Development Level

Tbio 5,270 | 10,625
Tchem 1,142 | 1,890
Tdark 1,075 | 7,003
Tclin 343 | 602

Collection

Eligible Kinase Proteins 64 | 134
Eligible Ion Channel Proteins 21 | 117
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 376 | 633
embryonic lethality prior to t... 122 | 187
preweaning lethality, incomple... 121 | 260
abnormal behavior 110 | 226
decreased lean body mass 105 | 195
embryonic lethality prior to o... 99 | 148
decreased total body fat amoun... 94 | 186
decreased bone mineral content 93 | 157
decreased body weight 89 | 174
abnormal embryo size 72 | 112
decreased bone mineral density 67 | 126
decreased grip strength 66 | 123
abnormal bone structure 65 | 131
increased circulating alkaline... 65 | 119
decreased circulating glucose ... 60 | 121
abnormal retina morphology 59 | 100
increased or absent threshold ... 59 | 128
increased lean body mass 52 | 107
decreased body length 51 | 108
increased mean corpuscular hem... 51 | 93
decreased circulating choleste... 48 | 85
abnormal lens morphology 47 | 73
hyperactivity 47 | 108
hypoactivity 46 | 89
increased mean corpuscular vol... 46 | 91
enlarged heart 44 | 111
increased bone mineral content 44 | 92
decreased circulating HDL chol... 43 | 77
decreased circulating triglyce... 42 | 83
abnormal retinal pigmentation 39 | 61
short tibia 39 | 82
increased grip strength 38 | 83
prenatal lethality prior to he... 37 | 64
decreased circulating serum al... 36 | 79
decreased mean corpuscular vol... 36 | 50
decreased circulating insulin ... 35 | 75
increased fasted circulating g... 35 | 68
increased circulating sodium l... 34 | 71
abnormal sleep behavior 32 | 63
decreased fasted circulating g... 32 | 49
decreased startle reflex 31 | 48
increased bone mineral density 31 | 52
increased total body fat amoun... 31 | 57
abnormal bone mineralization 30 | 55
decreased circulating alanine ... 30 | 53
decreased prepulse inhibition 30 | 52
decreased hemoglobin content 29 | 53
impaired glucose tolerance 29 | 52
increased circulating HDL chol... 29 | 63
decreased lumbar vertebrae num... 27 | 62
decreased rib number 27 | 59
increased circulating choleste... 27 | 53
decreased leukocyte cell numbe... 26 | 54
improved glucose tolerance 26 | 56
increased blood urea nitrogen ... 26 | 44
abnormal behavioral response t... 25 | 52
increased body weight 25 | 42
increased sacral vertebrae num... 25 | 62
male infertility 25 | 62
thrombocytopenia 25 | 46
decreased T cell number 24 | 31
decreased heart weight 24 | 44
decreased mean corpuscular hem... 24 | 34
increased heart weight 24 | 37
increased leukocyte cell numbe... 24 | 37
abnormal coat/hair pigmentatio... 23 | 54
abnormal neural tube closure 23 | 37
increased circulating chloride... 23 | 43
increased hemoglobin content 23 | 45
decreased erythrocyte cell num... 22 | 43
abnormal gait 21 | 51
abnormal heart morphology 21 | 51
decreased caudal vertebrae num... 21 | 49
decreased circulating alkaline... 21 | 41
embryonic growth retardation 21 | 28
decreased circulating LDL chol... 20 | 37
increased exploration in new e... 20 | 56
increased hematocrit 20 | 36
cardiovascular system phenotyp... 19 | 35
decreased circulating fructosa... 19 | 31
decreased circulating iron lev... 19 | 25
decreased circulating total pr... 19 | 41
decreased eosinophil cell numb... 19 | 41
increased circulating calcium ... 19 | 32
limb grasping 19 | 35
abnormal eye morphology 18 | 38
abnormal seminal vesicle morph... 18 | 47
decreased CD8-positive, alpha-... 18 | 26
enlarged lymph nodes 18 | 27
abnormal rib morphology 17 | 28
abnormal testis morphology 17 | 30
decreased NK T cell number 17 | 28
decreased circulating aspartat... 17 | 27
decreased circulating creatini... 17 | 31
decreased monocyte cell number 17 | 28
increased red blood cell distr... 17 | 21
increased startle reflex 17 | 38
small testis 17 | 37
increased erythrocyte cell num... 16 | 26
increased prepulse inhibition 16 | 21

