Development Level

Tbio 571 | 11,651
Tchem 140 | 1,388
Tclin 91 | 612
Tdark 39 | 6,593

Collection

GPCR: IDG Consortium (Targets) 4 | 126
RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 37 | 979
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 17 | 278
decreased vertical activity 16 | 208
embryonic lethality prior to o... 13 | 239
enlarged heart 13 | 210
abnormal embryo size 11 | 220
increased total body fat amoun... 11 | 134
abnormal heart morphology 9 | 162
abnormal seminal vesicle morph... 9 | 114
decreased lean body mass 9 | 135
abnormal behavior 8 | 298
embryonic growth retardation 8 | 106
increased lean body mass 8 | 172
increased startle reflex 8 | 112
abnormal bone structure 7 | 187
decreased grip strength 7 | 116
decreased lymphocyte cell numb... 7 | 83
decreased mean corpuscular vol... 7 | 79
decreased total body fat amoun... 7 | 207
increased circulating HDL chol... 7 | 80
small superior vagus ganglion 7 | 74
abnormal eye morphology 6 | 68
decreased body weight 6 | 161
improved glucose tolerance 6 | 79
short tibia 6 | 97
tremors 6 | 39
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
cardiovascular system phenotyp... 5 | 36
decreased bone mineral content 5 | 151
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular hem... 5 | 50
decreased startle reflex 5 | 75
hydrometra 5 | 53
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased mean corpuscular vol... 5 | 92
abnormal limb bud morphology 4 | 17
abnormal pericardium morpholog... 4 | 26
cataract 4 | 92
decreased circulating creatini... 4 | 39
decreased circulating insulin ... 4 | 76
decreased heart weight 4 | 27
decreased threshold for audito... 4 | 26
hypoactivity 4 | 132
increased circulating triglyce... 4 | 42
increased erythrocyte cell num... 4 | 39
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
increased leukocyte cell numbe... 4 | 47
increased mean corpuscular hem... 4 | 96
increased neutrophil cell numb... 4 | 46
increased or absent threshold ... 4 | 101
limb grasping 4 | 41
pale yolk sac 4 | 25
pallor 4 | 34
prenatal lethality prior to he... 4 | 87
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
abnormal liver morphology 3 | 17
abnormal lung morphology 3 | 26
abnormal optic disc morphology 3 | 10
abnormal placenta size 3 | 20
abnormal spleen morphology 3 | 55
abnormal vibrissa morphology 3 | 25
absent startle reflex 3 | 24
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased cardiac muscle contr... 3 | 11
decreased circulating alkaline... 3 | 46
decreased circulating calcium ... 3 | 36
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased fasted circulating g... 3 | 65
decreased mean corpuscular hem... 3 | 31
decreased prepulse inhibition 3 | 82
decreased red blood cell distr... 3 | 41
edema 3 | 59
enlarged lymph nodes 3 | 37
enlarged uterus 3 | 11
female infertility 3 | 60
hemorrhage 3 | 23
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased circulating magnesiu... 3 | 10
increased circulating potassiu... 3 | 29
increased lymphocyte cell numb... 3 | 32
prolonged QT interval 3 | 38
small testis 3 | 58
abnormal locomotor behavior 2 | 24

