Development Level

Tbio 1,053 | 11,445
Tchem 269 | 1,598
Tdark 175 | 6,588
Tclin 144 | 613

Collection

Kinase: IDG Consortium (Target... 9 | 125
RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 202 | 979
embryonic lethality prior to o... 66 | 239
preweaning lethality, incomple... 63 | 499
embryonic lethality prior to t... 61 | 278
abnormal behavior 32 | 298
abnormal embryo size 30 | 220
decreased lean body mass 23 | 135
decreased total body fat amoun... 23 | 207
abnormal bone structure 22 | 187
increased total body fat amoun... 22 | 134
decreased body weight 21 | 161
decreased bone mineral content 21 | 151
increased lean body mass 21 | 172
increased startle reflex 21 | 112
embryonic growth retardation 20 | 106
decreased vertical activity 19 | 208
enlarged heart 19 | 210
increased mean corpuscular vol... 18 | 92
abnormal heart morphology 17 | 162
decreased circulating glucose ... 17 | 126
hypoactivity 17 | 132
male infertility 16 | 123
increased circulating HDL chol... 15 | 80
increased circulating alkaline... 15 | 122
short tibia 15 | 97
decreased bone mineral density 14 | 126
impaired glucose tolerance 14 | 75
increased circulating choleste... 14 | 66
increased mean corpuscular hem... 14 | 96
abnormal retina morphology 13 | 71
abnormal seminal vesicle morph... 13 | 114
cataract 13 | 92
hyperactivity 13 | 148
decreased circulating insulin ... 12 | 76
decreased erythrocyte cell num... 12 | 62
increased circulating sodium l... 12 | 71
abnormal gait 11 | 69
abnormal lens morphology 11 | 81
decreased circulating triglyce... 11 | 79
decreased leukocyte cell numbe... 11 | 73
prenatal lethality prior to he... 11 | 87
decreased body length 10 | 101
decreased circulating alkaline... 10 | 46
decreased grip strength 10 | 116
decreased lymphocyte cell numb... 10 | 83
decreased red blood cell distr... 10 | 41
increased fasted circulating g... 10 | 76
increased lymphocyte cell numb... 10 | 32
decreased circulating choleste... 9 | 93
decreased prepulse inhibition 9 | 82
decreased startle reflex 9 | 75
edema 9 | 59
increased bone mineral content 9 | 108
increased grip strength 9 | 41
increased heart weight 9 | 62
increased monocyte cell number 9 | 63
increased neutrophil cell numb... 9 | 46
thrombocytopenia 9 | 56
abnormal bone mineralization 8 | 38
decreased circulating amylase ... 8 | 28
decreased hemoglobin content 8 | 68
abnormal neural tube closure 7 | 46
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating LDL chol... 7 | 38
decreased circulating chloride... 7 | 30
decreased circulating creatini... 7 | 39
decreased mean corpuscular vol... 7 | 79
decreased neutrophil cell numb... 7 | 42
increased bone mineral density 7 | 72
increased circulating creatini... 7 | 38
increased circulating serum al... 7 | 22
increased circulating triglyce... 7 | 42
increased leukocyte cell numbe... 7 | 47
small testis 7 | 58
decreased blood urea nitrogen ... 6 | 51
decreased caudal vertebrae num... 6 | 53
decreased circulating alanine ... 6 | 47
decreased circulating sodium l... 6 | 22
decreased mean platelet volume 6 | 25
enlarged spleen 6 | 41
female infertility 6 | 60
increased blood urea nitrogen ... 6 | 48
increased circulating calcium ... 6 | 34
increased circulating chloride... 6 | 41
increased mean platelet volume 6 | 45
persistence of hyaloid vascula... 6 | 33
prolonged QT interval 6 | 38
prolonged ST segment 6 | 36
small superior vagus ganglion 6 | 74
vertebral fusion 6 | 23
cardiovascular system phenotyp... 5 | 36
decreased circulating iron lev... 5 | 32
decreased hematocrit 5 | 46
increased circulating bilirubi... 5 | 16
increased circulating free fat... 5 | 20
increased circulating potassiu... 5 | 29
increased hematocrit 5 | 46
increased hemoglobin content 5 | 45
thrombocytosis 5 | 27

