Development Level

Tbio 505 | 10,625
Tchem 187 | 1,890
Tclin 86 | 602
Tdark 58 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 5 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 27 | 633
preweaning lethality, incomple... 17 | 260
decreased grip strength 12 | 123
embryonic lethality prior to t... 11 | 187
abnormal behavior 10 | 226
enlarged heart 9 | 111
decreased total body fat amoun... 8 | 186
decreased lean body mass 7 | 195
embryonic lethality prior to o... 7 | 148
tremors 7 | 34
decreased body weight 6 | 174
decreased bone mineral density 6 | 126
decreased leukocyte cell numbe... 6 | 54
increased or absent threshold ... 6 | 128
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating glucose ... 5 | 121
impaired glucose tolerance 5 | 52
improved glucose tolerance 5 | 56
increased circulating alkaline... 5 | 119
increased circulating sodium l... 5 | 71
increased lean body mass 5 | 107
increased total body fat amoun... 5 | 57
abnormal eye morphology 4 | 38
abnormal heart morphology 4 | 51
abnormal sleep behavior 4 | 63
decreased NK T cell number 4 | 28
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
hyperactivity 4 | 108
increased body weight 4 | 42
increased circulating HDL chol... 4 | 63
increased circulating choleste... 4 | 53
increased fasted circulating g... 4 | 68
increased grip strength 4 | 83
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
limb grasping 4 | 35
short tibia 4 | 82
abnormal QRS complex 3 | 25
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal lens morphology 3 | 73
abnormal limb bud morphology 3 | 15
abnormal locomotor activation 3 | 26
abnormal retinal pigmentation 3 | 61
abnormal tooth morphology 3 | 24
abnormal vibrissa morphology 3 | 17
absent startle reflex 3 | 15
cardiovascular system phenotyp... 3 | 35
decreased circulating calcium ... 3 | 33
decreased circulating insulin ... 3 | 75
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased mean corpuscular hem... 3 | 34
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased bone mineral density 3 | 52
increased circulating bilirubi... 3 | 16
increased heart weight 3 | 37
thrombocytopenia 3 | 46
abnormal coat appearance 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal head morphology 2 | 10
abnormal heart left ventricle ... 2 | 20
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
corneal opacity 2 | 25
decreased T cell number 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased pulmonary respirator... 2 | 4
enlarged spleen 2 | 26
enlarged stomach 2 | 2
female infertility 2 | 34
increased circulating calcium ... 2 | 32
increased circulating magnesiu... 2 | 10
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
lethargy 2 | 5
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
small thymus 2 | 11

Disease

Cancer 457 | 2,346
psoriasis 427 | 6,685
ovarian cancer 385 | 8,484
osteosarcoma 372 | 7,933
glioblastoma 307 | 5,572
lung cancer 306 | 4,466
medulloblastoma, large-cell 271 | 6,234
lung carcinoma 265 | 2,844
diabetes mellitus 235 | 1,663
interstitial cystitis 225 | 2,299
invasive ductal carcinoma 220 | 2,950
pilocytic astrocytoma 220 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 207 | 3,289
ulcerative colitis 207 | 2,087
malignant mesothelioma 206 | 3,162
lung adenocarcinoma 204 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 203 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 200 | 2,956
atypical teratoid / rhabdoid tumor 199 | 4,369
non-small cell lung cancer 195 | 2,798
pancreatic cancer 194 | 2,300
Breast cancer 188 | 3,094
tuberculosis 168 | 1,557
pediatric high grade glioma 163 | 2,712
Hypersensitivity reaction type II disease 162 | 235
Rheumatoid Arthritis 156 | 1,160
cystic fibrosis 155 | 1,665
Arthritis 140 | 248
subependymal giant cell astrocytoma 140 | 2,287
Carcinoma 137 | 2,147
cutaneous lupus erythematosus 133 | 1,056
Kidney disease 130 | 396
ductal carcinoma in situ 128 | 1,745
Multiple Sclerosis 127 | 498
oligodendroglioma 123 | 2,849
pituitary cancer 120 | 1,972
breast carcinoma 118 | 1,614
group 4 medulloblastoma 117 | 1,875
posterior fossa group A ependymoma 117 | 1,511
primitive neuroectodermal tumor 117 | 3,031
colon cancer 115 | 1,475
adrenocortical carcinoma 109 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 105 | 1,795
ependymoma 104 | 2,514
primary pancreatic ductal adenocarcinoma 102 | 1,271
adult high grade glioma 99 | 2,148
Liver disease 97 | 219
juvenile dermatomyositis 95 | 1,189
Anemia 93 | 252
Acquired immunodeficiency syndrome 92 | 164
Atherosclerosis 91 | 275
Ankylosing spondylitis 89 | 138
astrocytoma 89 | 1,493
Alzheimer's disease 86 | 644
Asthma 86 | 349
astrocytic glioma 85 | 2,241
esophageal adenocarcinoma 85 | 737
nasopharyngeal carcinoma 84 | 1,056
Uveitis 81 | 103
gastric carcinoma 80 | 832
Duchenne muscular dystrophy 79 | 602
primary Sjogren syndrome 78 | 789
Multiple myeloma 77 | 1,327
dermatomyositis 77 | 933
Atopic dermatitis 71 | 944
Lung disease 71 | 132
Juvenile rheumatoid arthritis 70 | 104
Prostatic Neoplasms 70 | 471
Vascular disease 69 | 281
acute quadriplegic myopathy 69 | 1,157
group 3 medulloblastoma 69 | 2,254
Cerebrovascular disease 68 | 231
Coronary artery disease 68 | 240
Down syndrome 68 | 548
Heart disease 68 | 279
Mammary Neoplasms 66 | 410
active Crohn's disease 66 | 918
Human immunodeficiency virus infectious disease 64 | 92
sonic hedgehog group medulloblastoma 64 | 1,482
Hypertension 63 | 287
Pick disease 63 | 1,893
Inflammatory bowel disease 62 | 142
Psoriatic arthritis 61 | 83
mucosa-associated lymphoid tissue lymphoma 61 | 480
posterior fossa group B ependymoma 61 | 1,530
Behcet's disease 60 | 74
Obesity 59 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 59 | 499
Endometriosis 58 | 535
Schizophrenia 58 | 501
Hepatitis B 56 | 103
spina bifida 56 | 1,064
atypical teratoid/rhabdoid tumor 54 | 1,095
medulloblastoma 54 | 1,524
Thrombocytopenia 52 | 105
IGA Glomerulonephritis 51 | 454
Stomach Neoplasms 51 | 282
non-small cell lung carcinoma 51 | 413
sarcoidosis 51 | 358
Neoplasm Metastasis 49 | 138

Tissue

Nervous System 740 | 18,561
Female tissues 739 | 18,647
Digestive Tract 736 | 18,473
Endocrine System 736 | 18,512
Urinary Tract 736 | 18,444
Liver and Pancreas 725 | 18,136
Blood and immune system 723 | 17,995
Male tissues 722 | 17,969
Respiratory system 721 | 17,484
Cardiovascular System 719 | 17,958
Skin and soft tissues 719 | 18,115

Target Family

Non-IDG 593 | 11,971
Enzyme 126 | 4,146
GPCR 36 | 406
Kinase 31 | 634
Ion Channel 19 | 341
Transporter 19 | 473
Transcription Factor 9 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Cell surface 836 | 836
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Stereocilin STRC Tbio Non-IDG 35.9 7
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269