Development Level

Tbio 1,496 | 11,651
Tdark 216 | 6,593
Tchem 175 | 1,388
Tclin 69 | 612

Collection

RFA-RM-18-021 21 | 328
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 7 | 126
Kinase: IDG Consortium (Target... 7 | 125
GPCR: IDG Consortium (Complete... 3 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 122 | 979
preweaning lethality, incomple... 55 | 499
embryonic lethality prior to t... 51 | 278
abnormal behavior 44 | 298
embryonic lethality prior to o... 37 | 239
decreased total body fat amoun... 32 | 207
abnormal embryo size 30 | 220
abnormal bone structure 28 | 187
decreased body weight 28 | 161
increased lean body mass 27 | 172
hypoactivity 26 | 132
decreased bone mineral content 25 | 151
hyperactivity 25 | 148
decreased vertical activity 24 | 208
decreased bone mineral density 22 | 126
increased mean corpuscular hem... 21 | 96
increased startle reflex 21 | 112
enlarged heart 20 | 210
abnormal lens morphology 19 | 81
cataract 18 | 92
increased circulating alkaline... 18 | 122
increased mean corpuscular vol... 18 | 92
edema 17 | 59
increased bone mineral content 17 | 108
increased total body fat amoun... 17 | 134
decreased circulating choleste... 16 | 93
decreased circulating serum al... 16 | 82
decreased grip strength 16 | 116
abnormal eye morphology 15 | 68
abnormal heart morphology 15 | 162
abnormal sleep behavior 15 | 70
decreased mean corpuscular vol... 15 | 79
increased heart weight 15 | 62
abnormal retina morphology 14 | 71
abnormal seminal vesicle morph... 14 | 114
decreased body length 14 | 101
decreased circulating HDL chol... 14 | 68
decreased lean body mass 14 | 135
increased bone mineral density 14 | 72
short tibia 14 | 97
abnormal kidney morphology 13 | 65
decreased circulating glucose ... 13 | 126
decreased mean corpuscular hem... 13 | 50
decreased circulating LDL chol... 12 | 38
decreased lymphocyte cell numb... 12 | 83
embryonic growth retardation 12 | 106
increased circulating sodium l... 12 | 71
decreased circulating insulin ... 11 | 76
decreased prepulse inhibition 11 | 82
increased or absent threshold ... 11 | 101
abnormal behavioral response t... 10 | 66
abnormal craniofacial morpholo... 10 | 33
abnormal gait 10 | 69
decreased circulating triglyce... 10 | 79
impaired glucose tolerance 10 | 75
cardiovascular system phenotyp... 9 | 36
decreased hemoglobin content 9 | 68
increased circulating chloride... 9 | 41
increased monocyte cell number 9 | 63
small superior vagus ganglion 9 | 74
abnormal neural tube closure 8 | 46
decreased heart weight 8 | 27
prolonged QT interval 8 | 38
abnormal coat appearance 7 | 31
abnormal limb bud morphology 7 | 17
abnormal pericardium morpholog... 7 | 26
abnormal skin morphology 7 | 50
decreased circulating alanine ... 7 | 47
decreased circulating alkaline... 7 | 46
decreased circulating total pr... 7 | 49
decreased fasted circulating g... 7 | 65
improved glucose tolerance 7 | 79
increased blood urea nitrogen ... 7 | 48
increased circulating potassiu... 7 | 29
increased circulating triglyce... 7 | 42
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 47
male infertility 7 | 123
prenatal lethality 7 | 28
thrombocytopenia 7 | 56
tremors 7 | 39
abnormal coat-hair pigmentatio... 6 | 64
abnormal cranium morphology 6 | 36
abnormal epididymis morphology 6 | 42
anophthalmia 6 | 33
decreased caudal vertebrae num... 6 | 53
decreased circulating aspartat... 6 | 34
decreased circulating calcium ... 6 | 36
decreased circulating creatini... 6 | 39
enlarged kidney 6 | 14
enlarged lymph nodes 6 | 37
enlarged spleen 6 | 41
hydrometra 6 | 53
increased circulating total pr... 6 | 28
increased erythrocyte cell num... 6 | 39
increased fasted circulating g... 6 | 76
increased mean corpuscular hem... 6 | 36
limb grasping 6 | 41
pallor 6 | 34
persistence of hyaloid vascula... 6 | 33

