Development Level

Tbio 1,077 | 11,651
Tchem 246 | 1,388
Tdark 175 | 6,593
Tclin 144 | 612

Collection

Kinase: IDG Consortium (Target... 9 | 125
RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 202 | 979
embryonic lethality prior to o... 66 | 239
preweaning lethality, incomple... 63 | 499
embryonic lethality prior to t... 61 | 278
abnormal behavior 32 | 298
abnormal embryo size 30 | 220
decreased lean body mass 23 | 135
decreased total body fat amoun... 23 | 207
abnormal bone structure 22 | 187
increased total body fat amoun... 22 | 134
decreased body weight 21 | 161
decreased bone mineral content 21 | 151
increased lean body mass 21 | 172
increased startle reflex 21 | 112
embryonic growth retardation 20 | 106
decreased vertical activity 19 | 208
enlarged heart 19 | 210
increased mean corpuscular vol... 18 | 92
abnormal heart morphology 17 | 162
decreased circulating glucose ... 17 | 126
hypoactivity 17 | 132
male infertility 16 | 123
increased circulating HDL chol... 15 | 80
increased circulating alkaline... 15 | 122
short tibia 15 | 97
decreased bone mineral density 14 | 126
impaired glucose tolerance 14 | 75
increased circulating choleste... 14 | 66
increased mean corpuscular hem... 14 | 96
abnormal retina morphology 13 | 71
abnormal seminal vesicle morph... 13 | 114
cataract 13 | 92
hyperactivity 13 | 148
decreased circulating insulin ... 12 | 76
decreased erythrocyte cell num... 12 | 62
increased circulating sodium l... 12 | 71
abnormal gait 11 | 69
abnormal lens morphology 11 | 81
decreased circulating triglyce... 11 | 79
decreased leukocyte cell numbe... 11 | 73
prenatal lethality prior to he... 11 | 87
decreased body length 10 | 101
decreased circulating alkaline... 10 | 46
decreased grip strength 10 | 116
decreased lymphocyte cell numb... 10 | 83
decreased red blood cell distr... 10 | 41
increased fasted circulating g... 10 | 76
increased lymphocyte cell numb... 10 | 32
decreased circulating choleste... 9 | 93
decreased prepulse inhibition 9 | 82
decreased startle reflex 9 | 75
edema 9 | 59
increased bone mineral content 9 | 108
increased grip strength 9 | 41
increased heart weight 9 | 62
increased monocyte cell number 9 | 63
increased neutrophil cell numb... 9 | 46
thrombocytopenia 9 | 56
abnormal bone mineralization 8 | 38
decreased circulating amylase ... 8 | 28
decreased hemoglobin content 8 | 68
abnormal neural tube closure 7 | 46
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating LDL chol... 7 | 38
decreased circulating chloride... 7 | 30
decreased circulating creatini... 7 | 39
decreased mean corpuscular vol... 7 | 79
decreased neutrophil cell numb... 7 | 42
increased bone mineral density 7 | 72
increased circulating creatini... 7 | 38
increased circulating serum al... 7 | 22
increased circulating triglyce... 7 | 42
increased leukocyte cell numbe... 7 | 47
small testis 7 | 58
decreased blood urea nitrogen ... 6 | 51
decreased caudal vertebrae num... 6 | 53
decreased circulating alanine ... 6 | 47
decreased circulating sodium l... 6 | 22
decreased mean platelet volume 6 | 25
enlarged spleen 6 | 41
female infertility 6 | 60
increased blood urea nitrogen ... 6 | 48
increased circulating calcium ... 6 | 34
increased circulating chloride... 6 | 41
increased mean platelet volume 6 | 45
persistence of hyaloid vascula... 6 | 33
prolonged QT interval 6 | 38
prolonged ST segment 6 | 36
small superior vagus ganglion 6 | 74
vertebral fusion 6 | 23
cardiovascular system phenotyp... 5 | 36
decreased circulating iron lev... 5 | 32
decreased hematocrit 5 | 46
increased circulating bilirubi... 5 | 16
increased circulating free fat... 5 | 20
increased circulating potassiu... 5 | 29
increased hematocrit 5 | 46
increased hemoglobin content 5 | 45
thrombocytosis 5 | 27

