Development Level

Tbio 45 | 11,445
Tdark 20 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal kidney morphology 2 | 65
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
preweaning lethality, complete... 2 | 979
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal vibrissa morphology 1 | 25
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased IgE level 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small kidney 1 | 16

Disease

psoriasis 40 | 6,694
Carcinoma 34 | 11,493
esophageal adenocarcinoma 21 | 737
ovarian cancer 20 | 8,520
Breast cancer 19 | 3,578
lung cancer 18 | 4,740
non-small cell lung cancer 17 | 2,890
Atopic dermatitis 16 | 952
cystic fibrosis 15 | 1,696
Kidney cancer 13 | 2,613
diabetes mellitus 13 | 1,728
interstitial cystitis 13 | 2,312
nasopharyngeal carcinoma 13 | 1,058
osteosarcoma 13 | 7,950
spina bifida 13 | 1,074
Palmoplantar keratosis 12 | 74
medulloblastoma, large-cell 12 | 6,241
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
periodontitis 10 | 293
Cancer 9 | 2,499
Congenital ichthyosiform erythroderma 9 | 28
Epidermolytic hyperkeratosis 9 | 14
Melanoma 9 | 711
Skin cancer 9 | 469
adult high grade glioma 9 | 3,801
lung adenocarcinoma 9 | 2,716
Autosomal recessive predisposition 8 | 1,442
Erythema 8 | 58
Flushing 8 | 60
atypical teratoid / rhabdoid tumor 8 | 5,112
cutaneous lupus erythematosus 8 | 1,057
glioblastoma 8 | 5,792
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Dermatitis 7 | 157
Ichthyosis vulgaris 7 | 11
Squamous cell carcinoma 7 | 129
breast carcinoma 7 | 1,638
ependymoma 7 | 4,679
Carcinoma, Squamous Cell 6 | 110
Hypotrichosis 6 | 47
Ichthyoses 6 | 41
Pemphigus 6 | 23
lung carcinoma 6 | 2,843
Abnormal blistering of the skin 5 | 54
Alopecia 5 | 115
Astrocytoma, Pilocytic 5 | 3,081
Blister of skin 5 | 54
Bullous pemphigoid 5 | 18
Cardiomyopathy 5 | 116
Cardiomyopathy, right ventricular 5 | 7
Dilated cardiomyopathy 5 | 56
Eczema 5 | 45
Ichthyosis 5 | 56
Keratosis 5 | 37
Liver cancer 5 | 604
Nail Diseases 5 | 24
Nail abnormality 5 | 22
Peeling of skin 5 | 8
Ritter's disease 5 | 10
Skin bulla 5 | 54
Skin disease 5 | 66
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Afro-textured hair 4 | 13
Asthma 4 | 385
Contact Dermatitis 4 | 81
DOID:2627 4 | 94
Dermatitis, Contact 4 | 71
Dystrophia unguium 4 | 53
Endometrial cancer 4 | 311
Exfoliative dermatitis 4 | 24
Hyperkeratosis, Epidermolytic 4 | 7
Kinky hair texture 4 | 13
Nappy hair texture 4 | 13
Netherton syndrome 4 | 15
Peeling skin syndrome 4 | 17
Rheumatoid arthritis 4 | 1,191
Skin Neoplasms 4 | 69
Sudden Cardiac Death 4 | 29
Wooly hair 4 | 17
atypical teratoid/rhabdoid tumor 4 | 357
cystic fibrosis and chronic rhinosinusitis 4 | 214
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
subependymal giant cell astrocytoma 4 | 2,287
Cardiomyopathy, Dilated 3 | 83
Failure to gain weight 3 | 365
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
acute myeloid leukemia 3 | 783
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
urothelial carcinoma 3 | 318

Tissue

Skin and soft tissues 66 | 17,230
Female tissues 62 | 17,400
Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Endocrine System 50 | 18,159
Urinary Tract 39 | 16,678
Liver and Pancreas 38 | 16,750
Nervous System 38 | 16,725
Male tissues 37 | 17,142
Cardiovascular System 32 | 15,192
Respiratory system 29 | 16,393

Target Family

Non-IDG 63 | 12,091
Enzyme 4 | 4,145
Transcription Factor 1 | 1,400

Compartment GO Term

Cornified envelope 68 | 68
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Small proline-rich protein 2F SPRR2F Tbio Non-IDG 0.44 0.31 12
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Small proline-rich protein 4 SPRR4 Tdark Non-IDG -0.32647 2.13 9
Late cornified envelope protein 3D LCE3D Tdark Non-IDG -0.13175 1.11 0
Late cornified envelope protein 5A LCE5A Tdark Non-IDG 0.50 0.32 0
Small proline-rich protein 2G SPRR2G Tbio Non-IDG 0.39 0.31 1
Cornifelin CNFN Tdark Non-IDG -0.56002 3.82 7
Hornerin HRNR Tbio Non-IDG -1.33117 22.2 69
Late cornified envelope protein 2C LCE2C Tdark Non-IDG 0.00000 0