Development Level

Tbio 356 | 10,625
Tchem 117 | 1,890
Tdark 49 | 7,003
Tclin 25 | 602

IMPC Term

preweaning lethality, complete... 32 | 633
preweaning lethality, incomple... 24 | 260
abnormal behavior 12 | 226
embryonic lethality prior to o... 12 | 148
embryonic lethality prior to t... 12 | 187
decreased total body fat amoun... 11 | 186
decreased body weight 10 | 174
decreased lean body mass 10 | 195
abnormal embryo size 8 | 112
decreased body length 8 | 108
increased grip strength 8 | 83
increased sacral vertebrae num... 7 | 62
decreased lumbar vertebrae num... 6 | 62
decreased caudal vertebrae num... 5 | 49
decreased circulating choleste... 5 | 85
decreased mean corpuscular hem... 5 | 34
decreased rib number 5 | 59
enlarged heart 5 | 111
hypoactivity 5 | 89
increased bone mineral content 5 | 92
increased bone mineral density 5 | 52
increased circulating choleste... 5 | 53
increased circulating triglyce... 5 | 24
increased lean body mass 5 | 107
increased mean corpuscular hem... 5 | 93
abnormal bone structure 4 | 131
abnormal eye morphology 4 | 38
abnormal gait 4 | 51
abnormal retina morphology 4 | 100
decreased bone mineral content 4 | 157
decreased circulating LDL chol... 4 | 37
decreased circulating serum al... 4 | 79
decreased circulating total pr... 4 | 41
decreased grip strength 4 | 123
decreased hemoglobin content 4 | 53
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular vol... 4 | 50
female infertility 4 | 34
hydrops fetalis 4 | 22
increased circulating HDL chol... 4 | 63
increased circulating sodium l... 4 | 71
increased or absent threshold ... 4 | 128
male infertility 4 | 62
prenatal lethality prior to he... 4 | 64
abnormal coat/hair pigmentatio... 3 | 54
abnormal lens morphology 3 | 73
abnormal neural tube closure 3 | 37
abnormal seminal vesicle morph... 3 | 47
abnormal spleen morphology 3 | 36
abnormal tooth morphology 3 | 24
cataract 3 | 26
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating alanine ... 3 | 53
decreased circulating alkaline... 3 | 41
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased heart weight 3 | 44
decreased prepulse inhibition 3 | 52
hyperactivity 3 | 108
increased body weight 3 | 42
increased circulating alkaline... 3 | 119
increased mean corpuscular vol... 3 | 91
oligodactyly 3 | 14
short tibia 3 | 82
small testis 3 | 37
thrombocytopenia 3 | 46
vertebral fusion 3 | 23
abnormal coat appearance 2 | 25
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 51
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal startle reflex 2 | 14
abnormal testis morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
corneal opacity 2 | 25
decreased Ly6C high monocyte n... 2 | 18
decreased circulating insulin ... 2 | 75
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased lactate dehydrogenas... 2 | 14
embryonic growth retardation 2 | 28
increased CD4-positive, CD25-p... 2 | 18
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 25
increased mean platelet volume 2 | 19
increased startle reflex 2 | 38
microphthalmia 2 | 15

