Development Level

Tbio 1,250 | 10,625
Tdark 223 | 7,003
Tchem 202 | 1,890
Tclin 54 | 602

Collection

Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 7 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 74 | 633
embryonic lethality prior to t... 31 | 187
abnormal behavior 29 | 226
decreased total body fat amoun... 29 | 186
decreased body weight 27 | 174
decreased bone mineral content 24 | 157
decreased lean body mass 24 | 195
preweaning lethality, incomple... 24 | 260
increased mean corpuscular hem... 22 | 93
decreased bone mineral density 20 | 126
abnormal bone structure 19 | 131
decreased grip strength 19 | 123
hypoactivity 19 | 89
embryonic lethality prior to o... 18 | 148
decreased circulating HDL chol... 17 | 77
decreased circulating choleste... 17 | 85
decreased body length 16 | 108
decreased circulating triglyce... 16 | 83
abnormal lens morphology 15 | 73
decreased mean corpuscular vol... 15 | 50
increased circulating alkaline... 14 | 119
increased mean corpuscular vol... 14 | 91
abnormal retina morphology 13 | 100
hyperactivity 13 | 108
increased bone mineral content 13 | 92
increased lean body mass 13 | 107
decreased prepulse inhibition 12 | 52
increased or absent threshold ... 12 | 128
abnormal bone mineralization 11 | 55
abnormal sleep behavior 11 | 63
cardiovascular system phenotyp... 11 | 35
decreased circulating glucose ... 11 | 121
decreased heart weight 11 | 44
decreased mean corpuscular hem... 11 | 34
abnormal retinal pigmentation 10 | 61
decreased circulating LDL chol... 10 | 37
decreased hemoglobin content 10 | 53
enlarged heart 10 | 111
increased bone mineral density 10 | 52
increased circulating sodium l... 10 | 71
short tibia 10 | 82
decreased circulating alanine ... 9 | 53
decreased circulating serum al... 9 | 79
increased heart weight 9 | 37
abnormal embryo size 8 | 112
abnormal eye morphology 8 | 38
decreased eosinophil cell numb... 8 | 41
increased blood urea nitrogen ... 8 | 44
increased circulating chloride... 8 | 43
increased fasted circulating g... 8 | 68
increased grip strength 8 | 83
abnormal QRS complex 7 | 25
cataract 7 | 26
decreased circulating insulin ... 7 | 75
decreased rib number 7 | 59
decreased vertical activity 7 | 22
impaired glucose tolerance 7 | 52
increased body weight 7 | 42
increased sacral vertebrae num... 7 | 62
increased total body fat amoun... 7 | 57
abnormal kidney morphology 6 | 30
abnormal limb bud morphology 6 | 15
decreased circulating amylase ... 6 | 24
decreased erythrocyte cell num... 6 | 43
decreased fasted circulating g... 6 | 49
decreased lumbar vertebrae num... 6 | 62
decreased mean corpuscular hem... 6 | 19
hydrops fetalis 6 | 22
improved glucose tolerance 6 | 56
increased circulating potassiu... 6 | 31
increased erythrocyte cell num... 6 | 26
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 37
increased startle reflex 6 | 38
male infertility 6 | 62
thrombocytopenia 6 | 46
thrombocytosis 6 | 23
abnormal behavioral response t... 5 | 52
abnormal coat/hair pigmentatio... 5 | 54
abnormal epididymis morphology 5 | 31
abnormal eye size 5 | 11
abnormal gait 5 | 51
decreased CD8-positive, alpha-... 5 | 26
decreased T cell number 5 | 31
decreased caudal vertebrae num... 5 | 49
decreased circulating calcium ... 5 | 33
decreased heart rate variabili... 5 | 11
decreased hematocrit 5 | 25
decreased leukocyte cell numbe... 5 | 54
increased exploration in new e... 5 | 56
abnormal body wall morphology 4 | 7
abnormal coat appearance 4 | 25
abnormal vertebrae morphology 4 | 14
decreased NK T cell number 4 | 28
decreased circulating bilirubi... 4 | 14
decreased circulating potassiu... 4 | 17
enlarged spleen 4 | 26
increased circulating serum al... 4 | 25
increased hematocrit 4 | 36
increased prepulse inhibition 4 | 21

