Development Level

Tbio 499 | 10,625
Tchem 96 | 1,890
Tdark 82 | 7,003
Tclin 62 | 602

Collection

Eligible non-olfactory GPCR Proteins 7 | 145
Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 38 | 633
preweaning lethality, incomple... 23 | 260
abnormal behavior 21 | 226
decreased grip strength 14 | 123
decreased lean body mass 14 | 195
decreased total body fat amoun... 14 | 186
embryonic lethality prior to t... 14 | 187
increased lean body mass 13 | 107
decreased body weight 12 | 174
increased or absent threshold ... 12 | 128
increased circulating alkaline... 11 | 119
abnormal bone structure 10 | 131
decreased bone mineral content 10 | 157
decreased circulating choleste... 10 | 85
decreased circulating HDL chol... 9 | 77
increased fasted circulating g... 9 | 68
impaired glucose tolerance 8 | 52
decreased bone mineral density 7 | 126
decreased circulating LDL chol... 7 | 37
decreased circulating insulin ... 7 | 75
decreased fasted circulating g... 7 | 49
hyperactivity 7 | 108
hypoactivity 7 | 89
increased circulating sodium l... 7 | 71
abnormal embryo size 6 | 112
decreased circulating alanine ... 6 | 53
decreased circulating alkaline... 6 | 41
decreased circulating serum al... 6 | 79
decreased circulating triglyce... 6 | 83
increased blood urea nitrogen ... 6 | 44
increased body weight 6 | 42
increased bone mineral content 6 | 92
increased circulating chloride... 6 | 43
increased grip strength 6 | 83
tremors 6 | 34
abnormal gait 5 | 51
abnormal retina morphology 5 | 100
abnormal sleep behavior 5 | 63
cardiovascular system phenotyp... 5 | 35
decreased circulating aspartat... 5 | 27
decreased circulating total pr... 5 | 41
enlarged heart 5 | 111
increased circulating choleste... 5 | 53
increased mean corpuscular hem... 5 | 93
increased startle reflex 5 | 38
increased total body fat amoun... 5 | 57
short tibia 5 | 82
abnormal behavioral response t... 4 | 52
abnormal lens morphology 4 | 73
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
increased bone mineral density 4 | 52
male infertility 4 | 62
prenatal lethality prior to he... 4 | 64
abnormal QRS complex 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal nail morphology 3 | 7
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
decreased circulating glucose ... 3 | 121
decreased exploration in new e... 3 | 9
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased pulmonary respirator... 3 | 4
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased circulating free fat... 3 | 17
increased circulating iron lev... 3 | 25
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased mean corpuscular vol... 3 | 91
increased prepulse inhibition 3 | 21
increased rib number 3 | 41
limb grasping 3 | 35
persistence of hyaloid vascula... 3 | 22
small thymus 3 | 11
abnormal epididymis morphology 2 | 31
abnormal heart left ventricle ... 2 | 20
abnormal optic disc morphology 2 | 10
abnormal spleen morphology 2 | 36
abnormal whole-body plethysmog... 2 | 4
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased circulating calcium ... 2 | 33
decreased heart rate variabili... 2 | 11
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
increased circulating aspartat... 2 | 17
increased circulating calcium ... 2 | 32
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
small testis 2 | 37

