Development Level

Tbio 173 | 10,625
Tchem 17 | 1,890
Tdark 14 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

abnormal behavior 5 | 226
decreased total body fat amoun... 5 | 186
preweaning lethality, complete... 5 | 633
abnormal lens morphology 4 | 73
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
abnormal bone structure 3 | 131
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
increased or absent threshold ... 3 | 128
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased body weight 2 | 174
decreased circulating free fat... 2 | 39
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased prepulse inhibition 2 | 52
hyperactivity 2 | 108
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 93
increased total body fat amoun... 2 | 57
preweaning lethality, incomple... 2 | 260
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal nail morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal skin condition 1 | 6
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased heart rate variabili... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged heart atrium 1 | 2
hydrops fetalis 1 | 22
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased erythrocyte cell num... 1 | 26
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased vertical activity 1 | 18
limb grasping 1 | 35
male infertility 1 | 62
microphthalmia 1 | 15
mydriasis 1 | 9
short tibia 1 | 82
shortened RR interval 1 | 19
small testis 1 | 37
thrombocytosis 1 | 23

Disease

psoriasis 107 | 6,685
Cancer 92 | 2,346
diabetes mellitus 90 | 1,663
ovarian cancer 85 | 8,484
Ankylosing spondylitis 71 | 138
Hypersensitivity reaction type II disease 64 | 235
osteosarcoma 64 | 7,933
Juvenile rheumatoid arthritis 61 | 104
glioblastoma 60 | 5,572
Arthritis 59 | 248
Acquired immunodeficiency syndrome 58 | 164
Uveitis 57 | 103
Behcet's disease 56 | 74
Rheumatoid Arthritis 56 | 1,160
Psoriatic arthritis 52 | 83
medulloblastoma, large-cell 50 | 6,234
atypical teratoid / rhabdoid tumor 43 | 4,369
lung cancer 39 | 4,466
pilocytic astrocytoma 39 | 3,086
Stevens-Johnson syndrome 37 | 78
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
lung carcinoma 34 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
Multiple Sclerosis 31 | 498
astrocytoma 29 | 1,493
malignant mesothelioma 29 | 3,162
pediatric high grade glioma 29 | 2,712
Breast cancer 28 | 3,094
Liver disease 28 | 219
invasive ductal carcinoma 28 | 2,950
lung adenocarcinoma 27 | 2,713
subependymal giant cell astrocytoma 26 | 2,287
Kidney disease 25 | 396
Multiple myeloma 25 | 1,327
interstitial cystitis 25 | 2,299
non-small cell lung cancer 25 | 2,798
posterior fossa group A ependymoma 25 | 1,511
Anemia 24 | 252
Leprosy 24 | 77
Hemochromatosis 23 | 55
Hepatitis B 23 | 103
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
primitive neuroectodermal tumor 23 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
oligodendroglioma 22 | 2,849
pancreatic cancer 22 | 2,300
Primary immunodeficiency disease 21 | 52
Skin disease 21 | 65
breast carcinoma 20 | 1,614
Pick disease 19 | 1,893
adult high grade glioma 19 | 2,148
dermatomyositis 19 | 933
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
pituitary cancer 19 | 1,972
cutaneous lupus erythematosus 18 | 1,056
group 4 medulloblastoma 18 | 1,875
ependymoma 17 | 2,514
juvenile dermatomyositis 17 | 1,189
pre-eclampsia 16 | 67
Human immunodeficiency virus infectious disease 15 | 92
tuberculosis 15 | 1,557
acute quadriplegic myopathy 14 | 1,157
astrocytic glioma 14 | 2,241
medulloblastoma 14 | 1,524
posterior fossa group B ependymoma 14 | 1,530
Carcinoma 13 | 2,147
active Crohn's disease 13 | 918
adrenocortical carcinoma 13 | 1,427
cystic fibrosis 13 | 1,665
ductal carcinoma in situ 13 | 1,745
spina bifida 13 | 1,064
ulcerative colitis 13 | 2,087
Down syndrome 11 | 548
Duchenne muscular dystrophy 11 | 602
esophageal adenocarcinoma 11 | 737
sonic hedgehog group medulloblastoma 11 | 1,482
group 3 medulloblastoma 10 | 2,254
primary Sjogren syndrome 10 | 789
primary pancreatic ductal adenocarcinoma 10 | 1,271
gastric carcinoma 9 | 832
Alzheimer's disease 8 | 644
Parkinson's disease 8 | 364
active ulcerative colitis 8 | 477
non-small cell lung carcinoma 8 | 413
pancreatic carcinoma 8 | 567
Atherosclerosis 7 | 275
Becker muscular dystrophy 7 | 187
Epilepsy 7 | 346
Schizophrenia 7 | 501
Stomach Neoplasms 7 | 282
Vascular disease 7 | 281
Obesity 6 | 616
Prostatic Neoplasms 6 | 471
Waldenstrons macroglobulinemia 6 | 765
colon cancer 6 | 1,475
fibroadenoma 6 | 557
inflammatory breast cancer 6 | 404
limb girdle muscular dystrophy 2I 6 | 56

Tissue

Endocrine System 143 | 18,512
Blood and immune system 142 | 17,995
Cardiovascular System 142 | 17,958
Digestive Tract 142 | 18,473
Female tissues 142 | 18,647
Liver and Pancreas 142 | 18,136
Nervous System 142 | 18,561
Male tissues 141 | 17,969
Urinary Tract 141 | 18,444
Respiratory system 140 | 17,484
Skin and soft tissues 134 | 18,115

Target Family

Non-IDG 177 | 11,971
Enzyme 14 | 4,146
Transporter 6 | 473
GPCR 3 | 406
Transcription Factor 3 | 1,400
Kinase 2 | 634
Ion Channel 1 | 341

Compartment GO Term

Coated vesicle membrane 206 | 206
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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