Development Level

Tbio 7,698 | 11,445
Tdark 1,694 | 6,588
Tchem 1,177 | 1,598
Tclin 414 | 613

Collection

RFA-RM-18-021 145 | 328
Kinase: IDG Consortium (Target... 100 | 125
Kinase: IDG Consortium (Comple... 34 | 37
Ion Channel: IDG Consortium (T... 31 | 99
GPCR: IDG Consortium (Targets) 16 | 126
GPCR: IDG Consortium (Complete... 7 | 25

IMPC Phenotype

preweaning lethality, complete... 728 | 979
preweaning lethality, incomple... 343 | 499
embryonic lethality prior to t... 215 | 278
abnormal behavior 186 | 298
embryonic lethality prior to o... 186 | 239
abnormal embryo size 164 | 220
decreased total body fat amoun... 144 | 207
abnormal bone structure 128 | 187
enlarged heart 120 | 210
increased lean body mass 120 | 172
decreased body weight 115 | 161
decreased vertical activity 114 | 208
decreased bone mineral content 110 | 151
decreased lean body mass 101 | 135
increased total body fat amoun... 101 | 134
hypoactivity 93 | 132
abnormal heart morphology 91 | 162
hyperactivity 91 | 148
decreased grip strength 87 | 116
increased startle reflex 87 | 112
decreased bone mineral density 84 | 126
increased circulating alkaline... 83 | 122
embryonic growth retardation 80 | 106
decreased circulating glucose ... 78 | 126
male infertility 72 | 123
decreased circulating choleste... 70 | 93
abnormal seminal vesicle morph... 68 | 114
cataract 68 | 92
increased bone mineral content 67 | 108
increased or absent threshold ... 66 | 101
prenatal lethality prior to he... 66 | 87
decreased body length 65 | 101
increased mean corpuscular hem... 63 | 96
increased mean corpuscular vol... 63 | 92
abnormal lens morphology 62 | 81
short tibia 62 | 97
decreased mean corpuscular vol... 61 | 79
decreased circulating serum al... 58 | 82
decreased lymphocyte cell numb... 57 | 83
improved glucose tolerance 57 | 79
decreased prepulse inhibition 56 | 82
impaired glucose tolerance 54 | 75
increased bone mineral density 53 | 72
increased circulating HDL chol... 53 | 80
decreased circulating HDL chol... 52 | 68
decreased circulating triglyce... 52 | 79
decreased startle reflex 52 | 75
abnormal retina morphology 51 | 71
increased fasted circulating g... 51 | 76
increased heart weight 51 | 62
decreased circulating insulin ... 50 | 76
edema 50 | 59
decreased hemoglobin content 48 | 68
increased circulating choleste... 48 | 66
abnormal eye morphology 47 | 68
decreased fasted circulating g... 47 | 65
abnormal sleep behavior 46 | 70
decreased leukocyte cell numbe... 46 | 73
increased circulating sodium l... 46 | 71
abnormal gait 45 | 69
small superior vagus ganglion 45 | 74
abnormal kidney morphology 43 | 65
increased monocyte cell number 42 | 63
thrombocytopenia 42 | 56
abnormal behavioral response t... 40 | 66
abnormal coat-hair pigmentatio... 40 | 64
decreased erythrocyte cell num... 40 | 62
decreased mean corpuscular hem... 40 | 50
small testis 37 | 58
decreased circulating total pr... 34 | 49
increased blood urea nitrogen ... 34 | 48
increased leukocyte cell numbe... 34 | 47
abnormal neural tube closure 33 | 46
abnormal spleen morphology 33 | 55
abnormal skin morphology 32 | 50
decreased blood urea nitrogen ... 32 | 51
decreased circulating alanine ... 32 | 47
increased hematocrit 32 | 46
increased neutrophil cell numb... 32 | 46
decreased circulating alkaline... 31 | 46
decreased circulating creatini... 31 | 39
decreased hematocrit 31 | 46
female infertility 31 | 60
increased circulating chloride... 31 | 41
abnormal cranium morphology 30 | 36
decreased circulating LDL chol... 30 | 38
hydrometra 30 | 53
increased hemoglobin content 30 | 45
decreased caudal vertebrae num... 29 | 53
increased mean platelet volume 29 | 45
limb grasping 29 | 41
pallor 29 | 34
abnormal bone mineralization 28 | 38
abnormal testis morphology 28 | 43
anophthalmia 28 | 33
decreased neutrophil cell numb... 28 | 42
prolonged QT interval 28 | 38
increased grip strength 27 | 41
increased prepulse inhibition 26 | 32
prolonged ST segment 26 | 36

