Development Level

Tbio 954 | 10,625
Tchem 207 | 1,890
Tdark 160 | 7,003
Tclin 105 | 602

Collection

Eligible non-olfactory GPCR Proteins 12 | 143
Eligible Kinase Proteins 10 | 134
Eligible Ion Channel Proteins 9 | 117

IMPC Term

preweaning lethality, complete... 61 | 633
preweaning lethality, incomple... 32 | 260
abnormal behavior 29 | 226
decreased total body fat amoun... 21 | 186
decreased body weight 20 | 174
embryonic lethality prior to t... 20 | 187
abnormal bone structure 18 | 131
decreased grip strength 18 | 123
decreased lean body mass 18 | 195
increased or absent threshold ... 18 | 128
decreased circulating choleste... 16 | 85
increased circulating alkaline... 16 | 119
increased lean body mass 16 | 107
decreased bone mineral content 15 | 157
decreased circulating HDL chol... 14 | 77
increased circulating sodium l... 14 | 71
abnormal retina morphology 13 | 100
hyperactivity 13 | 108
increased fasted circulating g... 13 | 68
abnormal embryo size 12 | 112
decreased bone mineral density 12 | 126
increased mean corpuscular hem... 12 | 93
abnormal bone mineralization 11 | 55
decreased circulating glucose ... 11 | 121
decreased prepulse inhibition 11 | 52
increased body weight 11 | 42
increased mean corpuscular vol... 11 | 91
decreased circulating insulin ... 10 | 75
impaired glucose tolerance 10 | 52
increased heart weight 10 | 37
decreased circulating alanine ... 9 | 53
decreased circulating alkaline... 9 | 41
decreased circulating triglyce... 9 | 83
embryonic lethality prior to o... 9 | 148
hypoactivity 9 | 89
increased circulating chloride... 9 | 43
limb grasping 9 | 35
prenatal lethality prior to he... 9 | 64
decreased circulating LDL chol... 8 | 37
decreased mean corpuscular vol... 8 | 50
improved glucose tolerance 8 | 56
increased blood urea nitrogen ... 8 | 44
increased bone mineral content 8 | 92
male infertility 8 | 62
abnormal behavioral response t... 7 | 52
abnormal gait 7 | 51
abnormal neural tube closure 7 | 37
abnormal retinal pigmentation 7 | 61
abnormal sleep behavior 7 | 63
cardiovascular system phenotyp... 7 | 35
decreased circulating serum al... 7 | 79
decreased circulating total pr... 7 | 41
decreased fasted circulating g... 7 | 49
decreased startle reflex 7 | 48
enlarged heart 7 | 111
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
increased total body fat amoun... 7 | 57
persistence of hyaloid vascula... 7 | 22
short tibia 7 | 82
abnormal hindbrain development 6 | 24
decreased circulating aspartat... 6 | 27
decreased rib number 6 | 59
increased bone mineral density 6 | 52
increased circulating HDL chol... 6 | 63
tremors 6 | 34
abnormal locomotor activation 5 | 26
abnormal midbrain development 5 | 22
decreased T cell number 5 | 31
decreased circulating potassiu... 5 | 17
decreased hemoglobin content 5 | 53
increased circulating free fat... 5 | 17
increased circulating iron lev... 5 | 25
increased startle reflex 5 | 38
abnormal QRS complex 4 | 25
abnormal coat/hair pigmentatio... 4 | 54
abnormal lens morphology 4 | 73
absent startle reflex 4 | 15
decreased CD4-positive, alpha ... 4 | 19
decreased circulating amylase ... 4 | 24
decreased circulating free fat... 4 | 39
decreased circulating iron lev... 4 | 25
decreased lumbar vertebrae num... 4 | 62
hemorrhage 4 | 12
increased circulating calcium ... 4 | 32
increased rib number 4 | 41
straub tail 4 | 26
abnormal heart left ventricle ... 3 | 20
abnormal vibrissa morphology 3 | 17
decreased body length 3 | 108
decreased circulating glycerol... 3 | 19
decreased total retina thickne... 3 | 20
decreased vertical activity 3 | 22
increased circulating potassiu... 3 | 31
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 21
thrombocytopenia 3 | 46
thrombocytosis 3 | 23