Disease

Carcinoma 1,030 | 11,493
ovarian cancer 986 | 8,520
osteosarcoma 797 | 7,950
psoriasis 632 | 6,694
Cancer 602 | 2,499
glioblastoma 584 | 5,792
medulloblastoma, large-cell 582 | 6,241
lung cancer 545 | 4,740
atypical teratoid / rhabdoid tumor 465 | 5,112
ependymoma 416 | 4,679
group 3 medulloblastoma 395 | 4,104
Breast cancer 372 | 3,578
malignant mesothelioma 347 | 3,232
adult high grade glioma 316 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 311 | 3,291
diabetes mellitus 310 | 1,728
Multiple myeloma 306 | 1,332
Kidney cancer 290 | 2,613
oligodendroglioma 286 | 2,850
primitive neuroectodermal tumor 282 | 3,035
invasive ductal carcinoma 263 | 2,951
non-small cell lung cancer 258 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 247 | 2,989
lung adenocarcinoma 238 | 2,716
astrocytic glioma 236 | 2,597
subependymal giant cell astrocytoma 229 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 226 | 2,955
Astrocytoma, Pilocytic 222 | 3,081
pancreatic cancer 219 | 2,398
tuberculosis 214 | 2,010
Autosomal recessive predisposition 209 | 1,442
lung carcinoma 209 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 198 | 1,962
Pick disease 196 | 1,894
group 4 medulloblastoma 191 | 1,855
Schizophrenia 184 | 1,160
Intellectual disability 177 | 1,016
astrocytoma 177 | 1,146
ulcerative colitis 172 | 1,819
acute quadriplegic myopathy 169 | 1,158
Rheumatoid arthritis 161 | 1,191
breast carcinoma 159 | 1,638
interstitial cystitis 156 | 2,312
juvenile dermatomyositis 151 | 1,187
Waldenstrons macroglobulinemia 150 | 765
dermatomyositis 150 | 966
pituitary cancer 150 | 1,972
Epilepsy 149 | 792
Obesity 145 | 678
adrenocortical carcinoma 145 | 1,428
colon cancer 145 | 1,478
Alzheimer's disease 143 | 658
ductal carcinoma in situ 142 | 1,745
Seizures 140 | 596
cystic fibrosis 132 | 1,696
Breast Neoplasms 124 | 445
Dull intelligence 124 | 645
Kidney disease 124 | 430
Low intelligence 124 | 645
Mental Retardation 124 | 645
Mental deficiency 124 | 645
Poor school performance 124 | 645
Mammary Neoplasms 120 | 425
Hypertension 119 | 396
Cognitive delay 115 | 608
Global developmental delay 115 | 608
Mental and motor retardation 115 | 608
Vascular disease 113 | 319
pediatric high grade glioma 112 | 1,064
acute myeloid leukemia 111 | 783
Prostatic Neoplasms 110 | 495
Bipolar Disorder 109 | 666
Muscle hypotonia 105 | 571
Neurodegenerative disease 105 | 414
Heart disease 99 | 306
nasopharyngeal carcinoma 98 | 1,058
primary pancreatic ductal adenocarcinoma 98 | 1,109
Short stature 97 | 531
cutaneous lupus erythematosus 97 | 1,057
Depressive disorder 94 | 409
Liver Cirrhosis, Experimental 94 | 769
Parkinson's disease 94 | 392
Stomach Neoplasms 93 | 300
non primary Sjogren syndrome sicca 93 | 891
Arthritis 89 | 290
Cerebrovascular disease 88 | 238
Atherosclerosis 86 | 291
Hypertensive disease 85 | 292
Asthma 84 | 385
Carcinoma, Hepatocellular 84 | 228
Liver carcinoma 84 | 240
hepatocellular carcinoma 84 | 547
Anemia 82 | 365
spina bifida 82 | 1,074
Melanoma 81 | 711
Liver cancer 80 | 604
Osteoporosis 79 | 363
Endometriosis 78 | 540
Small head 78 | 374
Multiple Sclerosis 76 | 540

Tissue

Endocrine System 1,609 | 18,159
Digestive Tract 1,595 | 17,369
Skin and soft tissues 1,595 | 17,230
Female tissues 1,591 | 17,400
Male tissues 1,591 | 17,142
Nervous System 1,581 | 16,725
Blood and immune system 1,578 | 16,909
Liver and Pancreas 1,578 | 16,750
Urinary Tract 1,577 | 16,678
Respiratory system 1,571 | 16,393
Cardiovascular System 1,524 | 15,192

Target Family

Non-IDG 791 | 12,091
Enzyme 546 | 4,145
Kinase 107 | 634
Epigenetic 82 | 242
Transcription Factor 65 | 1,400
Transporter 29 | 473
GPCR 7 | 408
Nuclear Receptor 7 | 48
Ion Channel 4 | 344
TF/Epigenetic 3 | 38

Compartment GO Term

Catalytic complex 1,641 | 1,641
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Tensin-1 TNS1 Tbio Non-IDG -2.74141 354.5 133
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
Calicin CCIN Tbio Non-IDG -1.20185 15.2 106
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
TFIIA-alpha and beta-like factor GTF2A1L Tbio Non-IDG -0.66901 3.86 222
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.52158 32564.4 32
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519