Development Level

Tbio 404 | 11,651
Tchem 93 | 1,388
Tdark 41 | 6,593
Tclin 27 | 612

IMPC Phenotype

preweaning lethality, complete... 61 | 979
preweaning lethality, incomple... 30 | 499
embryonic lethality prior to t... 21 | 278
embryonic lethality prior to o... 17 | 239
abnormal behavior 15 | 298
abnormal embryo size 13 | 220
decreased body weight 11 | 161
decreased total body fat amoun... 11 | 207
increased startle reflex 10 | 112
decreased vertical activity 9 | 208
enlarged heart 9 | 210
abnormal bone structure 7 | 187
abnormal heart morphology 7 | 162
decreased body length 7 | 101
decreased bone mineral density 7 | 126
embryonic growth retardation 7 | 106
increased bone mineral content 7 | 108
increased bone mineral density 7 | 72
abnormal retina morphology 6 | 71
abnormal seminal vesicle morph... 6 | 114
decreased lean body mass 6 | 135
hyperactivity 6 | 148
hypoactivity 6 | 132
impaired glucose tolerance 6 | 75
increased lean body mass 6 | 172
increased mean corpuscular hem... 6 | 96
abnormal gait 5 | 69
abnormal lens morphology 5 | 81
cataract 5 | 92
decreased circulating LDL chol... 5 | 38
decreased circulating choleste... 5 | 93
decreased circulating serum al... 5 | 82
decreased circulating total pr... 5 | 49
decreased prepulse inhibition 5 | 82
increased circulating triglyce... 5 | 42
increased total body fat amoun... 5 | 134
abnormal spleen morphology 4 | 55
decreased blood urea nitrogen ... 4 | 51
decreased bone mineral content 4 | 151
decreased caudal vertebrae num... 4 | 53
decreased circulating HDL chol... 4 | 68
decreased circulating alanine ... 4 | 47
decreased grip strength 4 | 116
decreased leukocyte cell numbe... 4 | 73
increased body length 4 | 32
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal epididymis morphology 3 | 42
abnormal eye morphology 3 | 68
abnormal neural tube closure 3 | 46
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
cardiovascular system phenotyp... 3 | 36
decreased circulating alkaline... 3 | 46
decreased circulating glucose ... 3 | 126
decreased erythrocyte cell num... 3 | 62
decreased mean corpuscular vol... 3 | 79
decreased threshold for audito... 3 | 26
edema 3 | 59
female infertility 3 | 60
increased body weight 3 | 25
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased grip strength 3 | 41
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
small spleen 3 | 19
small testis 3 | 58
thrombocytopenia 3 | 56
vertebral transformation 3 | 12
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal head morphology 2 | 10
abnormal testis morphology 2 | 43
abnormal tooth morphology 2 | 24
absent pinna reflex 2 | 23
anophthalmia 2 | 33
decreased circulating aspartat... 2 | 34
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
enlarged spleen 2 | 41
increased circulating calcium ... 2 | 34
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
thin ventricular wall 2 | 24
vertebral fusion 2 | 23

