Development Level

Tbio 9,599 | 10,625
Tdark 3,808 | 7,003
Tchem 1,810 | 1,890
Tclin 590 | 602

Collection

Eligible non-olfactory GPCR Proteins 131 | 145
Eligible Kinase Proteins 124 | 134
Eligible Ion Channel Proteins 107 | 117

IMPC Term

preweaning lethality, complete... 604 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 208 | 226
embryonic lethality prior to t... 181 | 187
decreased lean body mass 179 | 195
decreased total body fat amoun... 166 | 186
decreased body weight 163 | 174
decreased bone mineral content 145 | 157
embryonic lethality prior to o... 145 | 148
abnormal bone structure 119 | 131
decreased bone mineral density 116 | 126
increased or absent threshold ... 115 | 128
decreased grip strength 111 | 123
increased circulating alkaline... 110 | 119
decreased circulating glucose ... 108 | 121
abnormal embryo size 103 | 112
decreased body length 101 | 108
hyperactivity 97 | 108
increased lean body mass 95 | 107
abnormal retina morphology 92 | 100
enlarged heart 89 | 111
increased bone mineral content 83 | 92
increased mean corpuscular vol... 83 | 91
increased mean corpuscular hem... 82 | 93
decreased circulating choleste... 81 | 85
hypoactivity 81 | 89
decreased circulating triglyce... 76 | 83
increased grip strength 76 | 83
decreased circulating HDL chol... 74 | 77
decreased circulating insulin ... 71 | 75
abnormal lens morphology 69 | 73
short tibia 69 | 82
decreased circulating serum al... 68 | 79
increased circulating sodium l... 64 | 71
prenatal lethality prior to he... 61 | 64
increased fasted circulating g... 60 | 68
increased circulating HDL chol... 59 | 63
decreased lumbar vertebrae num... 55 | 62
increased sacral vertebrae num... 55 | 62
abnormal retinal pigmentation 54 | 61
abnormal sleep behavior 53 | 63
male infertility 53 | 62
increased circulating choleste... 52 | 53
increased total body fat amoun... 52 | 57
improved glucose tolerance 51 | 56
abnormal bone mineralization 50 | 55
decreased rib number 50 | 59
increased exploration in new e... 50 | 56
decreased mean corpuscular vol... 49 | 50
decreased prepulse inhibition 49 | 52
decreased hemoglobin content 48 | 53
decreased leukocyte cell numbe... 48 | 54
increased bone mineral density 48 | 52
abnormal coat/hair pigmentatio... 47 | 54
abnormal gait 47 | 51
decreased circulating alanine ... 47 | 53
decreased fasted circulating g... 47 | 49
abnormal behavioral response t... 46 | 52
decreased startle reflex 45 | 48
impaired glucose tolerance 45 | 52
increased circulating chloride... 43 | 43
decreased caudal vertebrae num... 42 | 49
decreased heart weight 41 | 44
increased blood urea nitrogen ... 41 | 44
thrombocytopenia 41 | 46
abnormal seminal vesicle morph... 40 | 47
increased body weight 40 | 42
increased hemoglobin content 40 | 45
abnormal heart morphology 37 | 51
decreased circulating alkaline... 37 | 41
decreased eosinophil cell numb... 37 | 41
increased heart weight 37 | 37
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
abnormal eye morphology 34 | 38
decreased circulating LDL chol... 34 | 37
decreased erythrocyte cell num... 34 | 43
abnormal spleen morphology 33 | 36
cardiovascular system phenotyp... 33 | 35
increased leukocyte cell numbe... 33 | 37
increased rib number 33 | 41
increased startle reflex 33 | 38
tremors 33 | 34
decreased circulating total pr... 32 | 41
increased hematocrit 32 | 36
limb grasping 32 | 35
small testis 32 | 37
decreased circulating calcium ... 31 | 33
decreased T cell number 30 | 31
decreased mean corpuscular hem... 30 | 34
decreased blood urea nitrogen ... 29 | 31
decreased circulating fructosa... 29 | 31
female infertility 29 | 34
abnormal epididymis morphology 28 | 31
abnormal kidney morphology 28 | 30
decreased circulating chloride... 28 | 32
decreased circulating creatini... 28 | 31
decreased neutrophil cell numb... 28 | 37
increased circulating calcium ... 28 | 32
increased circulating creatini... 28 | 29