Disease

Carcinoma 6,804 | 11,493
ovarian cancer 5,710 | 8,520
osteosarcoma 5,020 | 7,950
psoriasis 4,174 | 6,694
medulloblastoma, large-cell 3,970 | 6,241
glioblastoma 3,822 | 5,792
atypical teratoid / rhabdoid tumor 3,275 | 5,112
lung cancer 3,272 | 4,740
ependymoma 2,944 | 4,679
group 3 medulloblastoma 2,533 | 4,104
adult high grade glioma 2,430 | 3,801
Breast cancer 2,355 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,257 | 3,291
malignant mesothelioma 2,165 | 3,232
Astrocytoma, Pilocytic 2,021 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 1,996 | 2,989
invasive ductal carcinoma 1,985 | 2,951
non-small cell lung cancer 1,955 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 1,952 | 2,955
primitive neuroectodermal tumor 1,928 | 3,035
Cancer 1,905 | 2,499
oligodendroglioma 1,833 | 2,850
lung carcinoma 1,799 | 2,843
lung adenocarcinoma 1,787 | 2,716
astrocytic glioma 1,684 | 2,597
pancreatic cancer 1,654 | 2,398
Kidney cancer 1,603 | 2,613
subependymal giant cell astrocytoma 1,548 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,466 | 1,962
interstitial cystitis 1,419 | 2,312
tuberculosis 1,382 | 2,010
Pick disease 1,290 | 1,894
ulcerative colitis 1,233 | 1,819
diabetes mellitus 1,229 | 1,728
pituitary cancer 1,209 | 1,972
group 4 medulloblastoma 1,205 | 1,855
ductal carcinoma in situ 1,156 | 1,745
breast carcinoma 1,123 | 1,638
Autosomal recessive predisposition 1,119 | 1,442
cystic fibrosis 1,118 | 1,696
Multiple myeloma 1,096 | 1,332
colon cancer 990 | 1,478
adrenocortical carcinoma 959 | 1,428
juvenile dermatomyositis 858 | 1,187
acute quadriplegic myopathy 854 | 1,158
astrocytoma 832 | 1,146
Rheumatoid arthritis 823 | 1,191
Schizophrenia 789 | 1,160
dermatomyositis 777 | 966
primary pancreatic ductal adenocarcinoma 771 | 1,109
Intellectual disability 755 | 1,016
pediatric high grade glioma 707 | 1,064
spina bifida 703 | 1,074
cutaneous lupus erythematosus 690 | 1,057
nasopharyngeal carcinoma 686 | 1,058
Atopic dermatitis 641 | 952
Waldenstrons macroglobulinemia 625 | 765
active Crohn's disease 617 | 922
non primary Sjogren syndrome sicca 615 | 891
Epilepsy 611 | 792
Liver Cirrhosis, Experimental 580 | 769
esophageal adenocarcinoma 564 | 737
gastric carcinoma 564 | 807
acute myeloid leukemia 538 | 783
active ulcerative colitis 510 | 764
primary Sjogren syndrome 503 | 735
Cognitive delay 498 | 608
Global developmental delay 498 | 608
Mental and motor retardation 498 | 608
Obesity 496 | 678
Alzheimer's disease 492 | 658
Dull intelligence 489 | 645
Low intelligence 489 | 645
Mental Retardation 489 | 645
Mental deficiency 489 | 645
Poor school performance 489 | 645
Seizures 487 | 596
Bipolar Disorder 469 | 666
aldosterone-producing adenoma 461 | 665
Duchenne muscular dystrophy 456 | 601
medulloblastoma 452 | 720
Muscle hypotonia 448 | 571
progressive supranuclear palsy 444 | 676
Melanoma 439 | 711
Short stature 397 | 531
pancreatic carcinoma 390 | 562
Prostatic Neoplasms 385 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 380 | 510
hepatocellular carcinoma 369 | 547
Down syndrome 367 | 499
Neurodegenerative disease 367 | 414
Multiple Sclerosis 366 | 540
Endometriosis 363 | 540
fibroadenoma 358 | 559
Liver cancer 353 | 604
Amyotrophic lateral sclerosis 350 | 451
Kidney disease 348 | 430
Breast Neoplasms 344 | 445
mucosa-associated lymphoid tissue lymphoma 331 | 484
Mammary Neoplasms 326 | 425

Tissue

Endocrine System 10,540 | 18,159
Digestive Tract 10,381 | 17,369
Female tissues 10,363 | 17,400
Skin and soft tissues 10,351 | 17,230
Male tissues 10,240 | 17,142
Blood and immune system 10,190 | 16,909
Liver and Pancreas 10,163 | 16,750
Urinary Tract 10,118 | 16,678
Nervous System 10,098 | 16,725
Respiratory system 9,977 | 16,393
Cardiovascular System 9,526 | 15,192

Target Family

Non-IDG 6,242 | 12,091
Enzyme 3,209 | 4,145
Kinase 556 | 634
Transcription Factor 358 | 1,400
Transporter 227 | 473
Ion Channel 129 | 344
GPCR 107 | 408
Epigenetic 104 | 242
Nuclear Receptor 26 | 48
TF/Epigenetic 20 | 38
oGPCR 5 | 421

Compartment GO Term

Cytoplasm 10,983 | 10,983
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29