Disease

ovarian cancer 4,227 | 8,484
osteosarcoma 3,612 | 7,933
psoriasis 3,040 | 6,685
medulloblastoma, large-cell 2,893 | 6,234
glioblastoma 2,722 | 5,572
lung cancer 2,347 | 4,466
atypical teratoid / rhabdoid tumor 2,021 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,710 | 3,289
malignant mesothelioma 1,564 | 3,162
pilocytic astrocytoma 1,511 | 3,086
Breast cancer 1,502 | 3,094
invasive ductal carcinoma 1,496 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 1,480 | 2,988
Cancer 1,448 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 1,442 | 2,956
primitive neuroectodermal tumor 1,399 | 3,031
non-small cell lung cancer 1,383 | 2,798
oligodendroglioma 1,358 | 2,849
pediatric high grade glioma 1,354 | 2,712
lung adenocarcinoma 1,338 | 2,713
lung carcinoma 1,317 | 2,844
pancreatic cancer 1,199 | 2,300
ependymoma 1,163 | 2,514
subependymal giant cell astrocytoma 1,144 | 2,287
ulcerative colitis 1,098 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 1,085 | 1,795
astrocytic glioma 1,042 | 2,241
interstitial cystitis 1,017 | 2,299
group 3 medulloblastoma 967 | 2,254
Pick disease 964 | 1,893
diabetes mellitus 935 | 1,663
adult high grade glioma 923 | 2,148
Carcinoma 902 | 2,147
Multiple myeloma 896 | 1,327
ductal carcinoma in situ 884 | 1,745
group 4 medulloblastoma 882 | 1,875
pituitary cancer 879 | 1,972
astrocytoma 829 | 1,493
breast carcinoma 829 | 1,614
tuberculosis 822 | 1,557
cystic fibrosis 792 | 1,665
colon cancer 765 | 1,475
posterior fossa group A ependymoma 735 | 1,511
medulloblastoma 729 | 1,524
adrenocortical carcinoma 713 | 1,427
primary pancreatic ductal adenocarcinoma 665 | 1,271
sonic hedgehog group medulloblastoma 660 | 1,482
juvenile dermatomyositis 640 | 1,189
acute quadriplegic myopathy 635 | 1,157
posterior fossa group B ependymoma 624 | 1,530
Rheumatoid Arthritis 603 | 1,160
dermatomyositis 557 | 933
atypical teratoid/rhabdoid tumor 517 | 1,095
cutaneous lupus erythematosus 513 | 1,056
active Crohn's disease 503 | 918
Waldenstrons macroglobulinemia 501 | 765
spina bifida 471 | 1,064
nasopharyngeal carcinoma 464 | 1,056
Atopic dermatitis 451 | 944
non primary Sjogren syndrome sicca 440 | 840
gastric carcinoma 437 | 832
esophageal adenocarcinoma 426 | 737
Alzheimer's disease 400 | 644
Obesity 394 | 616
acute myeloid leukemia 391 | 780
primary Sjogren syndrome 390 | 789
Duchenne muscular dystrophy 348 | 602
aldosterone-producing adenoma 339 | 664
tuberculosis and treatment for 6 months 326 | 686
Intellectual disability 320 | 573
progressive supranuclear palsy 315 | 674
Down syndrome 314 | 548
Prostatic Neoplasms 304 | 471
Neurodegenerative disease 302 | 383
pancreatic carcinoma 302 | 567
IGA Glomerulonephritis 282 | 454
Kidney disease 282 | 396
fibroadenoma 278 | 557
Multiple Sclerosis 273 | 498
Schizophrenia 272 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 272 | 499
Endometriosis 270 | 535
hepatocellular carcinoma 265 | 532
Amyotrophic Lateral Sclerosis 258 | 431
mucosa-associated lymphoid tissue lymphoma 244 | 480
Mammary Neoplasms 242 | 410
Parkinson's disease 239 | 364
active ulcerative colitis 231 | 477
hereditary spastic paraplegia 224 | 313
gastric cancer 213 | 430
Hypertension 208 | 287
Vascular disease 208 | 281
Arthritis 202 | 248
inflammatory breast cancer 201 | 404
Epilepsy 200 | 346
Anemia 196 | 252
Asthma 196 | 349
Atherosclerosis 196 | 275
Heart disease 196 | 279
chronic rhinosinusitis 196 | 512

Tissue

Nervous System 7,663 | 18,561
Female tissues 7,657 | 18,647
Digestive Tract 7,646 | 18,473
Endocrine System 7,637 | 18,512
Urinary Tract 7,633 | 18,444
Liver and Pancreas 7,631 | 18,136
Blood and immune system 7,618 | 17,995
Male tissues 7,595 | 17,969
Cardiovascular System 7,594 | 17,958
Skin and soft tissues 7,581 | 18,115
Respiratory system 7,532 | 17,484

Target Family

Non-IDG 4,154 | 11,971
Enzyme 2,683 | 4,146
Kinase 404 | 634
Transporter 202 | 473
Transcription Factor 147 | 1,400
Ion Channel 103 | 341
GPCR 67 | 406
Epigenetic 50 | 242
Nuclear Receptor 14 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

Compartment GO Term

Cytoplasmic part 7,830 | 7,830
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108