Development Level

Tbio 9,961 | 11,178
Tdark 3,505 | 6,569
Tchem 1,720 | 1,885
Tclin 593 | 612

Collection

GPCR: IDG Consortium (Targets) 119 | 126
Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 91 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 24 | 25

IMPC Phenotype

preweaning lethality, complete... 925 | 979
preweaning lethality, incomple... 452 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 232 | 239
abnormal embryo size 201 | 220
decreased total body fat amoun... 183 | 207
enlarged heart 174 | 210
decreased vertical activity 173 | 208
abnormal bone structure 171 | 187
increased lean body mass 153 | 172
decreased body weight 146 | 161
decreased bone mineral content 135 | 151
abnormal heart morphology 134 | 162
hyperactivity 129 | 148
increased total body fat amoun... 121 | 134
decreased lean body mass 118 | 135
hypoactivity 117 | 132
decreased bone mineral density 111 | 126
decreased circulating glucose ... 111 | 126
decreased grip strength 109 | 116
increased circulating alkaline... 109 | 122
increased startle reflex 105 | 112
male infertility 105 | 123
abnormal seminal vesicle morph... 102 | 114
embryonic growth retardation 100 | 106
increased bone mineral content 93 | 108
increased or absent threshold ... 92 | 101
decreased circulating choleste... 87 | 93
decreased body length 86 | 101
increased mean corpuscular vol... 85 | 92
cataract 82 | 92
increased mean corpuscular hem... 81 | 96
short tibia 81 | 97
prenatal lethality prior to he... 79 | 87
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased mean corpuscular vol... 76 | 79
decreased lymphocyte cell numb... 75 | 83
decreased prepulse inhibition 75 | 82
improved glucose tolerance 74 | 79
impaired glucose tolerance 70 | 75
increased fasted circulating g... 70 | 76
decreased circulating triglyce... 69 | 79
decreased circulating insulin ... 68 | 76
decreased hemoglobin content 67 | 68
decreased startle reflex 67 | 75
increased bone mineral density 67 | 72
increased circulating HDL chol... 67 | 80
small superior vagus ganglion 67 | 74
decreased circulating HDL chol... 63 | 68
decreased leukocyte cell numbe... 62 | 73
increased circulating sodium l... 62 | 71
abnormal gait 61 | 69
abnormal retina morphology 61 | 71
increased heart weight 60 | 62
abnormal behavioral response t... 59 | 66
abnormal sleep behavior 59 | 70
increased circulating choleste... 59 | 66
increased monocyte cell number 58 | 63
abnormal eye morphology 57 | 68
abnormal kidney morphology 57 | 65
decreased fasted circulating g... 57 | 65
edema 57 | 59
abnormal spleen morphology 53 | 55
decreased erythrocyte cell num... 53 | 62
small testis 52 | 58
abnormal coat-hair pigmentatio... 51 | 64
female infertility 51 | 60
thrombocytopenia 49 | 56
decreased caudal vertebrae num... 46 | 53
decreased mean corpuscular hem... 46 | 50
hydrometra 46 | 53
abnormal neural tube closure 43 | 46
decreased blood urea nitrogen ... 43 | 51
decreased circulating alanine ... 43 | 47
decreased circulating total pr... 43 | 49
increased hemoglobin content 43 | 45
increased leukocyte cell numbe... 43 | 47
abnormal skin morphology 42 | 50
decreased circulating alkaline... 42 | 46
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased blood urea nitrogen ... 41 | 48
abnormal testis morphology 39 | 43
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
increased mean platelet volume 39 | 45
increased neutrophil cell numb... 39 | 46
abnormal epididymis morphology 38 | 42
enlarged spleen 38 | 41
tremors 38 | 39
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
decreased circulating creatini... 36 | 39
limb grasping 36 | 41
abnormal bone mineralization 35 | 38
decreased neutrophil cell numb... 35 | 42
increased circulating creatini... 35 | 38
prolonged QT interval 35 | 38

