Development Level

Tbio 941 | 10,625
Tchem 177 | 1,890
Tclin 94 | 602
Tdark 89 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 18 | 102
Kinase: IDG Consortium (Targets) 7 | 125
Kinase: IDG Consortium (Complete/Control) 5 | 37
GPCR: IDG Consortium (Complete/Control) 3 | 24
GPCR: IDG Consortium (Targets) 3 | 128

IMPC Phenotype

preweaning lethality, complete... 58 | 633
preweaning lethality, incomple... 30 | 260
decreased total body fat amoun... 22 | 186
decreased body weight 21 | 174
abnormal behavior 20 | 226
decreased lean body mass 18 | 195
embryonic lethality prior to t... 18 | 187
decreased circulating choleste... 16 | 85
decreased bone mineral content 15 | 157
increased lean body mass 15 | 107
abnormal retina morphology 14 | 100
decreased circulating HDL chol... 14 | 77
increased or absent threshold ... 14 | 128
decreased grip strength 13 | 123
enlarged heart 12 | 111
abnormal embryo size 11 | 112
abnormal bone structure 10 | 131
abnormal sleep behavior 9 | 63
decreased bone mineral density 9 | 126
decreased circulating insulin ... 9 | 75
embryonic lethality prior to o... 9 | 148
decreased circulating alanine ... 8 | 53
decreased circulating glucose ... 8 | 121
decreased mean corpuscular vol... 8 | 50
hyperactivity 8 | 108
hypoactivity 8 | 89
improved glucose tolerance 8 | 56
increased circulating alkaline... 8 | 119
increased mean corpuscular vol... 8 | 91
decreased fasted circulating g... 7 | 49
increased blood urea nitrogen ... 7 | 44
increased body weight 7 | 42
increased bone mineral content 7 | 92
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
increased mean corpuscular hem... 7 | 93
short tibia 7 | 82
shortened RR interval 7 | 19
tremors 7 | 34
abnormal retinal pigmentation 6 | 61
abnormal skin morphology 6 | 23
decreased circulating triglyce... 6 | 83
decreased startle reflex 6 | 48
increased bone mineral density 6 | 52
increased circulating HDL chol... 6 | 63
increased circulating chloride... 6 | 43
increased circulating sodium l... 6 | 71
increased total body fat amoun... 6 | 57
abnormal gait 5 | 51
abnormal pericardium morpholog... 5 | 11
cardiovascular system phenotyp... 5 | 35
decreased body length 5 | 108
decreased circulating free fat... 5 | 39
decreased circulating serum al... 5 | 79
decreased eosinophil cell numb... 5 | 41
decreased mean corpuscular hem... 5 | 34
impaired glucose tolerance 5 | 52
increased fasted circulating g... 5 | 68
increased vertical activity 5 | 18
abnormal bone mineralization 4 | 55
abnormal coat-hair pigmentatio... 4 | 54
abnormal cornea morphology 4 | 24
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
decreased threshold for audito... 4 | 32
decreased vertical activity 4 | 22
increased circulating phosphat... 4 | 24
increased heart rate 4 | 17
increased hematocrit 4 | 36
increased leukocyte cell numbe... 4 | 37
increased startle reflex 4 | 38
male infertility 4 | 62
abnormal behavioral response t... 3 | 52
abnormal coat appearance 3 | 25
abnormal head morphology 3 | 10
abnormal heart left ventricle ... 3 | 20
abnormal locomotor activation 3 | 26
decreased circulating calcium ... 3 | 33
decreased circulating chloride... 3 | 32
decreased circulating iron lev... 3 | 25
decreased heart weight 3 | 44
decreased rib number 3 | 59
hydrops fetalis 3 | 22
increased body length 3 | 20
increased circulating calcium ... 3 | 32
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased heart weight 3 | 37
limb grasping 3 | 35
persistence of hyaloid vascula... 3 | 22
prenatal lethality prior to he... 3 | 64
small thymus 3 | 11
straub tail 3 | 26
thrombocytopenia 3 | 46

