Development Level

Tbio 90 | 10,625
Tdark 10 | 7,003
Tchem 7 | 1,890

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavior 5 | 226
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating insulin ... 2 | 75
decreased effector memory CD8-... 2 | 24
decreased grip strength 2 | 123
hyperactivity 2 | 108
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cervical vertebrae mo... 1 | 4
abnormal coat appearance 1 | 25
abnormal craniofacial morpholo... 1 | 12
abnormal ear morphology 1 | 5
abnormal embryo size 1 | 112
abnormal forebrain morphology 1 | 4
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cyanosis 1 | 6
decreased body weight 1 | 174
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart rate 1 | 10
decreased mature B cell number 1 | 25
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged uterus 1 | 3
hemorrhage 1 | 12
hydrometra 1 | 13
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
increased CD8-positive, naive ... 1 | 3
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating insulin ... 1 | 2
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased grip strength 1 | 83
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
increased transitional stage T... 1 | 1
male infertility 1 | 62
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened QRS complex duration 1 | 1
shortened RR interval 1 | 19
small superior vagus ganglion 1 | 20
small testis 1 | 37

Disease

ovarian cancer 66 | 8,492
osteosarcoma 51 | 7,933
psoriasis 50 | 6,685
medulloblastoma, large-cell 47 | 6,234
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
glioblastoma 37 | 5,572
non-small cell lung cancer 36 | 2,798
atypical teratoid / rhabdoid tumor 35 | 4,369
interstitial cystitis 35 | 2,299
Breast cancer 32 | 3,099
invasive ductal carcinoma 32 | 2,950
lung adenocarcinoma 30 | 2,714
lung cancer 30 | 4,473
pancreatic cancer 28 | 2,300
ductal carcinoma in situ 27 | 1,745
lung carcinoma 25 | 2,844
spina bifida 23 | 1,064
Cancer 22 | 2,346
Carcinoma 22 | 2,147
primitive neuroectodermal tumor 22 | 3,031
subependymal giant cell astrocytoma 22 | 2,287
pilocytic astrocytoma 21 | 3,086
pituitary cancer 20 | 1,972
group 4 medulloblastoma 19 | 1,875
malignant mesothelioma 19 | 3,163
oligodendroglioma 19 | 2,849
pediatric high grade glioma 19 | 2,712
astrocytic glioma 18 | 2,241
ulcerative colitis 18 | 2,087
ependymoma 17 | 2,514
primary pancreatic ductal adenocarcinoma 17 | 1,271
breast carcinoma 16 | 1,614
cystic fibrosis 15 | 1,670
posterior fossa group B ependymoma 15 | 1,530
active Crohn's disease 14 | 918
medulloblastoma 14 | 1,524
adult high grade glioma 12 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Down syndrome 11 | 548
Pick disease 11 | 1,893
Prostatic Neoplasms 11 | 471
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
Atopic dermatitis 10 | 944
posterior fossa group A ependymoma 10 | 1,511
adrenocortical carcinoma 8 | 1,427
astrocytoma 8 | 1,493
atypical teratoid/rhabdoid tumor 8 | 1,095
colon cancer 8 | 1,475
group 3 medulloblastoma 8 | 2,254
juvenile dermatomyositis 8 | 1,189
sonic hedgehog group medulloblastoma 8 | 1,482
Inflammatory bowel disease 7 | 142
Kidney disease 7 | 397
Mammary Neoplasms 7 | 410
active ulcerative colitis 7 | 477
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 967
diabetes mellitus 7 | 1,663
tuberculosis 7 | 1,563
urothelial carcinoma 7 | 318
acute quadriplegic myopathy 6 | 1,157
aldosterone-producing adenoma 6 | 664
non primary Sjogren syndrome sicca 6 | 840
primary Sjogren syndrome 6 | 789
progressive supranuclear palsy 6 | 674
Cerebrovascular disease 5 | 231
Colorectal Neoplasms 5 | 217
Duchenne muscular dystrophy 5 | 602
Endometriosis 5 | 535
Multiple myeloma 5 | 1,328
Muscle Weakness 5 | 92
Retinitis pigmentosa 5 | 156
acute myeloid leukemia 5 | 785
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 557
interstitial lung disease 5 | 292
nephrosclerosis 5 | 329
periodontitis 5 | 269
Adenoma 4 | 165
Alzheimer's disease 4 | 644
Animal Mammary Neoplasms 4 | 136
Autistic Disorder 4 | 320
Barrett's esophagus 4 | 185
Cholestasis 4 | 93
Diabetic Retinopathy 4 | 53
Leber congenital amaurosis 4 | 72
Multiple Sclerosis 4 | 498
Obesity 4 | 616
Osteoporosis 4 | 259
Polycystic Ovary Syndrome 4 | 335
Prostate cancer 4 | 172
Rheumatoid Arthritis 4 | 1,171
Schizophrenia 4 | 503
Stomach Neoplasms 4 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
sarcoidosis 4 | 368

Tissue

Digestive Tract 105 | 18,473
Endocrine System 105 | 18,512
Female tissues 105 | 18,647
Nervous System 105 | 18,561
Liver and Pancreas 104 | 18,136
Skin and soft tissues 104 | 18,115
Urinary Tract 104 | 18,444
Respiratory system 103 | 17,484
Blood and immune system 102 | 17,995
Cardiovascular System 102 | 17,958
Male tissues 102 | 17,969

Target Family

Non-IDG 91 | 11,969
Enzyme 11 | 4,146
Kinase 3 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Compartment GO Term

Bicellular tight junction 107 | 107
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.34433 25.0 58
Rho GTPase-activating protein 17 ARHGAP17 Tbio Enzyme -1.80007 60.0 111
Epithelial cell adhesion molecule EPCAM Tbio Non-IDG -3.16288 1470.6 1441
Protein lin-7 homolog C LIN7C Tbio Non-IDG -1.00151 10.5 97
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.52265 31.6 171
Ras-related protein Rap-2c RAP2C Tbio Enzyme -0.44605 2.90 92
Protein LYRIC MTDH Tbio Non-IDG -2.55932 379.1 228
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.89186 64.6 443
Partitioning defective 6 homolog beta PARD6B Tbio Non-IDG -0.82013 5.86 101
Partitioning defective 6 homolog gamma PARD6G Tbio Non-IDG -0.39051 2.62 59