Disease

Carcinoma 1,221 | 11,493
ovarian cancer 1,038 | 8,520
osteosarcoma 916 | 7,950
psoriasis 754 | 6,694
glioblastoma 745 | 5,792
medulloblastoma, large-cell 742 | 6,241
atypical teratoid / rhabdoid tumor 613 | 5,112
ependymoma 558 | 4,679
lung cancer 548 | 4,740
Astrocytoma, Pilocytic 440 | 3,081
adult high grade glioma 436 | 3,801
lung carcinoma 399 | 2,843
Breast cancer 393 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 386 | 3,291
invasive ductal carcinoma 382 | 2,951
group 3 medulloblastoma 376 | 4,104
malignant mesothelioma 375 | 3,232
Cancer 372 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 367 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 351 | 2,989
oligodendroglioma 337 | 2,850
non-small cell lung cancer 331 | 2,890
astrocytic glioma 322 | 2,597
pancreatic cancer 322 | 2,398
lung adenocarcinoma 321 | 2,716
primitive neuroectodermal tumor 305 | 3,035
tuberculosis 302 | 2,010
subependymal giant cell astrocytoma 289 | 2,287
Kidney cancer 279 | 2,613
interstitial cystitis 279 | 2,312
diabetes mellitus 268 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 255 | 1,962
Pick disease 253 | 1,894
Autosomal recessive predisposition 240 | 1,442
group 4 medulloblastoma 235 | 1,855
pituitary cancer 231 | 1,972
ulcerative colitis 211 | 1,819
Rheumatoid arthritis 202 | 1,191
ductal carcinoma in situ 198 | 1,745
Multiple myeloma 197 | 1,332
breast carcinoma 190 | 1,638
cystic fibrosis 189 | 1,696
dermatomyositis 179 | 966
juvenile dermatomyositis 174 | 1,187
astrocytoma 166 | 1,146
pediatric high grade glioma 157 | 1,064
Schizophrenia 156 | 1,160
acute quadriplegic myopathy 154 | 1,158
primary pancreatic ductal adenocarcinoma 152 | 1,109
colon cancer 149 | 1,478
cutaneous lupus erythematosus 147 | 1,057
adrenocortical carcinoma 145 | 1,428
Intellectual disability 143 | 1,016
active Crohn's disease 138 | 922
Epilepsy 127 | 792
Alzheimer's disease 119 | 658
spina bifida 119 | 1,074
esophageal adenocarcinoma 114 | 737
Liver Cirrhosis, Experimental 113 | 769
gastric carcinoma 111 | 807
active ulcerative colitis 107 | 764
primary Sjogren syndrome 106 | 735
non primary Sjogren syndrome sicca 104 | 891
Dull intelligence 96 | 645
Low intelligence 96 | 645
Mental Retardation 96 | 645
Mental deficiency 96 | 645
Poor school performance 96 | 645
Seizures 96 | 596
Waldenstrons macroglobulinemia 96 | 765
mucosa-associated lymphoid tissue lymphoma 96 | 484
aldosterone-producing adenoma 95 | 665
Hypersensitivity reaction type II disease 94 | 253
Multiple Sclerosis 94 | 540
nasopharyngeal carcinoma 94 | 1,058
Cognitive delay 92 | 608
Global developmental delay 92 | 608
Mental and motor retardation 92 | 608
Muscle hypotonia 91 | 571
Obesity 91 | 678
Arthritis 90 | 290
Bipolar Disorder 90 | 666
Neurodegenerative disease 90 | 414
Duchenne muscular dystrophy 89 | 601
Melanoma 89 | 711
Atopic dermatitis 86 | 952
Kidney disease 86 | 430
acute myeloid leukemia 85 | 783
Short stature 83 | 531
pancreatic carcinoma 83 | 562
progressive supranuclear palsy 82 | 676
Ankylosing spondylitis 78 | 140
Down syndrome 78 | 499
medulloblastoma 75 | 720
fibroadenoma 74 | 559
Anemia 73 | 365
Liver cancer 73 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 71 | 510
Behcet's disease 70 | 89
Prostatic Neoplasms 70 | 495

Tissue

Endocrine System 1,836 | 18,159
Digestive Tract 1,811 | 17,369
Female tissues 1,804 | 17,400
Skin and soft tissues 1,798 | 17,230
Male tissues 1,787 | 17,142
Blood and immune system 1,786 | 16,909
Nervous System 1,781 | 16,725
Liver and Pancreas 1,780 | 16,750
Urinary Tract 1,774 | 16,678
Respiratory system 1,756 | 16,393
Cardiovascular System 1,667 | 15,192

Target Family

Non-IDG 1,136 | 12,091
Enzyme 555 | 4,145
Transporter 96 | 473
Kinase 60 | 634
Ion Channel 47 | 344
GPCR 40 | 408
Transcription Factor 14 | 1,400
oGPCR 4 | 421
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Bounding membrane of organelle 1,956 | 1,956
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509