Development Level

Tbio 332 | 11,445
Tdark 108 | 6,588
Tchem 42 | 1,598
Tclin 17 | 613

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 5 | 37
GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 22 | 499
abnormal behavior 12 | 298
embryonic lethality prior to t... 11 | 278
male infertility 10 | 123
decreased body weight 9 | 161
increased lean body mass 9 | 172
increased fasted circulating g... 7 | 76
prenatal lethality prior to he... 7 | 87
abnormal embryo size 6 | 220
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
hyperactivity 6 | 148
increased circulating sodium l... 6 | 71
increased mean corpuscular hem... 6 | 96
embryonic growth retardation 5 | 106
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
increased circulating chloride... 5 | 41
increased startle reflex 5 | 112
increased total body fat amoun... 5 | 134
limb grasping 5 | 41
decreased circulating alkaline... 4 | 46
decreased circulating triglyce... 4 | 79
decreased lean body mass 4 | 135
decreased prepulse inhibition 4 | 82
edema 4 | 59
embryonic lethality prior to o... 4 | 239
increased bone mineral content 4 | 108
increased circulating alkaline... 4 | 122
increased mean corpuscular vol... 4 | 92
short tibia 4 | 97
abnormal embryo turning 3 | 31
abnormal heart morphology 3 | 162
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating amylase ... 3 | 28
decreased circulating insulin ... 3 | 76
decreased fasted circulating g... 3 | 65
decreased startle reflex 3 | 75
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
enlarged heart 3 | 210
female infertility 3 | 60
increased blood urea nitrogen ... 3 | 48
increased leukocyte cell numbe... 3 | 47
increased or absent threshold ... 3 | 101
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal humerus morphology 2 | 11
abnormal limb morphology 2 | 13
abnormal nail morphology 2 | 8
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
absent pinna reflex 2 | 23
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating potassiu... 2 | 20
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating glycerol... 2 | 9
increased circulating iron lev... 2 | 30
increased grip strength 2 | 41
increased lymphocyte cell numb... 2 | 32
long tibia 2 | 25
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
small superior vagus ganglion 2 | 74
stereotypic behavior 2 | 3
trunk curl 2 | 16
vertebral fusion 2 | 23
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal retinal inner nuclear... 1 | 8
abnormal whole-body plethysmog... 1 | 4
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
tremors 1 | 39

Disease

Carcinoma 368 | 11,493
osteosarcoma 208 | 7,950
ependymoma 193 | 4,679
ovarian cancer 193 | 8,520
medulloblastoma, large-cell 149 | 6,241
psoriasis 148 | 6,694
glioblastoma 137 | 5,792
atypical teratoid / rhabdoid tumor 132 | 5,112
group 3 medulloblastoma 106 | 4,104
Kidney cancer 101 | 2,613
lung cancer 99 | 4,740
adult high grade glioma 94 | 3,801
Autosomal recessive predisposition 93 | 1,442
Breast cancer 89 | 3,578
Intellectual disability 81 | 1,016
chronic rhinosinusitis 78 | 512
primitive neuroectodermal tumor 76 | 3,035
lung adenocarcinoma 74 | 2,716
nasopharyngeal carcinoma 73 | 1,058
Retinitis Pigmentosa 71 | 226
malignant mesothelioma 71 | 3,232
astrocytic glioma 69 | 2,597
lung carcinoma 69 | 2,843
Astrocytoma, Pilocytic 67 | 3,081
Polydactyly 63 | 107
oligodendroglioma 63 | 2,850
Dull intelligence 61 | 645
Low intelligence 61 | 645
Mental Retardation 61 | 645
Mental deficiency 61 | 645
Poor school performance 61 | 645
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
Pick disease 58 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,989
Obesity 57 | 678
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
non-small cell lung cancer 56 | 2,890
invasive ductal carcinoma 55 | 2,951
Nephronophthisis 54 | 80
Ciliopathy 53 | 71
Nystagmus 52 | 317
Primary ciliary dyskinesia 52 | 76
pancreatic cancer 49 | 2,398
Cancer 46 | 2,499
tuberculosis 46 | 2,010
group 4 medulloblastoma 45 | 1,855
pituitary cancer 45 | 1,972
Cataract 44 | 297
Electroretinogram abnormal 43 | 95
Joubert syndrome 43 | 66
subependymal giant cell astrocytoma 43 | 2,287
Congenital hypoplasia of penis 42 | 176
Lens Opacities 42 | 231
Abnormality of retinal pigmentation 39 | 111
Cognitive delay 39 | 608
Global developmental delay 39 | 608
Hypogonadism 39 | 173
Mental and motor retardation 39 | 608
Retinal pigment epithelial abnormality 39 | 111
Short stature 39 | 531
Bardet-Biedl syndrome 38 | 51
Fundus dystrophy 38 | 83
interstitial cystitis 38 | 2,312
Situs Inversus 37 | 65
Broad flat nasal bridge 36 | 236
Nasal bridge wide 36 | 236
ulcerative colitis 36 | 1,819
Glaucoma 35 | 239
Optic Atrophy 35 | 242
Retinal Degeneration 35 | 106
Schizophrenia 35 | 1,160
ductal carcinoma in situ 35 | 1,745
Anteverted nostril 34 | 191
Cone dystrophy 34 | 71
colon cancer 34 | 1,478
Ciliary Motility Disorders 33 | 38
Photodysphoria 33 | 121
Photophobia 33 | 121
Sensorineural Hearing Loss (disorder) 33 | 284
Blind Vision 31 | 111
Night Blindness 31 | 101
breast carcinoma 31 | 1,638
Blindness, Legal 30 | 110
Kartagener Syndrome 30 | 38
Liver cancer 30 | 604
Meckel syndrome 30 | 46
Difficulties with night vision 29 | 87
Hypertensive disease 29 | 292
posterior fossa group B ependymoma 28 | 416
Asphyxiating thoracic dystrophy 27 | 44
Conductive hearing loss 27 | 123
Keratoconus 27 | 113
Low Vision 27 | 174
Male infertility 27 | 206
Visual Impairment 27 | 174
diabetes mellitus 27 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Blindness 26 | 88
Epilepsy 26 | 792
pediatric high grade glioma 26 | 1,064

Tissue

Endocrine System 490 | 18,159
Female tissues 461 | 17,400
Digestive Tract 459 | 17,369
Skin and soft tissues 459 | 17,230
Male tissues 455 | 17,142
Nervous System 450 | 16,725
Respiratory system 444 | 16,393
Liver and Pancreas 439 | 16,750
Urinary Tract 439 | 16,678
Blood and immune system 438 | 16,909
Cardiovascular System 387 | 15,192

Target Family

Non-IDG 342 | 12,091
Enzyme 69 | 4,145
Kinase 29 | 634
GPCR 23 | 408
Ion Channel 14 | 344
Transcription Factor 12 | 1,400
Transporter 9 | 473
Epigenetic 1 | 242

Compartment GO Term

Cilium 499 | 499
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
T-complex protein 11 homolog TCP11 Tbio Non-IDG -1.26152 18.0 80
Cell growth-regulating nucleolar protein LYAR Tbio Non-IDG -1.22816 19.3 156
Transmembrane protein 17 TMEM17 Tbio Non-IDG 0.61 0.56 52
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Protocadherin-15 PCDH15 Tbio Non-IDG -1.83877 74.3 42
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Growth arrest-specific protein 8 GAS8 Tbio Non-IDG -1.20822 17.3 102
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188