Development Level

Tbio 941 | 10,625
Tchem 177 | 1,890
Tclin 94 | 602
Tdark 89 | 7,003

Collection

Eligible Ion Channel Proteins 26 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 58 | 633
preweaning lethality, incomple... 30 | 260
decreased total body fat amoun... 22 | 186
decreased body weight 21 | 174
abnormal behavior 20 | 226
decreased lean body mass 18 | 195
embryonic lethality prior to t... 18 | 187
decreased circulating choleste... 16 | 85
decreased bone mineral content 15 | 157
increased lean body mass 15 | 107
abnormal retina morphology 14 | 100
decreased circulating HDL chol... 14 | 77
increased or absent threshold ... 14 | 128
decreased grip strength 13 | 123
enlarged heart 12 | 111
abnormal embryo size 11 | 112
abnormal bone structure 10 | 131
abnormal sleep behavior 9 | 63
decreased bone mineral density 9 | 126
decreased circulating insulin ... 9 | 75
embryonic lethality prior to o... 9 | 148
decreased circulating alanine ... 8 | 53
decreased circulating glucose ... 8 | 121
decreased mean corpuscular vol... 8 | 50
hyperactivity 8 | 108
hypoactivity 8 | 89
improved glucose tolerance 8 | 56
increased circulating alkaline... 8 | 119
increased mean corpuscular vol... 8 | 91
decreased fasted circulating g... 7 | 49
increased blood urea nitrogen ... 7 | 44
increased body weight 7 | 42
increased bone mineral content 7 | 92
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
increased mean corpuscular hem... 7 | 93
short tibia 7 | 82
shortened RR interval 7 | 19
tremors 7 | 34
abnormal retinal pigmentation 6 | 61
abnormal skin morphology 6 | 23
decreased circulating triglyce... 6 | 83
decreased startle reflex 6 | 48
increased bone mineral density 6 | 52
increased circulating HDL chol... 6 | 63
increased circulating chloride... 6 | 43
increased circulating sodium l... 6 | 71
increased total body fat amoun... 6 | 57
abnormal gait 5 | 51
abnormal pericardium morpholog... 5 | 11
cardiovascular system phenotyp... 5 | 35
decreased body length 5 | 108
decreased circulating free fat... 5 | 39
decreased circulating serum al... 5 | 79
decreased eosinophil cell numb... 5 | 41
decreased mean corpuscular hem... 5 | 34
impaired glucose tolerance 5 | 52
increased fasted circulating g... 5 | 68
increased vertical activity 5 | 18
abnormal bone mineralization 4 | 55
abnormal coat/hair pigmentatio... 4 | 54
abnormal cornea morphology 4 | 24
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
decreased threshold for audito... 4 | 32
decreased vertical activity 4 | 22
increased circulating phosphat... 4 | 24
increased heart rate 4 | 17
increased hematocrit 4 | 36
increased leukocyte cell numbe... 4 | 37
increased startle reflex 4 | 38
male infertility 4 | 62
abnormal behavioral response t... 3 | 52
abnormal coat appearance 3 | 25
abnormal head morphology 3 | 10
abnormal heart left ventricle ... 3 | 20
abnormal locomotor activation 3 | 26
decreased circulating calcium ... 3 | 33
decreased circulating chloride... 3 | 32
decreased circulating iron lev... 3 | 25
decreased heart weight 3 | 44
decreased rib number 3 | 59
hydrops fetalis 3 | 22
increased body length 3 | 20
increased circulating calcium ... 3 | 32
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased heart weight 3 | 37
limb grasping 3 | 35
persistence of hyaloid vascula... 3 | 22
prenatal lethality prior to he... 3 | 64
small thymus 3 | 11
straub tail 3 | 26
thrombocytopenia 3 | 46

