Development Level

Tbio 10,648 | 11,651
Tdark 3,579 | 6,593
Tchem 1,347 | 1,388
Tclin 603 | 612

Collection

RFA-RM-18-021 301 | 328
GPCR: IDG Consortium (Targets) 119 | 126
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 91 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 24 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 460 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 176 | 210
decreased vertical activity 174 | 208
abnormal bone structure 173 | 187
increased lean body mass 155 | 172
decreased body weight 151 | 161
decreased bone mineral content 138 | 151
abnormal heart morphology 136 | 162
hyperactivity 134 | 148
decreased lean body mass 124 | 135
hypoactivity 124 | 132
increased total body fat amoun... 124 | 134
decreased bone mineral density 113 | 126
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 112 | 122
decreased grip strength 110 | 116
increased startle reflex 107 | 112
male infertility 107 | 123
embryonic growth retardation 105 | 106
abnormal seminal vesicle morph... 103 | 114
increased bone mineral content 95 | 108
increased or absent threshold ... 93 | 101
decreased body length 92 | 101
decreased circulating choleste... 91 | 93
increased mean corpuscular vol... 87 | 92
increased mean corpuscular hem... 86 | 96
short tibia 84 | 97
cataract 82 | 92
prenatal lethality prior to he... 82 | 87
decreased prepulse inhibition 78 | 82
decreased lymphocyte cell numb... 77 | 83
decreased mean corpuscular vol... 77 | 79
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
improved glucose tolerance 74 | 79
decreased circulating triglyce... 73 | 79
increased fasted circulating g... 72 | 76
impaired glucose tolerance 70 | 75
decreased circulating insulin ... 69 | 76
increased circulating HDL chol... 69 | 80
decreased startle reflex 68 | 75
increased bone mineral density 68 | 72
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 67 | 68
small superior vagus ganglion 67 | 74
increased circulating sodium l... 65 | 71
abnormal gait 64 | 69
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 64 | 73
increased circulating choleste... 61 | 66
increased heart weight 61 | 62
abnormal sleep behavior 60 | 70
decreased fasted circulating g... 60 | 65
abnormal behavioral response t... 59 | 66
abnormal eye morphology 59 | 68
abnormal kidney morphology 58 | 65
increased monocyte cell number 58 | 63
edema 57 | 59
abnormal coat-hair pigmentatio... 54 | 64
decreased erythrocyte cell num... 54 | 62
abnormal spleen morphology 53 | 55
female infertility 53 | 60
small testis 52 | 58
thrombocytopenia 51 | 56
decreased mean corpuscular hem... 47 | 50
decreased blood urea nitrogen ... 46 | 51
decreased caudal vertebrae num... 46 | 53
hydrometra 46 | 53
increased leukocyte cell numbe... 45 | 47
abnormal neural tube closure 44 | 46
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
increased blood urea nitrogen ... 44 | 48
decreased circulating alkaline... 43 | 46
decreased circulating total pr... 43 | 49
increased hematocrit 43 | 46
increased hemoglobin content 43 | 45
decreased hematocrit 42 | 46
increased circulating chloride... 41 | 41
increased mean platelet volume 41 | 45
increased neutrophil cell numb... 40 | 46
abnormal epididymis morphology 39 | 42
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
tremors 39 | 39
decreased circulating creatini... 38 | 39
decreased circulating LDL chol... 37 | 38
decreased neutrophil cell numb... 37 | 42
increased circulating creatini... 37 | 38
increased grip strength 37 | 41
limb grasping 37 | 41
abnormal bone mineralization 36 | 38
prolonged QT interval 36 | 38