Disease

ovarian cancer 940 | 8,484
osteosarcoma 794 | 7,933
medulloblastoma, large-cell 673 | 6,234
psoriasis 661 | 6,685
glioblastoma 646 | 5,572
atypical teratoid / rhabdoid tumor 497 | 4,369
lung cancer 445 | 4,466
pilocytic astrocytoma 380 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 345 | 3,289
invasive ductal carcinoma 331 | 2,950
lung carcinoma 331 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 322 | 2,956
Cancer 314 | 2,346
oligodendroglioma 310 | 2,849
pediatric high grade glioma 308 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 303 | 2,988
malignant mesothelioma 303 | 3,162
Breast cancer 293 | 3,094
primitive neuroectodermal tumor 283 | 3,031
pancreatic cancer 279 | 2,300
ependymoma 265 | 2,514
lung adenocarcinoma 265 | 2,713
non-small cell lung cancer 256 | 2,798
subependymal giant cell astrocytoma 249 | 2,287
astrocytic glioma 242 | 2,241
Pick disease 238 | 1,893
diabetes mellitus 233 | 1,663
adult high grade glioma 221 | 2,148
interstitial cystitis 219 | 2,299
pituitary cancer 213 | 1,972
astrocytoma 207 | 1,493
group 4 medulloblastoma 205 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 204 | 1,795
ulcerative colitis 201 | 2,087
Carcinoma 198 | 2,147
posterior fossa group A ependymoma 183 | 1,511
tuberculosis 183 | 1,557
Multiple myeloma 179 | 1,327
Rheumatoid Arthritis 178 | 1,160
ductal carcinoma in situ 174 | 1,745
cystic fibrosis 164 | 1,665
group 3 medulloblastoma 162 | 2,254
breast carcinoma 161 | 1,614
medulloblastoma 158 | 1,524
juvenile dermatomyositis 156 | 1,189
primary pancreatic ductal adenocarcinoma 155 | 1,271
posterior fossa group B ependymoma 151 | 1,530
sonic hedgehog group medulloblastoma 142 | 1,482
acute quadriplegic myopathy 132 | 1,157
adrenocortical carcinoma 128 | 1,427
colon cancer 126 | 1,475
dermatomyositis 123 | 933
active Crohn's disease 119 | 918
cutaneous lupus erythematosus 114 | 1,056
spina bifida 111 | 1,064
atypical teratoid/rhabdoid tumor 105 | 1,095
Alzheimer's disease 103 | 644
gastric carcinoma 96 | 832
esophageal adenocarcinoma 95 | 737
primary Sjogren syndrome 94 | 789
aldosterone-producing adenoma 89 | 664
Neurodegenerative disease 85 | 383
Hypersensitivity reaction type II disease 84 | 235
non primary Sjogren syndrome sicca 81 | 840
progressive supranuclear palsy 81 | 674
Arthritis 77 | 248
Obesity 77 | 616
Waldenstrons macroglobulinemia 77 | 765
pancreatic carcinoma 77 | 567
Ankylosing spondylitis 76 | 138
Intellectual disability 76 | 573
Atopic dermatitis 74 | 944
Multiple Sclerosis 74 | 498
nasopharyngeal carcinoma 74 | 1,056
acute myeloid leukemia 72 | 780
Down syndrome 71 | 548
fibroadenoma 71 | 557
Schizophrenia 70 | 501
Kidney disease 69 | 396
tuberculosis and treatment for 6 months 69 | 686
IGA Glomerulonephritis 68 | 454
Duchenne muscular dystrophy 67 | 602
mucosa-associated lymphoid tissue lymphoma 65 | 480
Acquired immunodeficiency syndrome 64 | 164
Juvenile rheumatoid arthritis 62 | 104
Uveitis 61 | 103
hereditary spastic paraplegia 60 | 313
hepatocellular carcinoma 59 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 58 | 499
active ulcerative colitis 57 | 477
Behcet's disease 56 | 74
Prostatic Neoplasms 56 | 471
Parkinson's disease 54 | 364
Amyotrophic Lateral Sclerosis 53 | 431
Psoriatic arthritis 53 | 83
gastric cancer 53 | 430
Liver disease 52 | 219
Anemia 48 | 252
Epilepsy 48 | 346
Polycystic Ovary Syndrome 45 | 332

Tissue

Nervous System 1,642 | 18,561
Digestive Tract 1,635 | 18,473
Endocrine System 1,634 | 18,512
Female tissues 1,633 | 18,647
Liver and Pancreas 1,631 | 18,136
Urinary Tract 1,630 | 18,444
Cardiovascular System 1,627 | 17,958
Male tissues 1,625 | 17,969
Blood and immune system 1,623 | 17,995
Skin and soft tissues 1,613 | 18,115
Respiratory system 1,608 | 17,484

Target Family

Non-IDG 995 | 11,971
Enzyme 510 | 4,146
Transporter 88 | 473
Kinase 57 | 634
Ion Channel 40 | 341
GPCR 23 | 406
Transcription Factor 12 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Bounding membrane of organelle 1,729 | 1,729
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Vacuolar ATPase assembly integral membrane protein VMA21 VMA21 Tbio Enzyme 1.00 53