Disease

Carcinoma 9,991 | 11,192
ovarian cancer 7,405 | 8,297
osteosarcoma 6,798 | 7,766
psoriasis 5,645 | 6,514
medulloblastoma, large-cell 5,367 | 6,086
glioblastoma 5,035 | 5,635
atypical teratoid / rhabdoid tumor 4,405 | 4,971
lung cancer 4,232 | 4,607
ependymoma 3,975 | 4,559
group 3 medulloblastoma 3,567 | 4,002
adult high grade glioma 3,255 | 3,701
Breast cancer 3,098 | 3,469
malignant mesothelioma 2,864 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,856 | 3,204
Astrocytoma, Pilocytic 2,648 | 3,006
primitive neuroectodermal tumor 2,641 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,584 | 2,902
invasive ductal carcinoma 2,541 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,535 | 2,872
non-small cell lung cancer 2,512 | 2,799
oligodendroglioma 2,454 | 2,768
lung carcinoma 2,409 | 2,755
lung adenocarcinoma 2,326 | 2,627
Kidney cancer 2,323 | 2,548
Cancer 2,322 | 2,388
astrocytic glioma 2,218 | 2,530
pancreatic cancer 2,082 | 2,322
subependymal giant cell astrocytoma 1,974 | 2,230
interstitial cystitis 1,931 | 2,237
tuberculosis 1,746 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,721 | 1,911
Pick disease 1,691 | 1,856
pituitary cancer 1,674 | 1,915
group 4 medulloblastoma 1,620 | 1,806
ulcerative colitis 1,551 | 1,765
diabetes mellitus 1,513 | 1,683
ductal carcinoma in situ 1,489 | 1,686
cystic fibrosis 1,422 | 1,629
breast carcinoma 1,419 | 1,589
Autosomal recessive predisposition 1,347 | 1,407
colon cancer 1,303 | 1,428
Multiple myeloma 1,239 | 1,296
adrenocortical carcinoma 1,226 | 1,385
Rheumatoid arthritis 1,073 | 1,156
Schizophrenia 1,066 | 1,136
juvenile dermatomyositis 1,038 | 1,147
astrocytoma 1,034 | 1,113
acute quadriplegic myopathy 1,033 | 1,133
Intellectual disability 977 | 998
primary pancreatic ductal adenocarcinoma 942 | 1,071
spina bifida 933 | 1,053
pediatric high grade glioma 931 | 1,035
cutaneous lupus erythematosus 921 | 1,016
dermatomyositis 901 | 941
nasopharyngeal carcinoma 882 | 1,024
Atopic dermatitis 797 | 915
active Crohn's disease 795 | 882
non primary Sjogren syndrome sicca 772 | 861
Epilepsy 762 | 775
Waldenstrons macroglobulinemia 722 | 742
acute myeloid leukemia 698 | 760
gastric carcinoma 682 | 781
Liver Cirrhosis, Experimental 669 | 733
active ulcerative colitis 663 | 736
primary Sjogren syndrome 648 | 710
esophageal adenocarcinoma 645 | 696
Obesity 627 | 655
Dull intelligence 624 | 634
Low intelligence 624 | 634
Melanoma 624 | 689
Mental Retardation 624 | 634
Mental deficiency 624 | 634
Poor school performance 624 | 634
Bipolar Disorder 608 | 646
Alzheimer's disease 598 | 640
progressive supranuclear palsy 598 | 656
medulloblastoma 594 | 702
aldosterone-producing adenoma 591 | 646
Cognitive delay 588 | 596
Global developmental delay 588 | 596
Mental and motor retardation 588 | 596
Seizures 578 | 584
Muscle hypotonia 553 | 562
Liver cancer 533 | 589
Duchenne muscular dystrophy 525 | 587
pancreatic carcinoma 505 | 555
Short stature 496 | 514
Multiple Sclerosis 485 | 527
hepatocellular carcinoma 482 | 536
Endometriosis 474 | 521
fibroadenoma 454 | 538
Prostatic Neoplasms 451 | 472
Down syndrome 450 | 480
autosomal dominant Emery-Dreifuss muscular dystrophy 440 | 492
mucosa-associated lymphoid tissue lymphoma 431 | 473
chronic rhinosinusitis 416 | 505
Amyotrophic lateral sclerosis 414 | 437
Skin cancer 407 | 451
Breast Neoplasms 402 | 423
sonic hedgehog group medulloblastoma 400 | 459

Tissue

Endocrine System 14,896 | 18,159
Digestive Tract 14,433 | 17,369
Female tissues 14,416 | 17,400
Skin and soft tissues 14,343 | 17,230
Male tissues 14,252 | 17,142
Blood and immune system 14,086 | 16,909
Nervous System 14,012 | 16,725
Liver and Pancreas 13,997 | 16,750
Urinary Tract 13,962 | 16,678
Respiratory system 13,719 | 16,393
Cardiovascular System 12,906 | 15,192

Target Family

Non-IDG 8,585 | 12,091
Enzyme 3,432 | 4,145
Transcription Factor 1,304 | 1,400
Kinase 609 | 634
Transporter 438 | 473
GPCR 392 | 408
oGPCR 380 | 421
Ion Channel 331 | 344
Epigenetic 226 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 37 | 38

Compartment GO Term

Cell 15,779 | 15,779
cellular_component 17,863 | 17,863
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83