Disease

Carcinoma 10,249 | 11,493
ovarian cancer 7,603 | 8,520
osteosarcoma 6,956 | 7,950
psoriasis 5,802 | 6,694
medulloblastoma, large-cell 5,500 | 6,241
glioblastoma 5,169 | 5,792
atypical teratoid / rhabdoid tumor 4,525 | 5,112
lung cancer 4,354 | 4,740
ependymoma 4,076 | 4,679
group 3 medulloblastoma 3,654 | 4,104
adult high grade glioma 3,337 | 3,801
Breast cancer 3,192 | 3,578
malignant mesothelioma 2,953 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,933 | 3,291
Astrocytoma, Pilocytic 2,715 | 3,081
primitive neuroectodermal tumor 2,708 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,662 | 2,989
invasive ductal carcinoma 2,610 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,608 | 2,955
non-small cell lung cancer 2,587 | 2,890
oligodendroglioma 2,525 | 2,850
lung carcinoma 2,482 | 2,843
Cancer 2,428 | 2,499
lung adenocarcinoma 2,399 | 2,716
Kidney cancer 2,375 | 2,613
astrocytic glioma 2,273 | 2,597
pancreatic cancer 2,147 | 2,398
subependymal giant cell astrocytoma 2,026 | 2,287
interstitial cystitis 1,991 | 2,312
tuberculosis 1,787 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,768 | 1,962
Pick disease 1,724 | 1,894
pituitary cancer 1,722 | 1,972
group 4 medulloblastoma 1,665 | 1,855
ulcerative colitis 1,595 | 1,819
diabetes mellitus 1,557 | 1,728
ductal carcinoma in situ 1,537 | 1,745
cystic fibrosis 1,477 | 1,696
breast carcinoma 1,460 | 1,638
Autosomal recessive predisposition 1,381 | 1,442
colon cancer 1,345 | 1,478
Multiple myeloma 1,275 | 1,332
adrenocortical carcinoma 1,263 | 1,428
Rheumatoid arthritis 1,105 | 1,191
Schizophrenia 1,086 | 1,160
juvenile dermatomyositis 1,077 | 1,187
astrocytoma 1,065 | 1,146
acute quadriplegic myopathy 1,057 | 1,158
Intellectual disability 994 | 1,016
primary pancreatic ductal adenocarcinoma 978 | 1,109
pediatric high grade glioma 958 | 1,064
cutaneous lupus erythematosus 952 | 1,057
spina bifida 950 | 1,074
dermatomyositis 926 | 966
nasopharyngeal carcinoma 913 | 1,058
active Crohn's disease 829 | 922
Atopic dermatitis 826 | 952
non primary Sjogren syndrome sicca 798 | 891
Epilepsy 779 | 792
Waldenstrons macroglobulinemia 745 | 765
acute myeloid leukemia 720 | 783
gastric carcinoma 705 | 807
Liver Cirrhosis, Experimental 704 | 769
active ulcerative colitis 690 | 764
esophageal adenocarcinoma 682 | 737
primary Sjogren syndrome 670 | 735
Obesity 649 | 678
Melanoma 637 | 711
Dull intelligence 635 | 645
Low intelligence 635 | 645
Mental Retardation 635 | 645
Mental deficiency 635 | 645
Poor school performance 635 | 645
Bipolar Disorder 625 | 666
progressive supranuclear palsy 615 | 676
Alzheimer's disease 614 | 658
medulloblastoma 611 | 720
aldosterone-producing adenoma 608 | 665
Cognitive delay 600 | 608
Global developmental delay 600 | 608
Mental and motor retardation 600 | 608
Seizures 590 | 596
Muscle hypotonia 562 | 571
Liver cancer 544 | 604
Duchenne muscular dystrophy 539 | 601
Short stature 513 | 531
pancreatic carcinoma 511 | 562
Multiple Sclerosis 496 | 540
hepatocellular carcinoma 493 | 547
Endometriosis 491 | 540
fibroadenoma 472 | 559
Prostatic Neoplasms 471 | 495
Down syndrome 468 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 458 | 510
mucosa-associated lymphoid tissue lymphoma 441 | 484
Amyotrophic lateral sclerosis 428 | 451
Breast Neoplasms 423 | 445
chronic rhinosinusitis 423 | 512
Skin cancer 416 | 469
Kidney disease 411 | 430

Tissue

Endocrine System 15,263 | 18,159
Digestive Tract 14,780 | 17,369
Female tissues 14,769 | 17,400
Skin and soft tissues 14,693 | 17,230
Male tissues 14,592 | 17,142
Blood and immune system 14,429 | 16,909
Nervous System 14,354 | 16,725
Liver and Pancreas 14,330 | 16,750
Urinary Tract 14,298 | 16,678
Respiratory system 14,046 | 16,393
Cardiovascular System 13,202 | 15,192

Target Family

Non-IDG 8,659 | 12,091
Enzyme 3,658 | 4,145
Transcription Factor 1,386 | 1,400
Kinase 614 | 634
Transporter 446 | 473
GPCR 392 | 408
oGPCR 380 | 421
Ion Channel 331 | 344
Epigenetic 227 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Compartment GO Term

Cell part 16,177 | 16,177
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115