Disease

Carcinoma 1,030 | 11,493
ovarian cancer 987 | 8,520
osteosarcoma 798 | 7,950
psoriasis 633 | 6,694
Cancer 602 | 2,499
glioblastoma 584 | 5,792
medulloblastoma, large-cell 582 | 6,241
lung cancer 545 | 4,740
atypical teratoid / rhabdoid tumor 466 | 5,112
ependymoma 417 | 4,679
group 3 medulloblastoma 395 | 4,104
Breast cancer 373 | 3,578
malignant mesothelioma 348 | 3,232
adult high grade glioma 316 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 312 | 3,291
diabetes mellitus 310 | 1,728
Multiple myeloma 306 | 1,332
Kidney cancer 290 | 2,613
oligodendroglioma 286 | 2,850
primitive neuroectodermal tumor 282 | 3,035
invasive ductal carcinoma 263 | 2,951
non-small cell lung cancer 258 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 248 | 2,989
lung adenocarcinoma 239 | 2,716
astrocytic glioma 236 | 2,597
subependymal giant cell astrocytoma 229 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 226 | 2,955
Astrocytoma, Pilocytic 222 | 3,081
pancreatic cancer 219 | 2,398
tuberculosis 214 | 2,010
lung carcinoma 210 | 2,843
Autosomal recessive predisposition 209 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 198 | 1,962
Pick disease 196 | 1,894
group 4 medulloblastoma 192 | 1,855
Schizophrenia 184 | 1,160
Intellectual disability 178 | 1,016
astrocytoma 177 | 1,146
ulcerative colitis 172 | 1,819
acute quadriplegic myopathy 169 | 1,158
Rheumatoid arthritis 161 | 1,191
breast carcinoma 159 | 1,638
interstitial cystitis 157 | 2,312
dermatomyositis 151 | 966
juvenile dermatomyositis 151 | 1,187
Waldenstrons macroglobulinemia 150 | 765
pituitary cancer 150 | 1,972
Epilepsy 149 | 792
colon cancer 146 | 1,478
Obesity 145 | 678
adrenocortical carcinoma 145 | 1,428
Alzheimer's disease 143 | 658
ductal carcinoma in situ 142 | 1,745
Seizures 140 | 596
cystic fibrosis 132 | 1,696
Breast Neoplasms 124 | 445
Dull intelligence 124 | 645
Kidney disease 124 | 430
Low intelligence 124 | 645
Mental Retardation 124 | 645
Mental deficiency 124 | 645
Poor school performance 124 | 645
Mammary Neoplasms 120 | 425
Hypertension 119 | 396
Cognitive delay 115 | 608
Global developmental delay 115 | 608
Mental and motor retardation 115 | 608
Vascular disease 113 | 319
acute myeloid leukemia 112 | 783
pediatric high grade glioma 112 | 1,064
Prostatic Neoplasms 110 | 495
Bipolar Disorder 109 | 666
Muscle hypotonia 105 | 571
Neurodegenerative disease 105 | 414
Heart disease 99 | 306
nasopharyngeal carcinoma 98 | 1,058
primary pancreatic ductal adenocarcinoma 98 | 1,109
Short stature 97 | 531
cutaneous lupus erythematosus 97 | 1,057
Depressive disorder 94 | 409
Liver Cirrhosis, Experimental 94 | 769
Parkinson's disease 94 | 392
Stomach Neoplasms 93 | 300
non primary Sjogren syndrome sicca 93 | 891
Arthritis 89 | 290
Cerebrovascular disease 88 | 238
Atherosclerosis 86 | 291
Hypertensive disease 85 | 292
Asthma 84 | 385
Carcinoma, Hepatocellular 84 | 228
Liver carcinoma 84 | 240
hepatocellular carcinoma 84 | 547
Anemia 82 | 365
spina bifida 82 | 1,074
Melanoma 81 | 711
Liver cancer 80 | 604
Osteoporosis 79 | 363
Endometriosis 78 | 540
Small head 78 | 374
Multiple Sclerosis 76 | 540

Tissue

Endocrine System 1,610 | 18,159
Digestive Tract 1,596 | 17,369
Skin and soft tissues 1,596 | 17,230
Female tissues 1,592 | 17,400
Male tissues 1,592 | 17,142
Nervous System 1,582 | 16,725
Blood and immune system 1,579 | 16,909
Liver and Pancreas 1,579 | 16,750
Urinary Tract 1,578 | 16,678
Respiratory system 1,572 | 16,393
Cardiovascular System 1,525 | 15,192

Target Family

Non-IDG 792 | 12,091
Enzyme 546 | 4,145
Kinase 107 | 634
Epigenetic 82 | 242
Transcription Factor 65 | 1,400
Transporter 29 | 473
GPCR 7 | 408
Nuclear Receptor 7 | 48
Ion Channel 4 | 344
TF/Epigenetic 3 | 38

Compartment GO Term

Catalytic complex 1,642 | 1,642
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Protein phosphatase 1 regulatory subunit 15B PPP1R15B Tbio Enzyme -1.42081 25.8 85
E1A-binding protein p400 EP400 Tbio Non-IDG -1.47248 27.6 69