Development Level

Tbio 21 | 11,445

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 3 | 239
abnormal embryo size 2 | 220
abnormal maxilla morphology 2 | 17
abnormal tooth morphology 2 | 24
decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal snout morphology 1 | 23
absent pinna reflex 1 | 23
anophthalmia 1 | 33
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
vertebral fusion 1 | 23

Disease

ovarian cancer 16 | 8,520
Carcinoma 15 | 11,493
Kidney cancer 9 | 2,613
osteosarcoma 9 | 7,950
Multiple myeloma 7 | 1,332
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
medulloblastoma, large-cell 7 | 6,241
atypical teratoid / rhabdoid tumor 6 | 5,112
psoriasis 6 | 6,694
Cancer 5 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Breast cancer 4 | 3,578
Cockayne syndrome 4 | 60
Waldenstrons macroglobulinemia 4 | 765
malignant mesothelioma 4 | 3,232
primitive neuroectodermal tumor 4 | 3,035
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Cryptorchidism 3 | 296
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Global developmental delay 3 | 608
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Mandibular hypoplasia 3 | 275
Mental and motor retardation 3 | 608
Micrognathism 3 | 275
Penile hypospadias 3 | 106
Upward slant of palpebral fissure 3 | 75
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
group 4 medulloblastoma 3 | 1,855
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
Abnormal behavior 2 | 52
Addison Disease 2 | 18
Adrenal cortical hypofunction 2 | 23
Adrenoleukodystrophy, Neonatal 2 | 13
Blepharoptosis 2 | 231
Chondrodysplasia punctata 2 | 41
Clouding of corneal stroma 2 | 50
Corneal Opacity 2 | 53
Death in early childhood 2 | 82
Decreased to absent deep tendon reflexes 2 | 42
Developmental regression 2 | 95
Electroencephalogram abnormal 2 | 101
Embryotoxon 2 | 28
Flat face 2 | 52
Flat occiput 2 | 26
Global developmental delay, severe 2 | 47
High forehead 2 | 102
Hydronephrosis 2 | 89
Hyperreflexia 2 | 209
Hypotonia, neonatal, generalized 2 | 7
Hypotonia, severe 2 | 33
Icterus 2 | 82
Impaired cognition 2 | 96
Infantile Refsum Disease (disorder) 2 | 13
Infantile Refsum disease 2 | 23
Liver Failure 2 | 73
Liver diseases 2 | 87
Long narrow head 2 | 75
Loss of developmental milestones 2 | 95
Low Vision 2 | 174
Malaria 2 | 160
Malformations of Cortical Development, Group II 2 | 31
Malformed pinnae 2 | 37
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Movement Disorders 2 | 55
Muscle Spasticity 2 | 195
Muscle weakness, progressive 2 | 22
Neonatal Hypotonia 2 | 64
Neurodevelopmental regression 2 | 95
Night Blindness 2 | 101
Osteochondrodysplasias 2 | 72
Peroxisomal disease 2 | 22
Peroxisome biogenesis disorders 2 | 11
Polymicrogyria 2 | 48
Posterior embryotoxon 2 | 28
Premature Birth 2 | 77
Premature birth of newborn 2 | 67
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Psychomotor retardation, profound 2 | 17
Pyloric Stenosis 2 | 47
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Retinal pigment epithelial abnormality 2 | 111
Sensorineural Hearing Loss (disorder) 2 | 284
Severe psychomotor retardation 2 | 47
Visual Impairment 2 | 174
Visual field constriction 2 | 36
Zellweger syndrome 2 | 37

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 7 | 4,145
Epigenetic 3 | 242

Compartment GO Term

Cdc73/Paf1 complex 21 | 21
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription elongation factor SPT6 SUPT6H Tbio Non-IDG -1.80696 66.9 123
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.57679 365.2 125
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324
Peroxisome assembly factor 2 PEX6 Tbio Enzyme -1.89379 79.8 148
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
Transcription elongation factor A protein 2 TCEA2 Tbio Non-IDG -1.75059 52.7 123
Transcription elongation factor SPT5 SUPT5H Tbio Non-IDG -1.92374 80.5 135
Transcription elongation factor A protein 3 TCEA3 Tbio Non-IDG -1.74698 55.0 154
Transcription elongation factor A protein 1 TCEA1 Tbio Non-IDG -2.61306 406.8 161
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135