Disease

ovarian cancer 649 | 8,484
osteosarcoma 645 | 7,933
medulloblastoma, large-cell 632 | 6,234
glioblastoma 592 | 5,572
psoriasis 550 | 6,685
atypical teratoid / rhabdoid tumor 465 | 4,369
pilocytic astrocytoma 393 | 3,086
lung cancer 383 | 4,466
oligodendroglioma 360 | 2,849
pediatric high grade glioma 341 | 2,712
lung carcinoma 326 | 2,844
primitive neuroectodermal tumor 325 | 3,031
Carcinoma 324 | 2,147
malignant mesothelioma 303 | 3,162
Breast cancer 290 | 3,094
Cancer 280 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 280 | 2,956
invasive ductal carcinoma 270 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 265 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 265 | 3,289
ependymoma 262 | 2,514
astrocytic glioma 258 | 2,241
lung adenocarcinoma 257 | 2,713
non-small cell lung cancer 245 | 2,798
subependymal giant cell astrocytoma 241 | 2,287
posterior fossa group B ependymoma 240 | 1,530
Pick disease 224 | 1,893
adult high grade glioma 213 | 2,148
interstitial cystitis 211 | 2,299
pancreatic cancer 207 | 2,300
pituitary cancer 205 | 1,972
ulcerative colitis 196 | 2,087
group 4 medulloblastoma 186 | 1,875
medulloblastoma 181 | 1,524
astrocytoma 180 | 1,493
group 3 medulloblastoma 178 | 2,254
colon cancer 170 | 1,475
cystic fibrosis 164 | 1,665
posterior fossa group A ependymoma 163 | 1,511
ductal carcinoma in situ 161 | 1,745
diabetes mellitus 156 | 1,663
Alzheimer's disease 154 | 644
sonic hedgehog group medulloblastoma 152 | 1,482
breast carcinoma 151 | 1,614
Schizophrenia 138 | 501
tuberculosis 135 | 1,557
Obesity 125 | 616
nasopharyngeal carcinoma 125 | 1,056
atypical teratoid/rhabdoid tumor 119 | 1,095
primary pancreatic ductal adenocarcinoma 119 | 1,271
adrenocortical carcinoma 118 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 113 | 1,795
Intellectual disability 108 | 573
Parkinson's disease 108 | 364
Epilepsy 107 | 346
cutaneous lupus erythematosus 99 | 1,056
Neurodegenerative disease 96 | 383
chronic rhinosinusitis 95 | 512
acute quadriplegic myopathy 94 | 1,157
juvenile dermatomyositis 91 | 1,189
spina bifida 91 | 1,064
Rheumatoid Arthritis 89 | 1,160
gastric carcinoma 86 | 832
Kidney disease 85 | 396
Autistic Disorder 79 | 320
Down syndrome 79 | 548
Multiple myeloma 76 | 1,327
Amyotrophic Lateral Sclerosis 74 | 431
Toxic encephalopathy 73 | 131
Atopic dermatitis 72 | 944
dermatomyositis 69 | 933
progressive supranuclear palsy 69 | 674
Bipolar Disorder 68 | 266
non primary Sjogren syndrome sicca 68 | 840
active Crohn's disease 67 | 918
Cerebrovascular disease 66 | 231
Retinitis pigmentosa 66 | 153
aldosterone-producing adenoma 66 | 664
Duchenne muscular dystrophy 64 | 602
Endometriosis 64 | 535
Hypertension 64 | 287
Neuropathy 64 | 210
Multiple Sclerosis 63 | 498
Waldenstrons macroglobulinemia 62 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 62 | 499
esophageal adenocarcinoma 62 | 737
acute myeloid leukemia 58 | 780
fibroadenoma 58 | 557
Dementia 55 | 129
Polydactyly 54 | 93
pancreatic carcinoma 53 | 567
Asthma 52 | 349
primary Sjogren syndrome 51 | 789
tuberculosis and treatment for 6 months 51 | 686
Heart disease 50 | 279
Prostatic Neoplasms 49 | 471
Seizures 48 | 95
Vascular disease 48 | 281
non-small cell lung carcinoma 47 | 413
Cocaine-Related Disorders 46 | 88

Tissue

Nervous System 1,411 | 18,561
Female tissues 1,410 | 18,647
Digestive Tract 1,406 | 18,473
Endocrine System 1,405 | 18,512
Urinary Tract 1,404 | 18,444
Liver and Pancreas 1,395 | 18,136
Skin and soft tissues 1,387 | 18,115
Cardiovascular System 1,386 | 17,958
Blood and immune system 1,378 | 17,995
Male tissues 1,374 | 17,969
Respiratory system 1,358 | 17,484

Target Family

Non-IDG 909 | 11,971
Enzyme 211 | 4,146
Kinase 86 | 634
Ion Channel 69 | 341
GPCR 61 | 406
Transporter 52 | 473
Transcription Factor 20 | 1,400
oGPCR 10 | 421
Epigenetic 7 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Cell projection 1,426 | 1,426
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Stereocilin STRC Tbio Non-IDG 35.9 7
Ropporin-1B ROPN1B Tbio Non-IDG 1.00 0.10 52
Cilia- and flagella-associated protein 77 CFAP77 Tdark Non-IDG 0.00000 11
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67