Development Level

Tclin 89 | 613
Tbio 80 | 11,445
Tchem 46 | 1,598
Tdark 16 | 6,588

Collection

Ion Channel: IDG Consortium (T... 32 | 99
RFA-RM-18-021 32 | 328

IMPC Phenotype

preweaning lethality, complete... 19 | 979
abnormal behavior 9 | 298
hyperactivity 7 | 148
abnormal embryo size 5 | 220
decreased body weight 5 | 161
decreased total body fat amoun... 5 | 207
embryonic lethality prior to t... 5 | 278
increased startle reflex 5 | 112
preweaning lethality, incomple... 5 | 499
abnormal behavioral response t... 4 | 66
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
abnormal bone structure 3 | 187
abnormal gait 3 | 69
decreased grip strength 3 | 116
decreased mean platelet volume 3 | 25
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
prolonged ST segment 3 | 36
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
decreased bone mineral content 2 | 151
decreased cardiac stroke volum... 2 | 6
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
edema 2 | 59
embryonic growth retardation 2 | 106
increased circulating triglyce... 2 | 42
limb grasping 2 | 41
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
tremors 2 | 39
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal pelvic girdle bone mo... 1 | 12
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased vertical activity 1 | 24
long tibia 1 | 25
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened ST segment 1 | 10
small seminal vesicle 1 | 10

Disease

Carcinoma 182 | 11,493
medulloblastoma, large-cell 113 | 6,241
glioblastoma 112 | 5,792
atypical teratoid / rhabdoid tumor 105 | 5,112
ependymoma 105 | 4,679
adult high grade glioma 101 | 3,801
psoriasis 90 | 6,694
Astrocytoma, Pilocytic 81 | 3,081
Kidney cancer 81 | 2,613
group 3 medulloblastoma 80 | 4,104
osteosarcoma 80 | 7,950
primitive neuroectodermal tumor 79 | 3,035
oligodendroglioma 75 | 2,850
ovarian cancer 74 | 8,520
Epilepsy 69 | 792
astrocytic glioma 62 | 2,597
lung cancer 61 | 4,740
Schizophrenia 59 | 1,160
lung carcinoma 56 | 2,843
subependymal giant cell astrocytoma 52 | 2,287
Breast cancer 51 | 3,578
Pick disease 50 | 1,894
Bipolar Disorder 48 | 666
malignant mesothelioma 46 | 3,232
pituitary cancer 45 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
lung adenocarcinoma 37 | 2,716
Intellectual disability 36 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
Hypertension 34 | 396
Autosomal recessive predisposition 33 | 1,442
Seizures 33 | 596
Heart disease 32 | 306
Depressive disorder 30 | 409
Melanoma 30 | 711
invasive ductal carcinoma 30 | 2,951
Atrial Fibrillation 29 | 124
colon cancer 29 | 1,478
Cancer 28 | 2,499
Mental Depression 28 | 333
Multiple Sclerosis 28 | 540
interstitial cystitis 28 | 2,312
Skin cancer 27 | 469
cystic fibrosis 26 | 1,696
non-small cell lung cancer 26 | 2,890
pancreatic cancer 26 | 2,398
Autistic Disorder 25 | 364
Major Depressive Disorder 25 | 301
Muscle hypotonia 24 | 571
Alzheimer's disease 23 | 658
Dull intelligence 23 | 645
Eaton-Lambert syndrome 23 | 40
Liver cancer 23 | 604
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
diabetes mellitus 23 | 1,728
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Hypertensive disease 22 | 292
Mental and motor retardation 22 | 608
ductal carcinoma in situ 22 | 1,745
Local anesthesia 21 | 40
Neuropathy 21 | 261
Parkinson's disease 21 | 392
Alcoholic Intoxication, Chronic 20 | 289
Long QT syndrome 20 | 39
Migraine 20 | 83
Brugada syndrome 19 | 29
Endometrial cancer 19 | 311
Mood Disorders 19 | 184
group 4 medulloblastoma 19 | 1,855
Cerebellar Ataxia 18 | 304
Toxic encephalopathy 18 | 141
Unipolar Depression 18 | 250
adrenocortical carcinoma 18 | 1,428
Cardiac Arrhythmia 17 | 103
Cerebrovascular disease 17 | 238
Infantile onset 17 | 238
Neurodegenerative disease 17 | 414
Obesity 17 | 678
breast carcinoma 17 | 1,638
Hypokalemia 16 | 52
Malignant hyperthermia 16 | 26
Pain agnosia 16 | 104
Amyotrophic lateral sclerosis 15 | 451
Constipation 15 | 181
Diarrhea 15 | 253
General anesthesia 15 | 53
Lennox-Gastaut syndrome 15 | 34
Vascular disease 15 | 319
Ventricular arrhythmia 15 | 27
Hyperalgesia 14 | 83
Kidney disease 14 | 430
Status Epilepticus 14 | 98
non primary Sjogren syndrome sicca 14 | 891
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
tuberculosis 14 | 2,010

Tissue

Endocrine System 227 | 18,159
Nervous System 219 | 16,725
Digestive Tract 215 | 17,369
Female tissues 211 | 17,400
Skin and soft tissues 209 | 17,230
Male tissues 208 | 17,142
Liver and Pancreas 199 | 16,750
Blood and immune system 198 | 16,909
Urinary Tract 198 | 16,678
Respiratory system 190 | 16,393
Cardiovascular System 163 | 15,192

Target Family

Ion Channel 150 | 344
Non-IDG 49 | 12,091
Enzyme 16 | 4,145
GPCR 10 | 408
Transporter 4 | 473
Kinase 2 | 634

Compartment GO Term

Cation channel complex 231 | 231
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121
Calbindin CALB1 Tbio Non-IDG -3.31956 2149.9 287
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Calcium-activated potassium channel subunit beta-2 KCNMB2 Tbio Ion Channel 1.28 0.09 191
Leucine-rich repeat-containing protein 26 LRRC26 Tbio Ion Channel -1.02699 11.3 81