Development Level

Tbio 586 | 10,625
Tchem 152 | 1,890
Tdark 92 | 7,003
Tclin 32 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 70 | 633
preweaning lethality, incomple... 27 | 260
embryonic lethality prior to o... 24 | 148
embryonic lethality prior to t... 23 | 187
abnormal behavior 14 | 226
decreased total body fat amoun... 14 | 186
decreased body weight 12 | 174
abnormal embryo size 11 | 112
decreased lean body mass 11 | 195
decreased body length 10 | 108
increased grip strength 9 | 83
increased mean corpuscular hem... 9 | 93
abnormal retina morphology 8 | 100
increased circulating sodium l... 8 | 71
increased mean corpuscular vol... 8 | 91
increased sacral vertebrae num... 8 | 62
male infertility 8 | 62
abnormal bone structure 7 | 131
decreased caudal vertebrae num... 7 | 49
enlarged heart 7 | 111
hypoactivity 7 | 89
increased bone mineral content 7 | 92
increased bone mineral density 7 | 52
increased lean body mass 7 | 107
prenatal lethality prior to he... 7 | 64
decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased circulating serum al... 6 | 79
decreased lumbar vertebrae num... 6 | 62
hydrops fetalis 6 | 22
increased circulating HDL chol... 6 | 63
increased circulating alkaline... 6 | 119
increased circulating triglyce... 6 | 24
small testis 6 | 37
abnormal coat-hair pigmentatio... 5 | 54
abnormal eye morphology 5 | 38
abnormal lens morphology 5 | 73
cataract 5 | 26
decreased circulating LDL chol... 5 | 37
decreased circulating choleste... 5 | 85
decreased eosinophil cell numb... 5 | 41
decreased grip strength 5 | 123
decreased leukocyte cell numbe... 5 | 54
decreased mean corpuscular hem... 5 | 34
decreased mean corpuscular vol... 5 | 50
decreased rib number 5 | 59
female infertility 5 | 34
increased circulating choleste... 5 | 53
increased mean platelet volume 5 | 19
increased or absent threshold ... 5 | 128
thrombocytopenia 5 | 46
abnormal cornea morphology 4 | 24
abnormal gait 4 | 51
abnormal seminal vesicle morph... 4 | 47
abnormal spleen morphology 4 | 36
corneal opacity 4 | 25
decreased circulating alanine ... 4 | 53
decreased circulating glucose ... 4 | 121
decreased effector memory CD8-... 4 | 24
decreased fasted circulating g... 4 | 49
decreased hemoglobin content 4 | 53
embryonic growth retardation 4 | 28
increased circulating chloride... 4 | 43
short tibia 4 | 82
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal heart morphology 3 | 51
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal rib morphology 3 | 28
abnormal testis morphology 3 | 30
abnormal tooth morphology 3 | 24
cardiovascular system phenotyp... 3 | 35
decreased Ly6C high monocyte n... 3 | 18
decreased basophil cell number 3 | 11
decreased blood urea nitrogen ... 3 | 31
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating chloride... 3 | 32
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased heart weight 3 | 44
decreased hematocrit 3 | 25
decreased prepulse inhibition 3 | 52
hyperactivity 3 | 108
increased CD4-positive, CD25-p... 3 | 18
increased body weight 3 | 42
increased circulating creatini... 3 | 29
increased circulating iron lev... 3 | 25
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased hematocrit 3 | 36
increased mean corpuscular hem... 3 | 25
narrow eye opening 3 | 15
oligodactyly 3 | 14
tremors 3 | 34
vertebral fusion 3 | 23
vertebral transformation 3 | 12

