Development Level

Tbio 246 | 10,625
Tchem 34 | 1,890
Tdark 21 | 7,003
Tclin 4 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 12 | 633
abnormal behavior 8 | 226
embryonic lethality prior to t... 7 | 187
increased or absent threshold ... 6 | 128
decreased circulating HDL chol... 5 | 77
decreased total body fat amoun... 5 | 186
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased grip strength 4 | 123
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 195
embryonic lethality prior to o... 3 | 148
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
increased mean corpuscular hem... 3 | 93
preweaning lethality, incomple... 3 | 260
abnormal embryo size 2 | 112
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased circulating free fat... 2 | 39
decreased fasted circulating g... 2 | 49
decreased gamma-delta T cell n... 2 | 18
decreased mean corpuscular hem... 2 | 34
decreased prepulse inhibition 2 | 52
hypoactivity 2 | 89
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased total body fat amoun... 2 | 57
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal spinal cord morpholog... 1 | 8
abnormal vibrissa morphology 1 | 17
absent heartbeat 1 | 6
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating serum al... 1 | 79
decreased effector memory CD4-... 1 | 6
decreased heart rate variabili... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased vertical activity 1 | 22
enlarged heart atrium 1 | 2
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired pupillary reflex 1 | 14
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased erythrocyte cell num... 1 | 26
increased mature B cell number 1 | 12
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased thoracic vertebrae n... 1 | 8
increased vertical activity 1 | 18
limb grasping 1 | 35
microphthalmia 1 | 15
mydriasis 1 | 9
short tibia 1 | 82
small testis 1 | 37
thrombocytosis 1 | 23

Disease

ovarian cancer 153 | 8,484
psoriasis 153 | 6,685
Cancer 117 | 2,346
osteosarcoma 116 | 7,933
diabetes mellitus 108 | 1,663
glioblastoma 101 | 5,572
medulloblastoma, large-cell 93 | 6,234
Hypersensitivity reaction type II disease 73 | 235
atypical teratoid / rhabdoid tumor 73 | 4,369
lung cancer 72 | 4,466
Ankylosing spondylitis 71 | 138
Rheumatoid Arthritis 68 | 1,160
Arthritis 64 | 248
Juvenile rheumatoid arthritis 61 | 104
Acquired immunodeficiency syndrome 59 | 164
Uveitis 59 | 103
pilocytic astrocytoma 58 | 3,086
Behcet's disease 57 | 74
lung carcinoma 57 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
Psoriatic arthritis 52 | 83
invasive ductal carcinoma 48 | 2,950
lung adenocarcinoma 47 | 2,713
pediatric high grade glioma 47 | 2,712
Breast cancer 46 | 3,094
oligodendroglioma 46 | 2,849
astrocytoma 43 | 1,493
malignant mesothelioma 43 | 3,162
pancreatic cancer 43 | 2,300
Multiple myeloma 42 | 1,327
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
non-small cell lung cancer 42 | 2,798
primitive neuroectodermal tumor 42 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
interstitial cystitis 39 | 2,299
subependymal giant cell astrocytoma 39 | 2,287
ependymoma 38 | 2,514
Pick disease 37 | 1,893
Stevens-Johnson syndrome 37 | 78
Liver disease 36 | 219
Retinal vasculitis 36 | 36
Congenital adrenal hyperplasia 35 | 74
Takayasu's arteritis 35 | 52
Carcinoma 34 | 2,147
Kidney disease 34 | 396
Multiple Sclerosis 34 | 498
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
Anemia 31 | 252
astrocytic glioma 31 | 2,241
posterior fossa group A ependymoma 31 | 1,511
dermatomyositis 30 | 933
pituitary cancer 30 | 1,972
tuberculosis 30 | 1,557
breast carcinoma 29 | 1,614
adult high grade glioma 28 | 2,148
cutaneous lupus erythematosus 28 | 1,056
group 4 medulloblastoma 28 | 1,875
Hepatitis B 26 | 103
Hemochromatosis 25 | 55
Leprosy 25 | 77
juvenile dermatomyositis 25 | 1,189
acute quadriplegic myopathy 24 | 1,157
cystic fibrosis 24 | 1,665
medulloblastoma 24 | 1,524
ulcerative colitis 23 | 2,087
Skin disease 22 | 65
ductal carcinoma in situ 22 | 1,745
Primary immunodeficiency disease 21 | 52
primary pancreatic ductal adenocarcinoma 21 | 1,271
sonic hedgehog group medulloblastoma 21 | 1,482
esophageal adenocarcinoma 20 | 737
posterior fossa group B ependymoma 20 | 1,530
Alzheimer's disease 19 | 644
group 3 medulloblastoma 19 | 2,254
active Crohn's disease 18 | 918
Human immunodeficiency virus infectious disease 17 | 92
Down syndrome 16 | 548
adrenocortical carcinoma 16 | 1,427
pancreatic carcinoma 16 | 567
pre-eclampsia 15 | 67
spina bifida 15 | 1,064
Duchenne muscular dystrophy 14 | 602
Waldenstrons macroglobulinemia 14 | 765
gastric carcinoma 14 | 832
mucosa-associated lymphoid tissue lymphoma 14 | 480
atypical teratoid/rhabdoid tumor 13 | 1,095
non primary Sjogren syndrome sicca 13 | 840
primary Sjogren syndrome 13 | 789
Asthma 12 | 349
Neurodegenerative disease 12 | 383
Parkinson's disease 12 | 364
Vascular disease 12 | 281
acute myeloid leukemia 12 | 780
colon cancer 12 | 1,475
progressive supranuclear palsy 12 | 674
Atherosclerosis 11 | 275
Atopic dermatitis 11 | 944
Heart disease 11 | 279
Schizophrenia 11 | 501
Stomach Neoplasms 11 | 282

Tissue

Endocrine System 242 | 18,512
Blood and immune system 241 | 17,995
Cardiovascular System 241 | 17,958
Digestive Tract 241 | 18,473
Female tissues 241 | 18,647
Liver and Pancreas 241 | 18,136
Nervous System 241 | 18,561
Male tissues 240 | 17,969
Urinary Tract 240 | 18,444
Respiratory system 239 | 17,484
Skin and soft tissues 233 | 18,115

Target Family

Non-IDG 249 | 11,971
Enzyme 32 | 4,146
Transporter 10 | 473
Kinase 7 | 634
GPCR 3 | 406
Transcription Factor 3 | 1,400
Ion Channel 1 | 341

Compartment GO Term

Coated vesicle 305 | 305
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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