Development Level

Tbio 90 | 10,625
Tdark 10 | 7,003
Tchem 7 | 1,890

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
abnormal behavior 5 | 226
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating insulin ... 2 | 75
decreased effector memory CD8-... 2 | 24
decreased grip strength 2 | 123
hyperactivity 2 | 108
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cervical vertebrae mo... 1 | 4
abnormal coat appearance 1 | 25
abnormal craniofacial morpholo... 1 | 12
abnormal ear morphology 1 | 5
abnormal embryo size 1 | 112
abnormal forebrain morphology 1 | 4
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cyanosis 1 | 6
decreased body weight 1 | 174
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart rate 1 | 10
decreased mature B cell number 1 | 25
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged uterus 1 | 3
hemorrhage 1 | 12
hydrometra 1 | 13
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
increased CD8-positive, naive ... 1 | 3
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating insulin ... 1 | 2
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased grip strength 1 | 83
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
increased transitional stage T... 1 | 1
male infertility 1 | 62
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened QRS complex duration 1 | 1
shortened RR interval 1 | 19
small superior vagus ganglion 1 | 20
small testis 1 | 37

Disease

ovarian cancer 66 | 8,491
osteosarcoma 51 | 7,933
psoriasis 50 | 6,685
medulloblastoma, large-cell 47 | 6,234
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
glioblastoma 37 | 5,572
non-small cell lung cancer 36 | 2,798
atypical teratoid / rhabdoid tumor 35 | 4,369
interstitial cystitis 35 | 2,299
Breast cancer 32 | 3,098
invasive ductal carcinoma 32 | 2,950
lung adenocarcinoma 30 | 2,714
lung cancer 30 | 4,473
pancreatic cancer 28 | 2,300
ductal carcinoma in situ 27 | 1,745
lung carcinoma 25 | 2,844
spina bifida 23 | 1,064
Cancer 22 | 2,346
Carcinoma 22 | 2,147
primitive neuroectodermal tumor 22 | 3,031
subependymal giant cell astrocytoma 22 | 2,287
pilocytic astrocytoma 21 | 3,086
pituitary cancer 20 | 1,972
group 4 medulloblastoma 19 | 1,875
malignant mesothelioma 19 | 3,163
oligodendroglioma 19 | 2,849
pediatric high grade glioma 19 | 2,712
astrocytic glioma 18 | 2,241
ulcerative colitis 18 | 2,087
ependymoma 17 | 2,514
primary pancreatic ductal adenocarcinoma 17 | 1,271
breast carcinoma 16 | 1,614
cystic fibrosis 15 | 1,670
posterior fossa group B ependymoma 15 | 1,530
active Crohn's disease 14 | 918
medulloblastoma 14 | 1,524
adult high grade glioma 12 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Down syndrome 11 | 548
Pick disease 11 | 1,893
Prostatic Neoplasms 11 | 471
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
Atopic dermatitis 10 | 944
posterior fossa group A ependymoma 10 | 1,511
adrenocortical carcinoma 8 | 1,427
astrocytoma 8 | 1,493
atypical teratoid/rhabdoid tumor 8 | 1,095
colon cancer 8 | 1,475
group 3 medulloblastoma 8 | 2,254
juvenile dermatomyositis 8 | 1,189
sonic hedgehog group medulloblastoma 8 | 1,482
Inflammatory bowel disease 7 | 142
Kidney disease 7 | 397
Mammary Neoplasms 7 | 410
active ulcerative colitis 7 | 477
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 966
diabetes mellitus 7 | 1,663
tuberculosis 7 | 1,563
urothelial carcinoma 7 | 318
acute quadriplegic myopathy 6 | 1,157
aldosterone-producing adenoma 6 | 664
non primary Sjogren syndrome sicca 6 | 840
primary Sjogren syndrome 6 | 788
progressive supranuclear palsy 6 | 674
Cerebrovascular disease 5 | 231
Colorectal Neoplasms 5 | 217
Duchenne muscular dystrophy 5 | 602
Endometriosis 5 | 535
Multiple myeloma 5 | 1,327
Muscle Weakness 5 | 92
Retinitis pigmentosa 5 | 156
acute myeloid leukemia 5 | 785
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 557
interstitial lung disease 5 | 292
nephrosclerosis 5 | 329
periodontitis 5 | 269
Adenoma 4 | 165
Alzheimer's disease 4 | 644
Animal Mammary Neoplasms 4 | 135
Autistic Disorder 4 | 320
Barrett's esophagus 4 | 185
Cholestasis 4 | 93
Diabetic Retinopathy 4 | 53
Leber congenital amaurosis 4 | 72
Multiple Sclerosis 4 | 498
Obesity 4 | 616
Osteoporosis 4 | 259
Polycystic Ovary Syndrome 4 | 334
Prostate cancer 4 | 172
Rheumatoid Arthritis 4 | 1,170
Schizophrenia 4 | 503
Stomach Neoplasms 4 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
sarcoidosis 4 | 368

Tissue

Digestive Tract 105 | 18,472
Endocrine System 105 | 18,511
Female tissues 105 | 18,646
Nervous System 105 | 18,560
Liver and Pancreas 104 | 18,135
Skin and soft tissues 104 | 18,114
Urinary Tract 104 | 18,443
Respiratory system 103 | 17,483
Blood and immune system 102 | 17,994
Cardiovascular System 102 | 17,957
Male tissues 102 | 17,968

Target Family

Non-IDG 91 | 11,969
Enzyme 11 | 4,146
Kinase 3 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Compartment GO Term

Bicellular tight junction 107 | 107
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Protein POF1B POF1B Tbio Non-IDG -0.75369 6.14 60
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 MAGI3 Tbio Enzyme -1.19156 16.8 33
Cingulin-like protein 1 CGNL1 Tbio Non-IDG -0.82235 7.70 53
Ras-related protein Rab-13 RAB13 Tbio Enzyme -1.38773 26.2 55
Blood vessel epicardial substance BVES Tbio Non-IDG -1.46714 36.1 156
Junctional adhesion molecule-like JAML Tbio Non-IDG -1.64347 42.3 170
TNF receptor-associated factor 4 TRAF4 Tbio Non-IDG -1.61714 49.8 213
Claudin-18 CLDN18 Tchem Non-IDG -1.57275 38.7 120
Claudin-9 CLDN9 Tbio Non-IDG -0.87632 6.84 58