Disease

ovarian cancer 495 | 8,491
osteosarcoma 432 | 7,933
medulloblastoma, large-cell 382 | 6,234
psoriasis 363 | 6,685
lung cancer 339 | 4,473
glioblastoma 335 | 5,572
Cancer 332 | 2,346
atypical teratoid / rhabdoid tumor 250 | 4,369
malignant mesothelioma 250 | 3,163
primitive neuroectodermal tumor 245 | 3,031
Breast cancer 242 | 3,098
non-small cell lung cancer 203 | 2,798
pediatric high grade glioma 198 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 192 | 3,289
group 3 medulloblastoma 189 | 2,254
lung adenocarcinoma 182 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 180 | 2,988
invasive ductal carcinoma 175 | 2,950
oligodendroglioma 154 | 2,849
Carcinoma 153 | 2,147
adrenocortical carcinoma 135 | 1,427
ependymoma 129 | 2,514
ductal carcinoma in situ 126 | 1,745
colon cancer 123 | 1,475
pancreatic cancer 115 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 111 | 2,956
Multiple myeloma 108 | 1,327
astrocytoma 107 | 1,493
breast carcinoma 106 | 1,614
astrocytic glioma 104 | 2,241
diabetes mellitus 101 | 1,663
group 4 medulloblastoma 100 | 1,875
pilocytic astrocytoma 99 | 3,086
posterior fossa group A ependymoma 94 | 1,511
sonic hedgehog group medulloblastoma 94 | 1,482
subependymal giant cell astrocytoma 94 | 2,287
ulcerative colitis 91 | 2,087
Rheumatoid Arthritis 89 | 1,170
pituitary cancer 88 | 1,972
Waldenstrons macroglobulinemia 87 | 764
Pick disease 83 | 1,893
lung carcinoma 82 | 2,844
atypical teratoid/rhabdoid tumor 81 | 1,095
nasopharyngeal carcinoma 81 | 1,056
acute quadriplegic myopathy 79 | 1,157
dermatomyositis 78 | 966
Endometriosis 77 | 535
medulloblastoma 76 | 1,524
juvenile dermatomyositis 72 | 1,189
Intellectual disability 70 | 573
interstitial cystitis 70 | 2,299
Mammary Neoplasms 69 | 410
adult high grade glioma 69 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 69 | 1,795
tuberculosis 65 | 1,563
Atopic dermatitis 62 | 944
acute myeloid leukemia 56 | 785
primary Sjogren syndrome 54 | 788
Prostatic Neoplasms 50 | 471
cystic fibrosis 48 | 1,670
primary pancreatic ductal adenocarcinoma 48 | 1,271
Alzheimer's disease 47 | 644
IGA Glomerulonephritis 46 | 454
Obesity 44 | 616
Stomach Neoplasms 44 | 282
non primary Sjogren syndrome sicca 44 | 840
pancreatic carcinoma 42 | 567
cutaneous lupus erythematosus 41 | 1,056
gastric carcinoma 41 | 832
hepatocellular carcinoma 41 | 550
posterior fossa group B ependymoma 40 | 1,530
spina bifida 40 | 1,064
tuberculosis and treatment for 6 months 40 | 686
progressive supranuclear palsy 39 | 674
Adenoma 38 | 165
Lung Neoplasms 38 | 171
Liver carcinoma 37 | 217
aldosterone-producing adenoma 37 | 664
gastric cancer 36 | 436
inflammatory breast cancer 36 | 404
Kidney disease 35 | 397
non-small cell lung carcinoma 34 | 413
Down syndrome 32 | 548
Heart disease 32 | 279
esophageal adenocarcinoma 32 | 737
Amyotrophic Lateral Sclerosis 31 | 432
Anemia 31 | 252
Fanconi's anemia 31 | 50
Melanoma 31 | 261
Adenoid Cystic Carcinoma 30 | 99
Infertility 30 | 163
Peripheral Neuropathy 30 | 303
Colorectal Neoplasms 29 | 217
Vascular disease 29 | 281
Male infertility 28 | 170
Neurodegenerative disease 28 | 383
Parkinson's disease 28 | 364
Schizophrenia 28 | 503
Adenocarcinoma 27 | 115
Bladder Neoplasm 27 | 109

Tissue

Female tissues 855 | 18,646
Blood and immune system 851 | 17,994
Male tissues 850 | 17,968
Digestive Tract 848 | 18,472
Liver and Pancreas 848 | 18,135
Endocrine System 846 | 18,511
Nervous System 846 | 18,560
Urinary Tract 845 | 18,443
Cardiovascular System 840 | 17,957
Respiratory system 831 | 17,483
Skin and soft tissues 830 | 18,114

Target Family

Non-IDG 454 | 11,969
Transcription Factor 144 | 1,400
Enzyme 123 | 4,146
Epigenetic 88 | 242
Kinase 27 | 634
Nuclear Receptor 14 | 48
TF/Epigenetic 12 | 38

Compartment GO Term

Chromosomal part 862 | 862
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Trafficking protein particle complex subunit 12 TRAPPC12 Tbio Non-IDG -0.28255 1.52 54
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.53825 36.6 184
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Ribosomal RNA-processing protein 8 RRP8 Tbio Enzyme -2.24766 174.5 99
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48