Development Level

Tbio 263 | 11,178
Tchem 32 | 1,885
Tdark 16 | 6,569
Tclin 11 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 9 | 499
abnormal behavior 6 | 298
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
abnormal embryo size 5 | 220
abnormal lens morphology 5 | 81
decreased total body fat amoun... 5 | 207
abnormal sleep behavior 4 | 70
cataract 4 | 92
decreased circulating choleste... 4 | 93
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
enlarged heart 3 | 210
hydrometra 3 | 53
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal cecum morphology 2 | 7
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
decreased body length 2 | 101
decreased circulating free fat... 2 | 31
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
enlarged cecum 2 | 5
enlarged lymph nodes 2 | 37
enlarged seminal vesicle 2 | 10
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased prepulse inhibition 2 | 32
increased vertical activity 2 | 24
microphthalmia 2 | 26
pallor 2 | 34
small testis 2 | 58
syndactyly 2 | 23
thrombocytosis 2 | 27
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal sensory capabilities-... 1 | 8
abnormal tooth morphology 1 | 24
abnormal vitelline vasculature... 1 | 6
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
brachydactyly 1 | 19
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged epididymis 1 | 31
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
limb grasping 1 | 41
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 191 | 11,192
psoriasis 164 | 6,514
ovarian cancer 163 | 8,297
osteosarcoma 125 | 7,766
Cancer 120 | 2,388
glioblastoma 113 | 5,635
diabetes mellitus 111 | 1,683
medulloblastoma, large-cell 100 | 6,086
atypical teratoid / rhabdoid tumor 81 | 4,971
lung cancer 79 | 4,607
ependymoma 76 | 4,559
Ankylosing spondylitis 73 | 134
Hypersensitivity reaction type II disease 72 | 245
Behcet's disease 71 | 87
Rheumatoid arthritis 68 | 1,156
Arthritis 65 | 276
Juvenile rheumatoid arthritis 63 | 110
Astrocytoma, Pilocytic 61 | 3,006
dermatomyositis 61 | 941
tuberculosis 60 | 1,963
Acquired immunodeficiency syndrome 59 | 192
Uveitis 59 | 102
lung carcinoma 59 | 2,755
Breast cancer 56 | 3,469
Herpes zoster 56 | 68
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,872
adult high grade glioma 55 | 3,701
Human immunodeficiency virus infectious disease 53 | 136
malignant mesothelioma 53 | 3,135
Psoriatic arthritis 52 | 84
lung adenocarcinoma 52 | 2,627
Stevens-Johnson syndrome 50 | 92
invasive ductal carcinoma 50 | 2,867
oligodendroglioma 50 | 2,768
astrocytic glioma 49 | 2,530
group 3 medulloblastoma 49 | 4,002
Kidney cancer 48 | 2,548
non-small cell lung cancer 46 | 2,799
pancreatic cancer 45 | 2,322
primitive neuroectodermal tumor 44 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,902
Multiple myeloma 42 | 1,296
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,204
subependymal giant cell astrocytoma 42 | 2,230
Autosomal recessive predisposition 41 | 1,407
interstitial cystitis 41 | 2,237
Pick disease 40 | 1,856
Dermatitis 39 | 154
Kidney disease 38 | 411
Liver disease 37 | 227
Congenital adrenal hyperplasia 36 | 71
Multiple Sclerosis 36 | 527
Retinal vasculitis 36 | 36
Behcet's syndrome 35 | 49
Nephritis 35 | 51
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 75
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,911
cutaneous lupus erythematosus 34 | 1,016
pituitary cancer 34 | 1,915
Anemia 32 | 353
Schizophrenia 31 | 1,136
Hepatitis B 30 | 105
breast carcinoma 30 | 1,589
group 4 medulloblastoma 30 | 1,806
cystic fibrosis 28 | 1,629
astrocytoma 27 | 1,113
juvenile dermatomyositis 27 | 1,147
acute quadriplegic myopathy 26 | 1,133
Bipolar Disorder 25 | 646
Leprosy 25 | 72
pediatric high grade glioma 25 | 1,035
Cataract 8 multiple types 24 | 33
Hemochromatosis 24 | 52
Skin disease 22 | 64
ductal carcinoma in situ 22 | 1,686
Birdshot chorioretinopathy 21 | 22
Primary immunodeficiency disease 21 | 54
Alzheimer's disease 20 | 640
esophageal adenocarcinoma 20 | 696
primary pancreatic ductal adenocarcinoma 20 | 1,071
ulcerative colitis 20 | 1,765
Epilepsy 18 | 775
Intellectual disability 18 | 998
Melanoma 17 | 689
Pre-Eclampsia 17 | 64
active Crohn's disease 17 | 882
adrenocortical carcinoma 17 | 1,385
non primary Sjogren syndrome sicca 17 | 861
pancreatic carcinoma 17 | 555
Down syndrome 16 | 480
spina bifida 16 | 1,053
Dull intelligence 15 | 634
Low intelligence 15 | 634
Mental Retardation 15 | 634
Mental deficiency 15 | 634
Poor school performance 15 | 634
Vascular disease 15 | 294

Tissue

Digestive Tract 247 | 17,369
Endocrine System 247 | 18,159
Skin and soft tissues 246 | 17,230
Female tissues 245 | 17,400
Male tissues 243 | 17,142
Blood and immune system 241 | 16,909
Respiratory system 240 | 16,393
Liver and Pancreas 239 | 16,750
Nervous System 238 | 16,725
Urinary Tract 238 | 16,678
Cardiovascular System 227 | 15,192

Target Family

Non-IDG 262 | 12,091
Enzyme 31 | 4,145
Transporter 10 | 473
Kinase 8 | 634
GPCR 6 | 408
Transcription Factor 3 | 1,400
Ion Channel 2 | 344

Compartment GO Term

Coated vesicle 322 | 322
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
AP2-associated protein kinase 1 AAK1 Tchem Kinase -1.28486 18.8 271
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Vacuolar protein sorting-associated protein 18 homolog VPS18 Tbio Non-IDG -1.92505 80.9 117
Protein YIF1A YIF1A Tdark Non-IDG -1.22548 14.6 29
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
HLA class I histocompatibility antigen, Cw-16 alpha chain HLA-C Tbio Non-IDG -1.90661 830.5 0
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
HLA class I histocompatibility antigen, B-59 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0