Development Level

Tbio 709 | 10,625
Tchem 253 | 1,890
Tdark 161 | 7,003
Tclin 111 | 602

Collection

Eligible Kinase Proteins 11 | 134

IMPC Term

preweaning lethality, complete... 104 | 633
embryonic lethality prior to o... 31 | 148
embryonic lethality prior to t... 30 | 187
preweaning lethality, incomple... 28 | 260
abnormal behavior 18 | 226
decreased lean body mass 18 | 195
decreased total body fat amoun... 16 | 186
decreased body weight 15 | 174
decreased bone mineral content 14 | 157
decreased bone mineral density 14 | 126
abnormal bone mineralization 13 | 55
abnormal embryo size 13 | 112
decreased grip strength 12 | 123
increased lean body mass 12 | 107
abnormal bone structure 11 | 131
increased grip strength 11 | 83
increased mean corpuscular vol... 11 | 91
decreased circulating insulin ... 10 | 75
decreased body length 9 | 108
decreased circulating glucose ... 9 | 121
increased circulating choleste... 9 | 53
increased circulating sodium l... 9 | 71
increased heart weight 9 | 37
increased mean corpuscular hem... 9 | 93
male infertility 9 | 62
abnormal retina morphology 8 | 100
decreased circulating triglyce... 8 | 83
decreased leukocyte cell numbe... 8 | 54
decreased rib number 8 | 59
hypoactivity 8 | 89
abnormal gait 7 | 51
abnormal lens morphology 7 | 73
decreased lumbar vertebrae num... 7 | 62
increased bone mineral content 7 | 92
increased bone mineral density 7 | 52
increased circulating HDL chol... 7 | 63
increased fasted circulating g... 7 | 68
increased sacral vertebrae num... 7 | 62
short tibia 7 | 82
decreased circulating HDL chol... 6 | 77
decreased circulating alanine ... 6 | 53
decreased circulating alkaline... 6 | 41
decreased erythrocyte cell num... 6 | 43
decreased prepulse inhibition 6 | 52
decreased startle reflex 6 | 48
enlarged heart 6 | 111
enlarged spleen 6 | 26
hyperactivity 6 | 108
increased circulating alkaline... 6 | 119
increased circulating triglyce... 6 | 24
increased or absent threshold ... 6 | 128
small testis 6 | 37
abnormal epididymis morphology 5 | 31
abnormal neural tube closure 5 | 37
cataract 5 | 26
decreased blood urea nitrogen ... 5 | 31
decreased circulating LDL chol... 5 | 37
decreased circulating choleste... 5 | 85
decreased heart weight 5 | 44
decreased mean corpuscular vol... 5 | 50
enlarged epididymis 5 | 27
increased exploration in new e... 5 | 56
increased mean corpuscular hem... 5 | 25
prenatal lethality prior to he... 5 | 64
thrombocytopenia 5 | 46
vertebral fusion 5 | 23
abnormal QRS complex 4 | 25
abnormal forebrain development 4 | 18
abnormal heart left ventricle ... 4 | 20
abnormal heart morphology 4 | 51
abnormal hindbrain development 4 | 24
abnormal seminal vesicle morph... 4 | 47
abnormal spleen morphology 4 | 36
abnormal testis morphology 4 | 30
abnormal tooth morphology 4 | 24
decreased T cell number 4 | 31
decreased caudal vertebrae num... 4 | 49
decreased circulating creatini... 4 | 31
decreased circulating sodium l... 4 | 18
decreased lactate dehydrogenas... 4 | 14
decreased total retina thickne... 4 | 20
embryonic growth retardation 4 | 28
enlarged lymph nodes 4 | 27
impaired glucose tolerance 4 | 52
increased circulating LDL chol... 4 | 15
increased circulating free fat... 4 | 17
increased hemoglobin content 4 | 45
increased monocyte cell number 4 | 27
increased total body fat amoun... 4 | 57
small adrenal glands 4 | 15
decreased circulating calcium ... 3 | 33
decreased circulating serum al... 3 | 79
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
increased body weight 3 | 42
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 43
increased circulating serum al... 3 | 25
increased hematocrit 3 | 36
thrombocytosis 3 | 23

