Development Level

Tbio 233 | 10,625
Tchem 41 | 1,890
Tclin 15 | 602
Tdark 14 | 7,003

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 8 | 260
abnormal bone mineralization 7 | 55
abnormal bone structure 7 | 131
increased or absent threshold ... 7 | 128
abnormal behavior 6 | 226
decreased circulating choleste... 6 | 85
decreased total body fat amoun... 6 | 186
decreased circulating insulin ... 5 | 75
increased heart weight 5 | 37
abnormal embryo size 4 | 112
abnormal retina morphology 4 | 100
decreased body weight 4 | 174
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating triglyce... 4 | 83
decreased lean body mass 4 | 195
increased circulating alkaline... 4 | 119
decreased T cell number 3 | 31
decreased bone mineral content 3 | 157
decreased circulating alanine ... 3 | 53
decreased circulating glucose ... 3 | 121
decreased circulating iron lev... 3 | 25
embryonic lethality prior to t... 3 | 187
increased body weight 3 | 42
increased lean body mass 3 | 107
prenatal lethality prior to he... 3 | 64
abnormal coat/hair pigmentatio... 2 | 54
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal placenta size 2 | 10
abnormal respiratory quotient 2 | 9
abnormal retinal pigmentation 2 | 61
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal vibrissa morphology 2 | 17
cardiovascular system phenotyp... 2 | 35
decreased circulating potassiu... 2 | 17
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased grip strength 2 | 123
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
hyperactivity 2 | 108
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating free fat... 2 | 17
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
increased vertical activity 2 | 18
shortened ST segment 2 | 9
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal spleen morphology 1 | 36
abnormal vertebrae morphology 1 | 14
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 14
convulsive seizures 1 | 11
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased IgG1 level 1 | 4
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased vertical activity 1 | 22
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased blood urea nitrogen ... 1 | 44
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
shortened PQ interval 1 | 6
small thymus 1 | 11
tremors 1 | 34

Disease

ovarian cancer 187 | 8,484
osteosarcoma 164 | 7,933
medulloblastoma, large-cell 151 | 6,234
glioblastoma 145 | 5,572
psoriasis 135 | 6,685
atypical teratoid / rhabdoid tumor 102 | 4,369
lung cancer 98 | 4,466
pilocytic astrocytoma 91 | 3,086
Breast cancer 90 | 3,094
invasive ductal carcinoma 87 | 2,950
Cancer 86 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 85 | 2,956
lung carcinoma 81 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,988
pancreatic cancer 80 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 78 | 3,289
Carcinoma 77 | 2,147
oligodendroglioma 77 | 2,849
lung adenocarcinoma 75 | 2,713
pediatric high grade glioma 74 | 2,712
malignant mesothelioma 73 | 3,162
non-small cell lung cancer 70 | 2,798
interstitial cystitis 67 | 2,299
subependymal giant cell astrocytoma 65 | 2,287
ulcerative colitis 60 | 2,087
ependymoma 59 | 2,514
primitive neuroectodermal tumor 57 | 3,031
Pick disease 52 | 1,893
astrocytic glioma 52 | 2,241
breast carcinoma 51 | 1,614
group 4 medulloblastoma 51 | 1,875
cystic fibrosis 50 | 1,665
ductal carcinoma in situ 50 | 1,745
tuberculosis 50 | 1,557
adult high grade glioma 49 | 2,148
primary pancreatic ductal adenocarcinoma 49 | 1,271
pituitary cancer 47 | 1,972
colon cancer 46 | 1,475
astrocytoma 45 | 1,493
group 3 medulloblastoma 42 | 2,254
medulloblastoma 40 | 1,524
juvenile dermatomyositis 39 | 1,189
posterior fossa group A ependymoma 39 | 1,511
adrenocortical carcinoma 37 | 1,427
sonic hedgehog group medulloblastoma 37 | 1,482
acute quadriplegic myopathy 36 | 1,157
diabetes mellitus 36 | 1,663
spina bifida 36 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
posterior fossa group B ependymoma 33 | 1,530
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
gastric carcinoma 28 | 832
Duchenne muscular dystrophy 26 | 602
Alzheimer's disease 25 | 644
dermatomyositis 25 | 933
cutaneous lupus erythematosus 24 | 1,056
Down syndrome 23 | 548
atypical teratoid/rhabdoid tumor 23 | 1,095
Kidney disease 22 | 396
Multiple myeloma 22 | 1,327
Rheumatoid Arthritis 22 | 1,160
Waldenstrons macroglobulinemia 21 | 765
pancreatic carcinoma 21 | 567
Intellectual disability 19 | 573
aldosterone-producing adenoma 19 | 664
esophageal adenocarcinoma 19 | 737
mucosa-associated lymphoid tissue lymphoma 19 | 480
nasopharyngeal carcinoma 19 | 1,056
Atopic dermatitis 18 | 944
progressive supranuclear palsy 18 | 674
acute myeloid leukemia 17 | 780
primary Sjogren syndrome 17 | 789
Multiple Sclerosis 16 | 498
active Crohn's disease 16 | 918
non primary Sjogren syndrome sicca 16 | 840
Neurodegenerative disease 15 | 383
Amyotrophic Lateral Sclerosis 14 | 431
IGA Glomerulonephritis 14 | 454
Neoplasm Invasiveness 14 | 127
Neuropathy 13 | 210
fibroadenoma 13 | 557
hepatocellular carcinoma 13 | 532
Mammary Neoplasms 12 | 410
Obesity 12 | 616
Prostatic Neoplasms 12 | 471
non-small cell lung carcinoma 12 | 413
Autistic Disorder 11 | 320
Chronic Lymphocytic Leukemia 11 | 242
Neoplasm Metastasis 11 | 138
gastric cancer 11 | 430
tuberculosis and treatment for 6 months 11 | 686
Asthma 10 | 349
Epilepsy 10 | 346
Liver carcinoma 10 | 217
Melanoma 10 | 261
Parkinson's disease 10 | 364
Stomach Neoplasms 10 | 282
active ulcerative colitis 10 | 477
hereditary spastic paraplegia 10 | 313
Schizophrenia 9 | 501

Tissue

Blood and immune system 299 | 17,995
Digestive Tract 299 | 18,473
Endocrine System 299 | 18,512
Female tissues 299 | 18,647
Liver and Pancreas 299 | 18,136
Nervous System 299 | 18,561
Urinary Tract 299 | 18,444
Cardiovascular System 298 | 17,958
Male tissues 297 | 17,969
Respiratory system 297 | 17,484
Skin and soft tissues 295 | 18,115

Target Family

Non-IDG 204 | 11,971
Enzyme 53 | 4,146
Kinase 29 | 634
Ion Channel 8 | 341
Transporter 5 | 473
GPCR 3 | 406
Epigenetic 1 | 242

Compartment GO Term

Cell leading edge 303 | 303
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Protein KIBRA WWC1 Tbio Non-IDG -1.88892 84.4 96
C2 domain-containing protein 5 C2CD5 Tbio Non-IDG 0.27 0.49 34
Stathmin-2 STMN2 Tbio Non-IDG -1.95188 90.0 305
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.41770 25.0 106