Development Level

Tbio 706 | 11,651
Tclin 88 | 612
Tchem 87 | 1,388
Tdark 79 | 6,593

Collection

RFA-RM-18-021 22 | 328
Ion Channel: IDG Consortium (T... 18 | 99
Kinase: IDG Consortium (Comple... 5 | 37
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

preweaning lethality, complete... 65 | 979
preweaning lethality, incomple... 34 | 499
abnormal behavior 19 | 298
embryonic lethality prior to t... 19 | 278
decreased total body fat amoun... 17 | 207
decreased vertical activity 16 | 208
decreased body weight 14 | 161
abnormal embryo size 13 | 220
abnormal retina morphology 13 | 71
increased total body fat amoun... 13 | 134
enlarged heart 12 | 210
decreased bone mineral content 11 | 151
embryonic lethality prior to o... 11 | 239
hyperactivity 11 | 148
increased lean body mass 11 | 172
abnormal heart morphology 10 | 162
decreased grip strength 10 | 116
decreased lean body mass 10 | 135
hypoactivity 10 | 132
abnormal bone structure 9 | 187
decreased circulating choleste... 9 | 93
decreased lymphocyte cell numb... 9 | 83
decreased startle reflex 9 | 75
increased circulating alkaline... 9 | 122
increased or absent threshold ... 9 | 101
abnormal sleep behavior 8 | 70
decreased fasted circulating g... 8 | 65
edema 8 | 59
embryonic growth retardation 8 | 106
increased mean corpuscular vol... 8 | 92
increased startle reflex 8 | 112
abnormal skin morphology 7 | 50
decreased circulating HDL chol... 7 | 68
improved glucose tolerance 7 | 79
short tibia 7 | 97
tremors 7 | 39
abnormal testis morphology 6 | 43
decreased body length 6 | 101
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 126
increased heart weight 6 | 62
small testis 6 | 58
abnormal behavioral response t... 5 | 66
abnormal cornea morphology 5 | 31
abnormal gait 5 | 69
abnormal pericardium morpholog... 5 | 26
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
increased blood urea nitrogen ... 5 | 48
increased body weight 5 | 25
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased circulating chloride... 5 | 41
persistence of hyaloid vascula... 5 | 33
prenatal lethality prior to he... 5 | 87
small superior vagus ganglion 5 | 74
abnormal eye morphology 4 | 68
abnormal locomotor behavior 4 | 24
abnormal retinal vasculature m... 4 | 27
abnormal seminal vesicle morph... 4 | 114
abnormal spleen morphology 4 | 55
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular vol... 4 | 79
hemorrhage 4 | 23
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
increased circulating choleste... 4 | 66
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 76
increased grip strength 4 | 41
increased mean corpuscular hem... 4 | 96
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
limb grasping 4 | 41
male infertility 4 | 123
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
abnormal epididymis morphology 3 | 42
abnormal joint morphology 3 | 23
abnormal kidney morphology 3 | 65
abnormal liver morphology 3 | 17
abnormal neural tube closure 3 | 46
brachydactyly 3 | 19
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating phosphat... 3 | 27
decreased circulating triglyce... 3 | 79
decreased eosinophil cell numb... 3 | 24
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased circulating iron lev... 3 | 30
increased circulating triglyce... 3 | 42
increased mean corpuscular hem... 3 | 36
increased vertical activity 3 | 24
pale yolk sac 3 | 25
prenatal lethality 3 | 28
small thymus 3 | 16
syndactyly 3 | 23