Disease

ovarian cancer 333 | 8,492
osteosarcoma 331 | 7,933
medulloblastoma, large-cell 326 | 6,234
glioblastoma 308 | 5,572
psoriasis 288 | 6,685
atypical teratoid / rhabdoid tumor 251 | 4,369
pilocytic astrocytoma 208 | 3,086
oligodendroglioma 202 | 2,849
lung cancer 198 | 4,473
primitive neuroectodermal tumor 178 | 3,031
pediatric high grade glioma 176 | 2,712
Carcinoma 173 | 2,147
lung carcinoma 166 | 2,844
malignant mesothelioma 161 | 3,163
ependymoma 145 | 2,514
astrocytic glioma 144 | 2,241
Cancer 142 | 2,346
posterior fossa group B ependymoma 142 | 1,530
intraductal papillary-mucinous adenoma (IPMA) 137 | 2,956
Breast cancer 136 | 3,099
Pick disease 135 | 1,893
invasive ductal carcinoma 135 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 133 | 2,988
lung adenocarcinoma 131 | 2,714
non-small cell lung cancer 125 | 2,798
subependymal giant cell astrocytoma 123 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 121 | 3,289
adult high grade glioma 113 | 2,148
interstitial cystitis 105 | 2,299
pancreatic cancer 104 | 2,300
pituitary cancer 100 | 1,972
group 3 medulloblastoma 98 | 2,254
Schizophrenia 94 | 503
medulloblastoma 94 | 1,524
Alzheimer's disease 91 | 644
ulcerative colitis 91 | 2,087
astrocytoma 90 | 1,493
group 4 medulloblastoma 89 | 1,875
colon cancer 86 | 1,475
posterior fossa group A ependymoma 85 | 1,511
sonic hedgehog group medulloblastoma 82 | 1,482
breast carcinoma 80 | 1,614
ductal carcinoma in situ 79 | 1,745
diabetes mellitus 78 | 1,663
Obesity 76 | 616
cystic fibrosis 76 | 1,670
Intellectual disability 73 | 573
nasopharyngeal carcinoma 70 | 1,056
adrenocortical carcinoma 68 | 1,427
Epilepsy 67 | 346
atypical teratoid/rhabdoid tumor 67 | 1,095
Parkinson's disease 66 | 364
tuberculosis 63 | 1,563
primary pancreatic ductal adenocarcinoma 61 | 1,271
chronic rhinosinusitis 60 | 512
cutaneous lupus erythematosus 53 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,795
Neurodegenerative disease 49 | 383
Polydactyly 49 | 93
Toxic encephalopathy 48 | 131
acute quadriplegic myopathy 48 | 1,157
Autistic Disorder 47 | 320
spina bifida 47 | 1,064
Down syndrome 45 | 548
Kidney disease 44 | 397
Bipolar Disorder 43 | 266
Retinitis pigmentosa 43 | 156
Rheumatoid Arthritis 42 | 1,171
Hypertension 41 | 293
juvenile dermatomyositis 40 | 1,189
Cerebrovascular disease 39 | 231
Amyotrophic Lateral Sclerosis 37 | 432
Nephronophthisis 36 | 74
Atopic dermatitis 35 | 944
Ciliopathy 35 | 57
aldosterone-producing adenoma 35 | 664
Cocaine-Related Disorders 34 | 88
Neuropathy 34 | 210
gastric carcinoma 34 | 832
Pain agnosia 33 | 99
Seizures 33 | 95
active Crohn's disease 33 | 918
fibroadenoma 33 | 557
non primary Sjogren syndrome sicca 33 | 840
progressive supranuclear palsy 33 | 674
Dementia 32 | 129
Duchenne muscular dystrophy 32 | 602
Endometriosis 30 | 535
Primary ciliary dyskinesia 30 | 75
acute myeloid leukemia 30 | 785
dermatomyositis 30 | 967
Alcohol dependence 29 | 107
Multiple Sclerosis 29 | 498
Pain 29 | 70
Waldenstrons macroglobulinemia 29 | 765
Joubert syndrome 28 | 62
tuberculosis and treatment for 6 months 28 | 686
Bardet-Biedl Syndrome 27 | 40
Migraine 27 | 79
esophageal adenocarcinoma 27 | 737

Tissue

Nervous System 730 | 18,561
Female tissues 728 | 18,647
Endocrine System 726 | 18,512
Digestive Tract 725 | 18,473
Urinary Tract 724 | 18,444
Liver and Pancreas 722 | 18,136
Cardiovascular System 720 | 17,958
Skin and soft tissues 718 | 18,115
Blood and immune system 717 | 17,995
Male tissues 713 | 17,969
Respiratory system 702 | 17,484

Target Family

Non-IDG 480 | 11,969
Enzyme 110 | 4,146
Kinase 37 | 634
Ion Channel 36 | 341
Transporter 33 | 473
GPCR 31 | 408
Transcription Factor 7 | 1,400
Epigenetic 4 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Cell projection part 739 | 739
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Synapsin-1 SYN1 Tbio Non-IDG -2.85684 687.9 716
Noelin OLFM1 Tbio Non-IDG -1.26710 24.7 286
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha PIP5K1A Tbio Kinase -0.55632 4.98 106
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.72093 48.8 66
Calcium and integrin-binding protein 1 CIB1 Tbio Non-IDG -2.05927 116.0 218
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.18888 178.4 196
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Metabotropic glutamate receptor 7 GRM7 Tbio GPCR -2.23649 186.6 266
Talin-1 TLN1 Tbio Non-IDG -1.88948 80.4 340