Disease

ovarian cancer 719 | 8,491
medulloblastoma, large-cell 615 | 6,234
osteosarcoma 614 | 7,933
glioblastoma 604 | 5,572
psoriasis 550 | 6,685
atypical teratoid / rhabdoid tumor 484 | 4,369
lung cancer 395 | 4,473
pilocytic astrocytoma 377 | 3,086
pediatric high grade glioma 343 | 2,712
oligodendroglioma 336 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 334 | 3,289
primitive neuroectodermal tumor 332 | 3,031
Cancer 304 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 304 | 2,988
invasive ductal carcinoma 300 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 299 | 2,956
lung carcinoma 292 | 2,844
Breast cancer 290 | 3,098
non-small cell lung cancer 289 | 2,798
lung adenocarcinoma 288 | 2,714
malignant mesothelioma 285 | 3,163
Carcinoma 281 | 2,147
pancreatic cancer 278 | 2,300
ependymoma 277 | 2,514
subependymal giant cell astrocytoma 253 | 2,287
interstitial cystitis 232 | 2,299
astrocytic glioma 220 | 2,241
astrocytoma 212 | 1,493
Pick disease 205 | 1,893
group 4 medulloblastoma 195 | 1,875
adult high grade glioma 191 | 2,148
primary pancreatic ductal adenocarcinoma 188 | 1,271
ulcerative colitis 188 | 2,087
pituitary cancer 183 | 1,972
ductal carcinoma in situ 182 | 1,745
cystic fibrosis 180 | 1,670
medulloblastoma 176 | 1,524
breast carcinoma 173 | 1,614
posterior fossa group A ependymoma 170 | 1,511
diabetes mellitus 152 | 1,663
sonic hedgehog group medulloblastoma 152 | 1,482
tuberculosis 151 | 1,563
colon cancer 149 | 1,475
Multiple myeloma 143 | 1,327
acute quadriplegic myopathy 143 | 1,157
juvenile dermatomyositis 141 | 1,189
group 3 medulloblastoma 140 | 2,254
spina bifida 139 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 135 | 1,795
dermatomyositis 126 | 966
posterior fossa group B ependymoma 120 | 1,530
Rheumatoid Arthritis 116 | 1,170
adrenocortical carcinoma 115 | 1,427
esophageal adenocarcinoma 102 | 737
Waldenstrons macroglobulinemia 101 | 764
gastric carcinoma 100 | 832
Alzheimer's disease 98 | 644
atypical teratoid/rhabdoid tumor 95 | 1,095
Schizophrenia 92 | 503
Duchenne muscular dystrophy 91 | 602
Down syndrome 86 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 84 | 499
cutaneous lupus erythematosus 80 | 1,056
nasopharyngeal carcinoma 76 | 1,056
active Crohn's disease 73 | 918
Epilepsy 71 | 346
Intellectual disability 69 | 573
Prostatic Neoplasms 69 | 471
Parkinson's disease 65 | 364
Atopic dermatitis 64 | 944
Autistic Disorder 64 | 320
Mammary Neoplasms 64 | 410
progressive supranuclear palsy 63 | 674
acute myeloid leukemia 62 | 785
aldosterone-producing adenoma 62 | 664
non primary Sjogren syndrome sicca 62 | 840
Amyotrophic Lateral Sclerosis 59 | 432
Kidney disease 59 | 397
mucosa-associated lymphoid tissue lymphoma 59 | 480
primary Sjogren syndrome 59 | 788
fibroadenoma 58 | 557
Obesity 55 | 616
Multiple Sclerosis 54 | 498
Neurodegenerative disease 53 | 383
Vascular disease 49 | 281
active ulcerative colitis 48 | 477
pancreatic carcinoma 48 | 567
interstitial lung disease 47 | 292
hereditary spastic paraplegia 45 | 313
non-small cell lung carcinoma 45 | 413
IGA Glomerulonephritis 44 | 454
Osteoporosis 44 | 259
Stomach Neoplasms 44 | 282
tuberculosis and treatment for 6 months 44 | 686
Endometriosis 43 | 535
Heart disease 43 | 279
Hypertension 43 | 293
Neuropathy 43 | 210
Neoplasm Metastasis 41 | 138
Cerebrovascular disease 40 | 231

Tissue

Female tissues 1,283 | 18,646
Digestive Tract 1,282 | 18,472
Endocrine System 1,281 | 18,511
Liver and Pancreas 1,280 | 18,135
Nervous System 1,280 | 18,560
Urinary Tract 1,277 | 18,443
Blood and immune system 1,275 | 17,994
Cardiovascular System 1,273 | 17,957
Skin and soft tissues 1,271 | 18,114
Male tissues 1,270 | 17,968
Respiratory system 1,266 | 17,483

Target Family

Non-IDG 904 | 11,969
Enzyme 185 | 4,146
Ion Channel 84 | 341
Kinase 71 | 634
GPCR 21 | 408
Transporter 17 | 473
Transcription Factor 13 | 1,400
Epigenetic 6 | 242

Compartment GO Term

Cell junction 1,301 | 1,301
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
T-cell surface protein tactile CD96 Tbio Non-IDG -2.03517 108.7 142
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
Tyrosine-protein kinase Fer FER Tchem Kinase -1.84299 53.1 358
Small cell adhesion glycoprotein SMAGP Tdark Non-IDG 0.00000 1.85 72
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67051 512.2 639
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.52802 34.3 167
A-kinase anchor protein 12 AKAP12 Tbio Enzyme -1.97288 119.1 151
Protein phosphatase methylesterase 1 PPME1 Tchem Enzyme -1.49604 33.2 153