Disease

Carcinoma 528 | 11,493
Cancer 478 | 2,499
psoriasis 431 | 6,694
ovarian cancer 392 | 8,520
osteosarcoma 373 | 7,950
lung cancer 328 | 4,740
glioblastoma 326 | 5,792
medulloblastoma, large-cell 274 | 6,241
lung carcinoma 264 | 2,843
diabetes mellitus 239 | 1,728
atypical teratoid / rhabdoid tumor 231 | 5,112
Breast cancer 230 | 3,578
ependymoma 230 | 4,679
interstitial cystitis 230 | 2,312
Astrocytoma, Pilocytic 221 | 3,081
malignant mesothelioma 221 | 3,232
invasive ductal carcinoma 216 | 2,951
tuberculosis 213 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 211 | 3,291
lung adenocarcinoma 204 | 2,716
non-small cell lung cancer 204 | 2,890
pancreatic cancer 204 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 200 | 2,989
adult high grade glioma 199 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 198 | 2,955
ulcerative colitis 186 | 1,819
Hypersensitivity reaction type II disease 175 | 253
Rheumatoid arthritis 160 | 1,191
cystic fibrosis 155 | 1,696
Arthritis 153 | 290
Kidney cancer 147 | 2,613
cutaneous lupus erythematosus 138 | 1,057
Schizophrenia 137 | 1,160
subependymal giant cell astrocytoma 136 | 2,287
Multiple Sclerosis 132 | 540
Kidney disease 130 | 430
group 3 medulloblastoma 129 | 4,104
Autosomal recessive predisposition 126 | 1,442
ductal carcinoma in situ 124 | 1,745
breast carcinoma 122 | 1,638
pituitary cancer 121 | 1,972
oligodendroglioma 119 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 119 | 1,962
colon cancer 114 | 1,478
primitive neuroectodermal tumor 114 | 3,035
dermatomyositis 111 | 966
Anemia 109 | 365
Human immunodeficiency virus infectious disease 108 | 138
Liver Cirrhosis, Experimental 106 | 769
adrenocortical carcinoma 105 | 1,428
astrocytic glioma 105 | 2,597
group 4 medulloblastoma 103 | 1,855
Liver disease 100 | 237
juvenile dermatomyositis 98 | 1,187
Alzheimer's disease 97 | 658
Atherosclerosis 94 | 291
Acquired immunodeficiency syndrome 92 | 197
nasopharyngeal carcinoma 90 | 1,058
Ankylosing spondylitis 88 | 140
Asthma 88 | 385
esophageal adenocarcinoma 87 | 737
primary pancreatic ductal adenocarcinoma 86 | 1,109
Dermatitis 82 | 157
Uveitis 81 | 103
Vascular disease 81 | 319
Duchenne muscular dystrophy 80 | 601
Multiple myeloma 79 | 1,332
Juvenile rheumatoid arthritis 75 | 111
Behcet's disease 74 | 89
astrocytoma 74 | 1,146
primary Sjogren syndrome 74 | 735
Lung disease 73 | 142
Melanoma 73 | 711
Atopic dermatitis 72 | 952
Coronary artery disease 72 | 268
Hypertension 72 | 396
Prostatic Neoplasms 71 | 495
Bipolar Disorder 70 | 666
Breast Neoplasms 70 | 445
Heart disease 70 | 306
gastric carcinoma 70 | 807
Cerebrovascular disease 68 | 238
Mammary Neoplasms 68 | 425
acute quadriplegic myopathy 68 | 1,158
Obesity 67 | 678
active Crohn's disease 66 | 922
Down syndrome 65 | 499
pediatric high grade glioma 65 | 1,064
Herpes zoster 63 | 68
Inflammatory bowel disease 63 | 151
mucosa-associated lymphoid tissue lymphoma 62 | 484
Psoriatic arthritis 61 | 86
Stevens-Johnson syndrome 60 | 92
Thrombocytopenia 60 | 197
Pick disease 58 | 1,894
spina bifida 58 | 1,074
Endometriosis 57 | 540
Stomach Neoplasms 57 | 300
active ulcerative colitis 56 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 56 | 510

Tissue

Endocrine System 723 | 18,159
Male tissues 716 | 17,142
Digestive Tract 711 | 17,369
Female tissues 703 | 17,400
Blood and immune system 699 | 16,909
Skin and soft tissues 698 | 17,230
Liver and Pancreas 693 | 16,750
Urinary Tract 691 | 16,678
Respiratory system 679 | 16,393
Nervous System 666 | 16,725
Cardiovascular System 630 | 15,192

Target Family

Non-IDG 607 | 12,091
Enzyme 119 | 4,145
GPCR 34 | 408
Kinase 32 | 634
Ion Channel 20 | 344
Transporter 16 | 473
Transcription Factor 10 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Cell surface 841 | 841
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239