Development Level

Tbio 261 | 11,651
Tchem 34 | 1,388
Tclin 16 | 612
Tdark 15 | 6,593

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 10 | 298
abnormal bone structure 8 | 187
abnormal embryo size 8 | 220
decreased body weight 8 | 161
decreased circulating choleste... 7 | 93
abnormal retina morphology 6 | 71
increased circulating alkaline... 6 | 122
increased lean body mass 6 | 172
increased startle reflex 6 | 112
abnormal eye morphology 5 | 68
decreased circulating HDL chol... 5 | 68
decreased circulating serum al... 5 | 82
decreased circulating triglyce... 5 | 79
decreased total body fat amoun... 5 | 207
edema 5 | 59
embryonic growth retardation 5 | 106
embryonic lethality prior to t... 5 | 278
hyperactivity 5 | 148
increased heart weight 5 | 62
abnormal coat-hair pigmentatio... 4 | 64
decreased bone mineral content 4 | 151
decreased caudal vertebrae num... 4 | 53
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased vertical activity 4 | 208
hypoactivity 4 | 132
increased body weight 4 | 25
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
abnormal bone mineralization 3 | 38
abnormal placenta size 3 | 20
abnormal sleep behavior 3 | 70
cardiovascular system phenotyp... 3 | 36
decreased T cell number 3 | 15
decreased bone mineral density 3 | 126
decreased circulating iron lev... 3 | 32
decreased circulating total pr... 3 | 49
decreased grip strength 3 | 116
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased circulating calcium ... 3 | 34
increased total body fat amoun... 3 | 134
increased vertical activity 3 | 24
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal cornea morphology 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal hindbrain morphology 2 | 10
abnormal midbrain morphology 2 | 10
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal skin morphology 2 | 50
abnormal stomach morphology 2 | 10
abnormal urinary bladder morph... 2 | 11
abnormal vibrissa morphology 2 | 25
decreased circulating creatini... 2 | 39
decreased circulating potassiu... 2 | 20
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased threshold for audito... 2 | 26
impaired pupillary reflex 2 | 26
increased bone mineral density 2 | 72
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased heart rate variabili... 2 | 7
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
convulsive seizures 1 | 13
decreased IgG1 level 1 | 8
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
increased body length 1 | 32
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
small thymus 1 | 16
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 255 | 11,493
ovarian cancer 203 | 8,520
osteosarcoma 179 | 7,950
medulloblastoma, large-cell 162 | 6,241
glioblastoma 158 | 5,792
psoriasis 148 | 6,694
atypical teratoid / rhabdoid tumor 124 | 5,112
ependymoma 120 | 4,679
lung cancer 112 | 4,740
Breast cancer 110 | 3,578
adult high grade glioma 103 | 3,801
Cancer 97 | 2,499
Astrocytoma, Pilocytic 96 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 94 | 2,955
invasive ductal carcinoma 91 | 2,951
group 3 medulloblastoma 87 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 87 | 2,989
Kidney cancer 86 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 85 | 3,291
lung carcinoma 85 | 2,843
pancreatic cancer 85 | 2,398
malignant mesothelioma 84 | 3,232
oligodendroglioma 82 | 2,850
non-small cell lung cancer 80 | 2,890
lung adenocarcinoma 79 | 2,716
subependymal giant cell astrocytoma 73 | 2,287
interstitial cystitis 71 | 2,312
astrocytic glioma 67 | 2,597
primitive neuroectodermal tumor 60 | 3,035
ulcerative colitis 59 | 1,819
tuberculosis 57 | 2,010
breast carcinoma 56 | 1,638
group 4 medulloblastoma 55 | 1,855
Pick disease 53 | 1,894
ductal carcinoma in situ 52 | 1,745
pituitary cancer 52 | 1,972
cystic fibrosis 51 | 1,696
colon cancer 49 | 1,478
primary pancreatic ductal adenocarcinoma 44 | 1,109
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,962
juvenile dermatomyositis 42 | 1,187
adrenocortical carcinoma 39 | 1,428
diabetes mellitus 39 | 1,728
spina bifida 39 | 1,074
acute quadriplegic myopathy 38 | 1,158
astrocytoma 38 | 1,146
Liver Cirrhosis, Experimental 34 | 769
Intellectual disability 33 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 33 | 510
Autosomal recessive predisposition 32 | 1,442
gastric carcinoma 32 | 807
cutaneous lupus erythematosus 29 | 1,057
pediatric high grade glioma 29 | 1,064
Duchenne muscular dystrophy 28 | 601
dermatomyositis 28 | 966
Liver cancer 27 | 604
Down syndrome 25 | 499
Kidney disease 25 | 430
Multiple myeloma 25 | 1,332
Schizophrenia 25 | 1,160
Alzheimer's disease 24 | 658
Waldenstrons macroglobulinemia 24 | 765
Rheumatoid arthritis 23 | 1,191
esophageal adenocarcinoma 23 | 737
Melanoma 22 | 711
aldosterone-producing adenoma 22 | 665
medulloblastoma 21 | 720
pancreatic carcinoma 21 | 562
mucosa-associated lymphoid tissue lymphoma 20 | 484
primary Sjogren syndrome 20 | 735
Atopic dermatitis 19 | 952
Bipolar Disorder 19 | 666
Neoplasm Invasiveness 19 | 161
nasopharyngeal carcinoma 19 | 1,058
progressive supranuclear palsy 19 | 676
Amyotrophic lateral sclerosis 18 | 451
non primary Sjogren syndrome sicca 18 | 891
Breast Neoplasms 17 | 445
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Neurodegenerative disease 17 | 414
Obesity 17 | 678
Poor school performance 17 | 645
active Crohn's disease 17 | 922
active ulcerative colitis 17 | 764
acute myeloid leukemia 17 | 783
Multiple Sclerosis 16 | 540
Skin cancer 16 | 469
sonic hedgehog group medulloblastoma 16 | 467
Epilepsy 15 | 792
Mammary Neoplasms 14 | 425
Muscle hypotonia 14 | 571
Neoplasm Metastasis 14 | 168
Osteoporosis 14 | 363
Polycystic ovary syndrome 14 | 360
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608

Tissue

Endocrine System 317 | 18,159
Digestive Tract 316 | 17,369
Blood and immune system 315 | 16,909
Female tissues 315 | 17,400
Liver and Pancreas 315 | 16,750
Male tissues 315 | 17,142
Urinary Tract 315 | 16,678
Skin and soft tissues 314 | 17,230
Nervous System 313 | 16,725
Respiratory system 312 | 16,393
Cardiovascular System 304 | 15,192

Target Family

Non-IDG 225 | 12,091
Enzyme 53 | 4,145
Kinase 31 | 634
Ion Channel 8 | 344
Transporter 5 | 473
GPCR 3 | 408
Epigenetic 1 | 242

Compartment GO Term

Cell leading edge 326 | 326
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088