Development Level

Tbio 6,880 | 10,625
Tdark 1,726 | 7,003
Tchem 1,360 | 1,890
Tclin 386 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible Ion Channel Proteins 27 | 117
Eligible non-olfactory GPCR Proteins 13 | 143

IMPC Term

preweaning lethality, complete... 468 | 633
preweaning lethality, incomple... 179 | 260
embryonic lethality prior to t... 141 | 187
abnormal behavior 139 | 226
decreased lean body mass 132 | 195
decreased total body fat amoun... 120 | 186
decreased body weight 118 | 174
embryonic lethality prior to o... 115 | 148
decreased bone mineral content 110 | 157
decreased bone mineral density 88 | 126
abnormal bone structure 86 | 131
abnormal embryo size 86 | 112
increased or absent threshold ... 86 | 128
decreased grip strength 85 | 123
increased circulating alkaline... 83 | 119
decreased circulating glucose ... 79 | 121
decreased body length 73 | 108
abnormal retina morphology 70 | 100
increased lean body mass 70 | 107
increased mean corpuscular hem... 62 | 93
hyperactivity 60 | 108
decreased circulating choleste... 59 | 85
enlarged heart 59 | 111
increased mean corpuscular vol... 59 | 91
hypoactivity 58 | 89
increased bone mineral content 58 | 92
decreased circulating HDL chol... 57 | 77
decreased circulating triglyce... 56 | 83
abnormal lens morphology 55 | 73
decreased circulating insulin ... 51 | 75
increased grip strength 50 | 83
short tibia 50 | 82
prenatal lethality prior to he... 47 | 64
decreased circulating serum al... 45 | 79
increased circulating HDL chol... 45 | 63
increased circulating sodium l... 45 | 71
increased fasted circulating g... 43 | 68
abnormal sleep behavior 42 | 63
decreased mean corpuscular vol... 42 | 50
abnormal retinal pigmentation 41 | 61
increased circulating choleste... 41 | 53
improved glucose tolerance 40 | 56
abnormal bone mineralization 39 | 55
increased total body fat amoun... 39 | 57
decreased prepulse inhibition 38 | 52
decreased startle reflex 38 | 48
decreased fasted circulating g... 36 | 49
decreased lumbar vertebrae num... 36 | 62
male infertility 36 | 62
decreased circulating alanine ... 35 | 53
impaired glucose tolerance 35 | 52
increased bone mineral density 35 | 52
abnormal coat/hair pigmentatio... 34 | 54
decreased hemoglobin content 34 | 53
decreased leukocyte cell numbe... 34 | 54
increased sacral vertebrae num... 34 | 62
abnormal behavioral response t... 33 | 52
decreased rib number 33 | 59
thrombocytopenia 33 | 46
decreased heart weight 32 | 44
increased body weight 32 | 42
increased exploration in new e... 32 | 56
increased circulating chloride... 31 | 43
increased heart weight 30 | 37
increased blood urea nitrogen ... 29 | 44
abnormal gait 28 | 51
abnormal neural tube closure 28 | 37
decreased circulating alkaline... 28 | 41
increased hemoglobin content 28 | 45
decreased T cell number 27 | 31
decreased caudal vertebrae num... 27 | 49
decreased eosinophil cell numb... 27 | 41
abnormal eye morphology 26 | 38
abnormal heart morphology 26 | 51
decreased erythrocyte cell num... 26 | 43
increased leukocyte cell numbe... 26 | 37
abnormal seminal vesicle morph... 25 | 47
decreased circulating LDL chol... 25 | 37
decreased mean corpuscular hem... 25 | 34
increased startle reflex 25 | 38
limb grasping 25 | 35
abnormal cranium morphology 24 | 32
abnormal kidney morphology 23 | 30
abnormal spleen morphology 23 | 36
cardiovascular system phenotyp... 23 | 35
decreased circulating fructosa... 23 | 31
decreased circulating total pr... 23 | 41
embryonic growth retardation 23 | 28
abnormal rib morphology 22 | 28
decreased NK T cell number 22 | 28
decreased circulating creatini... 22 | 31
decreased neutrophil cell numb... 22 | 37
increased hematocrit 22 | 36
increased rib number 22 | 41
small testis 22 | 37
decreased circulating calcium ... 21 | 33
decreased circulating free fat... 21 | 39
increased circulating calcium ... 21 | 32
abnormal testis morphology 20 | 30
decreased blood urea nitrogen ... 20 | 31