Disease

Carcinoma 383 | 11,493
ovarian cancer 316 | 8,520
osteosarcoma 284 | 7,950
Cancer 278 | 2,499
psoriasis 236 | 6,694
lung cancer 235 | 4,740
glioblastoma 231 | 5,792
medulloblastoma, large-cell 228 | 6,241
atypical teratoid / rhabdoid tumor 194 | 5,112
Breast cancer 180 | 3,578
group 3 medulloblastoma 179 | 4,104
malignant mesothelioma 171 | 3,232
primitive neuroectodermal tumor 151 | 3,035
ependymoma 150 | 4,679
Kidney cancer 132 | 2,613
non-small cell lung cancer 128 | 2,890
invasive ductal carcinoma 122 | 2,951
lung adenocarcinoma 118 | 2,716
adult high grade glioma 109 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 107 | 3,291
oligodendroglioma 102 | 2,850
diabetes mellitus 90 | 1,728
pancreatic cancer 86 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 85 | 2,955
astrocytoma 81 | 1,146
ductal carcinoma in situ 81 | 1,745
Intellectual disability 80 | 1,016
breast carcinoma 80 | 1,638
Multiple myeloma 78 | 1,332
adrenocortical carcinoma 78 | 1,428
Astrocytoma, Pilocytic 75 | 3,081
Schizophrenia 74 | 1,160
astrocytic glioma 74 | 2,597
Rheumatoid arthritis 73 | 1,191
colon cancer 73 | 1,478
ulcerative colitis 70 | 1,819
subependymal giant cell astrocytoma 68 | 2,287
lung carcinoma 66 | 2,843
group 4 medulloblastoma 65 | 1,855
Breast Neoplasms 63 | 445
Mammary Neoplasms 61 | 425
interstitial cystitis 60 | 2,312
tuberculosis 60 | 2,010
Short stature 59 | 531
acute quadriplegic myopathy 59 | 1,158
pituitary cancer 59 | 1,972
pediatric high grade glioma 56 | 1,064
Pick disease 55 | 1,894
juvenile dermatomyositis 55 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,962
Dull intelligence 51 | 645
Low intelligence 51 | 645
Mental Retardation 51 | 645
Mental deficiency 51 | 645
Poor school performance 51 | 645
dermatomyositis 51 | 966
Obesity 47 | 678
Waldenstrons macroglobulinemia 47 | 765
Cognitive delay 46 | 608
Cryptorchidism 46 | 296
Endometriosis 46 | 540
Global developmental delay 46 | 608
Mental and motor retardation 46 | 608
cystic fibrosis 45 | 1,696
Prostatic Neoplasms 44 | 495
Epilepsy 43 | 792
nasopharyngeal carcinoma 43 | 1,058
Seizures 41 | 596
Autosomal recessive predisposition 40 | 1,442
Small head 40 | 374
Stomach Neoplasms 40 | 300
acute myeloid leukemia 40 | 783
Muscle hypotonia 39 | 571
Liver cancer 37 | 604
Alzheimer's disease 36 | 658
Atopic dermatitis 36 | 952
Carcinoma, Hepatocellular 36 | 228
Lung Neoplasms 36 | 232
Liver carcinoma 35 | 240
primary pancreatic ductal adenocarcinoma 35 | 1,109
Melanoma 34 | 711
aldosterone-producing adenoma 33 | 665
medulloblastoma 33 | 720
Bipolar Disorder 32 | 666
Hypoplastic mandible condyle 32 | 275
Kidney disease 32 | 430
Mandibular hypoplasia 32 | 275
Micrognathism 32 | 275
Strabismus 32 | 270
hepatocellular carcinoma 32 | 547
spina bifida 32 | 1,074
Failure to gain weight 31 | 365
Pediatric failure to thrive 31 | 365
Vascular disease 31 | 319
primary Sjogren syndrome 31 | 735
Immune system cancer 30 | 140
Lymphoid leukemia 30 | 160
Fetal Growth Retardation 29 | 189
Orbital separation excessive 29 | 244

Tissue

Endocrine System 550 | 18,159
Digestive Tract 544 | 17,369
Female tissues 539 | 17,400
Skin and soft tissues 536 | 17,230
Blood and immune system 534 | 16,909
Male tissues 534 | 17,142
Liver and Pancreas 527 | 16,750
Nervous System 525 | 16,725
Urinary Tract 525 | 16,678
Respiratory system 524 | 16,393
Cardiovascular System 506 | 15,192

Target Family

Non-IDG 243 | 12,091
Transcription Factor 128 | 1,400
Epigenetic 89 | 242
Enzyme 62 | 4,145
Kinase 15 | 634
Nuclear Receptor 14 | 48
TF/Epigenetic 14 | 38

Compartment GO Term

Chromatin 565 | 565
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Transcriptional repressor scratch 2 SCRT2 Tdark Transcription Factor 0.22 1.09 25
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
E1A-binding protein p400 EP400 Tbio Non-IDG -1.47248 27.6 69
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
NAD-dependent protein deacetylase sirtuin-7 SIRT7 Tbio Epigenetic -2.22094 153.0 348