Disease

ovarian cancer 302 | 8,484
osteosarcoma 274 | 7,933
Cancer 256 | 2,346
psoriasis 222 | 6,685
medulloblastoma, large-cell 219 | 6,234
glioblastoma 218 | 5,572
lung cancer 212 | 4,466
malignant mesothelioma 160 | 3,162
atypical teratoid / rhabdoid tumor 159 | 4,369
Breast cancer 144 | 3,094
primitive neuroectodermal tumor 144 | 3,031
pediatric high grade glioma 117 | 2,712
non-small cell lung cancer 116 | 2,798
invasive ductal carcinoma 115 | 2,950
lung adenocarcinoma 111 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 102 | 3,289
Carcinoma 101 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 99 | 2,988
oligodendroglioma 98 | 2,849
ependymoma 94 | 2,514
group 3 medulloblastoma 91 | 2,254
astrocytoma 87 | 1,493
diabetes mellitus 83 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 77 | 2,956
group 4 medulloblastoma 76 | 1,875
ductal carcinoma in situ 75 | 1,745
Rheumatoid Arthritis 73 | 1,160
pancreatic cancer 73 | 2,300
Multiple myeloma 72 | 1,327
colon cancer 72 | 1,475
pilocytic astrocytoma 72 | 3,086
adrenocortical carcinoma 70 | 1,427
breast carcinoma 69 | 1,614
ulcerative colitis 69 | 2,087
subependymal giant cell astrocytoma 63 | 2,287
astrocytic glioma 62 | 2,241
lung carcinoma 61 | 2,844
pituitary cancer 61 | 1,972
posterior fossa group A ependymoma 57 | 1,511
sonic hedgehog group medulloblastoma 56 | 1,482
Mammary Neoplasms 55 | 410
medulloblastoma 54 | 1,524
acute quadriplegic myopathy 53 | 1,157
Pick disease 52 | 1,893
interstitial cystitis 51 | 2,299
Intellectual disability 50 | 573
dermatomyositis 49 | 933
Waldenstrons macroglobulinemia 48 | 765
juvenile dermatomyositis 48 | 1,189
atypical teratoid/rhabdoid tumor 46 | 1,095
tuberculosis 46 | 1,557
Endometriosis 44 | 535
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,795
cystic fibrosis 43 | 1,665
adult high grade glioma 42 | 2,148
Obesity 41 | 616
Prostatic Neoplasms 40 | 471
primary pancreatic ductal adenocarcinoma 40 | 1,271
acute myeloid leukemia 39 | 780
nasopharyngeal carcinoma 39 | 1,056
Alzheimer's disease 35 | 644
Stomach Neoplasms 34 | 282
Liver carcinoma 33 | 217
Atopic dermatitis 31 | 944
Kidney disease 31 | 396
Lung Neoplasms 31 | 171
spina bifida 31 | 1,064
aldosterone-producing adenoma 30 | 664
primary Sjogren syndrome 30 | 789
Vascular disease 29 | 281
cutaneous lupus erythematosus 28 | 1,056
Adenoma 27 | 165
Heart disease 27 | 279
gastric carcinoma 26 | 832
hepatocellular carcinoma 26 | 532
pancreatic carcinoma 26 | 567
gastric cancer 25 | 430
IGA Glomerulonephritis 24 | 454
Melanoma 24 | 261
non-small cell lung carcinoma 24 | 413
Down syndrome 23 | 548
Parkinson's disease 23 | 364
inflammatory breast cancer 23 | 404
non primary Sjogren syndrome sicca 23 | 840
Adenocarcinoma 22 | 115
posterior fossa group B ependymoma 22 | 1,530
Adenoid Cystic Carcinoma 21 | 99
Anemia 21 | 252
Arthritis 21 | 248
esophageal adenocarcinoma 21 | 737
Bladder Neoplasm 20 | 109
Liver disease 20 | 219
Neoplastic Cell Transformation 20 | 81
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 499
Asthma 19 | 349
Diabetes Mellitus, Non-Insulin-Dependent 19 | 157
Schizophrenia 19 | 501
active Crohn's disease 19 | 918
progressive supranuclear palsy 19 | 674
tuberculosis and treatment for 6 months 19 | 686

Tissue

Female tissues 540 | 18,647
Blood and immune system 537 | 17,995
Digestive Tract 535 | 18,473
Liver and Pancreas 535 | 18,136
Male tissues 535 | 17,969
Nervous System 533 | 18,561
Endocrine System 532 | 18,512
Urinary Tract 531 | 18,444
Cardiovascular System 527 | 17,958
Respiratory system 519 | 17,484
Skin and soft tissues 516 | 18,115

Target Family

Non-IDG 236 | 11,971
Transcription Factor 125 | 1,400
Epigenetic 85 | 242
Enzyme 58 | 4,146
Kinase 16 | 634
Nuclear Receptor 14 | 48
TF/Epigenetic 13 | 38

Compartment GO Term

Chromatin 547 | 547
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373