Disease

ovarian cancer 5,455 | 8,484
osteosarcoma 4,755 | 7,933
psoriasis 3,901 | 6,685
medulloblastoma, large-cell 3,803 | 6,234
glioblastoma 3,528 | 5,572
lung cancer 2,978 | 4,466
atypical teratoid / rhabdoid tumor 2,671 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,158 | 3,289
malignant mesothelioma 2,015 | 3,162
Breast cancer 1,979 | 3,094
pilocytic astrocytoma 1,940 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 1,917 | 2,988
invasive ductal carcinoma 1,899 | 2,950
primitive neuroectodermal tumor 1,869 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,858 | 2,956
non-small cell lung cancer 1,798 | 2,798
oligodendroglioma 1,772 | 2,849
Cancer 1,748 | 2,346
pediatric high grade glioma 1,729 | 2,712
lung carcinoma 1,698 | 2,844
lung adenocarcinoma 1,695 | 2,713
ependymoma 1,557 | 2,514
pancreatic cancer 1,531 | 2,300
subependymal giant cell astrocytoma 1,468 | 2,287
astrocytic glioma 1,371 | 2,241
group 3 medulloblastoma 1,336 | 2,254
ulcerative colitis 1,333 | 2,087
interstitial cystitis 1,331 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 1,286 | 1,795
Carcinoma 1,256 | 2,147
adult high grade glioma 1,255 | 2,148
Pick disease 1,247 | 1,893
pituitary cancer 1,158 | 1,972
group 4 medulloblastoma 1,141 | 1,875
ductal carcinoma in situ 1,121 | 1,745
diabetes mellitus 1,085 | 1,663
Multiple myeloma 1,079 | 1,327
breast carcinoma 1,058 | 1,614
astrocytoma 1,043 | 1,493
cystic fibrosis 1,031 | 1,665
tuberculosis 1,011 | 1,557
colon cancer 960 | 1,475
medulloblastoma 951 | 1,524
posterior fossa group A ependymoma 938 | 1,511
adrenocortical carcinoma 917 | 1,427
sonic hedgehog group medulloblastoma 874 | 1,482
posterior fossa group B ependymoma 864 | 1,530
primary pancreatic ductal adenocarcinoma 845 | 1,271
acute quadriplegic myopathy 814 | 1,157
juvenile dermatomyositis 813 | 1,189
Rheumatoid Arthritis 776 | 1,160
dermatomyositis 714 | 933
atypical teratoid/rhabdoid tumor 674 | 1,095
spina bifida 671 | 1,064
nasopharyngeal carcinoma 670 | 1,056
cutaneous lupus erythematosus 647 | 1,056
Waldenstrons macroglobulinemia 603 | 765
active Crohn's disease 585 | 918
Atopic dermatitis 570 | 944
non primary Sjogren syndrome sicca 550 | 840
gastric carcinoma 543 | 832
esophageal adenocarcinoma 524 | 737
acute myeloid leukemia 500 | 780
primary Sjogren syndrome 500 | 789
Alzheimer's disease 466 | 644
Obesity 446 | 616
aldosterone-producing adenoma 445 | 664
tuberculosis and treatment for 6 months 439 | 686
progressive supranuclear palsy 436 | 674
Duchenne muscular dystrophy 423 | 602
Intellectual disability 402 | 573
Down syndrome 387 | 548
pancreatic carcinoma 384 | 567
Prostatic Neoplasms 356 | 471
Endometriosis 347 | 535
fibroadenoma 347 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 344 | 499
hepatocellular carcinoma 338 | 532
Neurodegenerative disease 337 | 383
IGA Glomerulonephritis 330 | 454
Schizophrenia 328 | 501
Amyotrophic Lateral Sclerosis 327 | 431
Multiple Sclerosis 319 | 498
Kidney disease 314 | 396
chronic rhinosinusitis 305 | 512
Mammary Neoplasms 298 | 410
mucosa-associated lymphoid tissue lymphoma 289 | 480
active ulcerative colitis 288 | 477
Parkinson's disease 271 | 364
gastric cancer 269 | 430
hereditary spastic paraplegia 256 | 313
inflammatory breast cancer 254 | 404
non-small cell lung carcinoma 241 | 413
Polycystic Ovary Syndrome 233 | 332
Vascular disease 228 | 281
Asthma 226 | 349
Epilepsy 226 | 346
Heart disease 225 | 279
Hypertension 225 | 287
sarcoidosis 225 | 358

Tissue

Female tissues 10,130 | 18,647
Nervous System 10,123 | 18,561
Digestive Tract 10,106 | 18,473
Endocrine System 10,104 | 18,512
Urinary Tract 10,070 | 18,444
Liver and Pancreas 10,061 | 18,136
Blood and immune system 10,050 | 17,995
Male tissues 10,022 | 17,969
Cardiovascular System 10,018 | 17,958
Skin and soft tissues 9,991 | 18,115
Respiratory system 9,893 | 17,484

Target Family

Non-IDG 5,783 | 11,971
Enzyme 3,118 | 4,146
Kinase 544 | 634
Transcription Factor 341 | 1,400
Transporter 219 | 473
Ion Channel 121 | 341
Epigenetic 103 | 242
GPCR 85 | 406
Nuclear Receptor 22 | 48
TF/Epigenetic 15 | 38
oGPCR 1 | 421

Compartment GO Term

Cytoplasm 10,352 | 10,352
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108