Development Level

Tbio 3,220 | 11,445
Tdark 984 | 6,588
Tchem 755 | 1,598
Tclin 423 | 613

Collection

RFA-RM-18-021 202 | 328
GPCR: IDG Consortium (Targets) 119 | 126
Ion Channel: IDG Consortium (T... 85 | 99
GPCR: IDG Consortium (Complete... 24 | 25
Kinase: IDG Consortium (Target... 21 | 125
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 233 | 979
preweaning lethality, incomple... 159 | 499
abnormal behavior 101 | 298
decreased vertical activity 79 | 208
embryonic lethality prior to t... 77 | 278
enlarged heart 69 | 210
decreased total body fat amoun... 67 | 207
abnormal bone structure 60 | 187
abnormal embryo size 58 | 220
embryonic lethality prior to o... 55 | 239
decreased body weight 53 | 161
hyperactivity 53 | 148
increased lean body mass 53 | 172
abnormal heart morphology 49 | 162
decreased bone mineral content 49 | 151
increased total body fat amoun... 49 | 134
abnormal seminal vesicle morph... 42 | 114
increased circulating alkaline... 40 | 122
decreased lean body mass 38 | 135
increased startle reflex 38 | 112
decreased bone mineral density 37 | 126
hypoactivity 35 | 132
increased bone mineral content 35 | 108
decreased circulating glucose ... 34 | 126
increased or absent threshold ... 34 | 101
decreased grip strength 31 | 116
embryonic growth retardation 31 | 106
short tibia 31 | 97
decreased lymphocyte cell numb... 30 | 83
improved glucose tolerance 30 | 79
decreased prepulse inhibition 29 | 82
abnormal retina morphology 28 | 71
decreased circulating choleste... 28 | 93
abnormal gait 27 | 69
decreased mean corpuscular vol... 27 | 79
impaired glucose tolerance 27 | 75
increased mean corpuscular vol... 27 | 92
small superior vagus ganglion 27 | 74
decreased body length 26 | 101
decreased fasted circulating g... 26 | 65
prenatal lethality prior to he... 26 | 87
decreased circulating insulin ... 25 | 76
decreased startle reflex 25 | 75
increased heart weight 24 | 62
limb grasping 24 | 41
abnormal sleep behavior 23 | 70
cataract 23 | 92
increased monocyte cell number 23 | 63
decreased leukocyte cell numbe... 22 | 73
increased circulating sodium l... 22 | 71
increased leukocyte cell numbe... 22 | 47
increased mean corpuscular hem... 22 | 96
abnormal kidney morphology 21 | 65
decreased circulating HDL chol... 21 | 68
decreased circulating triglyce... 21 | 79
edema 21 | 59
increased circulating chloride... 21 | 41
increased fasted circulating g... 21 | 76
abnormal eye morphology 20 | 68
decreased hemoglobin content 20 | 68
tremors 20 | 39
abnormal lens morphology 19 | 81
decreased circulating creatini... 19 | 39
increased circulating HDL chol... 19 | 80
increased neutrophil cell numb... 19 | 46
male infertility 19 | 123
decreased circulating serum al... 18 | 82
increased blood urea nitrogen ... 18 | 48
increased circulating choleste... 18 | 66
increased circulating triglyce... 18 | 42
thrombocytopenia 18 | 56
abnormal skin morphology 17 | 50
hydrometra 17 | 53
increased bone mineral density 17 | 72
increased hematocrit 17 | 46
abnormal epididymis morphology 16 | 42
abnormal spleen morphology 16 | 55
cardiovascular system phenotyp... 16 | 36
decreased erythrocyte cell num... 16 | 62
decreased mean corpuscular hem... 16 | 50
increased hemoglobin content 16 | 45
enlarged spleen 15 | 41
increased circulating calcium ... 15 | 34
prolonged QT interval 15 | 38
small testis 15 | 58
abnormal coat appearance 14 | 31
abnormal coat-hair pigmentatio... 14 | 64
abnormal neural tube closure 14 | 46
abnormal testis morphology 14 | 43
decreased neutrophil cell numb... 14 | 42
increased circulating creatini... 14 | 38
pallor 14 | 34
prolonged ST segment 14 | 36
abnormal behavioral response t... 13 | 66
decreased blood urea nitrogen ... 13 | 51
decreased circulating alkaline... 13 | 46
decreased circulating amylase ... 13 | 28
enlarged epididymis 13 | 31
increased mean platelet volume 13 | 45
persistence of hyaloid vascula... 13 | 33

