 | 56
decreased startle reflex 39 | 75
small superior vagus ganglion 39 | 74
decreased erythrocyte cell num... 38 | 62
increased circulating HDL chol... 38 | 80
abnormal eye morphology 37 | 68
decreased mean corpuscular hem... 35 | 50
increased monocyte cell number 35 | 63
abnormal behavioral response t... 34 | 66
abnormal kidney morphology 33 | 65
increased circulating choleste... 33 | 66
decreased circulating total pr... 32 | 49
abnormal coat-hair pigmentatio... 31 | 64
decreased circulating alanine ... 31 | 47
abnormal neural tube closure 30 | 46
decreased circulating creatini... 30 | 39
increased blood urea nitrogen ... 30 | 48
small testis 30 | 58
decreased circulating LDL chol... 29 | 38
increased circulating chloride... 29 | 41
increased leukocyte cell numbe... 29 | 47
decreased blood urea nitrogen ... 28 | 51
decreased hematocrit 28 | 46
increased hemoglobin content 28 | 45
decreased caudal vertebrae num... 27 | 53
decreased circulating alkaline... 27 | 46
increased neutrophil cell numb... 27 | 46
abnormal bone mineralization 26 | 38
hydrometra 26 | 53
increased hematocrit 26 | 46
increased prepulse inhibition 26 | 32
abnormal craniofacial morpholo... 25 | 33
female infertility 25 | 60
increased mean platelet volume 25 | 45
pallor 25 | 34
prolonged QT interval 25 | 38
abnormal cranium morphology 24 | 36
decreased circulating aspartat... 24 | 34
decreased circulating iron lev... 24 | 32
decreased neutrophil cell numb... 24 | 42
enlarged lymph nodes 24 | 37
abnormal skin morphology 23 | 50
increased mean corpuscular hem... 23 | 36
prolonged ST segment 23 | 36

Disease

Carcinoma 5,708 | 11,493
ovarian cancer 4,923 | 8,520
osteosarcoma 4,260 | 7,950
psoriasis 3,590 | 6,694
medulloblastoma, large-cell 3,351 | 6,241
glioblastoma 3,246 | 5,792
lung cancer 2,826 | 4,740
atypical teratoid / rhabdoid tumor 2,756 | 5,112
ependymoma 2,437 | 4,679
group 3 medulloblastoma 2,107 | 4,104
adult high grade glioma 2,051 | 3,801
Breast cancer 1,987 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,947 | 3,291
malignant mesothelioma 1,854 | 3,232
Astrocytoma, Pilocytic 1,733 | 3,081
invasive ductal carcinoma 1,713 | 2,951
Cancer 1,701 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 1,701 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,668 | 2,955
non-small cell lung cancer 1,658 | 2,890
primitive neuroectodermal tumor 1,605 | 3,035
oligodendroglioma 1,541 | 2,850
lung adenocarcinoma 1,539 | 2,716
lung carcinoma 1,527 | 2,843
astrocytic glioma 1,429 | 2,597
pancreatic cancer 1,419 | 2,398
Kidney cancer 1,339 | 2,613
subependymal giant cell astrocytoma 1,332 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,322 | 1,962
tuberculosis 1,208 | 2,010
interstitial cystitis 1,197 | 2,312
diabetes mellitus 1,128 | 1,728
Pick disease 1,107 | 1,894
ulcerative colitis 1,074 | 1,819
Autosomal recessive predisposition 1,037 | 1,442
group 4 medulloblastoma 1,019 | 1,855
pituitary cancer 1,007 | 1,972
ductal carcinoma in situ 985 | 1,745
Multiple myeloma 977 | 1,332
breast carcinoma 963 | 1,638
cystic fibrosis 947 | 1,696
colon cancer 852 | 1,478
adrenocortical carcinoma 819 | 1,428
juvenile dermatomyositis 733 | 1,187
acute quadriplegic myopathy 728 | 1,158
astrocytoma 722 | 1,146
Rheumatoid arthritis 716 | 1,191
Schizophrenia 710 | 1,160
dermatomyositis 674 | 966
Intellectual disability 671 | 1,016
primary pancreatic ductal adenocarcinoma 661 | 1,109
cutaneous lupus erythematosus 610 | 1,057
pediatric high grade glioma 599 | 1,064
spina bifida 585 | 1,074
Epilepsy 565 | 792
Waldenstrons macroglobulinemia 556 | 765
active Crohn's disease 556 | 922
Atopic dermatitis 555 | 952
nasopharyngeal carcinoma 550 | 1,058
non primary Sjogren syndrome sicca 541 | 891
Liver Cirrhosis, Experimental 525 | 769
esophageal adenocarcinoma 503 | 737
gastric carcinoma 489 | 807
Cognitive delay 463 | 608
Global developmental delay 463 | 608
Mental and motor retardation 463 | 608
acute myeloid leukemia 463 | 783
Seizures 459 | 596
Obesity 457 | 678
active ulcerative colitis 450 | 764
Alzheimer's disease 448 | 658
Dull intelligence 440 | 645
Low intelligence 440 | 645
Mental Retardation 440 | 645
Mental deficiency 440 | 645
Poor school performance 440 | 645
primary Sjogren syndrome 439 | 735
Muscle hypotonia 422 | 571
Bipolar Disorder 420 | 666
Duchenne muscular dystrophy 396 | 601
aldosterone-producing adenoma 391 | 665
medulloblastoma 378 | 720
Melanoma 375 | 711
Short stature 364 | 531
progressive supranuclear palsy 361 | 676
Prostatic Neoplasms 354 | 495
Neurodegenerative disease 340 | 414
pancreatic carcinoma 331 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 327 | 510
Kidney disease 325 | 430
Multiple Sclerosis 324 | 540
Down syndrome 317 | 499
hepatocellular carcinoma 315 | 547
Endometriosis 313 | 540
Amyotrophic lateral sclerosis 310 | 451
Hypertension 308 | 396
fibroadenoma 307 | 559
Breast Neoplasms 305 | 445
Anemia 298 | 365
mucosa-associated lymphoid tissue lymphoma 297 | 484

Tissue

Endocrine System 8,882 | 18,159
Digestive Tract 8,786 | 17,369
Female tissues 8,773 | 17,400
Skin and soft tissues 8,757 | 17,230
Male tissues 8,671 | 17,142
Blood and immune system 8,641 | 16,909
Liver and Pancreas 8,630 | 16,750
Urinary Tract 8,591 | 16,678
Nervous System 8,555 | 16,725
Respiratory system 8,475 | 16,393
Cardiovascular System 8,108 | 15,192

Target Family

Non-IDG 5,118 | 12,091
Enzyme 2,905 | 4,145
Kinase 442 | 634
Transcription Factor 248 | 1,400
Transporter 213 | 473
Ion Channel 112 | 344
GPCR 93 | 408
Epigenetic 79 | 242
Nuclear Receptor 18 | 48
TF/Epigenetic 14 | 38
oGPCR 5 | 421

Compartment GO Term

Cytoplasmic part 9,247 | 9,247
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181