Development Level

Tbio 227 | 10,625
Tdark 67 | 7,003
Tchem 18 | 1,890
Tclin 12 | 602

Collection

Eligible non-olfactory GPCR Proteins 6 | 145
Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 20 | 633
preweaning lethality, incomple... 8 | 260
abnormal behavior 6 | 226
decreased body weight 5 | 174
embryonic lethality prior to t... 5 | 187
increased fasted circulating g... 5 | 68
hyperactivity 4 | 108
increased body weight 4 | 42
increased mean corpuscular hem... 4 | 93
prenatal lethality prior to he... 4 | 64
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 75
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
impaired glucose tolerance 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased total body fat amoun... 3 | 57
abnormal QRS complex 2 | 25
abnormal embryo size 2 | 112
abnormal embryo turning 2 | 15
abnormal nail morphology 2 | 7
abnormal sleep behavior 2 | 63
cardiovascular system phenotyp... 2 | 35
decreased CD4-positive, alpha ... 2 | 19
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
hypoactivity 2 | 89
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating aspartat... 2 | 17
increased circulating chloride... 2 | 43
increased circulating glycerol... 2 | 11
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
increased prepulse inhibition 2 | 21
increased startle reflex 2 | 38
male infertility 2 | 62
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal whole-body plethysmog... 1 | 4
absent heartbeat 1 | 6
convulsive seizures 1 | 11
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased red blood cell distr... 1 | 11
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
pale yolk sac 1 | 12
pallor 1 | 13
polydactyly 1 | 22
small superior vagus ganglion 1 | 20
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

osteosarcoma 141 | 7,933
ovarian cancer 136 | 8,492
posterior fossa group B ependymoma 105 | 1,530
medulloblastoma, large-cell 96 | 6,234
psoriasis 94 | 6,685
glioblastoma 89 | 5,572
atypical teratoid / rhabdoid tumor 75 | 4,369
Carcinoma 63 | 2,147
lung cancer 59 | 4,473
chronic rhinosinusitis 57 | 512
Polydactyly 53 | 93
nasopharyngeal carcinoma 53 | 1,056
primitive neuroectodermal tumor 51 | 3,031
pediatric high grade glioma 49 | 2,712
lung adenocarcinoma 46 | 2,714
Breast cancer 45 | 3,099
lung carcinoma 45 | 2,844
malignant mesothelioma 45 | 3,163
pilocytic astrocytoma 45 | 3,086
Primary ciliary dyskinesia 44 | 75
Pick disease 42 | 1,893
Retinitis pigmentosa 42 | 156
group 3 medulloblastoma 42 | 2,254
oligodendroglioma 42 | 2,849
Ciliopathy 41 | 57
Nephronophthisis 41 | 74
ependymoma 41 | 2,514
astrocytic glioma 40 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
invasive ductal carcinoma 37 | 2,950
non-small cell lung cancer 37 | 2,798
Situs Inversus 33 | 52
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
Bardet-Biedl Syndrome 30 | 40
Joubert syndrome 30 | 62
group 4 medulloblastoma 30 | 1,875
Fundus dystrophy 29 | 77
Intellectual disability 29 | 573
Obesity 29 | 616
adult high grade glioma 28 | 2,148
interstitial cystitis 28 | 2,299
medulloblastoma 28 | 1,524
pancreatic cancer 28 | 2,300
pituitary cancer 27 | 1,972
Cone dystrophy 26 | 59
Asphyxiating thoracic dystrophy 25 | 34
Cancer 25 | 2,346
subependymal giant cell astrocytoma 25 | 2,287
ulcerative colitis 25 | 2,087
atypical teratoid/rhabdoid tumor 24 | 1,095
Kartagener Syndrome 23 | 32
Meckel syndrome 23 | 48
ductal carcinoma in situ 21 | 1,745
sonic hedgehog group medulloblastoma 21 | 1,482
Senior-Loken syndrome 20 | 22
breast carcinoma 19 | 1,614
tuberculosis 19 | 1,563
Ciliary Dyskinesia, Primary, 1 18 | 27
Leber congenital amaurosis 18 | 72
primary pancreatic ductal adenocarcinoma 18 | 1,271
Bardet-Biedl syndrome 1 17 | 22
colon cancer 17 | 1,475
Cystic kidney disease 16 | 26
Male infertility 16 | 170
astrocytoma 16 | 1,493
cystic fibrosis 16 | 1,670
cystic fibrosis and chronic rhinosinusitis 16 | 213
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
progressive supranuclear palsy 16 | 674
adrenocortical carcinoma 15 | 1,427
cone-rod dystrophy 15 | 60
cutaneous lupus erythematosus 15 | 1,056
non primary Sjogren syndrome sicca 15 | 840
Meckel-Gruber syndrome 14 | 15
Orofaciodigital syndrome 14 | 19
Schizophrenia 14 | 503
Blindness 13 | 84
Hydrocephalus 13 | 60
Polycystic kidney disease 13 | 54
Rheumatoid Arthritis 13 | 1,171
active Crohn's disease 13 | 918
tuberculosis and treatment for 6 months 13 | 686
Sensenbrenner syndrome 12 | 15
Ellis-Van Creveld syndrome 11 | 19
Multiple myeloma 11 | 1,328
Retinal Degeneration 11 | 49
diabetes mellitus 11 | 1,663
fibroadenoma 11 | 557
posterior fossa group A ependymoma 11 | 1,511
spina bifida 11 | 1,064
Kidney cancer 10 | 121
Kidney disease 10 | 397
Renal dysplasia and retinal aplasia (disorder) 10 | 10
acute myeloid leukemia 10 | 785
Endometriosis 9 | 535
Hydrolethalus syndrome 9 | 128
acute quadriplegic myopathy 9 | 1,157
gastric cancer 9 | 436
hepatocellular carcinoma 9 | 550

Tissue

Nervous System 322 | 18,561
Female tissues 319 | 18,647
Urinary Tract 319 | 18,444
Blood and immune system 318 | 17,995
Digestive Tract 318 | 18,473
Endocrine System 318 | 18,512
Liver and Pancreas 317 | 18,136
Cardiovascular System 316 | 17,958
Male tissues 316 | 17,969
Skin and soft tissues 314 | 18,115
Respiratory system 311 | 17,484

Target Family

Non-IDG 237 | 11,969
Enzyme 36 | 4,146
Kinase 17 | 634
GPCR 16 | 408
Ion Channel 8 | 341
Transcription Factor 6 | 1,400
Transporter 3 | 473
Epigenetic 1 | 242

Compartment GO Term

Ciliary part 324 | 324
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Dynein assembly factor 3, axonemal DNAAF3 Tbio Non-IDG -0.80163 6.22 0
Tektin-4 TEKT4 Tbio Non-IDG -0.86653 7.05 96
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.18888 178.4 196
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Smoothened homolog SMO Tclin GPCR -1.11229 12.5 388
WD repeat-containing protein 60 WDR60 Tdark Non-IDG -0.52001 2.69 13
Protein kintoun DNAAF2 Tbio Non-IDG -1.27669 17.1 22
Cilia- and flagella-associated protein 100 CFAP100 Tdark Non-IDG -0.60592 4.18 97
Tektin-2 TEKT2 Tbio Non-IDG -0.98847 9.72 93