Disease

Carcinoma 3,785 | 11,493
ovarian cancer 2,293 | 8,520
osteosarcoma 2,226 | 7,950
psoriasis 2,111 | 6,694
glioblastoma 1,910 | 5,792
medulloblastoma, large-cell 1,908 | 6,241
atypical teratoid / rhabdoid tumor 1,644 | 5,112
ependymoma 1,535 | 4,679
lung cancer 1,525 | 4,740
adult high grade glioma 1,342 | 3,801
Astrocytoma, Pilocytic 1,218 | 3,081
lung carcinoma 1,215 | 2,843
group 3 medulloblastoma 1,146 | 4,104
Breast cancer 1,114 | 3,578
Cancer 1,112 | 2,499
non-small cell lung cancer 1,030 | 2,890
Kidney cancer 1,020 | 2,613
malignant mesothelioma 1,015 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,013 | 3,291
invasive ductal carcinoma 1,010 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 992 | 2,955
lung adenocarcinoma 990 | 2,716
oligodendroglioma 965 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 951 | 2,989
interstitial cystitis 941 | 2,312
primitive neuroectodermal tumor 922 | 3,035
pancreatic cancer 877 | 2,398
subependymal giant cell astrocytoma 836 | 2,287
astrocytic glioma 824 | 2,597
tuberculosis 722 | 2,010
ulcerative colitis 695 | 1,819
diabetes mellitus 689 | 1,728
pituitary cancer 687 | 1,972
ductal carcinoma in situ 619 | 1,745
cystic fibrosis 615 | 1,696
group 4 medulloblastoma 581 | 1,855
Pick disease 577 | 1,894
Schizophrenia 567 | 1,160
breast carcinoma 547 | 1,638
Autosomal recessive predisposition 530 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 530 | 1,962
colon cancer 508 | 1,478
cutaneous lupus erythematosus 461 | 1,057
Rheumatoid arthritis 443 | 1,191
adrenocortical carcinoma 441 | 1,428
primary pancreatic ductal adenocarcinoma 405 | 1,109
astrocytoma 385 | 1,146
juvenile dermatomyositis 353 | 1,187
active Crohn's disease 336 | 922
pediatric high grade glioma 334 | 1,064
Melanoma 332 | 711
spina bifida 330 | 1,074
Intellectual disability 325 | 1,016
Bipolar Disorder 324 | 666
acute quadriplegic myopathy 324 | 1,158
nasopharyngeal carcinoma 319 | 1,058
Epilepsy 315 | 792
Liver Cirrhosis, Experimental 311 | 769
dermatomyositis 311 | 966
Atopic dermatitis 307 | 952
Obesity 307 | 678
active ulcerative colitis 306 | 764
gastric carcinoma 303 | 807
Alzheimer's disease 302 | 658
esophageal adenocarcinoma 298 | 737
Multiple myeloma 296 | 1,332
primary Sjogren syndrome 286 | 735
Multiple Sclerosis 285 | 540
Liver cancer 281 | 604
Kidney disease 263 | 430
Duchenne muscular dystrophy 253 | 601
Hypertension 253 | 396
Skin cancer 246 | 469
non primary Sjogren syndrome sicca 246 | 891
mucosa-associated lymphoid tissue lymphoma 236 | 484
Down syndrome 226 | 499
aldosterone-producing adenoma 219 | 665
Seizures 213 | 596
Asthma 212 | 385
Depressive disorder 212 | 409
Arthritis 211 | 290
Dull intelligence 205 | 645
Hypersensitivity reaction type II disease 205 | 253
Low intelligence 205 | 645
Mental Retardation 205 | 645
Mental deficiency 205 | 645
Poor school performance 205 | 645
fibroadenoma 202 | 559
medulloblastoma 200 | 720
acute myeloid leukemia 199 | 783
Autistic Disorder 198 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 196 | 510
Anemia 191 | 365
Parkinson's disease 191 | 392
Prostatic Neoplasms 190 | 495
Breast Neoplasms 183 | 445
Waldenstrons macroglobulinemia 183 | 765
progressive supranuclear palsy 183 | 676
Alcoholic Intoxication, Chronic 181 | 289
Endometriosis 180 | 540

Tissue

Endocrine System 4,842 | 18,159
Digestive Tract 4,653 | 17,369
Female tissues 4,652 | 17,400
Skin and soft tissues 4,598 | 17,230
Male tissues 4,555 | 17,142
Blood and immune system 4,514 | 16,909
Nervous System 4,497 | 16,725
Urinary Tract 4,480 | 16,678
Liver and Pancreas 4,474 | 16,750
Respiratory system 4,334 | 16,393
Cardiovascular System 3,962 | 15,192

Target Family

Non-IDG 2,799 | 12,091
Enzyme 821 | 4,145
GPCR 391 | 408
oGPCR 380 | 421
Transporter 361 | 473
Ion Channel 320 | 344
Kinase 239 | 634
Transcription Factor 44 | 1,400
Epigenetic 18 | 242
Nuclear Receptor 5 | 48
TF/Epigenetic 4 | 38

Compartment GO Term

Cell periphery 5,382 | 5,382
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155