Disease

ovarian cancer 7,433 | 8,492
osteosarcoma 6,813 | 7,933
psoriasis 5,626 | 6,685
medulloblastoma, large-cell 5,392 | 6,234
glioblastoma 4,888 | 5,572
lung cancer 4,058 | 4,473
atypical teratoid / rhabdoid tumor 3,771 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,884 | 3,289
malignant mesothelioma 2,840 | 3,163
Breast cancer 2,723 | 3,099
pilocytic astrocytoma 2,666 | 3,086
primitive neuroectodermal tumor 2,666 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,609 | 2,988
invasive ductal carcinoma 2,566 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,557 | 2,956
oligodendroglioma 2,492 | 2,849
non-small cell lung cancer 2,464 | 2,798
lung carcinoma 2,439 | 2,844
pediatric high grade glioma 2,398 | 2,712
lung adenocarcinoma 2,356 | 2,714
Cancer 2,274 | 2,346
ependymoma 2,177 | 2,514
pancreatic cancer 2,014 | 2,300
subependymal giant cell astrocytoma 1,980 | 2,287
group 3 medulloblastoma 1,970 | 2,254
interstitial cystitis 1,949 | 2,299
Carcinoma 1,916 | 2,147
astrocytic glioma 1,906 | 2,241
adult high grade glioma 1,812 | 2,148
ulcerative colitis 1,810 | 2,087
Pick disease 1,699 | 1,893
pituitary cancer 1,685 | 1,972
group 4 medulloblastoma 1,672 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,586 | 1,795
ductal carcinoma in situ 1,511 | 1,745
diabetes mellitus 1,442 | 1,663
cystic fibrosis 1,422 | 1,670
breast carcinoma 1,413 | 1,614
astrocytoma 1,365 | 1,493
tuberculosis 1,358 | 1,563
colon cancer 1,330 | 1,475
medulloblastoma 1,327 | 1,524
posterior fossa group A ependymoma 1,302 | 1,511
Multiple myeloma 1,269 | 1,328
sonic hedgehog group medulloblastoma 1,262 | 1,482
adrenocortical carcinoma 1,239 | 1,427
posterior fossa group B ependymoma 1,238 | 1,530
primary pancreatic ductal adenocarcinoma 1,098 | 1,271
Rheumatoid Arthritis 1,080 | 1,171
juvenile dermatomyositis 1,053 | 1,189
acute quadriplegic myopathy 1,034 | 1,157
atypical teratoid/rhabdoid tumor 970 | 1,095
cutaneous lupus erythematosus 932 | 1,056
spina bifida 923 | 1,064
dermatomyositis 912 | 967
nasopharyngeal carcinoma 894 | 1,056
active Crohn's disease 810 | 918
Atopic dermatitis 781 | 944
Waldenstrons macroglobulinemia 737 | 765
non primary Sjogren syndrome sicca 737 | 840
acute myeloid leukemia 710 | 785
gastric carcinoma 708 | 832
primary Sjogren syndrome 699 | 789
esophageal adenocarcinoma 669 | 737
progressive supranuclear palsy 609 | 674
tuberculosis and treatment for 6 months 602 | 686
aldosterone-producing adenoma 596 | 664
Alzheimer's disease 593 | 644
Obesity 576 | 616
Intellectual disability 553 | 573
Duchenne muscular dystrophy 520 | 602
Down syndrome 512 | 548
pancreatic carcinoma 509 | 567
hepatocellular carcinoma 492 | 550
Endometriosis 480 | 535
Schizophrenia 471 | 503
fibroadenoma 461 | 557
Multiple Sclerosis 451 | 498
Prostatic Neoplasms 444 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 436 | 499
mucosa-associated lymphoid tissue lymphoma 428 | 480
IGA Glomerulonephritis 417 | 454
active ulcerative colitis 417 | 477
chronic rhinosinusitis 411 | 512
Amyotrophic Lateral Sclerosis 407 | 432
Mammary Neoplasms 389 | 410
gastric cancer 382 | 436
Neurodegenerative disease 377 | 383
Kidney disease 375 | 397
non-small cell lung carcinoma 350 | 413
inflammatory breast cancer 345 | 404
Parkinson's disease 342 | 364
Epilepsy 334 | 346
Asthma 323 | 349
sarcoidosis 311 | 368
Polycystic Ovary Syndrome 310 | 335
Autistic Disorder 304 | 320
hereditary spastic paraplegia 298 | 313
nephrosclerosis 298 | 329
glioblastoma multiforme 297 | 347

Tissue

Female tissues 15,377 | 18,647
Nervous System 15,271 | 18,561
Endocrine System 15,253 | 18,512
Urinary Tract 15,229 | 18,444
Digestive Tract 15,207 | 18,473
Skin and soft tissues 14,978 | 18,115
Liver and Pancreas 14,972 | 18,136
Blood and immune system 14,915 | 17,995
Cardiovascular System 14,865 | 17,958
Male tissues 14,863 | 17,969
Respiratory system 14,547 | 17,484

Target Family

Non-IDG 8,340 | 11,969
Enzyme 3,609 | 4,146
Transcription Factor 1,389 | 1,400
Kinase 612 | 634
Transporter 447 | 473
GPCR 393 | 408
oGPCR 380 | 421
Ion Channel 326 | 341
Epigenetic 227 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Compartment GO Term

Cell 15,807 | 15,807
cellular_component 18,238 | 18,238
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240