Disease

Carcinoma 711 | 11,493
ovarian cancer 484 | 8,520
glioblastoma 472 | 5,792
medulloblastoma, large-cell 470 | 6,241
osteosarcoma 447 | 7,950
atypical teratoid / rhabdoid tumor 423 | 5,112
psoriasis 409 | 6,694
ependymoma 391 | 4,679
adult high grade glioma 341 | 3,801
Astrocytoma, Pilocytic 301 | 3,081
group 3 medulloblastoma 301 | 4,104
lung cancer 283 | 4,740
primitive neuroectodermal tumor 268 | 3,035
oligodendroglioma 261 | 2,850
Breast cancer 249 | 3,578
Kidney cancer 247 | 2,613
lung carcinoma 237 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 231 | 3,291
astrocytic glioma 230 | 2,597
non-small cell lung cancer 229 | 2,890
invasive ductal carcinoma 221 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 220 | 2,989
Cancer 219 | 2,499
malignant mesothelioma 216 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 213 | 2,955
subependymal giant cell astrocytoma 209 | 2,287
pancreatic cancer 197 | 2,398
interstitial cystitis 195 | 2,312
lung adenocarcinoma 190 | 2,716
Schizophrenia 167 | 1,160
Pick disease 163 | 1,894
pituitary cancer 160 | 1,972
ductal carcinoma in situ 142 | 1,745
breast carcinoma 136 | 1,638
cystic fibrosis 135 | 1,696
ulcerative colitis 126 | 1,819
group 4 medulloblastoma 119 | 1,855
tuberculosis 117 | 2,010
colon cancer 111 | 1,478
spina bifida 109 | 1,074
primary pancreatic ductal adenocarcinoma 105 | 1,109
pancreatic ductal adenocarcinoma liver metastasis 100 | 1,962
diabetes mellitus 98 | 1,728
Bipolar Disorder 96 | 666
Autosomal recessive predisposition 94 | 1,442
Intellectual disability 93 | 1,016
adrenocortical carcinoma 89 | 1,428
Epilepsy 88 | 792
astrocytoma 84 | 1,146
Liver cancer 81 | 604
esophageal adenocarcinoma 78 | 737
Melanoma 77 | 711
pediatric high grade glioma 76 | 1,064
Rheumatoid arthritis 75 | 1,191
acute quadriplegic myopathy 75 | 1,158
juvenile dermatomyositis 74 | 1,187
Alzheimer's disease 66 | 658
dermatomyositis 66 | 966
Skin cancer 65 | 469
nasopharyngeal carcinoma 65 | 1,058
Autistic Disorder 64 | 364
Liver Cirrhosis, Experimental 64 | 769
cutaneous lupus erythematosus 63 | 1,057
gastric carcinoma 63 | 807
active Crohn's disease 60 | 922
medulloblastoma 59 | 720
Alcoholic Intoxication, Chronic 58 | 289
Parkinson's disease 54 | 392
active ulcerative colitis 53 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 53 | 510
Atopic dermatitis 52 | 952
Down syndrome 52 | 499
Prostatic Neoplasms 52 | 495
Duchenne muscular dystrophy 51 | 601
Kidney disease 51 | 430
non primary Sjogren syndrome sicca 51 | 891
Depressive disorder 50 | 409
Seizures 50 | 596
Breast Neoplasms 48 | 445
Multiple myeloma 48 | 1,332
Dull intelligence 47 | 645
Low intelligence 47 | 645
Mental Retardation 47 | 645
Mental deficiency 47 | 645
Poor school performance 47 | 645
aldosterone-producing adenoma 47 | 665
Mental Depression 46 | 333
Muscle hypotonia 46 | 571
Mammary Neoplasms 45 | 425
acute myeloid leukemia 45 | 783
Neurodegenerative disease 44 | 414
Obesity 44 | 678
Major Depressive Disorder 43 | 301
fibroadenoma 43 | 559
Amyotrophic lateral sclerosis 42 | 451
Multiple Sclerosis 42 | 540
Heart disease 41 | 306
Hypertension 41 | 396
Cognitive delay 40 | 608
Global developmental delay 40 | 608

Tissue

Endocrine System 937 | 18,159
Digestive Tract 925 | 17,369
Female tissues 921 | 17,400
Skin and soft tissues 913 | 17,230
Nervous System 912 | 16,725
Male tissues 909 | 17,142
Urinary Tract 895 | 16,678
Blood and immune system 890 | 16,909
Liver and Pancreas 885 | 16,750
Respiratory system 863 | 16,393
Cardiovascular System 806 | 15,192

Target Family

Non-IDG 653 | 12,091
Enzyme 110 | 4,145
Ion Channel 85 | 344
Kinase 56 | 634
Transporter 18 | 473
GPCR 17 | 408
Transcription Factor 15 | 1,400
Epigenetic 6 | 242

Compartment GO Term

Cell junction 960 | 960
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314
Contactin-associated protein-like 4 CNTNAP4 Tbio Non-IDG -0.73408 0.00000 148
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Synaptic vesicle 2-related protein SVOP Tdark Non-IDG -0.57678 4.35 90
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381