Development Level

Tclin 74 | 602
Tbio 62 | 10,625
Tchem 51 | 1,890
Tdark 7 | 7,003

Collection

Eligible Ion Channel Proteins 33 | 117

IMPC Term

preweaning lethality, complete... 14 | 633
abnormal behavior 5 | 226
decreased body weight 4 | 174
embryonic lethality prior to t... 4 | 187
hyperactivity 4 | 108
abnormal embryo size 3 | 112
abnormal gait 3 | 51
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 195
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal epididymis morphology 2 | 31
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
increased bone mineral content 2 | 92
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
prenatal lethality 2 | 16
abnormal bone mineralization 1 | 55
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal sensory capabilities/... 1 | 3
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased NK T cell number 1 | 28
decreased anxiety-related resp... 1 | 12
decreased bone mineral content 1 | 157
decreased cardiac stroke volum... 1 | 3
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased gamma-delta T cell n... 1 | 18
decreased heart rate variabili... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
edema 1 | 11
hemorrhage 1 | 12
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating alanine ... 1 | 11
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
respiratory system phenotype 1 | 2
small epididymis 1 | 3
straub tail 1 | 26
tremors 1 | 34

Disease

medulloblastoma, large-cell 92 | 6,234
glioblastoma 90 | 5,572
psoriasis 77 | 6,685
osteosarcoma 70 | 7,933
atypical teratoid / rhabdoid tumor 68 | 4,369
Carcinoma 64 | 2,147
ovarian cancer 64 | 8,492
pilocytic astrocytoma 64 | 3,086
oligodendroglioma 62 | 2,849
primitive neuroectodermal tumor 62 | 3,031
pediatric high grade glioma 52 | 2,712
lung cancer 48 | 4,473
Epilepsy 47 | 346
ependymoma 47 | 2,514
lung carcinoma 46 | 2,844
subependymal giant cell astrocytoma 44 | 2,287
astrocytic glioma 43 | 2,241
malignant mesothelioma 43 | 3,163
Pick disease 41 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,956
pituitary cancer 40 | 1,972
adult high grade glioma 39 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
lung adenocarcinoma 34 | 2,714
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,289
Breast cancer 30 | 3,099
invasive ductal carcinoma 30 | 2,950
medulloblastoma 30 | 1,524
Atrial Fibrillation 29 | 110
Long QT syndrome 29 | 53
colon cancer 29 | 1,475
Hypertension 27 | 293
sonic hedgehog group medulloblastoma 27 | 1,482
Heart disease 26 | 279
Multiple Sclerosis 26 | 498
posterior fossa group A ependymoma 26 | 1,511
cystic fibrosis 25 | 1,670
Cancer 24 | 2,346
group 3 medulloblastoma 24 | 2,254
interstitial cystitis 24 | 2,299
Eaton-Lambert syndrome 23 | 40
atypical teratoid/rhabdoid tumor 23 | 1,095
Migraine 22 | 79
ductal carcinoma in situ 22 | 1,745
posterior fossa group B ependymoma 22 | 1,530
Schizophrenia 21 | 503
non-small cell lung cancer 21 | 2,798
pancreatic cancer 21 | 2,300
Intellectual disability 20 | 573
diabetes mellitus 20 | 1,663
Bipolar Disorder 19 | 266
Brugada syndrome 19 | 26
Hypertensive disease 19 | 193
Obesity 18 | 616
group 4 medulloblastoma 18 | 1,875
Alzheimer's disease 17 | 644
Pain agnosia 17 | 99
ulcerative colitis 17 | 2,087
adrenocortical carcinoma 16 | 1,427
breast carcinoma 16 | 1,614
Autistic Disorder 15 | 320
Malignant hyperthermia 15 | 25
Neurodegenerative disease 15 | 383
astrocytoma 15 | 1,493
Hypertensive disorder 14 | 58
Hypokalemia 14 | 40
Kidney disease 14 | 397
Neuropathy 14 | 210
primary pancreatic ductal adenocarcinoma 14 | 1,271
Cerebrovascular disease 13 | 231
Myopathy 13 | 128
non primary Sjogren syndrome sicca 13 | 840
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Amyotrophic Lateral Sclerosis 12 | 432
Brugada Syndrome (disorder) 12 | 15
Cardiac arrhythmia 12 | 26
Hyperalgesia 12 | 71
Major Depressive Disorder 12 | 106
Pain 12 | 70
Parkinson's disease 12 | 364
Sudden infant death syndrome 12 | 34
Endometriosis 11 | 535
Itching of skin 11 | 19
Short QT syndrome 11 | 12
Bipolar disorder in remission 10 | 19
Down syndrome 10 | 548
Dysuria 10 | 24
Familial atrial fibrillation 10 | 16
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Minor Skin Wound Pain 10 | 12
Premature ejaculation 10 | 16
Skin irritation 10 | 12
Status Epilepticus 10 | 85
Suppression of the Gag Reflex 10 | 12
Tinea pedis 10 | 30
Vascular disease 10 | 281
Ventricular arrhythmia 10 | 14
gastric carcinoma 10 | 832
nasopharyngeal carcinoma 10 | 1,056

Tissue

Nervous System 193 | 18,561
Endocrine System 191 | 18,512
Cardiovascular System 190 | 17,958
Female tissues 190 | 18,647
Liver and Pancreas 190 | 18,136
Urinary Tract 190 | 18,444
Digestive Tract 189 | 18,473
Skin and soft tissues 189 | 18,115
Blood and immune system 188 | 17,995
Male tissues 186 | 17,969
Respiratory system 183 | 17,484

Target Family

Ion Channel 134 | 341
Non-IDG 32 | 11,969
Enzyme 13 | 4,146
GPCR 10 | 408
Transporter 4 | 473
Kinase 1 | 634

Compartment GO Term

Cation channel complex 194 | 194
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Calcium-activated potassium channel subunit beta-4 KCNMB4 Tbio Ion Channel -0.88088 6.57 115
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.43407 268.0 184
Dipeptidyl aminopeptidase-like protein 6 DPP6 Tbio Enzyme -2.02374 108.0 115
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.46222 253.3 121
Transient receptor potential cation channel subfamily M member 3 TRPM3 Tbio Ion Channel -2.12218 123.9 117
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.44224 238.6 56
Potassium voltage-gated channel subfamily B member 1 KCNB1 Tclin Ion Channel -2.55260 357.6 349
Potassium channel subfamily U member 1 KCNU1 Tbio Ion Channel -1.59652 36.7 57
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.97802 99.5 138