Development Level

Tbio 2,879 | 10,625
Tdark 1,029 | 7,003
Tchem 829 | 1,890
Tclin 408 | 602

Collection

Eligible non-olfactory GPCR Proteins 129 | 143
Eligible Ion Channel Proteins 102 | 117
Eligible Kinase Proteins 21 | 134

IMPC Term

preweaning lethality, complete... 154 | 633
preweaning lethality, incomple... 88 | 260
abnormal behavior 67 | 226
decreased lean body mass 60 | 195
decreased total body fat amoun... 54 | 186
embryonic lethality prior to t... 52 | 187
decreased bone mineral content 51 | 157
decreased body weight 46 | 174
increased or absent threshold ... 43 | 128
decreased bone mineral density 42 | 126
abnormal bone structure 41 | 131
increased circulating alkaline... 41 | 119
decreased grip strength 40 | 123
hyperactivity 36 | 108
enlarged heart 34 | 111
abnormal retina morphology 33 | 100
decreased circulating choleste... 29 | 85
embryonic lethality prior to o... 29 | 148
abnormal embryo size 28 | 112
increased lean body mass 27 | 107
decreased circulating glucose ... 26 | 121
decreased circulating HDL chol... 24 | 77
decreased circulating triglyce... 24 | 83
hypoactivity 24 | 89
increased bone mineral content 23 | 92
increased mean corpuscular hem... 23 | 93
increased mean corpuscular vol... 23 | 91
short tibia 23 | 82
decreased body length 22 | 108
decreased circulating insulin ... 22 | 75
increased grip strength 22 | 83
decreased fasted circulating g... 21 | 49
decreased prepulse inhibition 21 | 52
improved glucose tolerance 21 | 56
increased circulating sodium l... 21 | 71
abnormal retinal pigmentation 20 | 61
decreased rib number 20 | 59
increased blood urea nitrogen ... 20 | 44
increased circulating HDL chol... 20 | 63
abnormal lens morphology 19 | 73
decreased circulating alanine ... 19 | 53
increased total body fat amoun... 19 | 57
abnormal gait 18 | 51
cardiovascular system phenotyp... 18 | 35
decreased lumbar vertebrae num... 18 | 62
impaired glucose tolerance 18 | 52
increased body weight 18 | 42
abnormal bone mineralization 17 | 55
increased circulating choleste... 17 | 53
increased heart weight 17 | 37
limb grasping 17 | 35
prenatal lethality prior to he... 17 | 64
tremors 17 | 34
decreased mean corpuscular vol... 16 | 50
increased circulating chloride... 16 | 43
increased fasted circulating g... 16 | 68
increased hemoglobin content 16 | 45
abnormal seminal vesicle morph... 15 | 47
decreased heart weight 15 | 44
decreased leukocyte cell numbe... 15 | 54
increased circulating calcium ... 15 | 32
increased hematocrit 15 | 36
abnormal sleep behavior 14 | 63
decreased circulating serum al... 14 | 79
decreased startle reflex 14 | 48
increased exploration in new e... 14 | 56
increased leukocyte cell numbe... 14 | 37
thrombocytopenia 14 | 46
abnormal kidney morphology 13 | 30
decreased circulating creatini... 13 | 31
decreased hemoglobin content 13 | 53
decreased mean corpuscular hem... 13 | 34
enlarged epididymis 13 | 27
increased bone mineral density 13 | 52
abnormal heart morphology 12 | 51
abnormal neural tube closure 12 | 37
decreased circulating alkaline... 12 | 41
decreased eosinophil cell numb... 12 | 41
increased sacral vertebrae num... 12 | 62
male infertility 12 | 62
abnormal epididymis morphology 11 | 31
decreased NK T cell number 11 | 28
decreased blood urea nitrogen ... 11 | 31
decreased caudal vertebrae num... 11 | 49
decreased circulating LDL chol... 11 | 37
decreased circulating chloride... 11 | 32
increased startle reflex 11 | 38
abnormal QRS complex 10 | 25
abnormal midbrain development 10 | 22
abnormal spleen morphology 10 | 36
abnormal vibrissa morphology 10 | 17
decreased circulating amylase ... 10 | 24
decreased circulating calcium ... 10 | 33
decreased circulating free fat... 10 | 39
decreased circulating fructosa... 10 | 31
decreased vertical activity 10 | 22
increased circulating creatini... 10 | 29
increased circulating potassiu... 10 | 31
increased circulating total pr... 10 | 20
increased rib number 10 | 41

