Development Level

Tbio 604 | 11,651
Tdark 88 | 6,593
Tchem 86 | 1,388
Tclin 72 | 612

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 4 | 99
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 61 | 979
preweaning lethality, incomple... 39 | 499
abnormal behavior 33 | 298
embryonic lethality prior to t... 20 | 278
increased lean body mass 20 | 172
decreased body weight 17 | 161
decreased total body fat amoun... 16 | 207
abnormal bone structure 14 | 187
abnormal embryo size 14 | 220
decreased grip strength 14 | 116
increased circulating sodium l... 14 | 71
increased circulating chloride... 13 | 41
hyperactivity 12 | 148
increased circulating alkaline... 12 | 122
increased fasted circulating g... 12 | 76
increased total body fat amoun... 12 | 134
decreased circulating choleste... 11 | 93
hypoactivity 11 | 132
impaired glucose tolerance 11 | 75
decreased bone mineral content 10 | 151
decreased circulating serum al... 10 | 82
decreased fasted circulating g... 10 | 65
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
increased bone mineral content 10 | 108
abnormal retina morphology 9 | 71
decreased circulating HDL chol... 9 | 68
decreased circulating alkaline... 9 | 46
decreased circulating glucose ... 9 | 126
decreased circulating triglyce... 9 | 79
embryonic growth retardation 9 | 106
embryonic lethality prior to o... 9 | 239
male infertility 9 | 123
short tibia 9 | 97
decreased circulating insulin ... 8 | 76
decreased circulating total pr... 8 | 49
increased or absent threshold ... 8 | 101
decreased circulating LDL chol... 7 | 38
improved glucose tolerance 7 | 79
increased mean corpuscular vol... 7 | 92
increased startle reflex 7 | 112
persistence of hyaloid vascula... 7 | 33
prolonged ST segment 7 | 36
tremors 7 | 39
abnormal behavioral response t... 6 | 66
abnormal eye morphology 6 | 68
abnormal sleep behavior 6 | 70
decreased leukocyte cell numbe... 6 | 73
edema 6 | 59
enlarged heart 6 | 210
increased blood urea nitrogen ... 6 | 48
increased mean corpuscular hem... 6 | 96
limb grasping 6 | 41
prenatal lethality prior to he... 6 | 87
prolonged QT interval 6 | 38
abnormal heart morphology 5 | 162
cardiovascular system phenotyp... 5 | 36
cataract 5 | 92
decreased bone mineral density 5 | 126
decreased caudal vertebrae num... 5 | 53
decreased circulating amylase ... 5 | 28
decreased circulating aspartat... 5 | 34
decreased hemoglobin content 5 | 68
decreased lymphocyte cell numb... 5 | 83
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
increased circulating choleste... 5 | 66
small testis 5 | 58
abnormal embryo turning 4 | 31
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
abnormal locomotor behavior 4 | 24
abnormal seminal vesicle morph... 4 | 114
abnormal spleen morphology 4 | 55
decreased circulating alanine ... 4 | 47
decreased mean corpuscular vol... 4 | 79
increased bone mineral density 4 | 72
increased circulating triglyce... 4 | 42
increased heart weight 4 | 62
increased lymphocyte cell numb... 4 | 32
increased prepulse inhibition 4 | 32
pallor 4 | 34
polycystic kidney 4 | 15
abnormal coat-hair pigmentatio... 3 | 64
abnormal retinal vasculature m... 3 | 27
convulsive seizures 3 | 13
corneal opacity 3 | 32
decreased body length 3 | 101
decreased circulating calcium ... 3 | 36
decreased circulating glycerol... 3 | 16
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased circulating free fat... 3 | 20
increased circulating iron lev... 3 | 30
increased circulating phosphat... 3 | 26
increased circulating total pr... 3 | 28
increased red blood cell distr... 3 | 34
small thymus 3 | 16
thin ventricular wall 3 | 24

