Development Level

Tbio 277 | 11,445
Tchem 25 | 1,598
Tdark 16 | 6,588
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to t... 10 | 278
preweaning lethality, incomple... 9 | 499
abnormal behavior 6 | 298
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
abnormal embryo size 5 | 220
abnormal lens morphology 5 | 81
decreased total body fat amoun... 5 | 207
abnormal sleep behavior 4 | 70
cataract 4 | 92
decreased circulating choleste... 4 | 93
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
enlarged heart 3 | 210
hydrometra 3 | 53
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal cecum morphology 2 | 7
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
brachydactyly 2 | 19
decreased body length 2 | 101
decreased circulating free fat... 2 | 31
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
enlarged cecum 2 | 5
enlarged lymph nodes 2 | 37
enlarged seminal vesicle 2 | 10
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased prepulse inhibition 2 | 32
increased vertical activity 2 | 24
microphthalmia 2 | 26
pallor 2 | 34
small testis 2 | 58
syndactyly 2 | 23
thrombocytosis 2 | 27
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal sensory capabilities-... 1 | 8
abnormal tooth morphology 1 | 24
abnormal vitelline vasculature... 1 | 6
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged epididymis 1 | 31
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
limb grasping 1 | 41
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 197 | 11,493
ovarian cancer 168 | 8,520
psoriasis 168 | 6,694
osteosarcoma 128 | 7,950
Cancer 124 | 2,499
glioblastoma 114 | 5,792
diabetes mellitus 112 | 1,728
medulloblastoma, large-cell 101 | 6,241
atypical teratoid / rhabdoid tumor 83 | 5,112
lung cancer 82 | 4,740
ependymoma 77 | 4,679
Hypersensitivity reaction type II disease 74 | 253
Ankylosing spondylitis 73 | 140
Behcet's disease 71 | 89
Rheumatoid arthritis 69 | 1,191
Arthritis 65 | 290
Astrocytoma, Pilocytic 63 | 3,081
Juvenile rheumatoid arthritis 63 | 111
lung carcinoma 63 | 2,843
dermatomyositis 61 | 966
tuberculosis 60 | 2,010
Acquired immunodeficiency syndrome 59 | 197
Breast cancer 59 | 3,578
Uveitis 59 | 103
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
Herpes zoster 56 | 68
adult high grade glioma 56 | 3,801
Human immunodeficiency virus infectious disease 54 | 138
malignant mesothelioma 54 | 3,232
invasive ductal carcinoma 53 | 2,951
lung adenocarcinoma 53 | 2,716
Psoriatic arthritis 52 | 86
astrocytic glioma 51 | 2,597
Stevens-Johnson syndrome 50 | 92
group 3 medulloblastoma 50 | 4,104
oligodendroglioma 50 | 2,850
Kidney cancer 49 | 2,613
non-small cell lung cancer 49 | 2,890
pancreatic cancer 47 | 2,398
subependymal giant cell astrocytoma 45 | 2,287
interstitial cystitis 44 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
primitive neuroectodermal tumor 44 | 3,035
Multiple myeloma 43 | 1,332
Autosomal recessive predisposition 42 | 1,442
Pick disease 41 | 1,894
Kidney disease 40 | 430
Dermatitis 39 | 157
Liver disease 38 | 237
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
Congenital adrenal hyperplasia 36 | 73
Multiple Sclerosis 36 | 540
Retinal vasculitis 36 | 36
Behcet's syndrome 35 | 50
Nephritis 35 | 51
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
cutaneous lupus erythematosus 35 | 1,057
drug-induced hepatitis 35 | 44
Anemia 34 | 365
pituitary cancer 34 | 1,972
Schizophrenia 31 | 1,160
breast carcinoma 31 | 1,638
Hepatitis B 30 | 108
group 4 medulloblastoma 30 | 1,855
cystic fibrosis 28 | 1,696
juvenile dermatomyositis 28 | 1,187
acute quadriplegic myopathy 27 | 1,158
astrocytoma 27 | 1,146
Bipolar Disorder 25 | 666
Hemochromatosis 25 | 54
Leprosy 25 | 73
pediatric high grade glioma 25 | 1,064
Cataract 8 multiple types 24 | 33
ductal carcinoma in situ 24 | 1,745
Alzheimer's disease 23 | 658
Skin disease 22 | 66
esophageal adenocarcinoma 22 | 737
ulcerative colitis 22 | 1,819
Birdshot chorioretinopathy 21 | 23
Primary immunodeficiency disease 21 | 54
primary pancreatic ductal adenocarcinoma 20 | 1,109
adrenocortical carcinoma 19 | 1,428
Down syndrome 18 | 499
Epilepsy 18 | 792
Intellectual disability 18 | 1,016
Melanoma 18 | 711
Pre-Eclampsia 18 | 68
active Crohn's disease 18 | 922
gastric carcinoma 17 | 807
non primary Sjogren syndrome sicca 17 | 891
pancreatic carcinoma 17 | 562
Duchenne muscular dystrophy 16 | 601
Vascular disease 16 | 319
spina bifida 16 | 1,074
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645

Tissue

Digestive Tract 254 | 17,369
Endocrine System 254 | 18,159
Skin and soft tissues 253 | 17,230
Female tissues 252 | 17,400
Male tissues 250 | 17,142
Blood and immune system 248 | 16,909
Respiratory system 247 | 16,393
Liver and Pancreas 246 | 16,750
Nervous System 245 | 16,725
Urinary Tract 245 | 16,678
Cardiovascular System 234 | 15,192

Target Family

Non-IDG 266 | 12,091
Enzyme 33 | 4,145
Transporter 11 | 473
Kinase 8 | 634
GPCR 6 | 408
Transcription Factor 3 | 1,400
Ion Channel 2 | 344

Compartment GO Term

Coated vesicle 329 | 329
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Solute carrier family 2, facilitated glucose transporter member 8 SLC2A8 Tbio Transporter -1.54482 35.6 110
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tbio Enzyme -2.95336 876.7 309
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Cell migration-inducing and hyaluronan-binding protein CEMIP Tbio Non-IDG -1.58210 41.5 144