Disease

ovarian cancer 2,169 | 8,484
osteosarcoma 2,133 | 7,933
psoriasis 2,013 | 6,685
medulloblastoma, large-cell 1,841 | 6,234
glioblastoma 1,765 | 5,572
lung cancer 1,350 | 4,466
atypical teratoid / rhabdoid tumor 1,329 | 4,369
pilocytic astrocytoma 1,180 | 3,086
lung carcinoma 1,179 | 2,844
Cancer 1,025 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 980 | 3,289
invasive ductal carcinoma 977 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 958 | 2,956
lung adenocarcinoma 954 | 2,713
non-small cell lung cancer 952 | 2,798
malignant mesothelioma 948 | 3,162
oligodendroglioma 941 | 2,849
pediatric high grade glioma 925 | 2,712
interstitial cystitis 914 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 909 | 2,988
primitive neuroectodermal tumor 903 | 3,031
Breast cancer 896 | 3,094
Carcinoma 863 | 2,147
subependymal giant cell astrocytoma 806 | 2,287
pancreatic cancer 800 | 2,300
ulcerative colitis 786 | 2,087
ependymoma 785 | 2,514
adult high grade glioma 688 | 2,148
pituitary cancer 663 | 1,972
astrocytic glioma 650 | 2,241
diabetes mellitus 637 | 1,663
ductal carcinoma in situ 607 | 1,745
group 4 medulloblastoma 590 | 1,875
cystic fibrosis 588 | 1,665
Pick disease 562 | 1,893
tuberculosis 549 | 1,557
posterior fossa group A ependymoma 528 | 1,511
group 3 medulloblastoma 519 | 2,254
breast carcinoma 518 | 1,614
astrocytoma 515 | 1,493
colon cancer 492 | 1,475
medulloblastoma 469 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 448 | 1,795
primary pancreatic ductal adenocarcinoma 445 | 1,271
cutaneous lupus erythematosus 439 | 1,056
adrenocortical carcinoma 431 | 1,427
Rheumatoid Arthritis 428 | 1,160
sonic hedgehog group medulloblastoma 424 | 1,482
posterior fossa group B ependymoma 402 | 1,530
atypical teratoid/rhabdoid tumor 364 | 1,095
juvenile dermatomyositis 343 | 1,189
active Crohn's disease 332 | 918
spina bifida 315 | 1,064
acute quadriplegic myopathy 311 | 1,157
nasopharyngeal carcinoma 307 | 1,056
gastric carcinoma 295 | 832
Multiple myeloma 294 | 1,327
primary Sjogren syndrome 294 | 789
Alzheimer's disease 287 | 644
Atopic dermatitis 285 | 944
esophageal adenocarcinoma 284 | 737
Obesity 275 | 616
dermatomyositis 270 | 933
Multiple Sclerosis 266 | 498
Schizophrenia 259 | 501
Kidney disease 245 | 396
Down syndrome 242 | 548
Duchenne muscular dystrophy 240 | 602
mucosa-associated lymphoid tissue lymphoma 224 | 480
non primary Sjogren syndrome sicca 210 | 840
aldosterone-producing adenoma 201 | 664
Epilepsy 200 | 346
fibroadenoma 198 | 557
Asthma 193 | 349
acute myeloid leukemia 189 | 780
Hypersensitivity reaction type II disease 187 | 235
Hypertension 186 | 287
autosomal dominant Emery-Dreifuss muscular dystrophy 184 | 499
Intellectual disability 183 | 573
active ulcerative colitis 183 | 477
Arthritis 182 | 248
Waldenstrons macroglobulinemia 182 | 765
Autistic Disorder 180 | 320
Prostatic Neoplasms 178 | 471
non-small cell lung carcinoma 177 | 413
pancreatic carcinoma 173 | 567
progressive supranuclear palsy 172 | 674
Parkinson's disease 171 | 364
Endometriosis 168 | 535
IGA Glomerulonephritis 166 | 454
Mammary Neoplasms 166 | 410
Atherosclerosis 157 | 275
Heart disease 152 | 279
Cerebrovascular disease 149 | 231
Vascular disease 149 | 281
Neurodegenerative disease 144 | 383
Anemia 142 | 252
Liver disease 141 | 219
tuberculosis and treatment for 6 months 139 | 686
Amyotrophic Lateral Sclerosis 135 | 431

Tissue

Female tissues 4,924 | 18,647
Urinary Tract 4,879 | 18,444
Nervous System 4,846 | 18,561
Endocrine System 4,838 | 18,512
Digestive Tract 4,812 | 18,473
Skin and soft tissues 4,720 | 18,115
Liver and Pancreas 4,670 | 18,136
Blood and immune system 4,628 | 17,995
Cardiovascular System 4,616 | 17,958
Male tissues 4,575 | 17,969
Respiratory system 4,498 | 17,484

Target Family

Non-IDG 2,624 | 11,971
Enzyme 769 | 4,146
GPCR 390 | 406
oGPCR 380 | 421
Transporter 363 | 473
Ion Channel 314 | 341
Kinase 238 | 634
Transcription Factor 44 | 1,400
Epigenetic 15 | 242
Nuclear Receptor 5 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Cell periphery 5,145 | 5,145
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5