Disease

ovarian cancer 728 | 8,492
osteosarcoma 602 | 7,933
psoriasis 463 | 6,685
medulloblastoma, large-cell 439 | 6,234
glioblastoma 423 | 5,572
Cancer 410 | 2,346
lung cancer 371 | 4,473
atypical teratoid / rhabdoid tumor 314 | 4,369
Breast cancer 246 | 3,099
malignant mesothelioma 237 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 232 | 3,289
primitive neuroectodermal tumor 226 | 3,031
oligodendroglioma 211 | 2,849
diabetes mellitus 208 | 1,663
Multiple myeloma 200 | 1,328
ependymoma 198 | 2,514
pediatric high grade glioma 198 | 2,712
invasive ductal carcinoma 195 | 2,950
Carcinoma 190 | 2,147
non-small cell lung cancer 188 | 2,798
lung adenocarcinoma 184 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 180 | 2,988
subependymal giant cell astrocytoma 176 | 2,287
pilocytic astrocytoma 175 | 3,086
group 3 medulloblastoma 172 | 2,254
lung carcinoma 170 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 165 | 2,956
astrocytic glioma 156 | 2,241
pancreatic cancer 155 | 2,300
astrocytoma 152 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 152 | 1,795
Pick disease 149 | 1,893
ulcerative colitis 149 | 2,087
group 4 medulloblastoma 140 | 1,875
tuberculosis 135 | 1,563
adult high grade glioma 133 | 2,148
medulloblastoma 125 | 1,524
Rheumatoid Arthritis 122 | 1,171
interstitial cystitis 117 | 2,299
acute quadriplegic myopathy 116 | 1,157
adrenocortical carcinoma 114 | 1,427
pituitary cancer 109 | 1,972
juvenile dermatomyositis 108 | 1,189
breast carcinoma 107 | 1,614
ductal carcinoma in situ 107 | 1,745
colon cancer 105 | 1,475
Obesity 102 | 616
cystic fibrosis 102 | 1,670
Kidney disease 101 | 397
Waldenstrons macroglobulinemia 99 | 765
dermatomyositis 96 | 967
Alzheimer's disease 92 | 644
posterior fossa group A ependymoma 92 | 1,511
Prostatic Neoplasms 87 | 471
acute myeloid leukemia 87 | 785
sonic hedgehog group medulloblastoma 85 | 1,482
Mammary Neoplasms 82 | 410
Vascular disease 81 | 281
primary pancreatic ductal adenocarcinoma 81 | 1,271
nasopharyngeal carcinoma 78 | 1,056
Heart disease 77 | 279
Hypertension 76 | 293
posterior fossa group B ependymoma 73 | 1,530
Intellectual disability 70 | 573
Parkinson's disease 70 | 364
cutaneous lupus erythematosus 69 | 1,056
Atherosclerosis 68 | 275
spina bifida 68 | 1,064
atypical teratoid/rhabdoid tumor 66 | 1,095
hepatocellular carcinoma 66 | 550
Arthritis 64 | 248
Asthma 64 | 349
Neurodegenerative disease 64 | 383
Stomach Neoplasms 63 | 282
Cerebrovascular disease 62 | 231
non primary Sjogren syndrome sicca 61 | 840
tuberculosis and treatment for 6 months 61 | 686
Endometriosis 60 | 535
Liver carcinoma 59 | 217
aldosterone-producing adenoma 59 | 664
Atopic dermatitis 58 | 944
Lung Neoplasms 54 | 171
Schizophrenia 53 | 503
Coronary artery disease 52 | 240
IGA Glomerulonephritis 52 | 454
Liver disease 52 | 219
Adenoma 51 | 165
Hyperglycemia 51 | 120
Hypertensive disease 51 | 193
Multiple Sclerosis 51 | 498
gastric carcinoma 51 | 832
Lung disease 50 | 136
Toxic encephalopathy 50 | 131
Diabetes Mellitus, Experimental 49 | 106
Diabetes mellitus type 2 49 | 69
Peripheral Neuropathy 49 | 303
pancreatic carcinoma 49 | 567
active Crohn's disease 48 | 918
primary Sjogren syndrome 47 | 789
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53

Tissue

Female tissues 1,222 | 18,647
Nervous System 1,221 | 18,561
Digestive Tract 1,220 | 18,473
Blood and immune system 1,219 | 17,995
Endocrine System 1,219 | 18,512
Liver and Pancreas 1,219 | 18,136
Male tissues 1,217 | 17,969
Urinary Tract 1,217 | 18,444
Cardiovascular System 1,216 | 17,958
Skin and soft tissues 1,212 | 18,115
Respiratory system 1,208 | 17,484

Target Family

Non-IDG 571 | 11,969
Enzyme 404 | 4,146
Kinase 97 | 634
Epigenetic 78 | 242
Transcription Factor 45 | 1,400
Transporter 27 | 473
TF/Epigenetic 4 | 38
Ion Channel 3 | 341
Nuclear Receptor 3 | 48
GPCR 2 | 408

Compartment GO Term

Catalytic complex 1,234 | 1,234
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
MRG/MORF4L-binding protein MRGBP Tbio Non-IDG -0.60412 4.30 131
Integrator complex subunit 9 INTS9 Tdark Non-IDG -0.71181 4.56 74
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Kelch repeat and BTB domain-containing protein 6 KBTBD6 Tdark Non-IDG 0.85 0.22 24
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561