Disease

ovarian cancer 719 | 8,484
medulloblastoma, large-cell 615 | 6,234
osteosarcoma 614 | 7,933
glioblastoma 604 | 5,572
psoriasis 550 | 6,685
atypical teratoid / rhabdoid tumor 484 | 4,369
lung cancer 395 | 4,466
pilocytic astrocytoma 377 | 3,086
pediatric high grade glioma 343 | 2,712
oligodendroglioma 336 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 334 | 3,289
primitive neuroectodermal tumor 332 | 3,031
Cancer 304 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 304 | 2,988
invasive ductal carcinoma 300 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 299 | 2,956
lung carcinoma 292 | 2,844
Breast cancer 290 | 3,094
non-small cell lung cancer 289 | 2,798
lung adenocarcinoma 288 | 2,713
malignant mesothelioma 285 | 3,162
Carcinoma 281 | 2,147
pancreatic cancer 278 | 2,300
ependymoma 277 | 2,514
subependymal giant cell astrocytoma 253 | 2,287
interstitial cystitis 232 | 2,299
astrocytic glioma 220 | 2,241
astrocytoma 212 | 1,493
Pick disease 205 | 1,893
group 4 medulloblastoma 195 | 1,875
adult high grade glioma 191 | 2,148
primary pancreatic ductal adenocarcinoma 188 | 1,271
ulcerative colitis 188 | 2,087
pituitary cancer 183 | 1,972
ductal carcinoma in situ 182 | 1,745
cystic fibrosis 179 | 1,665
medulloblastoma 176 | 1,524
breast carcinoma 173 | 1,614
posterior fossa group A ependymoma 170 | 1,511
diabetes mellitus 152 | 1,663
sonic hedgehog group medulloblastoma 152 | 1,482
tuberculosis 150 | 1,557
colon cancer 149 | 1,475
Multiple myeloma 143 | 1,327
acute quadriplegic myopathy 143 | 1,157
juvenile dermatomyositis 141 | 1,189
group 3 medulloblastoma 140 | 2,254
spina bifida 139 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 135 | 1,795
dermatomyositis 126 | 933
posterior fossa group B ependymoma 120 | 1,530
Rheumatoid Arthritis 116 | 1,160
adrenocortical carcinoma 115 | 1,427
esophageal adenocarcinoma 102 | 737
Waldenstrons macroglobulinemia 101 | 765
gastric carcinoma 100 | 832
Alzheimer's disease 98 | 644
atypical teratoid/rhabdoid tumor 95 | 1,095
Schizophrenia 92 | 501
Duchenne muscular dystrophy 91 | 602
Down syndrome 86 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 84 | 499
cutaneous lupus erythematosus 80 | 1,056
nasopharyngeal carcinoma 76 | 1,056
active Crohn's disease 73 | 918
Epilepsy 71 | 346
Intellectual disability 69 | 573
Prostatic Neoplasms 69 | 471
Parkinson's disease 65 | 364
Atopic dermatitis 64 | 944
Autistic Disorder 64 | 320
Mammary Neoplasms 64 | 410
progressive supranuclear palsy 63 | 674
acute myeloid leukemia 62 | 780
aldosterone-producing adenoma 62 | 664
non primary Sjogren syndrome sicca 62 | 840
Amyotrophic Lateral Sclerosis 59 | 431
mucosa-associated lymphoid tissue lymphoma 59 | 480
primary Sjogren syndrome 59 | 789
Kidney disease 58 | 396
fibroadenoma 58 | 557
Obesity 55 | 616
Multiple Sclerosis 54 | 498
Neurodegenerative disease 53 | 383
Vascular disease 49 | 281
active ulcerative colitis 48 | 477
pancreatic carcinoma 48 | 567
interstitial lung disease 47 | 291
hereditary spastic paraplegia 45 | 313
non-small cell lung carcinoma 45 | 413
IGA Glomerulonephritis 44 | 454
Osteoporosis 44 | 257
Stomach Neoplasms 44 | 282
tuberculosis and treatment for 6 months 44 | 686
Endometriosis 43 | 535
Heart disease 43 | 279
Hypertension 43 | 287
Neuropathy 43 | 210
Neoplasm Metastasis 41 | 138
Cerebrovascular disease 40 | 231

Tissue

Female tissues 1,283 | 18,647
Digestive Tract 1,282 | 18,473
Endocrine System 1,281 | 18,512
Liver and Pancreas 1,280 | 18,136
Nervous System 1,280 | 18,561
Urinary Tract 1,277 | 18,444
Blood and immune system 1,275 | 17,995
Cardiovascular System 1,273 | 17,958
Skin and soft tissues 1,271 | 18,115
Male tissues 1,270 | 17,969
Respiratory system 1,266 | 17,484

Target Family

Non-IDG 904 | 11,971
Enzyme 185 | 4,146
Ion Channel 84 | 341
Kinase 71 | 634
GPCR 21 | 406
Transporter 17 | 473
Transcription Factor 13 | 1,400
Epigenetic 6 | 242

Compartment GO Term

Cell junction 1,301 | 1,301
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Keratin, type II cytoskeletal 74 KRT74 Tbio Non-IDG -2.22050 159.7 35