Disease

Carcinoma 642 | 11,493
ovarian cancer 380 | 8,520
osteosarcoma 379 | 7,950
medulloblastoma, large-cell 371 | 6,241
ependymoma 360 | 4,679
glioblastoma 360 | 5,792
atypical teratoid / rhabdoid tumor 330 | 5,112
psoriasis 324 | 6,694
adult high grade glioma 263 | 3,801
group 3 medulloblastoma 252 | 4,104
lung cancer 240 | 4,740
Astrocytoma, Pilocytic 225 | 3,081
oligodendroglioma 214 | 2,850
Kidney cancer 213 | 2,613
astrocytic glioma 194 | 2,597
Breast cancer 193 | 3,578
primitive neuroectodermal tumor 190 | 3,035
lung carcinoma 186 | 2,843
malignant mesothelioma 183 | 3,232
Cancer 169 | 2,499
Schizophrenia 164 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 159 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 149 | 2,989
Pick disease 146 | 1,894
invasive ductal carcinoma 146 | 2,951
lung adenocarcinoma 143 | 2,716
non-small cell lung cancer 143 | 2,890
Autosomal recessive predisposition 140 | 1,442
subependymal giant cell astrocytoma 140 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 138 | 3,291
Intellectual disability 137 | 1,016
pancreatic cancer 129 | 2,398
pituitary cancer 117 | 1,972
Bipolar Disorder 116 | 666
interstitial cystitis 116 | 2,312
Alzheimer's disease 110 | 658
Epilepsy 106 | 792
colon cancer 98 | 1,478
ulcerative colitis 98 | 1,819
Obesity 97 | 678
tuberculosis 94 | 2,010
diabetes mellitus 90 | 1,728
Depressive disorder 88 | 409
group 4 medulloblastoma 88 | 1,855
breast carcinoma 86 | 1,638
cystic fibrosis 85 | 1,696
Dull intelligence 84 | 645
Low intelligence 84 | 645
Mental Retardation 84 | 645
Mental deficiency 84 | 645
Poor school performance 84 | 645
ductal carcinoma in situ 84 | 1,745
Seizures 81 | 596
Parkinson's disease 76 | 392
nasopharyngeal carcinoma 76 | 1,058
Liver cancer 73 | 604
Mental Depression 73 | 333
adrenocortical carcinoma 73 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 69 | 1,962
chronic rhinosinusitis 68 | 512
Retinitis Pigmentosa 66 | 226
Cognitive delay 65 | 608
Global developmental delay 65 | 608
Mental and motor retardation 65 | 608
Alcoholic Intoxication, Chronic 63 | 289
Melanoma 63 | 711
pediatric high grade glioma 63 | 1,064
primary pancreatic ductal adenocarcinoma 60 | 1,109
Major Depressive Disorder 59 | 301
astrocytoma 59 | 1,146
Autistic Disorder 58 | 364
Nystagmus 58 | 317
cutaneous lupus erythematosus 58 | 1,057
Hypertension 56 | 396
Kidney disease 55 | 430
spina bifida 55 | 1,074
Cataract 54 | 297
Polydactyly 54 | 107
Toxic encephalopathy 54 | 141
acute quadriplegic myopathy 54 | 1,158
Muscle hypotonia 53 | 571
Skin cancer 53 | 469
Rheumatoid arthritis 52 | 1,191
Unipolar Depression 52 | 250
Neurodegenerative disease 51 | 414
Down syndrome 49 | 499
Amyotrophic lateral sclerosis 48 | 451
Lens Opacities 48 | 231
Short stature 48 | 531
Congenital hypoplasia of penis 46 | 176
Hypertensive disease 46 | 292
juvenile dermatomyositis 46 | 1,187
Cerebrovascular disease 45 | 238
Hypogonadism 44 | 173
Mood Disorders 44 | 184
Neuropathy 44 | 261
Cerebellar Ataxia 41 | 304
Ciliopathy 41 | 71
Electroretinogram abnormal 41 | 95
Nephronophthisis 41 | 80

Tissue

Endocrine System 827 | 18,159
Skin and soft tissues 792 | 17,230
Female tissues 790 | 17,400
Digestive Tract 789 | 17,369
Nervous System 786 | 16,725
Male tissues 784 | 17,142
Liver and Pancreas 768 | 16,750
Urinary Tract 767 | 16,678
Blood and immune system 761 | 16,909
Respiratory system 751 | 16,393
Cardiovascular System 671 | 15,192

Target Family

Non-IDG 550 | 12,091
Enzyme 125 | 4,145
Kinase 49 | 634
Ion Channel 40 | 344
GPCR 37 | 408
Transporter 36 | 473
Transcription Factor 8 | 1,400
Epigenetic 4 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Cell projection part 850 | 850
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Phosducin PDC Tbio Non-IDG -2.36871 242.5 78
Cilia- and flagella-associated protein 74 CFAP74 Tdark Non-IDG 0.38 0.16 21
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Opsin-5 OPN5 Tbio GPCR -1.19753 14.2 151